RU2075313C1 - Agent and method of treatment of patients with malignant tumor - Google Patents

Abstract

FIELD: medicine, oncology. SUBSTANCE: method involves the use of preparations prepared of vegetable oils - flax, sunflower, sesame, soybean or other food oils. Before use the oily base is mixed with emulsifying agent - ethanol. Oil mixture is determined by the required iodine number taken at the range from 120 to 170. Preparation is prescribed 3 times per a day before eating at the dose 30-50 ml, 15-30 min before eating for 7-12 days every day; intervals between dosing are 3-6 days, total course - 5-6. Treatment can be repeated if necessary after 3-4 weeks, not early. Internal use of preparation is combined with its external oily base applications. Preparations were used for treatment of malignant oncological diseases. EFFECT: enhanced effectiveness of treatment. 5 cl, 3 tbl

Description

 The present invention relates to medicine, in particular to the treatment of pathological processes associated with serious impairment of system functions and metabolic disorders of the body, including those caused by malignant growth.

 It is known to use for the treatment of neoplastic diseases of organs and tissues of the body a wide variety of medicines, chemotherapy and radiation therapy. In particular, in traditional medicine, with the unreliable and variable success, for the treatment of malignant diseases, preparations of vegetable oils, in particular sea buckthorn oil, were used (see Mashkovsky M.D. Medicines, 1987, v. 1, p. 515).

 The use of various types of cancer of the stomach, intestines, lungs, female genital area and other oils is known, but the lack of reliable success has not led to the practical use of these funds in official medicine.

 As a result of lengthy scientific and practical research of drugs and the experience of traditional medicine on the use of natural vegetable oils for therapeutic purposes in oncological diseases, a drug and a method for its use have been developed, which are partially reflected in the materials of the central press (Narodnaya Gazeta, 1993 June 17, July 29).

 The aim of the invention is to find an effective drug for the treatment of malignant neoplasms, possibly effective for other severe pathologies affecting the metabolism and basic functions and systems of the body.

 This goal is achieved by the fact that the developed medicinal product consists of a base of raw vegetable oils from the group of flaxseed, sunflower, sesame, soya, taken separately or in ratios determined by the iodine number of the oil base in the range from 120 to 190, and an ethyl alcohol emulsifier at a fortress 40-96% constituting to the volume of the oil base 100-40 wt. moreover, the oil base and emulsifier are mixed immediately before use. As an oil base, in particular, unrefined sunflower oil is used, and as an emulsifier, 40% ethyl alcohol in a 1: 1 ratio.

 Raw linseed oil and equal amounts of raw sunflower oil can be used as the oil base.

 As an oil base, only raw linseed oil can be used.

 The drug is prescribed in courses 3 times a day on an empty stomach 15-30 minutes before meals for 7-12 days daily, with breaks between courses of 3-6 days, with a total number of courses of 3-5 with the resumption of treatment if necessary no earlier than 3- 4 weeks.

 A feature of the use of a medicinal product is the possibility of combining internal use with external applications of its oil base.

 To obtain the drug, flaxseed, sunflower, sesame, and soybean oils are commercially available and manufactured by the food industry. However, the quality of these oils is subject to a mandatory requirement that they contain no more than 15-20% saturated fatty acids. This requirement is ensured by the use of so-called crude oils, not refined, not subjected to hydrogenation or excessive heat treatment.

 The controlled ingredients of the drug are the oleic, linoleic, linolenic acids in the oil base. Another distinctive feature of the preparation of the drug is the use of its ex tempore, that is, the need for two components: an oil base and an emulsifier, ethyl alcohol is used as the latter.

 Thus, the preparation technology of the drug is relatively simple. The drug has a strict control of the content of unsaturated fatty acids, the ratio of oleic, linoleic, linolenic acids and the amount of ethyl alcohol. The remaining ingredients of the oil base, including phospholipids, potassium, calcium and iron salts, can be represented in the preparation in greater or lesser amounts by using a specific type of oil (for example, to increase the amount of potassium ions, it is advisable to introduce linseed oil to eliminate the undesirable effect of ions potassium on the heart of sunflower, etc.). However, in all cases, regardless of the composition of specific types of oils in the oil base, all components included in the preparation are food products and are completely safe.

 The apparent simplicity of the proposed drug is far from obvious to a specialist in this field, since it is even considered inappropriate to appoint significant doses of ethyl alcohol to cancer patients, as well as doctors' confidence in the uselessness of vegetable oils in oncology. Vegetable oils are completely discredited by the chaotic use in folk medicine, and any serious treatment of them as a means of choice for the treatment of malignant tumors seems to be frivolous for most oncologists. Moreover, in the scientific literature, the opinion is expressed that an increase in the proportion of unsaturated fatty acids of vegetable oils in the diet of more than 10 g per day leads to the development of a number of oncological diseases (see I. Skurikhin, ed. Chemical composition of food products, M. 1987 , book 2, p. 14).

 Under conditions when the mechanisms of action associated with the exchange of fatty acids in pathologically altered tissues and organs, their relationship with the membrane structures of a pathological cell, the effect of membrane lipid peroxidation on the reaction, etc., have not yet been fully disclosed. apparently, all the same, the decisive argument should be the proven reliable efficacy of the drug in practice.

 In any case, the non-obviousness of the use of the proposed drug for the effective treatment of malignant tumors is confirmed by the achievement of completely unexpected and outstanding results in reducing treatment time and the complete elimination of metastatic foci even with advanced stages of cancer of various organs and tissues. Further accumulation of experience with the use of the drug will clearly determine all the pathophysiological effects that occur during this.

 The clinical feasibility of using the drug is illustrated by the following specific examples of its use.

 Example 1. Patient Ganina L.N. 75 years (medical history N 2674, PMC RF) has been observed since 1940 in the annual medical examination. Diagnosis: stage II hypertension. IHD, angina pectoris, atherosclerotic cardiosclerosis.

 According to gastroduodenoscopy (March 1993) and biopsy data, polypoid (?) Cancer of the stomach and an infiltrative ulcer were established.

 The patient was offered urgent surgical treatment.

 The patient refused surgical treatment due to the general condition.

 The patient was prescribed treatment with a medicinal product based on vegetable oils with an emulsifier.

 The preparation was a mixture of 40 ml of raw linseed oil, which included 20% oleic. 30% linoleic, 40% linolenic, 10% saturated fatty acids (palmitic, stearic, myristic, etc.) and 40 ml of 40% ethyl alcohol. Alcohol was mixed with an oil base immediately before administration.

 The patient took the drug 3 times a day on an empty stomach 15 minutes before eating. The drug has an unpleasant taste, however, the patient was not allowed to seize and drink it with anything. The course of treatment was 10 days in a row, then 5 days off, then another 10 days. At the beginning, the patient noted the appearance and intensification of pain in the epigastric region, which passed after 2 days without any additional treatment. The first two weeks the patient used antihypertensive drugs. After the indicated courses of treatment, the patient showed signs of chronic gastritis, however, treatment with the drug based on vegetable oils with an emulsifier continued, but his dose was reduced to 30 ml of oil base and 30 ml of 40% ethyl alcohol.

 Esophagogastroduodenoscopy data dated May 25, 1993: in the lumen of the stomach, mucus and fluid stained with bile, folds of the stomach of medium size, elastic, peristalsis cf. waves. Mucous membrane of the stomach: areas of hyperemia and atrophy of the mucosa alternate. In the antrum, hyperemia in the form of spots. The gatekeeper yawns, bile reflux. The duodenal bulb is not changed. Postbulbar department without features. Conclusion: chronic gastritis, duodeno-gastric reflux.

 On her own initiative, the patient underwent an additional examination six months later in another medical institution. The diagnosis of the same chronic gastritis.

 Example 2. Patient Sedov P.P. 63 g. Medical history of the Moscow Regional Oncology Center B-4210.

 05/05/93 was discharged with a diagnosis of central cancer n / a right lung of the 4th stage with metastases to the mediastinal lymph nodes.

 The diagnosis was made in the clinic on the basis of x-rays, the results of bronchoscopy with a biopsy (twice).

 Histologically: from 6.04.93 (2418/93) "squamous non-keratinizing cancer".

 Cytological examination from 6.04.93 4888-9 / 93. In the smear imprint of the upper lobar bronchus on the right is a cytogram of low-grade cancer.

 X-ray conclusion: in area C6, thickening of the pulmonary pattern. On the tomogram, the posterior-zonal bronchus is amputated by dense peribronchial tissues.

 Bronchoscopically: B6 lumen on the right is obstructed by an exophytic tumor. Tumor infiltration spreads to 2/3 of the main bronchus.

 Due to the prevalence of the process, surgical treatment is not indicated, the patient was discharged under the supervision of an oncologist at the place of residence.

 No special treatment was given to the patient.

 From 12.06.93, the patient began to take 40 ml of raw flaxseed oil with 30 ml of 40% ethyl alcohol 3 times a day for 15-20 minutes before eating, mixed immediately before use. After 10 days, with a significant improvement, he began to get up, and the cough decreased. Take a five-day break. Given the significant improvement in general condition, in the next course, the dose is reduced to 30 ml of oil and 30 ml of alcohol, then again a five-day break and another repetition of the same day-long course.

 X-ray conclusion from 08.39.93: on the control x-ray, a certain decrease (such is the terminology of the radiologist) of the process in the resorption stage. The sinuses are free.

 After a three-week break, treatment was continued with a mixture of 20 ml of raw linseed oil and 20 ml of unrefined sunflower oil with 30 ml of 40% ethyl alcohol also 3 times a day before meals for 15-20 minutes. Such treatment was carried out three times for 10 days with five-day breaks between courses.

 Subjectively, the patient felt almost healthy.

 X-ray from 8.10.93 residual effects of chronic pneumonia.

 At a special request from the Russian Medical University, the histological preparation was revised on 10/28/93.

 Diagnosis: "squamous non-keratinizing bronchial cancer."

 Example 3. Patient Tikhonova E.I. 56 l. case history of VA-702 at the Herzen Institute of Oncology: was constantly observed in the 2nd oncology dispensary of the Frunze district of Moscow.

 For the first time, the diagnosis was made at the Moscow mammological center "cancer of the right breast" in early 1992. The patient was unsuccessfully treated with herbs at her discretion.

 According to the official conclusion of the 2nd Oncological Dispensary of August 10, 1993, "Cancer of the right breast T4 H3 MO, polychemotherapy was proposed in 62 hospitals in Moscow.

Objectively during the inspection 11.08.93:
The right mammary gland is enlarged. solid. dark red with a fully retracted nipple. The skin is not broken. The supraclavicular, subclavian, axillary lymph nodes on the right and left are enlarged, dense, sometimes in the form of conglomerates; the right hand from the shoulder joint to the hand is swollen, about 1.5 times larger in volume compared to the left.

 The diagnosis was confirmed histologically by biopsy of the tumor and cervical lymph node.

 On August 12, 1993, she began to ingest a mixture of 20 ml of raw flaxseed oil, 20 ml of unrefined sunflower oil and 30 ml of 40% ethyl alcohol three times a day, about half an hour before meals. The first 5 days, both the tumor and the lymph nodes increased in size, swollen, noted the appearance of lumbar pain (previously not). By the tenth day, the size of the tumor and lymph nodes are smaller than the original ones, the breast tumor along the edges and lymph nodes became softer, tingling pains, itching. On days 8, 9 and 10, there were shooting pains in the left chest (previously not noted). Swelling of the right arm decreased. After a five-day break, treatment was resumed according to the previous scheme.

 After the third course, the right mammary gland is soft, the code above it is of normal color, the nipple is in the normal position. Some swelling of the right arm in the elbow. The lymph nodes remain somewhat enlarged mainly in the left axillary cavity. The dynamics of the restoration of the external skin over the right gland is interesting: at first the skin “turned pink” on the periphery of the tumor in the form of a border about 1 cm wide, the patient noted an increase in itching in this place, then the skin took on a normal appearance, the border moved closer to the nipple.

 After the third course, the dose is reduced to 15 ml of linseed and 15 ml of sunflower oil with 30 ml of 40% ethyl alcohol.

 After the fourth course, the patient was examined at the Research Institute of Diagnostics and Surgery on 10/06/93. In the depths of the right mammary gland, soft tissue formation of an obscure nature was found. Lymph nodes without features (medical history MNIIDiH 6279/73).

 Currently, the clinical study of the effectiveness of various compositions of the oil base is ongoing, depending on the location of the primary tumor and previously used treatment methods, and only patients in the fourth stage of the disease are examined, when the possibilities of traditional methods of treatment are exhausted or when the diagnosis is made for the first time, but in the fourth stage, with which oncologists no longer consider it appropriate to conduct conventional therapy.

 Below are the observational data for only two locations with primary malignant lesions of the lungs and mammary gland. All patients observed were with the fourth stage of the disease, as a rule they were in serious condition (most of them were bedridden, in need of outside care), had metastases, etc., typical manifestations.

 The results are presented in table. one.

 The presented first data on the application of the invention suggests that even with all the shortcomings of the recognition of the disease too late and the already unsuccessful attempts at its traditional treatment, it was possible to at least prolong life without worsening the condition, and in some cases improve, and maybe cure, about 50% of patients , which can hardly be explained by a coincidence.

 Further accumulation of experience will allow us to better select the composition of the oil base, depending on the location of the primary tumor, previous treatment or its complete absence. Available data allow us to conclude the feasibility of a differentiated approach to such patients (see tab. 2, 3).

 Higher treatment efficacy was observed in groups of patients not exposed to radiation and chemotherapy, after extensive resections of the gastrointestinal tract and cholecystectomy. Perhaps this is due to some decrease in immunity from such a massive and, as a rule, long-term therapy.

 Depending on the location of the tumor and stage of the disease, drugs with different iodine numbers are preferred.

 The oil base of the drug immediately before use is mixed with an emulsifier until a homogeneous mass is obtained and taken orally 15-30 minutes before meals 3 times a day.

It is not recommended to drink or seize the drug immediately after administration; do not light; after 15-20 minutes, even with a complete lack of appetite, it is advisable to eat something. In case of vomiting at the first intake of the drug, repeated administration of the drug is not performed until the next meal
The drug is prescribed in courses in an oil-based dose of 30-50 ml per reception for 7-12 days daily, with breaks between courses of 3-6 days, with a total number of courses of 3-5, with the resumption of treatment if necessary not earlier than after 3- 4 weeks.

 The dose of the drug and its choice is determined by the doctor depending on the general condition of the patient, the location of the primary tumor, the presence of metastases, previous treatment. The best results are obtained in the absence of chemotherapeutic or surgical intervention. Unauthorized change in the dose to patients, both in the direction of increasing and decreasing the drug is not allowed.

 As a rule, treatment is carried out already when the patient is aware of his diagnosis, the patient realizes that this is his last chance and treats the treatment with great responsibility. It is recommended to take the drug during the day at approximately the same time.

 The internal use of the drug, if necessary, is combined with the external applications of its oil base.

 It is not recommended to combine the use of the drug with any other methods of treating malignant neoplasms.

 If necessary, detoxification therapy, painkillers, sleeping pills, diuretics, and other symptomatic treatment are allowed, but such treatment is usually required in patients who have already been treated before the use of drugs. Subsequently, the need for any additional treatment disappears. Including reduce the dose and gradually completely stop the drug, if they were used.

Claims (4)

 1. An agent for treating patients with a malignant tumor, containing vegetable oil and an ethyl alcohol emulsifier, characterized in that raw linseed, or sunflower, or sesame, or soya, or a mixture thereof with an iodine number of 120 to 190, is used as a vegetable oil mixed with 40 96% ethanol, in the following ratio, wt.h. Vegetable oil: raw linseed, or sunflower, or sesame, or soya, or a mixture thereof with an iodine number from 120 to 190 100
Emulsifier: Ethyl alcohol 40 96% 100 40
2. The tool according to p. 1, characterized in that as a vegetable oil use unrefined sunflower oil, and as an emulsifier 40% ethyl alcohol in a ratio of 1 to 1.  3. The tool according to p. 1, characterized in that as a vegetable oil use a mixture of raw linseed oil and raw sunflower oil, taken in equal quantities.  4. The tool according to p. 1, characterized in that the quality of the vegetable oil is used raw linseed oil.  5. A method of treating patients with a malignant tumor by administering an agent that is a mixture of vegetable oil and alcohol, characterized in that the mixture according to claim 1 is used, which is prepared before use and is administered in courses at a dose of 30 ml of oil 3 times a day for 15 30 minutes before meals for 7 to 12 days daily with breaks between courses of 3 to 6 days with a total number of courses of 3 to 5 with the resumption of treatment if necessary not earlier than after 3 to 4 weeks.

Images