RU2073521C1 - Agent for ventricular extrasystolia treatment - Google Patents

Abstract

FIELD: medicine, phytotherapy. SUBSTANCE: agent has the following components, p. p.: hawthorn fruits 1; catchfly tatarica or drooping 1; valerian roots with rhizomes 1, and 40% ethanol 12. Agent is used for prophylaxis of heart ischemic disease. EFFECT: enhanced effectiveness, simplified method of preparing, decreased cost.

Description

 The invention relates to medicine, namely to phytotherapeutic agents for the treatment and prophylaxis of coronary heart disease (CHD), used independently, as well as in combination with anti-inflammatory, antispasmodic, coronary expansion, non-specific immunocorrection therapy and physiotherapy.

 The tool has antiarrhythmic, coronary expansion, cardiotonic, antispasmodic, sedative activity.

 It is known to use herbal remedies used for a similar purpose, for example, cardiotonic glycosides of strophanthus, digitalis, adonis, lily of the valley, aymalia, quinidine, pulsorm, and some others (1). Many of these drugs, for example quinidine, aymalin, pulsnorm, and strophanthus preparations, are imported. They are scarce and expensive. Their production has a rather complicated technology, requiring special equipment and apparatus, a large number of solvents and reagents, as well as specially trained personnel of technologists and engineers. Many of these drugs are quite toxic, for example, pulsnorm can cause nausea, vomiting, pain in the epigastric region, loss of appetite, etc. Their therapeutic range is not too wide (1).

 Currently, the use of plant charges is recommended (2, 3). When compiling the collection, not only therapeutic factors are taken into account, but also the possible influence of the components of the collection on each other. Moreover, this influence can be diverse. Several plants can be introduced into the collection, some of which determine the main effect, others can enhance it or adjust in a more desirable direction, and still others will give the collection other effects and improve their organoleptic characteristics. Therefore, the preparation of fees is a task feasible only for specialists of a high level of appropriate professional training.

The basis of the invention is the creation of such a drug for the treatment and prevention of coronary heart disease with aggravating ventricular rhythm changes, which would be highly effective, had no undesirable side effects, was easy to manufacture even at home, and contained components that were affordable and inexpensive. The problem is solved in that the claimed tool is prepared on the basis of a drug collection having the following composition, wt. h:
Hawthorn fruits I
Grass of a drooping or Tatar I
Rhizome with valerian roots I
Ethyl alcohol 40% to obtain 15 hours of tincture.

 The tool is asked to assign the name "Beautiful".

 All components of the collection are not potent, do not have contraindications in therapeutic doses. The latter, with a single or daily intake, do not exceed the norms. The components of the collection are easily accessible, they can be processed in normal conditions. All plants are harvested at the optimum harvest time. The layout of the collection, preparation of the drug, treatment of patients was carried out by specialists with special education and extensive experience. The tool was prepared as follows. Components of the collection: grass of the tar, the rhizome with the roots of valerian was ground to a particle size of not more than 7 mm. The fruits of hawthorn were used entirely (4). Considering that the expected therapeutic effect is determined mainly by such chemical compounds as phytoecdysteroids, flavonoids, phenolcarboxylic acids, essential oils, saponins, they were extracted with 40% alcohol as follows: 50 g of the collection were filled with 100 g of 40% alcohol, insisted on for 3 days, after which the raw materials were squeezed out, 100 g of 40% alcohol were added, insisted for 1 day, the raw materials were squeezed out and 100 g of 40% alcohol were poured again. After daily infusion, the raw materials were squeezed, the extraction was combined. Received 250 ml of tincture, which was filtered through a paper filter (can be through a ball of cotton wool or gauze).

 The tincture is a clear reddish-brown liquid, spicy aromatic odor, bitter taste; Assigned to 25-30 drops 3 times a day before meals for 10-20 days.

 "Beautiful" was used in the treatment of 71 patients with coronary artery disease with various manifestations of angina, myocarditis and myocardiotonic cardiosclerosis, cardiac neurocirculatory dystonia. In addition, a group of patients (7 people) who were involved in the liquidation of the Chernobyl accident was treated, in the clinic of which the phenomena of IHD and discirculatory encephalopathy and ventricular extrasystole of 1-2 degrees of gradation according to Laun were observed. In all other patients, ventricular extrasystole of 1-3 degrees of gradation according to Laun was also observed.

 The invention is illustrated by the following examples.

 Example 1. Patient B. 42 years. Clinical diagnosis: ischemic heart disease, first-occurring angina pectoris. Hypertension stage II. Ventricular extrasystole (III degree of graduation according to Laun). For the first time, an attack of sternal pain, accompanied by ventricular extrasystole, arose against a background of a stressful situation, after which the patient became depressed, had an anxious sleep, and a fear of death appeared. He received treatment: a polarizing iv mixture, inside nitrosorbide, ethmosin, riboxin, aspartame. The patient's condition improved: heart pain decreased at rest, but remained when walking 300 m, the number of ventricular extrasystoles decreased in the daytime, but on Lenta-MT they were recorded in the evening and at night. Anxiety remains, a bad dream. “Beautiful” was added to the treatment after 1 week 30 drops 3 times a day. After 10 days, the heart rhythm was correct, sinus, the sleep became calm, the anxious mood disappeared.

 Example 2. Patient S. 33 years. Diagnosis: postmyocardial cardiosclerosis. Prolapse of the mitral valve of the I degree. Chronic sinusitis. Ventricular extrasystole such as bigemia. Sick for 5 years when she suffered myocarditis, after which there was a persistent rhythm disturbance persistent ventricular extrasystole. Previously treated with ethacisin, cordarone, verapamil without effect. For 1 month I took "Beautiful" 30 drops 3 times a day. On the 9th day after administration, the correct sinus rhythm was established. Treatment "Beautiful" was recommended to continue on an outpatient basis.

 Example 3. Patient B. 36 years old, diagnosis: neurocirculatory dystonia of the cardiac type with cardialgia syndrome, vegetovascular dystonia. Severe sinus tachycardia. Polytopic (supraventricular and ventricular) extrasystole. For 1 month I took "Beautiful" (monotherapy) 30 drops 3 times a day. On day 8, the correct sinus rhythm was restored with h. from. 72 beats / 1 min, no dynamic extrasystole was detected with a dynamic study on Lenta-MT.

 Example 4. Patient T. 40 years. A participant in the liquidation of the Chernobyl accident. In 1987, he worked in Chernobyl in the zone where the nuclear reactor was located for 1 month, and then 2 months in the 30-kilometer zone. Diagnosis: CHD: progressive angina pectoris. Hypertension stage II. Encephalopathy. Asthenic, irritable, persistent headaches of a pulsating nature in the temporal areas for many months, poor sleep, elements of aggression in behavior, a sharp general weakness. Persistent sinus tachycardia at rest, sometimes assuming the character of paroxysmal supraventricular tachycardia. The treatment was carried out: intravenously nitroglycerin, inside nitrosorbide, piracetam, amitriptyline, metabolic preparations (honey with apilac apitonus). Against the background of the treatment for 2 weeks, the pains in the heart area at rest disappeared, the feeling of general weakness in the morning decreased, the headache became less intense, but there remained: a feeling of general weakness, palpitations, headache in the afternoon, irritability, poor sleep . From the 10th day of treatment, “Beautiful” was added at a dose of 30 drops 3 times a day. The patient began to better tolerate physical exertion, stopped taking additional nitroglycerin for pain in the heart, sleep became calm, his mood more balanced. Heart rhythm became sinus correct with h.s. 74 bpm

 Based on the foregoing, it can be argued that the drug "Beautiful" is effective for the treatment and prevention of patients with coronary artery disease complicated by ventricular rhythm disturbances. The drug goes well with conventional antiarrhythmic, antihypertensive, antispasmodic and other drugs.

 During treatment no adverse side effects were observed.

Claims (1)

 A remedy for a treated ventricular extrasystole based on a plant component, characterized in that it contains hawthorn fruits, grass of a drooping or Tatar, rhizome with valerian roots and ethyl 40% alcohol at a ratio of 1: 1: 1: 12.