RU2082420C1 - Agent for treatment of heart ischemic disease accompanying with the expressed neurotic reactions - Google Patents

Abstract

FIELD: medicine, cardiology. SUBSTANCE: agent is 40-% alcoholic tincture of the following composition, wt.-%: blood-red haw-thorn fruits, 33; catchfly herb, 33; and Jacob's ladder rhizomes with roots, 34. EFFECT: enhanced effectiveness of agent, absence of by-side reactions, decreased price.

Description

 The invention relates to medicine, namely to phytotherapeutic agents for the treatment and prevention of coronary heart disease (CHD), used independently, as well as in combination with coronary expansion, antispasmodic, anti-inflammatory, non-specific immunocorrection therapy and physiotherapy.

 The tool has antiarrhythmic, coronary expansion, cardiotonic, antispasmodic, sedative activity.

 It is known to use herbal remedies used for a similar purpose, for example, tincture of hawthorn (1). However, the sedative and antiarrhythmic effect of this drug is not sufficiently pronounced, as well as the cardiotonic effect. These effects can be significantly enhanced and at the same time significantly expand the therapeutic spectrum of action, if not one plant is used, but a plant collection, which is currently recommended (2). In addition, it is very important that the most pronounced therapeutic effect is achieved with the combined use of various drugs (3).

 When compiling the fees, many factors are taken into account, the detailed development of which, followed by generalization and implementation in plant collection, is a rather difficult scientific and practical task.

 The basis of the invention is the goal of creating such a medicine for the treatment of coronary artery disease against the background of pronounced neurotic reactions, which would be highly effective, had no unwanted side effects, was easy to manufacture even at home, and contained affordable and affordable components.

 The problem is solved in that the tool is prepared on the basis of a collection having the following composition, wt.

Rhizomes with blue cyanosis roots 33
Grass of a pitching tar or pitch of a Tatar 34
Blood Hawthorn Fruits 33
The tool is invited to assign the name "Krasipol".

 The components of the collection are not potent, do not have contraindications in therapeutic doses. The latter, with a single or daily intake, do not exceed the norms. The components of the collection are available, their processing can be carried out in normal conditions. Plants were harvested at the optimum harvest time, carried out initial processing, dried and brought to standard condition according to the requirements of the State Pharmacopoeia (4). The assembly, preparation of the drug and treatment of patients were arranged by specialists with special education and extensive experience.

 Considering that the expected therapeutic effect is determined primarily by ecdysteroids, flavonoids, phenolcarboxylic acids, saponins, they were extracted with 40% alcohol as follows: 50 g of the collection was poured with 100 ml of 40% alcohol, insisted for 3 days, the extraction was drained, the raw materials were squeezed and re-filled 100 ml of 40% alcohol, insisted 1 day. After pressing the extract, the raw materials were again poured into 100 ml of 40% alcohol. After a day, the raw materials were squeezed, all extracts were combined. Received 250 ml of tincture, which was filtered through a paper filter (can be through a ball of cotton wool or gauze). At home, you can use, as an extractor, vodka. The tincture is a clear liquid with a reddish-brown color, bitter taste.

 Patients took 25-30 drops 3 times a day before meals for 10-12 days.

 Krasipol was used in the treatment of patients with coronary artery disease with various manifestations of neurotic reactions, patients with stable and progressive angina pectoris, as well as a group of patients with coronary artery disease accompanied by chronic bronchitis, pulmonary pulmonary disease and pneumosclerosis. In these groups of patients in the clinic, pronounced neurovegetative symptoms were observed. In addition, a group of patients with neurocirculatory dystonia with manifestations of cardalgia and autonomic crises was treated.

 The invention is illustrated by the following examples.

 Example 1. Patient S. 53 years. Diagnosis: coronary heart disease: progressive angina pectoris. Postinfarction cardiosclerosis. Hypertension stage II. Blockade of the anterior branch of the left leg of the bundle of Giss. Chronic obstructive bronchitis, diffuse pneumosclerosis. Enphysema, HIIA (circulatory failure stage IIA). He received treatment: Sydnopharm, Adelfan, Cordanum, Digoxin inside, Trental, adenosine triphosphoric acid intramuscularly for 10 days. The patient's condition improved: heart pain at rest stopped, blood pressure became 140/90 mm RT. Art. but tachycardia remained at rest up to 100 beats / min, shortness of breath up to 26 breaths per minute. “Krasipol” 30 drops 3 times a day was added to the treatment: the frequency of the core contractions became 74 beats / min, the cough decreased, the number of breaths was up to 18 per min.

 Example 2. Patient C. 55 years. Diagnosis: coronary heart disease: progressive angina pectoris. Violation of the rhythm by the type of polytopic supraventricular and ventricular extrasystoles (II graduation according to Laun), transient sino-auricular blockade of the II degree and Clerk-Levy-Kristek pre-excitation syndrome. Asthenoneurotic syndrome. In the past, it was treated with various antiarrhythmic drugs: ethacisin, cordarone, novocainamide. The treatment was ineffective. When conducting transesophageal electrostimulation with a heart rate of 145 beats / min, at first separate supraventricular extrasystoles appeared (from the compound), and then atrial fibrillation, a tachysystolic form, was first fixed. Received treatment: isosorbide dinitrate, aspartame. The heart rhythm was restored after two weeks with verapamil 40 mg 3 times a day and Krasipol 30 drops 3 times a day. The drug also had a pronounced sedative effect, as well as a tonic effect. His mood improved, his sleep improved, he became more cheerful. It is prescribed for maintenance therapy: “Krasipol” 20 drops 3 times a day and verapamil 40 mg 2 times a day.

 Example 3. Patient Z. 53 years. Diagnosis: coronary heart disease: progressive angina, post-infarction cardiosclerosis. Ventricular extrasystole (III degree of graduation according to Laun). He received treatment: Sustak-forte, Kordanum, Krasipol, 30 drops 3 times a day. Heart rate was restored on day 7.

 Example 4. Patient S. 54 years. Diagnosis: coronary heart disease: progressive angina pectoris. Wolf-Parkinson-White Syndrome. Polytopic supraventricular and ventricular extrasystoles. Paroxysms of supraventricular and ventricular tachycardia. Over the past 10 years, paroxysmal arrhythmias have arisen: first, according to the type of paroxysms of supraventricular tachycardia, and the last 2-3 years, paroxysms of ventricular tachycardia, for which diphibrillation was performed twice. The reason for the last hospitalization was ventricular extrasystole of the type of bigemia, which was managed to stop cordarone in a daily dose of 0.6 against the background of Krasipol 30 drops 3 times a day for 2 weeks. Discharged at a maintenance dose of cordarone 0.2 per day and Krasipol 30 drops 3 times a day.

 Thus, based on the foregoing, it can be argued that the drug "Krasipol" is very effective for the treatment and prevention of coronary heart disease with rhythm disorders, complicated, in some cases, by various lung diseases, as well as severe neurovegetative symptoms. The tool goes well with other drugs of this purpose, and does not have undesirable side effects.

Bibliography
1. M.D. Mashkovsky. Medicines, ed. 10, part 1. M. "Medicine", 1987, S. 467.

 2. E. A. Ladynina, R. S. Morozova. Phytotherapy. L. "Medicine", 1990, S. 16.

 3. A. N. Kudrin. Pharmacology with the basics of pathophysiology. M. "Medicine", 1977, S. 84.

 4. State Pharmacopoeia, ed. II, c. 2. M. "Medicine", 1990.

Claims (1)

 A remedy for the treatment of coronary heart disease, accompanied by pronounced neurotic reactions, based on a 40% alcohol tincture of the fruits of the blood-red hawthorn, characterized in that the tincture additionally contains rhizome with blue cyanosis roots, grass of drooling drooping or Tatar in the following ratio, wt . Rhizomes with blue cyanosis roots 33
Grass pitching drooping or Tatar 34
Blood Red Hawthorn Fruits 33%