RU2088250C1 - Medicinal species for treatment of patients with cardiac rhythm disorder - Google Patents

Abstract

FIELD: medicine, cardiology, phytotherapy. SUBSTANCE: medicinal species has the following composition, mas. p. p.: hawthorn fruits, 2; catchfly herb, 1; valerian roots and rhizomes, 1; and peppermint leaves, 1. EFFECT: enhanced effectiveness of species.

Description

 The invention relates to medicine, namely to phytotherapeutic agents for the treatment and prevention of heart diseases with rhythm disorders, used independently, as well as in combination with coronary-expanding, antispasmodic, anti-inflammatory, non-specific immunocorrection therapy and physiotherapy.

 The tool has antiarrhythmic, coronary expansion, cardiotonic, antispasmodic, analgesic, sedative activity.

It is known to use herbal remedies used for a similar purpose, for example, cardiotonic glycosides, quinidine alkaloids, aymalin, some combined preparations (pulse rate) and others, as well as individual plants, for example, fruits, flowers and leaves of hawthorn, rhizome with valerian roots, motherwort grass and some others [1]
However, many of these drugs are imported, their production is complicated, requiring special apparatus and equipment, expensive solvents and reagents, providing them with qualified engineering personnel, etc. For this and other reasons, these drugs are expensive and scarce. In addition, many of them are quite toxic, for example, quinidine, aymalin, pulse - the norm, with a not too wide range of their therapeutic effects.

The search and production of such drugs is extremely urgent, especially at the present time, when the number of patients does not decrease, and the shortage of drugs remains. It is very important that the most pronounced therapeutic effect is achieved with the combined use of various drugs [2] The materials of this work are exclusively shown in this regard, when the use of our collection had a decisive influence on the normalization of the rhythm. In addition, the use of plant collections is currently recommended [3], since many factors of both the therapeutic and physico-chemical plan are taken into account when compiling them, and the detailed development of these factors with subsequent generalization and implementation in the recipe of the plant collection is rather complicated scientific and practical task. The closest collection for the treatment of arrhythmia contains valerian [3]
The basis of the invention is the creation of such a drug collection for the treatment of patients with rhythm disturbances, which would be highly effective, had no unwanted side effects, was easy to manufacture even at home, contained components of our flora, affordable and inexpensive.

 The problem is solved in that the proposed collection has the following composition, wt. h

Hawthorn fruits 2
Grass pitchfork drooping or Tatar 1
Rhizome with valerian roots 1
Peppermint leaves 1
The collection is invited to assign the name "Kramensil".

 The components of the collection do not belong to potent ones, have no contraindications in therapeutic doses, which, with a single or daily intake, do not exceed the norms. The included plants are fairly affordable. They were collected in the optimal time, primary processing, drying and bringing the raw materials to standard conditions were carried out in accordance with the requirements of the State Pharmacopoeia [4]. All work on the compilation of the collection, its preparation, treatment of patients and interpretation of the results was carried out by specialists with special education, high qualifications and large experience.

 Considering that the expected therapeutic effect is mainly determined by ecdysteroids, flavonoids, phenolcarboxylic acids, terpenoids, they were extracted with 40% alcohol as follows: 50 g of the collection was filled with 100 ml of 40% alcohol, insisted for 3 days, after which the raw materials were squeezed, 100 ml of 40% alcohol was added, insisted for 1 day. The extract was squeezed and the raw material was again poured into 100 ml of 40% alcohol. After a day, the raw materials were squeezed, all extracts were combined. Received 250 ml of tincture, which was filtered through a paper filter (you can through a piece of cotton wool or gauze). At home, you can use vodka to prepare the drug. The tincture is a clear liquid of a reddish-brown color, bitter taste, spicy aromatic smell.

 Patients took 30-50 drops 3 times a day before meals for 10-15 days.

 Kramensil was used to treat patients with coronary artery disease: patients with stable and progressive angina, myocarditis and myocardiotonic cardiosclerosis, cardiac neurocirculatory dystonia, various ventricular cardiac arrhythmias, supraventricular extrasystole, paroxysms of the ventricular tachycardia and tachycardia tachycardia.

Example 1. Patient S. 41 years old, with a clinical diagnosis: post-myocardial cardiosclerosis, ventricular extrasystole of high gradations according to Laun. Urolithiasis disease. Chronic pyelonephritis, remission. After severe sore throat, he suffered myocarditis, after which there was a persistent rhythm disturbance in the form of ventricular extrasystole. On a tape-MT, ventricular extrasystole of high gradations according to Laun: at times paired ventricular extrasystoles, for 1 min up to 10 extrasystoles against a background of pronounced sinus tachycardia with a frequency of 100 y / h. In the hospital, antiarrhythmic treatment was started: lidocaine intramuscularly, then ethmosin, etatsizin, cordaron, sequentially the pulse norm, allapinin, quinidine durules against the background of potassium preparations (panangin), metabolic drugs (riboxin), sedatives (phenazepam) without effect, and recently
with a successive change in antiarrhythmic drugs, a pronounced arrhythmogenic effect is an increase in the number of ventricular extrasystoles, the appearance of paired J.E. All antiarrhythmic drugs were canceled, and the patient received Kramensil in a dose of 30 cap. 3 times a day. The rhythm recovered on day 4 and remained clearly correct. Subsequently, after 2 months of control, the heart rhythm remains correct.

 Example 2. Patient G. 64 years. Clinical diagnosis: IHD, progressive angina pectoris with outcome in angina pectoris FC-P. Atherosclerosis of the coronary arteries, aorta. Postinfarction cardiosclerosis (1988). NPA. Rhythm disturbance as frequent paroxysms of atrial fibrillation, atrial flutter: irregular shape. Hypertension stage II. In 1988, he suffered a myocardial infarction, after which atrial fibrillation first occurred, atrial flutter at times, periodically ventricular extrasystole. At the prehospital stage, antiarrhythmic therapy: stopping rhythm disturbances in the intravenous administration of a polarizing mixture with cardiac glycosides, is intravenously obstructed. Subsequently, maintenance therapy with ethacycin. Within 2 weeks before admission, atrial fibrillation failed to restore the disturbed rhythm by conventional means. In the hospital, intravenous administration of a polarizing mixture with cardiac glycosides was started: lanicore 2.0, intravenously / muscularly procainamide in a daily dose of up to 2.0, maintenance therapy with etacizine, but the rhythm was disturbed three times against the background of neuropsychic overstresses during the hospital stay and was additionally stopped by Kramensil in a dose of 50 cap. inside. Subsequently, the heart rhythm remained correct when Kramensil was added to the traditional therapy in a dose of 30 cap. 3 times a day.

Example 3. Patient K. 54 years. Clinical diagnosis: ischemic heart disease, first-occurring angina pectoris. The first paroxysm of atrial fibrillation. In a patient, rhythm disturbance occurred against the background of the first occurring compressive pain in the heart against stress 10 days before admission. Antiarrhythmic therapy was started: quinipec against the background of cordarone according to the scheme, then a change of drugs: the combination of cordarone and digoxin, but the heart rhythm was twice violated: atrial flutter occurred: the correct form was 3: 1, the rhythm was steadily restored during treatment with the addition of Kramensil in a dose of 30 drops . 3 times a day for 10 days. It was discharged with the correct sinus rhythm, part 72 s / 1 ^' . PQ 0.16 s, QT 0.34 s at a maintenance dose of cordarone 0.2 (1 t.) Per day + digoxin 0.25 mg (0.5 mg) per day + Kramensil 30 cap. 3 times a day.

 Based on the foregoing, it can be concluded that the Kramensil drug collection is effective for the treatment and prevention of patients with rhythm disturbances, for the relief of atrial fibrillation paroxysm, for maintenance therapy for cardiac arrhythmias. The tool goes well with conventional antiarrhythmic, antihypertensive and other drugs. During treatment, no unwanted side effects were detected.

Sources of information
1. Mashkovsky M. D. Medicines, ed. 10, part 1, M. Medicine, 1987, p. 400-409.

 2. Kudrin A. M. Pharmacology with the basics of pathophysiology. M. Medicine, 1977, p. 84.

 3. Ladynina EA Morozova R.S. Phytotherapy. L. Medicine, 1990, p. 42.45.

 4. State Pharmacopoeia, ed. 2, c. 2, M. Medicine, 1990.

Claims (1)

 A drug collection for the treatment of patients with cardiac arrhythmias, including valerian, characterized in that it additionally contains hawthorn fruit, grass of the drooping or Tatar, peppermint leaves, and as valerian rhizome with valerian roots in the following proportions, parts by weight Hawthorn fruits 2
Grass pitchfork drooping or Tatar 1
Rhizome with valerian roots 1
Peppermint leaves 1