RU2019129299A3 - - Google Patents
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- RU2019129299A3 RU2019129299A3 RU2019129299A RU2019129299A RU2019129299A3 RU 2019129299 A3 RU2019129299 A3 RU 2019129299A3 RU 2019129299 A RU2019129299 A RU 2019129299A RU 2019129299 A RU2019129299 A RU 2019129299A RU 2019129299 A3 RU2019129299 A3 RU 2019129299A3
- Authority
- RU
- Russia
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762480226P | 2017-03-31 | 2017-03-31 | |
| US62/480,226 | 2017-03-31 | ||
| PCT/US2018/025547 WO2018183947A1 (en) | 2017-03-31 | 2018-03-30 | Glucocorticoid receptor modulators to treat cervical cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2019129299A RU2019129299A (ru) | 2021-04-30 |
| RU2019129299A3 true RU2019129299A3 (ru) | 2021-04-30 |
Family
ID=63671917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019129299A RU2019129299A (ru) | 2017-03-31 | 2018-03-30 | Модуляторы глюкокортикоидного рецептора для лечения рака шейки матки |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US10413540B2 (ru) |
| EP (1) | EP3600282A4 (ru) |
| JP (2) | JP2020515563A (ru) |
| KR (1) | KR102342620B1 (ru) |
| CN (1) | CN110520121B (ru) |
| AU (1) | AU2018244928B2 (ru) |
| CA (1) | CA3055076C (ru) |
| IL (1) | IL269725B (ru) |
| MX (1) | MX2019011543A (ru) |
| PH (1) | PH12019502259A1 (ru) |
| RU (1) | RU2019129299A (ru) |
| SG (1) | SG11201908790PA (ru) |
| UA (1) | UA127409C2 (ru) |
| WO (1) | WO2018183947A1 (ru) |
| ZA (1) | ZA201905736B (ru) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| WO2018183947A1 (en) * | 2017-03-31 | 2018-10-04 | Corcept Therapeutics, Inc. | Glucocorticoid receptor modulators to treat cervical cancer |
| CN111202849B (zh) * | 2018-11-02 | 2022-06-03 | 四川大学 | 一种白蛋白结合型亚硝基脲类抗肿瘤药物制剂及其制备方法 |
| WO2020132046A1 (en) * | 2018-12-19 | 2020-06-25 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| SG11202105770YA (en) | 2018-12-19 | 2021-07-29 | Corcept Therapeutics Inc | Pharmaceutical formulations containing relacorilant, a heteroaryl-ketone fused azadecalin compound |
| AU2020211303A1 (en) | 2019-01-22 | 2021-07-15 | Akribes Biomedical Gmbh | Selective Glucocorticoid Receptor Modifiers for treating impaired skin wound healing |
| EP3927345A4 (en) | 2019-02-22 | 2022-12-21 | Corcept Therapeutics Incorporated | THERAPEUTIC USES OF RELACORILANT, A GLUCOCORTICOID RECEPTOR MODULATOR DERIVED FROM AZADECALIN FUSED TO A HETEROARYL KETONE |
| EP4045045A4 (en) * | 2019-10-16 | 2023-11-22 | Corcept Therapeutics Incorporated | METHOD FOR NORMALIZING THE RATIO OF NEUTROPHILS TO LYMPHOCYTES IN CANCER PATIENTS USING A SELECTIVE GLUCOCORTICOID RECEPTOR ANTAGONIST |
| AU2021220763B2 (en) * | 2020-02-10 | 2024-01-18 | Corcept Therapeutics Incorporated | Methods of stimulating an anti-tumor response using a selective glucocorticoid receptor modulator |
| CA3178756A1 (en) * | 2020-05-27 | 2021-12-02 | Hazel Hunt | Concomitant administration of glucocorticoid receptor modulator relacorilant and paclitaxel, a dual substrate of cyp2c8 and cyp3a4 |
| US20240091385A1 (en) * | 2022-09-02 | 2024-03-21 | Corcept Therapeutics Incorporated | Methods of assessing selective glucocorticoid receptor modulation and of identifying and treating patients likely to benefit from glucocorticoid receptor modulation |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL72729A (en) | 1983-09-26 | 1988-02-29 | Lilly Co Eli | Trans(+_)octahydropyrazole-ring alkylated pyrazoloquinolines,their preparation and pharmaceutical compositions containing them |
| GB8828669D0 (en) | 1988-12-08 | 1989-01-11 | Lilly Industries Ltd | Organic compounds |
| CN1043641C (zh) | 1993-08-06 | 1999-06-16 | 史密丝克莱恩比彻姆制药股份公司 | 氢化异喹啉衍生物 |
| US5696127A (en) | 1994-12-22 | 1997-12-09 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
| EP1061919A4 (en) | 1998-03-10 | 2002-09-04 | Res Triangle Inst | NEW OPIATES, METHOD FOR THE PRODUCTION AND USE THEREOF |
| GB9911053D0 (en) | 1999-05-12 | 1999-07-14 | Pharmacia & Upjohn Spa | 4,5,6,7-tetrahydroindazole derivatives process for their preparation and their use as antitumour agents |
| GB0010683D0 (en) | 2000-05-03 | 2000-06-28 | Univ Bristol | Cancer therapy |
| US6583180B2 (en) | 2001-02-14 | 2003-06-24 | Abbott Laboratories | Glucocorticoid receptor modulators |
| AU2002258399A1 (en) | 2001-02-16 | 2002-09-19 | Medical College Of Georgia Research Institute, Inc. | Use of trail and antiprogestins for treating cancer |
| AU2002355929A1 (en) | 2001-07-17 | 2003-03-03 | Smithkline Beecham Corporation | Crystallized glucocorticoid receptor ligand binding domain polypeptide and screening methods employing same |
| DK1408981T3 (da) | 2001-07-23 | 2009-01-12 | Corcept Therapeutics Inc | Fremgangsmåder til forebyggelse af vægtforögelse som fölge af antipsykotiske midler |
| AU2003214879B2 (en) | 2002-01-22 | 2008-02-07 | The Regents Of The University Of California | Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof |
| US20030162695A1 (en) | 2002-02-27 | 2003-08-28 | Schatzberg Alan F. | Glucocorticoid blocking agents for increasing blood-brain barrier permeability |
| WO2004004653A2 (en) | 2002-07-02 | 2004-01-15 | Corcept Therapeutics, Inc. | Methods for treating psychosis associated with interferon-alpha therapy |
| US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| EP1660081A1 (en) | 2003-09-03 | 2006-05-31 | Wyeth | Amorphous rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid and pharmaceutical compositions containing the same |
| DK1761497T3 (da) | 2004-01-09 | 2008-11-03 | Corcept Therapeutics Inc | Azadecalinglucocorticoidreceptormodulatorer |
| EP1723174A1 (en) | 2004-02-26 | 2006-11-22 | The Government of the U.S.A., as repr. by the Secretary, Dept. of Health & Human Services, the Nat. Inst. of Health | A novel modulator of glucocorticoid receptor activities |
| CA2558899C (en) * | 2004-03-09 | 2013-02-05 | Corcept Therapeutics, Inc. | Fused ring azadecalin glucocorticoid receptor modulators |
| CA2572544C (en) | 2004-07-02 | 2013-02-26 | Corcept Therapeutics, Inc. | Modified pyrimidine glucocorticoid receptor modulators |
| MX2007014049A (es) | 2005-05-12 | 2008-02-11 | Abbott Lab | Activadores de apoptosis. |
| US7790745B2 (en) | 2005-10-21 | 2010-09-07 | Bristol-Myers Squibb Company | Tetrahydroisoquinoline LXR Modulators |
| US7640389B2 (en) | 2006-02-28 | 2009-12-29 | Freescale Semiconductor, Inc. | Non-volatile memory having a multiple block erase mode and method therefor |
| EP1932843A1 (en) | 2006-12-14 | 2008-06-18 | sanofi-aventis | Sulfonyl-phenyl-2H-(1,2,4) oxadiazole-5-one derivatives, processes for their preparation and their use as pharmaceuticals |
| NZ586125A (en) | 2007-11-12 | 2012-12-21 | Bipar Sciences Inc | Treatment of breast cancer with a parp inhibitor alone or in combination with anti-tumor agents |
| US20120022121A1 (en) | 2007-11-29 | 2012-01-26 | Dalton James T | Indoles, derivatives and analogs thereof and uses therefor |
| US20090156672A1 (en) | 2007-12-17 | 2009-06-18 | Northwestern University | Substituted Phenyl Aziridine Precursor Analogs as Modulators of Steroid Receptor Activities |
| US8003689B2 (en) | 2008-06-20 | 2011-08-23 | Gtx, Inc. | Metabolites of selective androgen receptor modulators and methods of use thereof |
| US20100135956A1 (en) | 2008-11-21 | 2010-06-03 | Auspex Pharmaceuticals, Inc. | Steroid modulators of progesterone receptor and/or glucocorticoid receptor |
| WO2010132445A1 (en) | 2009-05-12 | 2010-11-18 | Corcept Therapeutics, Inc. | Solid forms and process for preparing |
| US8710035B2 (en) | 2010-03-24 | 2014-04-29 | The University Of Chicago | Methods and compositions related to glucocorticoid receptor antagonists and breast cancer |
| US8598154B2 (en) | 2010-08-27 | 2013-12-03 | Corcept Therapeutics, Inc. | Pyridyl-amine fused azadecalin modulators |
| US8318726B2 (en) * | 2010-12-06 | 2012-11-27 | Council Of Scientific & Industrial Research | Benzylidineanthracenone linked pyrrolobenzodiazepine hybrids useful as anticancer agents and process for the preparation thereof |
| US8658128B2 (en) | 2011-02-03 | 2014-02-25 | Pop Test Cortisol Llc | System and method for diagnosis and treatment |
| US9314473B2 (en) | 2011-02-03 | 2016-04-19 | Pop Test Oncology Limited Liability Company | System and method for diagnosis and treatment |
| JP6039587B2 (ja) | 2011-03-18 | 2016-12-07 | コーセプト セラピューティクス， インコーポレイテッド | ピリミジンシクロヘキシルグルココルチコイドレセプター調節因子 |
| WO2013039916A1 (en) | 2011-09-12 | 2013-03-21 | The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services | Compositions for and methods of treatment and enhanced detection of non-pituitary tumors |
| SI3329919T1 (sl) | 2011-11-11 | 2020-02-28 | Gilead Apollo, Llc | Inhibitorji ACC in njihove uporabe |
| EP3912626A1 (en) | 2012-02-24 | 2021-11-24 | The University of Chicago | Methods and compositions related to glucocorticoid receptor antagonism and prostate cancer |
| WO2013130420A1 (en) | 2012-02-27 | 2013-09-06 | Corcept Therapeutics, Inc. | Phenyl heterocycloalkyl glucocorticoid receptor modulators |
| US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| KR102062640B1 (ko) | 2012-05-25 | 2020-01-06 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 헤테로아릴-케톤 융합된 아자데칼린 글루코코르티코이드 수용체 조절제 |
| WO2013174962A1 (en) | 2012-05-25 | 2013-11-28 | Janssen R&D Ireland | Uracyl spirooxetane nucleosides |
| WO2013182668A1 (en) | 2012-06-08 | 2013-12-12 | F. Hoffmann-La Roche Ag | Mutant selectivity and combinations of a phosphoinositide 3 kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer |
| PL3074011T3 (pl) | 2013-11-25 | 2020-01-31 | Corcept Therapeutics Incorporated | Połączone fuzyjnie oktahydro związki azadekaliny jako modulatory receptora glukokortykoidowego |
| EP3006453A1 (en) | 2014-10-08 | 2016-04-13 | Cosmo Technologies Ltd. | 17alpha-monoesters and 17alpha,21-diesters of cortexolone for use in the treatment of tumors |
| US10047157B2 (en) | 2014-12-19 | 2018-08-14 | Alder Biopharmaceuticals, Inc. | Humanized anti-ACTH antibodies and use thereof |
| US20180064679A1 (en) * | 2015-03-05 | 2018-03-08 | Abraxis Bioscience, Llc | Method for treating cancer based on level of glucocorticoid receptor |
| US9598459B2 (en) * | 2015-08-03 | 2017-03-21 | Pop Test Oncology Llc | Pharmaceutical compositions and methods |
| WO2017027851A1 (en) | 2015-08-13 | 2017-02-16 | Corcept Therapeutics, Inc. | Method for differentially diagnosing acth-dependent cushing's syndrome |
| CN109071537A (zh) * | 2016-03-01 | 2018-12-21 | 科赛普特治疗学股份有限公司 | 用于加强检查点抑制剂的糖皮质激素受体调节剂的应用 |
| US9943505B2 (en) | 2016-09-09 | 2018-04-17 | Corcept Therapeutics, Inc. | Glucocorticoid receptor modulators to treat pancreatic cancer |
| WO2018183947A1 (en) * | 2017-03-31 | 2018-10-04 | Corcept Therapeutics, Inc. | Glucocorticoid receptor modulators to treat cervical cancer |
-
2018
- 2018-03-30 WO PCT/US2018/025547 patent/WO2018183947A1/en active Application Filing
- 2018-03-30 US US15/942,312 patent/US10413540B2/en active Active
- 2018-03-30 KR KR1020197031825A patent/KR102342620B1/ko active IP Right Grant
- 2018-03-30 RU RU2019129299A patent/RU2019129299A/ru unknown
- 2018-03-30 JP JP2019552958A patent/JP2020515563A/ja active Pending
- 2018-03-30 CA CA3055076A patent/CA3055076C/en active Active
- 2018-03-30 AU AU2018244928A patent/AU2018244928B2/en active Active
- 2018-03-30 UA UAA201909792A patent/UA127409C2/uk unknown
- 2018-03-30 SG SG11201908790P patent/SG11201908790PA/en unknown
- 2018-03-30 CN CN201880023127.1A patent/CN110520121B/zh active Active
- 2018-03-30 EP EP18777520.0A patent/EP3600282A4/en active Pending
- 2018-03-30 MX MX2019011543A patent/MX2019011543A/es unknown
- 2018-11-09 US US16/185,271 patent/US10568880B2/en active Active
-
2019
- 2019-08-30 ZA ZA2019/05736A patent/ZA201905736B/en unknown
- 2019-09-26 IL IL269725A patent/IL269725B/en active IP Right Grant
- 2019-09-30 PH PH12019502259A patent/PH12019502259A1/en unknown
-
2020
- 2020-01-14 US US16/742,198 patent/US10898478B2/en active Active
- 2020-12-02 US US17/110,170 patent/US11660295B2/en active Active
-
2022
- 2022-03-29 JP JP2022053345A patent/JP2022084888A/ja active Pending
-
2023
- 2023-04-18 US US18/136,210 patent/US20230355610A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3600282A1 (en) | 2020-02-05 |
| PH12019502259A1 (en) | 2020-07-13 |
| WO2018183947A1 (en) | 2018-10-04 |
| AU2018244928B2 (en) | 2023-10-19 |
| KR20190126442A (ko) | 2019-11-11 |
| CN110520121A (zh) | 2019-11-29 |
| JP2022084888A (ja) | 2022-06-07 |
| US20210085670A1 (en) | 2021-03-25 |
| KR102342620B1 (ko) | 2021-12-22 |
| AU2018244928A1 (en) | 2019-09-19 |
| JP2020515563A (ja) | 2020-05-28 |
| US20230355610A1 (en) | 2023-11-09 |
| ZA201905736B (en) | 2022-10-26 |
| UA127409C2 (uk) | 2023-08-16 |
| EP3600282A4 (en) | 2020-08-19 |
| IL269725A (en) | 2019-11-28 |
| US20190076424A1 (en) | 2019-03-14 |
| RU2019129299A (ru) | 2021-04-30 |
| CN110520121B (zh) | 2023-07-04 |
| IL269725B (en) | 2020-07-30 |
| US10568880B2 (en) | 2020-02-25 |
| MX2019011543A (es) | 2019-12-16 |
| CA3055076A1 (en) | 2018-10-04 |
| US10413540B2 (en) | 2019-09-17 |
| US10898478B2 (en) | 2021-01-26 |
| US11660295B2 (en) | 2023-05-30 |
| US20180280378A1 (en) | 2018-10-04 |
| SG11201908790PA (en) | 2019-10-30 |
| US20200147073A1 (en) | 2020-05-14 |
| CA3055076C (en) | 2022-02-22 |