RU2018144401A - СПОСОБ ПОЛУЧЕНИЯ Si-СОДЕРЖАЩИХ БИЦИКЛО[4.2.1]НОНА-2,4,7-ТРИЕНОВ, ПРОЯВЛЯЮЩИХ ПРОТИВООПУХОЛЕВУЮ АКТИВНОСТЬ - Google Patents
СПОСОБ ПОЛУЧЕНИЯ Si-СОДЕРЖАЩИХ БИЦИКЛО[4.2.1]НОНА-2,4,7-ТРИЕНОВ, ПРОЯВЛЯЮЩИХ ПРОТИВООПУХОЛЕВУЮ АКТИВНОСТЬ Download PDFInfo
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- RU2018144401A RU2018144401A RU2018144401A RU2018144401A RU2018144401A RU 2018144401 A RU2018144401 A RU 2018144401A RU 2018144401 A RU2018144401 A RU 2018144401A RU 2018144401 A RU2018144401 A RU 2018144401A RU 2018144401 A RU2018144401 A RU 2018144401A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2/00—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms
- C07C2/02—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by addition between unsaturated hydrocarbons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/0805—Compounds with Si-C or Si-Si linkages comprising only Si, C or H atoms
Claims (4)
1. Способ получения Si-содержащих бицикло[4.2.1]нона-2,4,7-триенов общей формулы (1):
каталитическим взаимодействием 1,3,5-циклогептатриена с Si-содержащими алкинами в присутствии каталитической системы Ti(acac)2Cl2-Et2AlCl, отличающийся тем, что, в качестве 1,3,5-циклогептатриена используют 1-метил(пропил)циклогепта-1,3,5-триен, реакцию 1-метил(пропил)циклогепта-1,3,5-триена (ЦГТ) с Si-содержащим алкином общей формулы 
(где R - указанные выше) проводят при мольном соотношении Si-содержащий алкин : ЦГТ : Ti(acac)2Cl2 : Et2AlCl = (1.7-2.4):2:(0.05-0.2):2, в ампуле при 20-120°С, в бензоле в течение 8-48 ч.
2. Применение Si-содержащих бицикло[4.2.1]нона-2,4,7-триенов в качестве средств с противоопухолевой активностью.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2018144401A RU2726195C2 (ru) | 2018-12-14 | 2018-12-14 | СПОСОБ ПОЛУЧЕНИЯ Si-СОДЕРЖАЩИХ БИЦИКЛО[4.2.1]НОНА-2,4,7-ТРИЕНОВ, ПРОЯВЛЯЮЩИХ ПРОТИВООПУХОЛЕВУЮ АКТИВНОСТЬ |
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| Application Number | Priority Date | Filing Date | Title |
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| RU2018144401A RU2726195C2 (ru) | 2018-12-14 | 2018-12-14 | СПОСОБ ПОЛУЧЕНИЯ Si-СОДЕРЖАЩИХ БИЦИКЛО[4.2.1]НОНА-2,4,7-ТРИЕНОВ, ПРОЯВЛЯЮЩИХ ПРОТИВООПУХОЛЕВУЮ АКТИВНОСТЬ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2018144401A3 RU2018144401A3 (ru) | 2020-06-15 |
| RU2018144401A true RU2018144401A (ru) | 2020-06-15 |
| RU2726195C2 RU2726195C2 (ru) | 2020-07-09 |
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| RU2018144401A RU2726195C2 (ru) | 2018-12-14 | 2018-12-14 | СПОСОБ ПОЛУЧЕНИЯ Si-СОДЕРЖАЩИХ БИЦИКЛО[4.2.1]НОНА-2,4,7-ТРИЕНОВ, ПРОЯВЛЯЮЩИХ ПРОТИВООПУХОЛЕВУЮ АКТИВНОСТЬ |
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Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2551278C1 (ru) * | 2013-11-06 | 2015-05-20 | Федеральное государственное бюджетное учреждение науки Институт нефтехимии и катализа Российской академии наук | Способ получения бицикло[4.2.1]нона-2,4-диенов |
| RU2541530C1 (ru) * | 2013-11-18 | 2015-02-20 | Федеральное государственное бюджетное учреждение науки Институт нефтехимии и катализа Российской академии наук | СПОСОБ ПОЛУЧЕНИЯ Si-СОДЕРЖАЩИХ БИС-(ЭНДО-БИЦИКЛО[4.2.1]НОНА-2,4,7-ТРИЕНОВ) |
| RU2559365C2 (ru) * | 2013-11-18 | 2015-08-10 | Федеральное государственное бюджетное учреждение науки Институт нефтехимии и катализа Российской академии наук | СПОСОБ ПОЛУЧЕНИЯ Si-СОДЕРЖАЩИХ БИЦИКЛО[4.2.1]НОНА-2,4,7-ТРИЕНОВ |
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| Publication number | Publication date |
|---|---|
| RU2726195C2 (ru) | 2020-07-09 |
| RU2018144401A3 (ru) | 2020-06-15 |
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