RU2018142209A - Применение фикоцианинов, очищенных или в том виде, как они присутствуют в цианобактериальных микроводорослях или их экстрактах, в качестве пребиотиков для повышения жизнеспособности пробиотических культур и продуктов, их выживаемости в желудочно-кишечном тракте, способности бороться с патогенами и общих свойств, улучшающих здоровье - Google Patents
Применение фикоцианинов, очищенных или в том виде, как они присутствуют в цианобактериальных микроводорослях или их экстрактах, в качестве пребиотиков для повышения жизнеспособности пробиотических культур и продуктов, их выживаемости в желудочно-кишечном тракте, способности бороться с патогенами и общих свойств, улучшающих здоровье Download PDFInfo
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- RU2018142209A RU2018142209A RU2018142209A RU2018142209A RU2018142209A RU 2018142209 A RU2018142209 A RU 2018142209A RU 2018142209 A RU2018142209 A RU 2018142209A RU 2018142209 A RU2018142209 A RU 2018142209A RU 2018142209 A RU2018142209 A RU 2018142209A
- Authority
- RU
- Russia
- Prior art keywords
- microalgae
- cyanobacterial
- ability
- phycocyanins
- probiotic
- Prior art date
Links
- 239000006041 probiotic Substances 0.000 title claims 11
- 235000018291 probiotics Nutrition 0.000 title claims 11
- 230000000529 probiotic effect Effects 0.000 title claims 10
- 244000052769 pathogen Species 0.000 title claims 2
- 235000013406 prebiotics Nutrition 0.000 title claims 2
- 230000035899 viability Effects 0.000 title claims 2
- 108010053210 Phycocyanin Proteins 0.000 title 1
- 239000000284 extract Substances 0.000 title 1
- 210000001035 gastrointestinal tract Anatomy 0.000 title 1
- 230000004083 survival effect Effects 0.000 title 1
- 239000007788 liquid Substances 0.000 claims 3
- 239000002417 nutraceutical Substances 0.000 claims 3
- 235000021436 nutraceutical agent Nutrition 0.000 claims 3
- 244000085413 Aphanizomenon flos aquae Species 0.000 claims 2
- 235000013781 Aphanizomenon flos aquae Nutrition 0.000 claims 2
- 229940054349 aphanizomenon flos-aquae Drugs 0.000 claims 2
- 235000013305 food Nutrition 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 229940127557 pharmaceutical product Drugs 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 241000222122 Candida albicans Species 0.000 claims 1
- 241000192700 Cyanobacteria Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 210000000941 bile Anatomy 0.000 claims 1
- 239000003833 bile salt Substances 0.000 claims 1
- 229940093761 bile salts Drugs 0.000 claims 1
- 229940095731 candida albicans Drugs 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 244000000074 intestinal pathogen Species 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 235000013618 yogurt Nutrition 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/748—Cyanobacteria, i.e. blue-green bacteria or blue-green algae, e.g. spirulina
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/195—Proteins from microorganisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/32—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the digestive tract
- A23V2200/3204—Probiotics, living bacteria to be ingested for action in the digestive tract
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/202—Algae extracts
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Physiology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (9)
1. Применение фикоцианинов, предпочтительно из микроводорослей Aphanizomenon flos-aquae и из любых других цианобактериальных сине-зеленых водорослей, в качестве добавки к культуре любого пробиотического штамма или к любому пробиотическому штамму после его культивирования, действующей в качестве пребиотика для увеличения жизнеспособности пробиотического штамма, его роста, резистентности к желчи и кислотной среде и способности уничтожать кишечные патогены, включающие, без ограничения, Е. coli, Staphylococcus aureus и Candida albicans.
2. Применение по п. 1, где фикоцианины, добавленные к пробиотическим штаммам, находятся в очищенной форме.
3. Применение по п. 1, где фикоцианины, добавленные к пробиотическому штамму, концентрируют из цианобактериальных микроводорослей посредством любого способа концентрирования и экстрагирования, например с использованием водных или других органических растворителей.
4. Применение по п. 1, где фикоцианины, добавленные к пробиотическому штамму, естественным образом содержатся в целых цианобактериальных микроводорослях, предпочтительно, но без ограничения, в штамме Aphanizomenon flos-aquae, особенно в отношении способности увеличивать способность пробиотического штамма уничтожать патогены и способности лучше выживать при прохождении через желчные соли.
5. Применение по пп. 1-4, где продукт, получаемый путем добавления фикоцианинов и/или цианобактериальных микроводорослей к пробиотическому (им) штамму или штаммам либо в течение, либо после фазы культивирования, добавляют в жидкой форме к любому напитку, йогурту или пищевому продукту вследствие его свойств, улучшающих здоровье; или к любому жидкому нутрицевтическому или фармацевтическому продукту, включая флаконы и кремы.
6. Применение по п. 5, где жидкую или кремообразную форму применяют местно при расстройствах кожи; или вагинально, или анально, при вагинальных или анальных бактериальных инфекциях.
7. Применение по пп. 1-4, где продукт, получаемый путем добавления фикоцианинов к пробиотикам либо перед, либо после их культивирования, сушат с получением порошка, который затем добавляют к любому пищевому, нутрицевтическому или фармацевтическому продукту.
8. Применение по п. 6, где высушенный порошок приготавливают в виде саше, таблеток или капсул или в виде любой другой нутрицевтической или фармацевтической формы.
9. Применение по пп. 5-7, где субъекты, которым вводят пробиотические продукты, представляют собой животное или человека.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662330450P | 2016-05-02 | 2016-05-02 | |
| US62/330,450 | 2016-05-02 | ||
| PCT/EP2017/060309 WO2017191078A1 (en) | 2016-05-02 | 2017-05-01 | The use of phycocyanins, purified or as present in cyanobacterial microalgae or extracts thereof, as prebiotics, to enhance the viability, gastrointestinal survival, pathogen-fighting ability, and the overall health-enhancing properties of probiotic cultures and products. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2018142209A true RU2018142209A (ru) | 2020-06-03 |
| RU2018142209A3 RU2018142209A3 (ru) | 2020-09-17 |
Family
ID=59296809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018142209A RU2018142209A (ru) | 2016-05-02 | 2017-05-01 | Применение фикоцианинов, очищенных или в том виде, как они присутствуют в цианобактериальных микроводорослях или их экстрактах, в качестве пребиотиков для повышения жизнеспособности пробиотических культур и продуктов, их выживаемости в желудочно-кишечном тракте, способности бороться с патогенами и общих свойств, улучшающих здоровье |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20190142880A1 (ru) |
| EP (1) | EP3452073A1 (ru) |
| CN (1) | CN109121394A (ru) |
| AU (1) | AU2017259736A1 (ru) |
| CA (1) | CA3023169A1 (ru) |
| RU (1) | RU2018142209A (ru) |
| WO (1) | WO2017191078A1 (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3794105A1 (en) * | 2018-05-15 | 2021-03-24 | Algavista Greentech Pvt. Ltd. | A process for extraction and isolation of biochemical constituents from algae |
| KR102287187B1 (ko) * | 2018-12-31 | 2021-08-06 | 재단법인 전남바이오산업진흥원 | 김 추출물을 유효성분으로 함유하는 프리바이오틱스 조성물 및 이의 용도 |
| WO2022110088A1 (zh) * | 2020-11-28 | 2022-06-02 | 南京溧水高新创业投资管理有限公司 | 用于筛选高产赤霉素菌种的培养基 |
| CN116084047A (zh) * | 2022-12-20 | 2023-05-09 | 大连工业大学 | 一种共载益生菌和抗氧化剂的功能性纳米纤维 |
| CN116686998A (zh) * | 2023-06-20 | 2023-09-05 | 南昌大学 | 基于藻蓝蛋白的益生菌运载体、制备方法与营养品 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090035490A (ko) * | 2006-06-27 | 2009-04-09 | 뉴트라테크 에스.알.엘. | 신경계 질환, 신경변성질환 및 기분 장애의 치료를 위한 아파니조메논 플로스 아쿠애 제제, 그의 추출물 및 그의 정제된 성분 |
| US7473427B2 (en) * | 2007-04-19 | 2009-01-06 | Cappellos, Inc. | Blue-green algae composition |
-
2017
- 2017-05-01 RU RU2018142209A patent/RU2018142209A/ru not_active Application Discontinuation
- 2017-05-01 EP EP17736878.4A patent/EP3452073A1/en not_active Withdrawn
- 2017-05-01 AU AU2017259736A patent/AU2017259736A1/en not_active Abandoned
- 2017-05-01 US US16/098,618 patent/US20190142880A1/en not_active Abandoned
- 2017-05-01 CA CA3023169A patent/CA3023169A1/en not_active Abandoned
- 2017-05-01 CN CN201780027704.XA patent/CN109121394A/zh active Pending
- 2017-05-01 WO PCT/EP2017/060309 patent/WO2017191078A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2018142209A3 (ru) | 2020-09-17 |
| US20190142880A1 (en) | 2019-05-16 |
| AU2017259736A1 (en) | 2018-12-20 |
| CA3023169A1 (en) | 2017-11-09 |
| EP3452073A1 (en) | 2019-03-13 |
| WO2017191078A1 (en) | 2017-11-09 |
| CN109121394A (zh) | 2019-01-01 |
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