RU2018131359A - Модуляция гипоксии, ассоциированной с инсультом - Google Patents
Модуляция гипоксии, ассоциированной с инсультом Download PDFInfo
- Publication number
- RU2018131359A RU2018131359A RU2018131359A RU2018131359A RU2018131359A RU 2018131359 A RU2018131359 A RU 2018131359A RU 2018131359 A RU2018131359 A RU 2018131359A RU 2018131359 A RU2018131359 A RU 2018131359A RU 2018131359 A RU2018131359 A RU 2018131359A
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- Russia
- Prior art keywords
- nox
- peg
- protein
- covalently linked
- approximately
- Prior art date
Links
- 206010021143 Hypoxia Diseases 0.000 title claims 18
- 230000007954 hypoxia Effects 0.000 title 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 107
- 229920001223 polyethylene glycol Polymers 0.000 claims 107
- 102000004169 proteins and genes Human genes 0.000 claims 96
- 108090000623 proteins and genes Proteins 0.000 claims 96
- 238000000034 method Methods 0.000 claims 71
- 239000000203 mixture Substances 0.000 claims 41
- 208000006011 Stroke Diseases 0.000 claims 20
- 208000032109 Transient ischaemic attack Diseases 0.000 claims 19
- 201000010875 transient cerebral ischemia Diseases 0.000 claims 19
- 230000001146 hypoxic effect Effects 0.000 claims 17
- 238000010494 dissociation reaction Methods 0.000 claims 15
- 230000005593 dissociations Effects 0.000 claims 15
- 238000005829 trimerization reaction Methods 0.000 claims 15
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 13
- 229910052760 oxygen Inorganic materials 0.000 claims 13
- 239000001301 oxygen Substances 0.000 claims 13
- 241000253373 Caldanaerobacter subterraneus subsp. tengcongensis Species 0.000 claims 12
- 102000001554 Hemoglobins Human genes 0.000 claims 12
- 108010054147 Hemoglobins Proteins 0.000 claims 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 239000000178 monomer Substances 0.000 claims 12
- 230000009257 reactivity Effects 0.000 claims 12
- 229920000642 polymer Polymers 0.000 claims 11
- 238000006467 substitution reaction Methods 0.000 claims 11
- 208000002381 Brain Hypoxia Diseases 0.000 claims 10
- 210000004556 brain Anatomy 0.000 claims 10
- 208000029028 brain injury Diseases 0.000 claims 10
- 241001599018 Melanogaster Species 0.000 claims 6
- 230000006378 damage Effects 0.000 claims 6
- 230000035772 mutation Effects 0.000 claims 6
- 238000006116 polymerization reaction Methods 0.000 claims 6
- 241000282414 Homo sapiens Species 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 101100121602 Caenorhabditis elegans gcy-35 gene Proteins 0.000 claims 3
- 241000282461 Canis lupus Species 0.000 claims 3
- 241000193401 Clostridium acetobutylicum Species 0.000 claims 3
- 102000008015 Hemeproteins Human genes 0.000 claims 3
- 108010089792 Hemeproteins Proteins 0.000 claims 3
- 108060003951 Immunoglobulin Proteins 0.000 claims 3
- 241000424623 Nostoc punctiforme Species 0.000 claims 3
- 241000700157 Rattus norvegicus Species 0.000 claims 3
- 241001223867 Shewanella oneidensis Species 0.000 claims 3
- 102000018358 immunoglobulin Human genes 0.000 claims 3
- 241001515965 unidentified phage Species 0.000 claims 3
- 206010058558 Hypoperfusion Diseases 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 210000001130 astrocyte Anatomy 0.000 claims 2
- 230000006735 deficit Effects 0.000 claims 2
- 230000003902 lesion Effects 0.000 claims 2
- 210000002540 macrophage Anatomy 0.000 claims 2
- 210000000274 microglia Anatomy 0.000 claims 2
- 230000002035 prolonged effect Effects 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 208000016988 Hemorrhagic Stroke Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000032382 Ischaemic stroke Diseases 0.000 claims 1
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 claims 1
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000009524 hypoxic brain injury Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 208000020658 intracerebral hemorrhage Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001067 neuroprotector Effects 0.000 claims 1
- 229960000187 tissue plasminogen activator Drugs 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
- A01H1/06—Processes for producing mutations, e.g. treatment with chemicals or with radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01247—Codeinone reductase (NADPH) (1.1.1.247)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
- C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
- C12Y205/01059—Protein geranylgeranyltransferase type I (2.5.1.59)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Environmental Sciences (AREA)
- Botany (AREA)
- Developmental Biology & Embryology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662296009P | 2016-02-16 | 2016-02-16 | |
| US62/296,009 | 2016-02-16 | ||
| PCT/US2017/018233 WO2017143104A1 (en) | 2016-02-16 | 2017-02-16 | Modulation hypoxia associated with stroke |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2018131359A true RU2018131359A (ru) | 2020-03-17 |
| RU2018131359A3 RU2018131359A3 (https=) | 2020-08-12 |
Family
ID=58191670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018131359A RU2018131359A (ru) | 2016-02-16 | 2017-02-16 | Модуляция гипоксии, ассоциированной с инсультом |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20200276265A1 (https=) |
| EP (1) | EP3416673B1 (https=) |
| JP (1) | JP2019511567A (https=) |
| KR (1) | KR20180123034A (https=) |
| CN (1) | CN109069582A (https=) |
| AU (1) | AU2017219869A1 (https=) |
| BR (1) | BR112018016829A2 (https=) |
| CA (1) | CA3014651A1 (https=) |
| DK (1) | DK3416673T3 (https=) |
| ES (1) | ES2939181T3 (https=) |
| IL (1) | IL261178A (https=) |
| MX (1) | MX2018009881A (https=) |
| RU (1) | RU2018131359A (https=) |
| SG (2) | SG11201806920SA (https=) |
| WO (1) | WO2017143104A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2886531T3 (es) * | 2013-01-07 | 2021-12-20 | Omniox Inc | Formas poliméricas de proteínas H-NOX |
| EP3836911A1 (en) | 2018-08-15 | 2021-06-23 | Omniox, Inc. | H-nox proteins for treating cardiovascular and pulmonary conditions |
| CN118076227A (zh) * | 2021-08-18 | 2024-05-24 | 欧姆尼奥克斯股份有限公司 | 用于器官保存的h-nox蛋白 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873192A (en) | 1987-02-17 | 1989-10-10 | The United States Of America As Represented By The Department Of Health And Human Services | Process for site specific mutagenesis without phenotypic selection |
| AU735799C (en) | 1997-02-28 | 2005-04-28 | Regents Of The University Of California, The | Methods and compositions for optimisation of oxygen transport by cell-free systems |
| JP2005517648A (ja) * | 2001-12-07 | 2005-06-16 | インターミューン インコーポレイテッド | 肝炎ウイルス感染症を治療するための組成物および方法 |
| US20030153491A1 (en) | 2002-01-11 | 2003-08-14 | Winslow Robert M. | Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
| DK2463297T3 (en) * | 2006-05-22 | 2017-01-09 | Univ California | Oxygen Compositions and Methods |
| ES2886531T3 (es) | 2013-01-07 | 2021-12-20 | Omniox Inc | Formas poliméricas de proteínas H-NOX |
-
2017
- 2017-02-16 EP EP17708103.1A patent/EP3416673B1/en active Active
- 2017-02-16 ES ES17708103T patent/ES2939181T3/es active Active
- 2017-02-16 RU RU2018131359A patent/RU2018131359A/ru not_active Application Discontinuation
- 2017-02-16 SG SG11201806920SA patent/SG11201806920SA/en unknown
- 2017-02-16 SG SG10202007517TA patent/SG10202007517TA/en unknown
- 2017-02-16 CA CA3014651A patent/CA3014651A1/en not_active Abandoned
- 2017-02-16 AU AU2017219869A patent/AU2017219869A1/en not_active Abandoned
- 2017-02-16 KR KR1020187026176A patent/KR20180123034A/ko not_active Withdrawn
- 2017-02-16 BR BR112018016829A patent/BR112018016829A2/pt not_active IP Right Cessation
- 2017-02-16 DK DK17708103.1T patent/DK3416673T3/da active
- 2017-02-16 JP JP2018561933A patent/JP2019511567A/ja active Pending
- 2017-02-16 US US15/998,557 patent/US20200276265A1/en not_active Abandoned
- 2017-02-16 WO PCT/US2017/018233 patent/WO2017143104A1/en not_active Ceased
- 2017-02-16 CN CN201780023823.8A patent/CN109069582A/zh active Pending
- 2017-02-16 MX MX2018009881A patent/MX2018009881A/es unknown
-
2018
- 2018-08-15 IL IL261178A patent/IL261178A/en unknown
-
2020
- 2020-12-23 US US17/133,180 patent/US20210121521A1/en not_active Abandoned
-
2023
- 2023-04-27 US US18/308,203 patent/US20240026399A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3416673A1 (en) | 2018-12-26 |
| SG11201806920SA (en) | 2018-09-27 |
| MX2018009881A (es) | 2019-01-31 |
| WO2017143104A1 (en) | 2017-08-24 |
| WO2017143104A8 (en) | 2018-09-07 |
| US20210121521A1 (en) | 2021-04-29 |
| CN109069582A (zh) | 2018-12-21 |
| ES2939181T3 (es) | 2023-04-19 |
| BR112018016829A2 (pt) | 2018-12-26 |
| CA3014651A1 (en) | 2017-08-24 |
| RU2018131359A3 (https=) | 2020-08-12 |
| KR20180123034A (ko) | 2018-11-14 |
| US20240026399A1 (en) | 2024-01-25 |
| SG10202007517TA (en) | 2020-09-29 |
| JP2019511567A (ja) | 2019-04-25 |
| IL261178A (en) | 2018-10-31 |
| AU2017219869A1 (en) | 2018-08-30 |
| US20200276265A1 (en) | 2020-09-03 |
| EP3416673B1 (en) | 2022-11-02 |
| DK3416673T3 (da) | 2023-01-23 |
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