RU2018114925A - Наполняющая текучая среда для струйных устройств - Google Patents

Наполняющая текучая среда для струйных устройств Download PDF

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RU2018114925A
RU2018114925A RU2018114925A RU2018114925A RU2018114925A RU 2018114925 A RU2018114925 A RU 2018114925A RU 2018114925 A RU2018114925 A RU 2018114925A RU 2018114925 A RU2018114925 A RU 2018114925A RU 2018114925 A RU2018114925 A RU 2018114925A
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filling fluid
block copolymer
siloxane block
filling
silicone oil
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RU2719991C2 (ru
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ХАТТЕН Хавьер ВОН
Майкл ПЕРБОСТ
Хэн ХУАН
Николь ЛИ
Вики В. ЛЭМ
Нильда ХУАН
Тимоти МЕРКЕЛЬ
Джон М. БАЙЕРЛЕ
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Иллюмина, Инк.
Иллюмина Кембридж Лимитед
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
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    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
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    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
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    • B01L2400/0424—Dielectrophoretic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427—Electrowetting
    • C—CHEMISTRY; METALLURGY
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    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/38—Polysiloxanes modified by chemical after-treatment
    • C08G77/382—Polysiloxanes modified by chemical after-treatment containing atoms other than carbon, hydrogen, oxygen or silicon
    • C08G77/388—Polysiloxanes modified by chemical after-treatment containing atoms other than carbon, hydrogen, oxygen or silicon containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C08G77/38—Polysiloxanes modified by chemical after-treatment
    • C08G77/382—Polysiloxanes modified by chemical after-treatment containing atoms other than carbon, hydrogen, oxygen or silicon
    • C08G77/392—Polysiloxanes modified by chemical after-treatment containing atoms other than carbon, hydrogen, oxygen or silicon containing sulfur
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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Claims (28)

1. Наполняющая текучая среда для струйного устройства, отличающаяся тем, что она содержит:
- силиконовое масло; и
- силоксановый блоксополимер, солюбилизированный в силиконовом масле, причем силоксановый блоксополимер является по существу несмешивающимся с водной жидкостью.
2. Наполняющая текучая среда по п. 1, отличающаяся тем, что менее чем примерно 0,1% объемной фракции силоксанового блоксополимера в наполняющей жидкости способно смешиваться с водной жидкостью.
3. Наполняющая текучая среда по п. 1, отличающаяся тем, что силоксановый блоксополимер содержит силоксановую основную цепь и функционализированную боковую цепь.
4. Наполняющая текучая среда по п. 3, отличающаяся тем, что функционализированная боковая цепь содержит гидрофильную концевую группу.
5. Наполняющая текучая среда по п. 4, отличающаяся тем, что гидрофильная концевая группа силоксанового блоксополимера выбрана из группы, состоящей из полиакриламида, полисахарида, полигликоля, карбоксилата, карбоновой кислоты, сульфоната, сульфата, этиленгликоля, амина, аммония, углевода, карбоната и силиката.
6. Наполняющая текучая среда по п. 5, отличающаяся тем, что силоксановый блоксополимер представлен Формулой I:
Figure 00000001
где n≥0, m≥0, а радикал R выбран из группы, состоящей из полиакриламида, полисахарида, полигликоля, карбоксилата, карбоновой кислоты, сульфоната, сульфата, этиленгликоля, амина, аммония, углевода, карбоната и силиката.
7. Наполняющая текучая среда по п. 1, отличающаяся тем, что концентрация силоксанового блоксополимера в наполняющей текучей среде лежит в диапазоне от примерно 0,02 масс. % до примерно 0,1 масс. %.
8. Наполняющая текучая среда по п. 1, отличающаяся тем, что концентрация силоксанового блоксополимера в наполняющей текучей среде составляет примерно 0,05 масс. %.
9. Наполняющая текучая среда по п. 1, отличающаяся тем, что силиконовое масло содержит полидиметилсилоксан (PDMS).
10. Наполняющая текучая среда по п. 9, отличающаяся тем, что силоксановый блоксополимер является сополимером (гидроксипропиленоксипропил)метилсилоксана и диметилсилоксана.
11. Наполняющая текучая среда по п. 1, отличающаяся тем, что поверхностное натяжение на границе раздела наполняющей текучей среды и капли водной жидкости лежит в диапазоне от примерно 3 дин/см до примерно 12 дин/см (от примерно 0,003 Н/м до примерно 0,012 Н/м).
12. Набор, отличающийся тем, что он содержит:
- струйное устройство; и
- контейнер, содержащий наполняющую текучую среду, причем наполняющая текучая среда содержит силоксановый блоксополимер и силиконовое масло.
13. Набор по п. 12, отличающийся тем, что он дополнительно содержит контейнер, содержащий водный буферный раствор, который является по существу несмешивающимся с силоксановым блоксополимером.
14. Набор по п. 13, отличающийся тем, что менее чем примерно 0,1% объемной фракции силоксанового блоксополимера в наполняющей жидкости способно смешиваться с водным буферным раствором.
15. Набор по п. 12, отличающийся тем, что силиконовое масло содержит полидиметилсилоксан (PDMS).
16. Набор по п. 15, отличающийся тем, что силоксановый блоксополимер является сополимером (гидроксипропиленоксипропил)метилсилоксана и диметилсилоксана.
17. Набор по п. 12, отличающийся тем, что струйное устройство является электросмачивающим, оптоэлектросмачивающим, электростатическим, электрофоретическим, диэлектрофоретическим или электроосмотическим устройством.
18. Способ выполнения операций с каплями в струйном устройстве, отличающийся тем, что он включает перемещение множества водных капель через наполняющую текучую среду внутри струйного устройства, причем наполняющая текучая среда содержит силоксановый блоксополимер, солюбилизированный в силиконовом масле, а множество водных капель является по существу несмешивающимся с наполняющей текучей средой.
19. Способ по п. 18, отличающийся тем, что перемещение множества водных капель включает использование электросмачивания, оптоэлектросмачивания, электростатического, электрофоретического, диэлектрофоретического, электроосмотического механизмов или их комбинации для перемещения множества водных капель.
20. Способ по п. 18, отличающийся тем, что поверхностное натяжение на границе раздела между множеством водных капель и наполняющей текучей средой лежит в диапазоне от примерно 3 дин/см до примерно 12 дин/см (от примерно 0,003 Н/м до примерно 0,012 Н/м).
21. Способ по п. 18, отличающийся тем, что перемещение множества капель включает выполнение полимеразной цепной реакции.
22. Способ по п. 18, отличающийся тем, что перемещение множества капель включает приготовление образца для реакции секвенирования полинуклеотида.
RU2018114925A 2015-10-22 2016-10-20 Наполняющая текучая среда для струйных устройств RU2719991C2 (ru)

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JP6936222B2 (ja) 2021-09-15
CN108290157B (zh) 2021-08-17
US20200179935A1 (en) 2020-06-11
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EP3365108A1 (en) 2018-08-29
HK1254546A1 (zh) 2019-07-19
JP2018538385A (ja) 2018-12-27
EP3365108B1 (en) 2024-06-12
RU2018114925A3 (ru) 2020-02-20
US20190217300A1 (en) 2019-07-18
CN108290157A (zh) 2018-07-17
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AU2016341948A1 (en) 2018-05-10
CA3002983A1 (en) 2017-04-27

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