RU2018102590A3 - - Google Patents

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Publication number
RU2018102590A3
RU2018102590A3 RU2018102590A RU2018102590A RU2018102590A3 RU 2018102590 A3 RU2018102590 A3 RU 2018102590A3 RU 2018102590 A RU2018102590 A RU 2018102590A RU 2018102590 A RU2018102590 A RU 2018102590A RU 2018102590 A3 RU2018102590 A3 RU 2018102590A3
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RU
Russia
Application number
RU2018102590A
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RU2018102590A (ru
RU2746858C2 (ru
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Publication of RU2018102590A publication Critical patent/RU2018102590A/ru
Publication of RU2018102590A3 publication Critical patent/RU2018102590A3/ru
Application granted granted Critical
Publication of RU2746858C2 publication Critical patent/RU2746858C2/ru

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
RU2018102590A 2015-06-23 2016-06-23 Соединения С,O-спиро-арил-гликозидов, их приготовление и их использование RU2746858C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201510353843.4 2015-06-23
CN201510353843.4A CN106317068A (zh) 2015-06-23 2015-06-23 一种c,o-螺环芳基糖苷类化合物及其制备和应用
PCT/CN2016/086892 WO2016206604A1 (zh) 2015-06-23 2016-06-23 一种c, o-螺环芳基糖苷类化合物及其制备和应用

Publications (3)

Publication Number Publication Date
RU2018102590A RU2018102590A (ru) 2019-07-23
RU2018102590A3 true RU2018102590A3 (ru) 2019-07-24
RU2746858C2 RU2746858C2 (ru) 2021-04-21

Family

ID=57584713

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2018102590A RU2746858C2 (ru) 2015-06-23 2016-06-23 Соединения С,O-спиро-арил-гликозидов, их приготовление и их использование

Country Status (11)

Country Link
US (1) US10550143B2 (ru)
EP (1) EP3315502A4 (ru)
JP (1) JP6644814B2 (ru)
KR (1) KR102130155B1 (ru)
CN (2) CN106317068A (ru)
AU (1) AU2016282151B2 (ru)
BR (1) BR112017027762A2 (ru)
CA (1) CA3002878C (ru)
HK (1) HK1249898A1 (ru)
RU (1) RU2746858C2 (ru)
WO (1) WO2016206604A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112661736B (zh) * 2021-01-12 2021-09-28 广州市力鑫药业有限公司 一种泰格列净中间体的合成方法
CN112645915B (zh) * 2021-01-13 2021-10-08 广州安岩仁医药科技有限公司 一种sglt2抑制剂中间体的合成方法
CN113429379A (zh) * 2021-06-28 2021-09-24 江苏法安德医药科技有限公司 一种lh-1801中间体及其制备方法和应用
CN115819398A (zh) * 2022-10-31 2023-03-21 江苏联环药业股份有限公司 一类sglt2抑制剂关键中间体及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6515117B2 (en) * 1999-10-12 2003-02-04 Bristol-Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
PH12000002657B1 (en) * 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
TW200637869A (en) * 2005-01-28 2006-11-01 Chugai Pharmaceutical Co Ltd The spiroketal derivatives and the use as therapeutical agent for diabetes of the same
ZA200706022B (en) * 2005-01-28 2008-11-26 Chugai Pharmaceutical Co Ltd Spiroketal derivatives and use thereof as diabetic medicine
EP2019679B1 (en) 2006-05-23 2018-06-20 Theracos, Inc. Glucose transport inhibitors and methods of use
TWI403516B (zh) * 2006-07-27 2013-08-01 Chugai Pharmaceutical Co Ltd To replace spirocyclic alcohol derivatives, and its use as a therapeutic agent for diabetes
CN101812043A (zh) * 2009-02-19 2010-08-25 上海恒瑞医药有限公司 C-芳基葡萄糖苷衍生物、其制备方法及其在医药上的应用

Also Published As

Publication number Publication date
CA3002878A1 (en) 2016-12-29
RU2018102590A (ru) 2019-07-23
RU2746858C2 (ru) 2021-04-21
EP3315502A4 (en) 2019-03-20
EP3315502A1 (en) 2018-05-02
KR20180020276A (ko) 2018-02-27
CN106317068A (zh) 2017-01-11
CN107709332A (zh) 2018-02-16
US10550143B2 (en) 2020-02-04
WO2016206604A1 (zh) 2016-12-29
US20180305390A1 (en) 2018-10-25
CA3002878C (en) 2020-08-04
AU2016282151A1 (en) 2018-02-15
JP2018520141A (ja) 2018-07-26
HK1249898A1 (zh) 2018-11-16
CN107709332B (zh) 2019-12-20
KR102130155B1 (ko) 2020-07-03
BR112017027762A2 (pt) 2018-11-06
AU2016282151B2 (en) 2019-07-11
JP6644814B2 (ja) 2020-02-12

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