RU2017140776A - Устройство для нейромодуляции - Google Patents
Устройство для нейромодуляции Download PDFInfo
- Publication number
- RU2017140776A RU2017140776A RU2017140776A RU2017140776A RU2017140776A RU 2017140776 A RU2017140776 A RU 2017140776A RU 2017140776 A RU2017140776 A RU 2017140776A RU 2017140776 A RU2017140776 A RU 2017140776A RU 2017140776 A RU2017140776 A RU 2017140776A
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- Prior art keywords
- signal
- nerve
- patient
- paragraphs
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- Prior art date
Links
- 230000004007 neuromodulation Effects 0.000 title claims 8
- 210000005036 nerve Anatomy 0.000 claims 39
- 238000000034 method Methods 0.000 claims 38
- 230000003393 splenic effect Effects 0.000 claims 18
- 230000002889 sympathetic effect Effects 0.000 claims 13
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 12
- 239000002260 anti-inflammatory agent Substances 0.000 claims 12
- 206010009887 colitis Diseases 0.000 claims 10
- 230000000694 effects Effects 0.000 claims 10
- 210000001519 tissue Anatomy 0.000 claims 10
- 230000000968 intestinal effect Effects 0.000 claims 9
- 210000000936 intestine Anatomy 0.000 claims 8
- 230000008035 nerve activity Effects 0.000 claims 7
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 claims 6
- 230000036982 action potential Effects 0.000 claims 6
- 229960002748 norepinephrine Drugs 0.000 claims 6
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 claims 6
- 210000001072 colon Anatomy 0.000 claims 5
- 210000000952 spleen Anatomy 0.000 claims 5
- 230000004936 stimulating effect Effects 0.000 claims 4
- 210000001186 vagus nerve Anatomy 0.000 claims 4
- 206010061218 Inflammation Diseases 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 206010016654 Fibrosis Diseases 0.000 claims 2
- 102100024304 Protachykinin-1 Human genes 0.000 claims 2
- 101800003906 Substance P Proteins 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 210000001815 ascending colon Anatomy 0.000 claims 2
- 230000017531 blood circulation Effects 0.000 claims 2
- 230000004761 fibrosis Effects 0.000 claims 2
- 238000002513 implantation Methods 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 230000003287 optical effect Effects 0.000 claims 2
- 230000007170 pathology Effects 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 210000000813 small intestine Anatomy 0.000 claims 2
- 230000000638 stimulation Effects 0.000 claims 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 229960002170 azathioprine Drugs 0.000 claims 1
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 230000004087 circulation Effects 0.000 claims 1
- 229930182912 cyclosporin Natural products 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 claims 1
- 229960004963 mesalazine Drugs 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 230000003227 neuromodulating effect Effects 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
- 230000018405 transmission of nerve impulse Effects 0.000 claims 1
- 239000002451 tumor necrosis factor inhibitor Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
- A61N1/0556—Cuff electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36135—Control systems using physiological parameters
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Radiology & Medical Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Electrotherapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562152119P | 2015-04-24 | 2015-04-24 | |
| US62/152,119 | 2015-04-24 | ||
| PCT/IB2016/052307 WO2016170510A1 (en) | 2015-04-24 | 2016-04-22 | Neuromodulation device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2017140776A true RU2017140776A (ru) | 2019-05-24 |
Family
ID=55963419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017140776A RU2017140776A (ru) | 2015-04-24 | 2016-04-22 | Устройство для нейромодуляции |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10974041B2 (https=) |
| EP (2) | EP3950049A1 (https=) |
| JP (1) | JP2018514354A (https=) |
| KR (1) | KR20180040516A (https=) |
| CN (1) | CN108290041A (https=) |
| AU (1) | AU2016252497A1 (https=) |
| BR (1) | BR112017022941A2 (https=) |
| CA (1) | CA2983652A1 (https=) |
| MA (1) | MA41950A (https=) |
| RU (1) | RU2017140776A (https=) |
| WO (1) | WO2016170510A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013134543A1 (en) | 2012-03-08 | 2013-09-12 | Medtronic Ardian Luxembourg Sarl | Immune system neuromodulation and associated systems and methods |
| JP2017536187A (ja) | 2014-12-03 | 2017-12-07 | メタベンション インコーポレイテッド | 神経または他の組織を調節するためのシステムおよび方法 |
| US20180193643A1 (en) * | 2015-06-05 | 2018-07-12 | The Johns Hopkins University | Method and device for sacral nerve stimulation |
| US10524859B2 (en) | 2016-06-07 | 2020-01-07 | Metavention, Inc. | Therapeutic tissue modulation devices and methods |
| PT3481284T (pt) | 2016-07-07 | 2021-10-14 | Univ California | Implantes utilizando retrodifusão ultrassónica para detetar sinais eletrofisiológicos |
| WO2019122904A1 (en) * | 2017-12-20 | 2019-06-27 | Galvani Bioelectronics Limited | Treatment of inflammatory disorders |
| JP2021507762A (ja) | 2017-12-20 | 2021-02-25 | ガルバニ バイオエレクトロニクス リミテッド | 急性疾患の治療 |
| US11446502B2 (en) | 2017-12-20 | 2022-09-20 | Galvani Bioelectronics Limited | Stimulation of a nerve supplying the spleen |
| JP2021507759A (ja) * | 2017-12-20 | 2021-02-25 | ガルバニ バイオエレクトロニクス リミテッド | 炎症に関連する疾患の治療 |
| WO2019122906A1 (en) | 2017-12-20 | 2019-06-27 | Galvani Bioelectronics Limited | Treatment of acute medical conditions |
| CN112272575B (zh) | 2018-04-19 | 2024-05-17 | 艾奧塔生物科技公司 | 使用用于神经感测和刺激的超声通信的植入物 |
| AU2019255373B2 (en) | 2018-04-19 | 2025-02-06 | Iota Biosciences, Inc. | Implants using ultrasonic communication for modulating splenic nerve activity |
| US10974079B2 (en) * | 2018-08-29 | 2021-04-13 | General Electric Company | Neuromodulation techniques |
| CA3109810A1 (en) | 2018-08-29 | 2020-03-05 | Jose M. Carmena | Implantable closed-loop neuromodulation device, systems, and methods of use |
| US12447343B2 (en) * | 2018-12-20 | 2025-10-21 | Galvani Bioelectronics Limited | Neurostimulation device for blocking blood flow between electrodes |
| WO2020254798A1 (en) * | 2019-06-19 | 2020-12-24 | Galvani Bioelectronics Limited | Stimulation of a nerve supplying the spleen |
| EP3986531A1 (en) * | 2019-06-19 | 2022-04-27 | Galvani Bioelectronics Limited | Treatment of acute medical conditions |
| US20220305259A1 (en) * | 2019-06-19 | 2022-09-29 | Galvani Bioelectronics Limited | System for the Treatment of Disorders Associated with Inflammation |
| CN114828945A (zh) | 2019-10-17 | 2022-07-29 | 艾奧塔生物科技公司 | 用于调节癌症患者的免疫系统活性和治疗癌症的装置和方法 |
| US12370383B2 (en) * | 2020-04-09 | 2025-07-29 | General Electric Company | Neuromodulation to treat physiological conditions |
| WO2022122833A1 (en) * | 2020-12-09 | 2022-06-16 | Galvani Bioelectronics Limited | Physiological effects of activation of the alox15 pathway |
| CN113197587A (zh) * | 2021-04-26 | 2021-08-03 | 中国科学院深圳先进技术研究院 | 一种用于迷走神经刺激和电生理检测的装置及植入方法 |
| WO2023017253A1 (en) * | 2021-08-10 | 2023-02-16 | Galvani Bioelectronics Limited | Neuromodulation device |
| KR20230078121A (ko) * | 2021-11-26 | 2023-06-02 | 주식회사 뉴라이브 | 동물용 미주신경 자극장치 |
| CN114177472A (zh) * | 2021-11-30 | 2022-03-15 | 中国人民解放军总医院第四医学中心 | 一种应用于下肢假肢的植入式电刺激感知反馈系统 |
| US20250229086A1 (en) | 2022-01-20 | 2025-07-17 | Setpoint Medical Corporation | Treatment of inflammatory disorders |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7389145B2 (en) | 2001-02-20 | 2008-06-17 | Case Western Reserve University | Systems and methods for reversibly blocking nerve activity |
| US20060116736A1 (en) | 2001-07-23 | 2006-06-01 | Dilorenzo Daniel J | Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of obesity |
| US7418292B2 (en) * | 2003-10-01 | 2008-08-26 | Medtronic, Inc. | Device and method for attenuating an immune response |
| US20050075702A1 (en) * | 2003-10-01 | 2005-04-07 | Medtronic, Inc. | Device and method for inhibiting release of pro-inflammatory mediator |
| US8214047B2 (en) * | 2004-09-27 | 2012-07-03 | Advanced Neuromodulation Systems, Inc. | Method of using spinal cord stimulation to treat gastrointestinal and/or eating disorders or conditions |
| CN102793972A (zh) | 2004-12-27 | 2012-11-28 | 范因斯坦医学研究院 | 通过电刺激迷走神经治疗炎症性疾病 |
| AU2006315829B2 (en) * | 2005-11-10 | 2011-01-27 | ElectroCore, LLC. | Electrical stimulation treatment of bronchial constriction |
| EP1984064A4 (en) * | 2006-02-10 | 2009-11-11 | Electrocore Inc | METHODS AND APPARATUS USED TO TREAT ANAPHYLAXIS USING ELECTRICAL MODULATION |
| US9539425B2 (en) * | 2006-10-13 | 2017-01-10 | Intelect Medical, Inc. | Systems and methods for treating medical conditions by stimulation of medial thalamic region |
| WO2008096730A1 (ja) * | 2007-02-09 | 2008-08-14 | National University Corporation Nagoya University | 抗炎症剤及びその用途 |
| US20090275997A1 (en) * | 2008-05-01 | 2009-11-05 | Michael Allen Faltys | Vagus nerve stimulation electrodes and methods of use |
| CN106264720A (zh) * | 2010-12-28 | 2017-01-04 | 西比姆公司 | 用于患者的交感再平衡的方法 |
| EP2707094B1 (en) * | 2011-05-09 | 2016-02-03 | Setpoint Medical Corporation | Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
| CA2834180C (en) | 2011-05-19 | 2019-04-30 | Neuros Medical, Inc. | High-frequency electrical nerve block |
| AU2012347470B2 (en) * | 2011-12-09 | 2017-02-02 | Medtronic Ireland Manufacturing Unlimited Company | Therapeutic neuromodulation of the hepatic system |
| CN104145466A (zh) * | 2012-02-24 | 2014-11-12 | 诺基亚公司 | 用于动态服务器/客户端控制的连通性逻辑的方法和装置 |
| WO2013134541A2 (en) * | 2012-03-08 | 2013-09-12 | Medtronic Ardian Luxembourg Sarl | Gastrointestinal neuromodulation and associated systems and methods |
| WO2014153223A1 (en) * | 2013-03-14 | 2014-09-25 | Perryman Laura Tyler | Treating inflammation, chronic pain and other disorders with neuromodulation |
-
2016
- 2016-04-22 BR BR112017022941-2A patent/BR112017022941A2/pt not_active Application Discontinuation
- 2016-04-22 EP EP21197806.9A patent/EP3950049A1/en not_active Withdrawn
- 2016-04-22 RU RU2017140776A patent/RU2017140776A/ru not_active Application Discontinuation
- 2016-04-22 MA MA041950A patent/MA41950A/fr unknown
- 2016-04-22 EP EP16721943.5A patent/EP3285856A1/en not_active Withdrawn
- 2016-04-22 WO PCT/IB2016/052307 patent/WO2016170510A1/en not_active Ceased
- 2016-04-22 KR KR1020177034006A patent/KR20180040516A/ko not_active Withdrawn
- 2016-04-22 CA CA2983652A patent/CA2983652A1/en not_active Abandoned
- 2016-04-22 US US15/568,964 patent/US10974041B2/en active Active
- 2016-04-22 CN CN201680037057.6A patent/CN108290041A/zh active Pending
- 2016-04-22 JP JP2018506492A patent/JP2018514354A/ja not_active Ceased
- 2016-04-22 AU AU2016252497A patent/AU2016252497A1/en not_active Abandoned
-
2021
- 2021-02-26 US US17/186,610 patent/US20210393949A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20180040516A (ko) | 2018-04-20 |
| CA2983652A1 (en) | 2016-10-27 |
| US20210393949A1 (en) | 2021-12-23 |
| MA41950A (fr) | 2018-02-28 |
| BR112017022941A2 (pt) | 2018-07-17 |
| JP2018514354A (ja) | 2018-06-07 |
| EP3950049A1 (en) | 2022-02-09 |
| CN108290041A (zh) | 2018-07-17 |
| AU2016252497A1 (en) | 2017-11-09 |
| US20180117319A1 (en) | 2018-05-03 |
| WO2016170510A1 (en) | 2016-10-27 |
| US10974041B2 (en) | 2021-04-13 |
| EP3285856A1 (en) | 2018-02-28 |
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