RU2016151724A - Термоотверждаемые биофотонные композиции и их применения - Google Patents
Термоотверждаемые биофотонные композиции и их применения Download PDFInfo
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- RU2016151724A RU2016151724A RU2016151724A RU2016151724A RU2016151724A RU 2016151724 A RU2016151724 A RU 2016151724A RU 2016151724 A RU2016151724 A RU 2016151724A RU 2016151724 A RU2016151724 A RU 2016151724A RU 2016151724 A RU2016151724 A RU 2016151724A
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- thermoset
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- biophotonic composition
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- 239000000203 mixture Substances 0.000 title claims 27
- 238000001029 thermal curing Methods 0.000 title 1
- 229920001187 thermosetting polymer Polymers 0.000 claims 20
- 238000000034 method Methods 0.000 claims 16
- 230000001678 irradiating effect Effects 0.000 claims 5
- 229920001400 block copolymer Polymers 0.000 claims 4
- 208000002874 Acne Vulgaris Diseases 0.000 claims 3
- 206010000496 acne Diseases 0.000 claims 3
- 208000017520 skin disease Diseases 0.000 claims 3
- 230000029663 wound healing Effects 0.000 claims 3
- 201000004624 Dermatitis Diseases 0.000 claims 2
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical group C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 2
- 229920001983 poloxamer Polymers 0.000 claims 2
- 229960000502 poloxamer Drugs 0.000 claims 2
- 230000003716 rejuvenation Effects 0.000 claims 2
- 239000003381 stabilizer Substances 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 239000001018 xanthene dye Substances 0.000 claims 2
- 208000032544 Cicatrix Diseases 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 238000000862 absorption spectrum Methods 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- OOYIOIOOWUGAHD-UHFFFAOYSA-L disodium;2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-3-oxospiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate Chemical compound [Na+].[Na+].O1C(=O)C(C(=C(Cl)C(Cl)=C2Cl)Cl)=C2C21C1=CC(Br)=C([O-])C(Br)=C1OC1=C(Br)C([O-])=C(Br)C=C21 OOYIOIOOWUGAHD-UHFFFAOYSA-L 0.000 claims 1
- RAGZEDHHTPQLAI-UHFFFAOYSA-L disodium;2',4',5',7'-tetraiodo-3-oxospiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate Chemical compound [Na+].[Na+].O1C(=O)C2=CC=CC=C2C21C1=CC(I)=C([O-])C(I)=C1OC1=C(I)C([O-])=C(I)C=C21 RAGZEDHHTPQLAI-UHFFFAOYSA-L 0.000 claims 1
- SEACYXSIPDVVMV-UHFFFAOYSA-L eosin Y Chemical group [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C([O-])=C(Br)C=C21 SEACYXSIPDVVMV-UHFFFAOYSA-L 0.000 claims 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 229920001992 poloxamer 407 Polymers 0.000 claims 1
- -1 polyethylene Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Substances CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 1
- 231100000241 scar Toxicity 0.000 claims 1
- 230000037387 scars Effects 0.000 claims 1
- 238000001228 spectrum Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Claims (37)
1. Термоотверждаемая биофотонная композиция, содержащая блок-сополимер в концентрации более чем приблизительно 20% по весу на единицу объема композиции и, по меньшей мере, один хромофор, солюбилизированный в блок-сополимере.
2. Термоотверждаемая биофотонная композиция по п. 1, где блок-сополимер содержит по меньшей мере одну последовательность полиэтиленгликоль-пропиленгликоль ((PEG)-(PPG)).
3. Термоотверждаемая биофотонная композиция по п. 1 или 2, где блок-сополимер представляет собой полоксамер.
4. Термоотверждаемая биофотонная композиция по п. 3, где полоксамер представляет собой pluronic F127.
5. Термоотверждаемая биофотонная композиция по любому из пп. 1-4, где хромофор может поглощать и испускать свет.
6. Термоотверждаемая биофотонная композиция по любому из пп. 1-5, где хромофор может поглощать и/или испускать свет в видимой области спектра.
7. Термоотверждаемая биофотонная композиция по любому из пп. 1-6, где хромофор представляет собой ксантеновый краситель.
8. Термоотверждаемая биофотонная композиция по п. 7, где ксантеновый краситель выбран из эозина Y, эритрозина B, флуоресцеина, бенгальского розового и флоксина B.
9. Термоотверждаемая биофотонная композиция по п. 8, где хромофор является водорастворимым.
10. Термоотверждаемая биофотонная композиция по любому из пп. 1-9, дополнительно содержащая стабилизатор.
11. Термоотверждаемая биофотонная композиция по п. 10, где стабилизатор выбран из желатина, HEC и CMC.
12. Способ биофотонного лечения кожного нарушения, включающий
нанесение термоотверждаемой биофотонной композиции по любому из пп. 1-11 на область кожной ткани и
облучение композиции светом, имеющим длину волны, которая поглощается, по меньшей мере, одним хромофором;
где с помощью способа стимулируют излечение указанного кожного нарушения.
13. Способ по п. 12, где кожное нарушение выбрано из акне, экземы, псориаза или дерматита.
14. Способ биофотонного лечения акне, включающий
нанесение термоотверждаемой биофотонной композиции по любому из пп. 1-11 на область кожной ткани и
облучение указанной биофотонной композиции светом, имеющим длину волны, которая перекрывается со спектром поглощения, по меньшей мере, одного хромофора;
где с помощью способа лечат акне.
15. Способ стимуляции заживления ран, включающий
нанесение термоотверждаемой биофотонной композиции по любому из пп. 1-11 на область кожной ткани и
облучение композиции светом, имеющим длину волны, которая поглощается, по меньшей мере, одним хромофором;
где с помощью способа стимулируют заживление ран.
16. Способ стимуляции омоложения кожи, включающий
нанесение термоотверждаемой биофотонной композиции по любому из пп. 1-11 на область кожной ткани и
облучение композиции светом, имеющим длину волны, которая поглощается. по меньшей мере, одним хромофором;
где с помощью способа стимулируют омоложение кожи.
17. Способ предупреждения образования или лечения рубцов, включающий
нанесение термоотверждаемой биофотонной композиции по любому из пп. 1-11 на область кожной ткани и
облучение композиции светом, имеющим длину волны, которая поглощается, по меньшей мере, одним хромофором;
где с помощью способа стимулируют заживление ран.
18. Способ по любому из пп. 12-17, где термоотверждаемую биофотонную композицию распыляют на область кожной ткани.
19. Способ по любому из пп. 12-18, где термоотверждаемую биофотонную композицию удаляют после облучения.
20. Способ по любому из пп. 12-18, где термоотверждаемую биофотонную композицию оставляют на том же месте после облучения.
21. Способ по любому из пп. 12-20, где хромофор подвергается, по меньшей, мере частичному фотообесцвечиванию после облучения.
22. Способ по любому из пп. 12-21, где термоотверждаемую биофотонную композицию облучают до тех пор, пока хромофор не подвергнется, по меньшей мере, частичному фотообесцвечиванию.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462009869P | 2014-06-09 | 2014-06-09 | |
| US62/009,869 | 2014-06-09 | ||
| PCT/CA2015/050530 WO2015188271A1 (en) | 2014-06-09 | 2015-06-09 | Thermosetting biophotonic compositions and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2016151724A true RU2016151724A (ru) | 2018-07-09 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016151724A RU2016151724A (ru) | 2014-06-09 | 2015-06-09 | Термоотверждаемые биофотонные композиции и их применения |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20170112755A1 (ru) |
| EP (1) | EP3151860B1 (ru) |
| JP (1) | JP6768525B2 (ru) |
| KR (1) | KR20170014000A (ru) |
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| US20130281913A1 (en) * | 2012-04-20 | 2013-10-24 | Klox Technologies Inc. | Biophotonic compositions and methods for providing biophotonic treatment |
| AU2015240385B2 (en) | 2014-04-01 | 2019-02-28 | Klox Technologies Inc. | Tissue filler compositions and methods of use |
| CA3037397A1 (en) * | 2016-09-23 | 2018-03-29 | Klox Technologies Inc. | Biophotonic compositions and methods for reducing scarring |
| EP3852806A4 (en) * | 2017-01-27 | 2022-12-28 | Klox Technologies Inc. | METHODS OF PHOTOBIOMODULATION OF BIOLOGICAL PROCESSES USING FLUORESCENCE GENERATED AND EMITTED BY A BIOPHOTONIC COMPOSITION OR SYSTEM |
| WO2018201257A1 (en) * | 2017-05-04 | 2018-11-08 | Klox Technologies Inc. | Absorbent biophotonic devices and systems for wound healing |
| US10967197B2 (en) | 2018-08-29 | 2021-04-06 | Azulite, Inc. | Phototherapy devices and methods for treating truncal acne and scars |
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| US8663692B1 (en) * | 1999-05-07 | 2014-03-04 | Pharmasol Gmbh | Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same |
| US6693093B2 (en) * | 2000-05-08 | 2004-02-17 | The University Of British Columbia (Ubc) | Drug delivery systems for photodynamic therapy |
| CN1224424C (zh) * | 2002-02-01 | 2005-10-26 | 发礮成生物科技有限公司 | 粘膜吸附性的热凝性医药载体组合物 |
| US20040009212A1 (en) * | 2002-01-30 | 2004-01-15 | Pharma Power Biotec Co. Ltd. | Mucoadhesive thermoresponsive medicament-carrier composition |
| US20040247624A1 (en) * | 2003-06-05 | 2004-12-09 | Unger Evan Charles | Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility |
| CN101166429A (zh) | 2005-04-13 | 2008-04-23 | 雪印乳业株式会社 | 营养组合物 |
| US8648119B2 (en) * | 2008-05-23 | 2014-02-11 | Otonomy, Inc. | Controlled release immunomodulator compositions and methods for the treatment of otic disorders |
| EA024827B1 (ru) * | 2008-11-07 | 2016-10-31 | Клокс Текнолоджиз Инк. | Комбинация оксиданта и фотоактиватора для заживления ран |
| CN102146200B (zh) * | 2011-04-19 | 2012-08-22 | 复旦大学 | 一种基于化学交联凝胶颗粒的温敏性水凝胶及其制备方法 |
| US20130281913A1 (en) | 2012-04-20 | 2013-10-24 | Klox Technologies Inc. | Biophotonic compositions and methods for providing biophotonic treatment |
| CN102731981B (zh) * | 2012-06-01 | 2014-08-27 | 华中科技大学 | 一种温度敏感性可注射混合水凝胶 |
| US20170106013A1 (en) * | 2014-06-04 | 2017-04-20 | Klox Technologies Inc. | Biophotonic hydrogels |
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| EP3151860B1 (en) | 2021-03-24 |
| CN106714837A (zh) | 2017-05-24 |
| MX2016016407A (es) | 2017-04-06 |
| ZA201608478B (en) | 2019-06-26 |
| CA2951467C (en) | 2023-08-08 |
| AR100864A1 (es) | 2016-11-09 |
| WO2015188271A1 (en) | 2015-12-17 |
| TW201609181A (zh) | 2016-03-16 |
| EP3151860A4 (en) | 2017-12-06 |
| JP2017517537A (ja) | 2017-06-29 |
| CA2951467A1 (en) | 2015-12-17 |
| BR112016028895A2 (pt) | 2017-08-22 |
| KR20170014000A (ko) | 2017-02-07 |
| IL249397A0 (en) | 2017-02-28 |
| AU2015274201A1 (en) | 2016-12-22 |
| JP6768525B2 (ja) | 2020-10-14 |
| US20170112755A1 (en) | 2017-04-27 |
| CN106714837B (zh) | 2021-04-16 |
| EP3151860A1 (en) | 2017-04-12 |
| AU2015274201B2 (en) | 2020-06-25 |
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