RU2016147362A - Препараты жидкого концетрата циклофосфамида - Google Patents
Препараты жидкого концетрата циклофосфамида Download PDFInfo
- Publication number
- RU2016147362A RU2016147362A RU2016147362A RU2016147362A RU2016147362A RU 2016147362 A RU2016147362 A RU 2016147362A RU 2016147362 A RU2016147362 A RU 2016147362A RU 2016147362 A RU2016147362 A RU 2016147362A RU 2016147362 A RU2016147362 A RU 2016147362A
- Authority
- RU
- Russia
- Prior art keywords
- cyclophosphamide
- composition containing
- solution
- container
- amount
- Prior art date
Links
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 title claims 34
- 229960004397 cyclophosphamide Drugs 0.000 title claims 34
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 235000014666 liquid concentrate Nutrition 0.000 title 1
- 239000000203 mixture Substances 0.000 claims 19
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 14
- 239000000243 solution Substances 0.000 claims 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 6
- 229960004106 citric acid Drugs 0.000 claims 4
- 239000003085 diluting agent Substances 0.000 claims 4
- 239000002535 acidifier Substances 0.000 claims 3
- 239000003963 antioxidant agent Substances 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 claims 2
- 229940035024 thioglycerol Drugs 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 239000008215 water for injection Substances 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- 229960004543 anhydrous citric acid Drugs 0.000 claims 1
- PWOQRKCAHTVFLB-UHFFFAOYSA-N cyclophosphamide hydrate Chemical group O.ClCCN(CCCl)P1(=O)NCCCO1 PWOQRKCAHTVFLB-UHFFFAOYSA-N 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 229960002433 cysteine Drugs 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 229960004452 methionine Drugs 0.000 claims 1
- 235000006109 methionine Nutrition 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 150000007524 organic acids Chemical group 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 claims 1
- 239000000473 propyl gallate Substances 0.000 claims 1
- 229940075579 propyl gallate Drugs 0.000 claims 1
- 235000010388 propyl gallate Nutrition 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/664—Amides of phosphorus acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461991247P | 2014-05-09 | 2014-05-09 | |
| US61/991,247 | 2014-05-09 | ||
| PCT/US2015/028862 WO2015171460A2 (en) | 2014-05-09 | 2015-05-01 | Formulations of cyclophosphamide liquid concentrate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2016147362A true RU2016147362A (ru) | 2018-06-13 |
| RU2016147362A3 RU2016147362A3 (enExample) | 2018-10-01 |
Family
ID=54366856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016147362A RU2016147362A (ru) | 2014-05-09 | 2015-05-01 | Препараты жидкого концетрата циклофосфамида |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US9662342B2 (enExample) |
| EP (1) | EP3139929A4 (enExample) |
| JP (1) | JP6516831B2 (enExample) |
| KR (1) | KR20170008252A (enExample) |
| CN (1) | CN106456654A (enExample) |
| AU (1) | AU2015256331B2 (enExample) |
| BR (1) | BR112016026140A2 (enExample) |
| CA (1) | CA2948148C (enExample) |
| RU (1) | RU2016147362A (enExample) |
| WO (1) | WO2015171460A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016005962A2 (en) | 2014-07-11 | 2016-01-14 | Dr. Reddy’S Laboratories Limited | Stable liquid formulations of cyclophosphamide and processes |
| WO2016132270A1 (en) | 2015-02-16 | 2016-08-25 | Leiutis Pharmaceuticals Pvt Ltd | Stable ready to use cyclophosphamide liquid formulations |
| US12453737B2 (en) | 2018-08-03 | 2025-10-28 | Sinotherapeutics Inc. | Method for hydrating lyophilized cyclophosphamide composition and product thereof |
| WO2020178725A1 (en) * | 2019-03-04 | 2020-09-10 | Alembic Pharmaceuticals Limited | Stable liquid composition of cyclophosphamide |
| BR112022000204A2 (pt) | 2019-07-10 | 2022-02-22 | Intas Pharmaceuticals Ltd | Composição oral estável de ciclofosfamida, pó estável para solução oral, pó estável para solução oral na forma de um kit, e processo para preparação de um kit |
| WO2021009595A1 (en) * | 2019-07-15 | 2021-01-21 | Hetero Healthcare Limited | Cyclophosphamide injectable composition and methods for producing same |
| US20230310468A1 (en) * | 2020-08-17 | 2023-10-05 | Sandoz Ag | Parenteral pharmaceutical composition comprising cyclophosphamide and a mixture of liquids |
| WO2023059885A1 (en) | 2021-10-08 | 2023-04-13 | Slayback Pharma Llc, | Stable pharmaceutical compositions of cyclophosphamide |
| US11642358B1 (en) | 2022-02-14 | 2023-05-09 | Extrovis Ag | Stable pharmaceutical formulation |
| US20240180935A1 (en) * | 2022-11-22 | 2024-06-06 | Navinta, Llc | Solution formulation of cyclophosphamide |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR75178E (enExample) | 1956-12-20 | 1961-09-08 | ||
| ES2038623T3 (es) * | 1986-07-11 | 1993-08-01 | Asta Medica Aktiengesellschaft | Procedimiento para preparar soluciones de oxazafosforinas con estabilidad mejorada. |
| US4879286A (en) | 1987-01-28 | 1989-11-07 | Lyphomed, Inc. | Cyclophosphamide |
| US5036060A (en) * | 1988-07-25 | 1991-07-30 | Fujisawa Usa, Inc. | Cyclophosphamide |
| CA2039742A1 (en) * | 1990-04-23 | 1991-10-24 | Andrew B. Dennis | Tablet composition and method for problem pharmaceutical materials |
| ATE348621T1 (de) * | 1997-10-13 | 2007-01-15 | Stada Arzneimittel Ag | Flüssige darreichungsformen oxazaphosphorinhaltiger pharmazeutischer produkte |
| US6811788B2 (en) * | 2000-01-19 | 2004-11-02 | Baofa Yu | Combinations and methods for treating neoplasms |
| AUPQ849900A0 (en) * | 2000-06-30 | 2000-07-27 | Dbl Australia Pty Ltd. | Injectable composition |
| CN101039699B (zh) * | 2004-10-15 | 2011-07-27 | 柳署弘 | 用于减小药物化合物毒性的方法和组合物 |
| US8436190B2 (en) | 2005-01-14 | 2013-05-07 | Cephalon, Inc. | Bendamustine pharmaceutical compositions |
| US7872050B2 (en) | 2005-03-14 | 2011-01-18 | Yaupon Therapeutics Inc. | Stabilized compositions of volatile alkylating agents and methods of using thereof |
| CN1923280A (zh) * | 2005-08-30 | 2007-03-07 | 孔庆忠 | 一种含双氯乙胺类药物的抗癌缓释注射剂 |
| JP5318403B2 (ja) * | 2007-11-30 | 2013-10-16 | 株式会社Ｓｏｋｕｄｏ | 基板処理装置 |
| US8278220B2 (en) * | 2008-08-08 | 2012-10-02 | Fei Company | Method to direct pattern metals on a substrate |
| CN104398471A (zh) * | 2008-11-28 | 2015-03-11 | Abbvie公司 | 稳定的抗体组合物和用于稳定其的方法 |
| EP2442789A1 (en) * | 2009-06-18 | 2012-04-25 | Abbott Laboratories | Stable nanoparticulate drug suspension |
| US20140005148A1 (en) * | 2012-06-29 | 2014-01-02 | Coldstream Laboratories Inc. | Stable liquid formulations of nitrogen mustards |
| WO2014068585A1 (en) * | 2012-10-29 | 2014-05-08 | Leiutis Pharmaceuticals Pvt. Ltd. | Novel lyophilized compositions of cyclophosphamide |
-
2015
- 2015-05-01 US US14/702,320 patent/US9662342B2/en active Active
- 2015-05-01 AU AU2015256331A patent/AU2015256331B2/en not_active Ceased
- 2015-05-01 BR BR112016026140A patent/BR112016026140A2/pt active Search and Examination
- 2015-05-01 US US14/702,287 patent/US20150320774A1/en not_active Abandoned
- 2015-05-01 KR KR1020167034447A patent/KR20170008252A/ko not_active Ceased
- 2015-05-01 EP EP15789798.4A patent/EP3139929A4/en not_active Withdrawn
- 2015-05-01 CN CN201580023235.5A patent/CN106456654A/zh active Pending
- 2015-05-01 CA CA2948148A patent/CA2948148C/en active Active
- 2015-05-01 WO PCT/US2015/028862 patent/WO2015171460A2/en not_active Ceased
- 2015-05-01 JP JP2017511153A patent/JP6516831B2/ja not_active Expired - Fee Related
- 2015-05-01 RU RU2016147362A patent/RU2016147362A/ru unknown
-
2017
- 2017-04-28 US US15/581,134 patent/US20170232015A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US9662342B2 (en) | 2017-05-30 |
| WO2015171460A3 (en) | 2016-04-21 |
| RU2016147362A3 (enExample) | 2018-10-01 |
| JP6516831B2 (ja) | 2019-05-22 |
| KR20170008252A (ko) | 2017-01-23 |
| US20150320775A1 (en) | 2015-11-12 |
| CA2948148C (en) | 2022-12-06 |
| BR112016026140A2 (pt) | 2018-08-07 |
| CA2948148A1 (en) | 2015-11-12 |
| EP3139929A4 (en) | 2018-01-03 |
| US20170232015A1 (en) | 2017-08-17 |
| US20150320774A1 (en) | 2015-11-12 |
| AU2015256331A1 (en) | 2016-11-17 |
| CN106456654A (zh) | 2017-02-22 |
| AU2015256331B2 (en) | 2020-03-12 |
| EP3139929A2 (en) | 2017-03-15 |
| JP2017514924A (ja) | 2017-06-08 |
| WO2015171460A2 (en) | 2015-11-12 |
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