RU2016117398A - Композиции полиинозиновой-полицитидиловой кислоты (поли (и:ц)) для лечения инфекций верхних дыхательных путей - Google Patents
Композиции полиинозиновой-полицитидиловой кислоты (поли (и:ц)) для лечения инфекций верхних дыхательных путей Download PDFInfo
- Publication number
- RU2016117398A RU2016117398A RU2016117398A RU2016117398A RU2016117398A RU 2016117398 A RU2016117398 A RU 2016117398A RU 2016117398 A RU2016117398 A RU 2016117398A RU 2016117398 A RU2016117398 A RU 2016117398A RU 2016117398 A RU2016117398 A RU 2016117398A
- Authority
- RU
- Russia
- Prior art keywords
- composition
- microparticle
- microparticles
- polyinosine
- polycytidylic acid
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 43
- 239000002253 acid Substances 0.000 title claims 16
- 229940115272 polyinosinic:polycytidylic acid Drugs 0.000 title claims 10
- 206010057190 Respiratory tract infections Diseases 0.000 title claims 3
- 208000020029 respiratory tract infectious disease Diseases 0.000 title 1
- 239000011859 microparticle Substances 0.000 claims 39
- 238000000034 method Methods 0.000 claims 15
- 229920000642 polymer Polymers 0.000 claims 11
- 230000009385 viral infection Effects 0.000 claims 10
- 229920002472 Starch Polymers 0.000 claims 9
- 235000019698 starch Nutrition 0.000 claims 9
- 239000008107 starch Substances 0.000 claims 9
- 229940032147 starch Drugs 0.000 claims 9
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims 8
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 8
- 229940014041 hyaluronate Drugs 0.000 claims 8
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 8
- 239000008108 microcrystalline cellulose Substances 0.000 claims 8
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 8
- 229920001592 potato starch Polymers 0.000 claims 8
- 229940116317 potato starch Drugs 0.000 claims 8
- 208000036142 Viral infection Diseases 0.000 claims 7
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 4
- 241000430519 Human rhinovirus sp. Species 0.000 claims 3
- 206010061494 Rhinovirus infection Diseases 0.000 claims 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 241000712461 unidentified influenza virus Species 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 206010046306 Upper respiratory tract infection Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 210000002345 respiratory system Anatomy 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000002953 phosphate buffered saline Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13191742.9 | 2013-11-06 | ||
| EP13191742 | 2013-11-06 | ||
| PCT/EP2014/073762 WO2015067632A1 (en) | 2013-11-06 | 2014-11-05 | Polylnosinic-polycytidylic acid (poly (i:c)) formulations for the treatment of upper respiratory tract infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2016117398A true RU2016117398A (ru) | 2017-12-11 |
| RU2016117398A3 RU2016117398A3 (cg-RX-API-DMAC7.html) | 2018-08-22 |
Family
ID=49517426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016117398A RU2016117398A (ru) | 2013-11-06 | 2014-11-05 | Композиции полиинозиновой-полицитидиловой кислоты (поли (и:ц)) для лечения инфекций верхних дыхательных путей |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20160271165A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3065714B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6629216B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20160072140A (cg-RX-API-DMAC7.html) |
| CN (1) | CN105939709A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2014345667A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2929142A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL245412A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2016005883A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2016117398A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015067632A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201406208QA (en) | 2012-05-03 | 2014-11-27 | Janssen Sciences Ireland Uc | Polyinosinic-polycytidylic acid (poly (i:c)) formulations for the treatment of upper respiratory tract infections |
| CN107820423A (zh) * | 2015-05-11 | 2018-03-20 | 爱尔兰詹森科学公司 | 用于预防和/或治疗上呼吸道感染的聚肌苷酸‑聚胞苷酸(聚(i:c))豌豆淀粉制剂 |
| PL3319587T3 (pl) | 2015-11-17 | 2020-05-18 | Bioncotech Therapeutics, S.L | Nowa kompozycja farmaceutyczna zawierająca cząstki zawierające kompleks dwuniciowego polirybonukleotydu i polialkilenoiminy |
| US20200060972A1 (en) | 2016-11-16 | 2020-02-27 | Janssen Sciences Ireland Unlimited Company | Formulations of polyinosinic acid and polycytidylic acid for the prevention of upper respiratory tract infections |
| DK3448363T3 (da) * | 2017-05-17 | 2022-08-08 | Highlight Therapeutics S L | Hidtil ukendt, farmaceutisk sammensætning, der omfatter partikler omfattende et kompleks af et dobbeltstrenget polyribonukleotid og en polyalkylenimin |
| KR102123489B1 (ko) | 2020-03-13 | 2020-06-16 | 주식회사 휴먼셀바이오 | 자연살해세포 배양액 조성물 및 이를 이용한 자연살해세포 배양방법 |
| EP4138909A1 (en) | 2020-04-19 | 2023-03-01 | Englmeier, Ludwig | Prophylaxis and treatment of coronavirus infection |
| CN118680868A (zh) * | 2023-03-24 | 2024-09-24 | 清华大学 | 一种核酸药物递送系统及其制备和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5707644A (en) * | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
| CN101229378A (zh) * | 2005-05-05 | 2008-07-30 | 国家淀粉及化学投资控股公司 | 用于送递活性剂的组合物 |
| US20070166239A1 (en) * | 2006-01-13 | 2007-07-19 | Haixiang Lin | Mucosal immunogenic substances comprising a polyinosinic acid - polycytidilic acid based adjuvant |
| CN101491503A (zh) * | 2008-12-17 | 2009-07-29 | 天津瑞普生物技术股份有限公司 | 一种用于宠物的聚肌胞滴丸及其制备方法 |
| CN101757018A (zh) * | 2008-12-24 | 2010-06-30 | 天津瑞普生物技术股份有限公司 | 一种用于畜禽的聚肌胞干粉及其制备方法 |
| CN102488703A (zh) * | 2011-12-15 | 2012-06-13 | 天津济命生生物科技有限公司 | 一种聚肌胞制剂的制备方法和抗肿瘤的用途 |
| SG11201406208QA (en) * | 2012-05-03 | 2014-11-27 | Janssen Sciences Ireland Uc | Polyinosinic-polycytidylic acid (poly (i:c)) formulations for the treatment of upper respiratory tract infections |
-
2014
- 2014-11-05 RU RU2016117398A patent/RU2016117398A/ru not_active Application Discontinuation
- 2014-11-05 EP EP14793168.7A patent/EP3065714B1/en active Active
- 2014-11-05 CN CN201480063745.0A patent/CN105939709A/zh active Pending
- 2014-11-05 CA CA2929142A patent/CA2929142A1/en not_active Abandoned
- 2014-11-05 KR KR1020167011935A patent/KR20160072140A/ko not_active Ceased
- 2014-11-05 WO PCT/EP2014/073762 patent/WO2015067632A1/en not_active Ceased
- 2014-11-05 US US15/034,347 patent/US20160271165A1/en not_active Abandoned
- 2014-11-05 MX MX2016005883A patent/MX2016005883A/es unknown
- 2014-11-05 JP JP2016551030A patent/JP6629216B2/ja not_active Expired - Fee Related
- 2014-11-05 AU AU2014345667A patent/AU2014345667A1/en not_active Abandoned
-
2016
- 2016-05-01 IL IL245412A patent/IL245412A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL245412A0 (en) | 2016-06-30 |
| KR20160072140A (ko) | 2016-06-22 |
| WO2015067632A1 (en) | 2015-05-14 |
| CN105939709A (zh) | 2016-09-14 |
| CA2929142A1 (en) | 2015-05-14 |
| MX2016005883A (es) | 2016-08-17 |
| JP2016535094A (ja) | 2016-11-10 |
| RU2016117398A3 (cg-RX-API-DMAC7.html) | 2018-08-22 |
| US20160271165A1 (en) | 2016-09-22 |
| JP6629216B2 (ja) | 2020-01-15 |
| AU2014345667A1 (en) | 2016-05-19 |
| EP3065714B1 (en) | 2020-02-12 |
| EP3065714A1 (en) | 2016-09-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HC9A | Changing information about inventors | ||
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20190227 |