RU2015155741A - Антибактериальные порошки на основе отрицательно заряженного диоксида кремния или титана, на котором адсорбированы фармацевтически активные катионы - Google Patents
Антибактериальные порошки на основе отрицательно заряженного диоксида кремния или титана, на котором адсорбированы фармацевтически активные катионы Download PDFInfo
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- titanium
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- 229910052719 titanium Inorganic materials 0.000 title claims 5
- 239000010936 titanium Substances 0.000 title claims 5
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 title claims 4
- 230000000844 anti-bacterial effect Effects 0.000 title claims 3
- 229910052710 silicon Inorganic materials 0.000 title claims 3
- 239000000843 powder Substances 0.000 title claims 2
- 239000010703 silicon Substances 0.000 title 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 6
- 239000002245 particle Substances 0.000 claims 6
- 229960003260 chlorhexidine Drugs 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- -1 chlorhexidine cations Chemical class 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 235000012239 silicon dioxide Nutrition 0.000 claims 3
- 239000000377 silicon dioxide Substances 0.000 claims 3
- 229910052709 silver Inorganic materials 0.000 claims 3
- 239000004332 silver Substances 0.000 claims 3
- BVPHXTUEZOQIBS-UHFFFAOYSA-N 6-methyl-1h-pyrimidine-2-thione Chemical compound CC1=CC=NC(S)=N1 BVPHXTUEZOQIBS-UHFFFAOYSA-N 0.000 claims 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims 2
- 206010011985 Decubitus ulcer Diseases 0.000 claims 2
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims 2
- 229920002413 Polyhexanide Polymers 0.000 claims 2
- 208000004210 Pressure Ulcer Diseases 0.000 claims 2
- 241000191967 Staphylococcus aureus Species 0.000 claims 2
- 230000000843 anti-fungal effect Effects 0.000 claims 2
- 230000000840 anti-viral effect Effects 0.000 claims 2
- 229940121375 antifungal agent Drugs 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000009881 electrostatic interaction Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000003330 sporicidal effect Effects 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 241000222122 Candida albicans Species 0.000 claims 1
- JGFDZZLUDWMUQH-UHFFFAOYSA-N Didecyldimethylammonium Chemical compound CCCCCCCCCC[N+](C)(C)CCCCCCCCCC JGFDZZLUDWMUQH-UHFFFAOYSA-N 0.000 claims 1
- 241000194032 Enterococcus faecalis Species 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 241000186779 Listeria monocytogenes Species 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000000474 Poliomyelitis Diseases 0.000 claims 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- 241000607142 Salmonella Species 0.000 claims 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 1
- 206010040943 Skin Ulcer Diseases 0.000 claims 1
- 206010040880 Skin irritation Diseases 0.000 claims 1
- 241001134658 Streptococcus mitis Species 0.000 claims 1
- 241000193996 Streptococcus pyogenes Species 0.000 claims 1
- 241000194024 Streptococcus salivarius Species 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 238000005299 abrasion Methods 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940095731 candida albicans Drugs 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940032049 enterococcus faecalis Drugs 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 230000035876 healing Effects 0.000 claims 1
- RWBSBQAUAJSGHY-UHFFFAOYSA-N hydron;quinoline-8-thiol;chloride Chemical class Cl.C1=CN=C2C(S)=CC=CC2=C1 RWBSBQAUAJSGHY-UHFFFAOYSA-N 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000036556 skin irritation Effects 0.000 claims 1
- 231100000475 skin irritation Toxicity 0.000 claims 1
- 231100000019 skin ulcer Toxicity 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- IRFHMTUHTBSEBK-QGZVFWFLSA-N tert-butyl n-[(2s)-2-(2,5-difluorophenyl)-3-quinolin-3-ylpropyl]carbamate Chemical class C1([C@H](CC=2C=C3C=CC=CC3=NC=2)CNC(=O)OC(C)(C)C)=CC(F)=CC=C1F IRFHMTUHTBSEBK-QGZVFWFLSA-N 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
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- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/025—Silicon compounds without C-silicon linkages
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- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
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Claims (28)
1. Производное формулы (I):
(MO2)-(Am+)y 
(I)
в которой:
М является атомом Si или Ti;
(MO2)- представляет собой отрицательно заряженную частицу диоксида, включающую тетраэдрические атомы кремния или октаэдрические атомы титана, связанные через мостиковые атомы кислорода,
Am+ представляет собой по меньшей мере одну положительно заряженную активную молекулу, связанную с отрицательно заряженной частицей диоксида посредством электростатического взаимодействия, где m представляет собой заряд указанной активной молекулы, и составляет от 1 до 20, предпочтительно от 1 до 10,
Y представляет собой количество различных активных молекул Am+, соадсорбированных на одной отрицательно заряженной частице диоксида кремния или титана, и составляет от 1 до 4, предпочтительно 2.
2. Производное формулы (I) по п.1, где M=Si.
3. Производное формулы (I) по п.1, отличающееся тем, что отрицательно заряженная частица диоксида кремния или титана имеет средний диаметр по меньшей мере 200 нм, предпочтительно от 500 нм до 1 μм.
4. Производное формулы (I) по п.1, где Am+ является антибактериальным, противогрибковым, противовирусным и/или спороцидным средством.
5. Производное формулы (I) по п.4, где Am+ является по меньшей мере одним соединением, выбранным из группы, состоящей из: катионов хлоргексидина, катиона гидрохлорида полигексаметиленбигуанида, катионов четверичного аммония, катионного комплексного соединения серебра общей формулы Ag-L и их смеси.
6. Производное формулы (I) по п.5, где Am+ является хлоргексидина биглюконатом или ацетатом.
7. Производное формулы (I) по п.5, где Am+ является катионом дидецилдиметиламмония.
8. Производное формулы (I) по п.5, где Am+ является катионом гидрохлорида полигексаметиленбигуанида.
9. Производное формулы (I) по п.5, где Am+ является катионным комплексным соединением серебра формулы Ag-L, где L выбрано из: необязательно замещенного гидрохлорида 8-меркапто-хинолина и гидрохлорида 2-меркапто-4-(C1-C6Аlk)пиримидина, предпочтительно 2-меркапто-4-метилпиримидина.
10. Производное формулы (I) по любому из пп.1-9, где Am+ является катионом хлоргексидина и комплексным соединением серебра формулы Ag-L, где последнее предпочтительно является таким, как определено в п.9.
11. Производное формулы (I) по п.10, где Am+ является хлоргексидина биглюконатом и 2-меркапто-4-метилпиримидином.
12. Производное формулы (I) по п.1 для применения в качестве лекарственного средства.
13. Производное формулы (I) для применения по п.12 в качестве антибактериального, противогрибкового, противовирусного или спороцидного средства.
14. Производное формулы (I) для применения по п.12 или 13 при лечении кожных раздражений, воспалений, царапин, ссадин и/или ожогов.
15. Производное формулы (I) для применения по п.12 или 13 при лечении: угревой сыпи, герпеса, пролежней, кожных язв, предпочтительно пролежневых язв.
16. Производное формулы (I) для применения по п.12 или 13 в качестве средства для заживления кожи.
17. Производное формулы (I) для применения по п.12 или 13 в качестве антибактериального средства для лечения заболеваний, вызванных по меньшей мере одним из микроорганизмов, выбранных из: HSV-1 (вируса простого герпеса 1), аденовируса, вируса полиомиелита, Pseudomonas aeruginosa, Enterococcus faecalis, Escherica coli, Salmonella eneridis D1, Listeria monocytogenes, Staphylococcus aureus MR, Staphylococcus aureus MS, Streptococcus pyogenes, Streptococcus salivarius, Streptococcus mitis, Candida albicans, Aspergillus niger.
18. Фармацевтическая композиция, включающая производное формулы (I) по любому из пп.1-11 в смеси с по меньшей мере одним физиологически приемлемым вспомогательным веществом и/или носителем и, необязательно, по меньшей мере с другим фармацевтическим активным веществом.
19. Фармацевтическая композиция по п.18 в форме крема, геля, пены или порошка.
20. Фармацевтическая композиция по пп.18-19 для наружного применения.
21. Способ лечения млекопитающего, в том числе человека, включающий наружное применение эффективного количества производного формулы (I) по любому из пп.1-11 или фармацевтической композиции по любому из пп.18-20.
22. Способ получения производного формулы (I) по любому из пп.1-11, включающий электростатическое взаимодействие отрицательно заряженных частиц диоксида кремния общей формулы (MO2)-, где М является атомом Si или Ti, имеющих величену частиц по меньшей мере 200 нм, с по меньшей мере одной положительно заряженной молекулой Am+ в присутствии системы на основе спиртового растворителя.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2013/054647 WO2014195762A1 (en) | 2013-06-06 | 2013-06-06 | Antibacterial powders based on anionic silicon or titanium dioxide adsorbed with pharmaceutically active cations |
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|---|---|
| RU2015155741A true RU2015155741A (ru) | 2017-07-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| RU2015155741A RU2015155741A (ru) | 2013-06-06 | 2013-06-06 | Антибактериальные порошки на основе отрицательно заряженного диоксида кремния или титана, на котором адсорбированы фармацевтически активные катионы |
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| US (1) | US20160122367A1 (ru) |
| EP (1) | EP3003251B1 (ru) |
| CN (1) | CN105263465A (ru) |
| CY (1) | CY1122192T1 (ru) |
| ES (1) | ES2749511T3 (ru) |
| PL (1) | PL3003251T3 (ru) |
| RU (1) | RU2015155741A (ru) |
| SI (1) | SI3003251T1 (ru) |
| WO (1) | WO2014195762A1 (ru) |
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| CN107773835B (zh) * | 2017-11-28 | 2023-01-31 | 无锡市第二人民医院 | 防逆流抗菌型导尿管及其制造方法 |
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| GB8616294D0 (en) * | 1986-07-03 | 1986-08-13 | Johnson Matthey Plc | Antimicrobial compositions |
| DE102005062606A1 (de) * | 2005-12-23 | 2007-07-05 | Deutsche Institute Für Textil- Und Faserforschung Denkendorf | Nanoskalige Teilchen auf der Basis von SiO2 und Mischoxiden hiervon, deren Herstellung und Verwendung zur Behandlung textiler Materialien |
| DE102006008535A1 (de) * | 2006-02-22 | 2007-08-30 | Stiftung Nano Innovations - For A Better Living, Olten | Anitbakterielle Beschichtungszusammensetzung auf Basis eines Siliziumdioxid erzeugenden Mittels, ein Anwendungsset, eine nanoskalige Beschichtung, die Herstellung der Beschichtung, die Weiterverarbeitung der Beschichtung sowie deren Verwendung |
| EP2079302B1 (en) * | 2006-10-12 | 2014-03-26 | NM Tech Nanomaterials Microdevice Technology, Ltd. | Use of a composition having anti-microbial properties |
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2013
- 2013-06-06 PL PL13742503T patent/PL3003251T3/pl unknown
- 2013-06-06 SI SI201331586T patent/SI3003251T1/sl unknown
- 2013-06-06 EP EP13742503.9A patent/EP3003251B1/en active Active
- 2013-06-06 ES ES13742503T patent/ES2749511T3/es active Active
- 2013-06-06 RU RU2015155741A patent/RU2015155741A/ru not_active Application Discontinuation
- 2013-06-06 US US14/896,310 patent/US20160122367A1/en not_active Abandoned
- 2013-06-06 WO PCT/IB2013/054647 patent/WO2014195762A1/en active Application Filing
- 2013-06-06 CN CN201380077207.2A patent/CN105263465A/zh active Pending
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- 2019-10-04 CY CY20191101040T patent/CY1122192T1/el unknown
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| Publication number | Publication date |
|---|---|
| US20160122367A1 (en) | 2016-05-05 |
| EP3003251B1 (en) | 2019-07-10 |
| WO2014195762A1 (en) | 2014-12-11 |
| PL3003251T3 (pl) | 2020-04-30 |
| EP3003251A1 (en) | 2016-04-13 |
| CY1122192T1 (el) | 2020-11-25 |
| SI3003251T1 (sl) | 2019-12-31 |
| ES2749511T3 (es) | 2020-03-20 |
| CN105263465A (zh) | 2016-01-20 |
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