RU2015148021A - METHOD FOR EVALUATING THE PROTECTIVE ACTIVITY OF PERFUMOR PREPARATIONS - Google Patents

METHOD FOR EVALUATING THE PROTECTIVE ACTIVITY OF PERFUMOR PREPARATIONS Download PDF

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Publication number
RU2015148021A
RU2015148021A RU2015148021A RU2015148021A RU2015148021A RU 2015148021 A RU2015148021 A RU 2015148021A RU 2015148021 A RU2015148021 A RU 2015148021A RU 2015148021 A RU2015148021 A RU 2015148021A RU 2015148021 A RU2015148021 A RU 2015148021A
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RU
Russia
Prior art keywords
pertussis
protective activity
perfumor
preparations
evaluating
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RU2015148021A
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Russian (ru)
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RU2623314C2 (en
Inventor
Геннадий Иванович Каратаев
Людмила Николаевна Синяшина
Алиса Юрьевна Медкова
Евгений Григорьевич Сёмин
Original Assignee
федеральное государственное бюджетное учреждение "Федеральный научно-исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации (ФГБУ "ФНИЦЭМ им. Н.Ф. Гамалеи" Минздрава России)
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Priority to RU2015148021A priority Critical patent/RU2623314C2/en
Publication of RU2015148021A publication Critical patent/RU2015148021A/en
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Publication of RU2623314C2 publication Critical patent/RU2623314C2/en

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    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
    • G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Claims (4)

1. Способ определения защитной активности коклюшных вакцин, предусматривающий вакцинацию мышей коклюшными вакцинами с последующим интраназальным заражением вирулентными бактериями B. pertussis, B. bronchiseptica, B. parapertussis, отличающийся тем, что осуществляют интраназальное заражение вирулентными бактериями B. bronchiseptica, B. parapertussis и B. pertussis в летальных дозах и определяют выживаемость вакцинированных животных.1. A method for determining the protective activity of pertussis vaccines, comprising vaccinating mice with pertussis vaccines followed by intranasal infection with virulent bacteria B. pertussis, B. bronchiseptica, B. parapertussis, characterized in that they carry out intranasal infection with virulent bacteria B. bronchiseptica, B. parapertussis and B pertussis in lethal doses and determine the survival of vaccinated animals. 2. Способ по п. 1, отличающийся тем, что в качестве вирулентного штамма используют штамм B. bronchiseptica 8220-17.2. The method according to p. 1, characterized in that the strain B. bronchiseptica 8220-17 is used as a virulent strain. 3. Способ по п. 1, отличающийся тем, что в качестве тестируемых вакцин используют цельноклеточные вакцины, состоящие из живых или инактивированных бактерий.3. The method according to p. 1, characterized in that as the test vaccines use whole-cell vaccines consisting of live or inactivated bacteria. 4. Способ по. 1, отличающийся тем, что вирулентные бактерии интраназально вводят мышам в дозе, составляющей не менее 8-10 ЛД50.4. The method according to. 1, characterized in that the virulent bacteria are intranasally administered to mice in a dose of at least 8-10 LD50.
RU2015148021A 2015-11-09 2015-11-09 Assessment method for protective potency of pertussis vaccines RU2623314C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2015148021A RU2623314C2 (en) 2015-11-09 2015-11-09 Assessment method for protective potency of pertussis vaccines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2015148021A RU2623314C2 (en) 2015-11-09 2015-11-09 Assessment method for protective potency of pertussis vaccines

Publications (2)

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RU2015148021A true RU2015148021A (en) 2017-05-16
RU2623314C2 RU2623314C2 (en) 2017-06-23

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RU2015148021A RU2623314C2 (en) 2015-11-09 2015-11-09 Assessment method for protective potency of pertussis vaccines

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Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2231793C1 (en) * 2003-03-11 2004-06-27 Москаленко Екатерина Петровна Method for evaluating anti-whooping vaccine immunogenicity
JP5245092B2 (en) * 2006-03-10 2013-07-24 アンスティテュ パストゥール ドゥ リル Live attenuated Bordetella strain as a single dose vaccine against pertussis
CN100537767C (en) * 2007-04-29 2009-09-09 中国药品生物制品检定所 Recombinant expressed and the application of pertussis vaccine protective antigen
WO2008146830A1 (en) * 2007-05-28 2008-12-04 The Kitasato Institute Bordetella parapertussis-containing whole-cell vaccine composition
RU2455024C1 (en) * 2010-12-30 2012-07-10 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи Министерства здравоохранения и социального развития РФ" Attenuated bacteria bordetella pertussis, whooping cough agent vaccine

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RU2623314C2 (en) 2017-06-23

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