RU2015128789A - Ароматизированное анисом лекарственное средство - Google Patents
Ароматизированное анисом лекарственное средство Download PDFInfo
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- RU2015128789A RU2015128789A RU2015128789A RU2015128789A RU2015128789A RU 2015128789 A RU2015128789 A RU 2015128789A RU 2015128789 A RU2015128789 A RU 2015128789A RU 2015128789 A RU2015128789 A RU 2015128789A RU 2015128789 A RU2015128789 A RU 2015128789A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/17—Nitrogen containing
- Y10T436/173845—Amine and quaternary ammonium
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Claims (30)
1. Ароматизированное анисом жидкое лекарственное средство, содержащее:
a. фенилэфрин; и
b. аналог анетола, который является, по существу, свободным от альдегидных групп.
2. Жидкое лекарственное средство по п. 1, отличающееся тем, что содержит от приблизительно 0,01% до приблизительно 0,1% фенилэфрина.
3. Жидкое лекарственное средство по п. 1, отличающееся тем, что содержит от приблизительно 1 м.д. до приблизительно 20 м.д. аналога анетола.
4. Жидкое лекарственное средство по п. 1, отличающееся тем, что аналог анетола представляет собой 1-метокси-4-н-пропилбензол.
5. Жидкое лекарственное средство по п. 4, отличающееся тем, что содержит от 1 м.д. до 10 м.д. 1-метокси-4-н-пропилбензола.
6. Жидкое лекарственное средство по п. 1, отличающееся тем, что дополнительно содержит болеутоляющее средство, выбранное из группы, состоящей из ацетаминофена, ибупрофена и их комбинаций.
7. Жидкое лекарственное средство по п. 6, отличающееся тем, что болеутоляющее средство представляет собой ацетаминофен.
8. Жидкое лекарственное средство по п. 1, отличающееся тем, что дополнительно содержит декстрометорфан.
9. Жидкое лекарственное средство по п. 1, отличающееся тем, что дополнительно содержит доксиламина сукцинат.
10. Жидкое лекарственное средство по п. 1, отличающееся тем, что дополнительно содержит от приблизительно 3% до приблизительно 15% этанола.
11. Жидкое лекарственное средство по п. 1, отличающееся тем, что лекарственное средство имеет зеленый цвет.
12. Жидкое лекарственное средство по п. 1, отличающееся тем, что лекарственное средство предназначено для применения на ночь.
13. Жидкое лекарственное средство по п. 1, отличающееся тем, что лекарственное средство имеет рН от приблизительно 2 до приблизительно 6.
14. Жидкое лекарственное средство по п. 1, отличающееся тем, что жидкое лекарственное средство имеет среднюю потерю фенилэфрина менее чем приблизительно 6% в пределах 95% доверительного интервала.
15. Доза ароматизированного анисом жидкого лекарственного средства, содержащая:
a. 650 мг ацетаминофена;
b. 20 мг декстрометорфана гидробромида;
c. 12,5 мг доксиламина сукцината;
d. 10 мг фенилэфрина гидрохлорида; и
e. аналог анетола.
16. Доза жидкого лекарственного средства по п. 15, отличающаяся тем, что аналог анетола представляет собой 1-метокси-4-н-пропилбензол.
17. Доза жидкого лекарственного средства по п. 16, отличающаяся тем, что содержит от 1 м.д. до 10 м.д. 1-метокси-4-н-пропилбензола.
18. Доза жидкого лекарственного средства по п. 15, отличающаяся тем, что доза имеет среднюю потерю фенилэфрина менее чем приблизительно 5% в пределах 95% доверительного интервала.
19. Способ определения скорости распада лекарственного активного вещества жидкого лекарственного средства, включающий стадии, на которых:
a. используют автоматизированное устройство для проведения реакции в потоке и контроля инкубации (Automated Flow Reaction and Incubation Control Apparatus) для принудительного распада жидкого лекарственного средства с использованием изменения температуры в диапазоне от 80°С до 140°С при давлении 6-7 бар в течение 20 мин с установленными инкрементами;
b. определяют количество лекарственного активного вещества в образце;
c. определяют скорость распада лекарственного активного вещества.
20. Способ по п. 19, отличающийся тем, что лекарственное активное вещество представляет собой фенилэфрин.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361764002P | 2013-02-13 | 2013-02-13 | |
| US61/764,002 | 2013-02-13 | ||
| PCT/US2014/016238 WO2014127118A1 (en) | 2013-02-13 | 2014-02-13 | Anise flavored medication |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015128789A true RU2015128789A (ru) | 2017-03-17 |
| RU2625550C2 RU2625550C2 (ru) | 2017-07-14 |
Family
ID=50193605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015128789A RU2625550C2 (ru) | 2013-02-13 | 2014-02-13 | Ароматизированное анисом лекарственное средство |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US9457085B2 (ru) |
| EP (1) | EP2956120B1 (ru) |
| CN (1) | CN104936578A (ru) |
| AU (1) | AU2014216275B2 (ru) |
| BR (1) | BR112015019347B1 (ru) |
| CA (1) | CA2899492C (ru) |
| ES (1) | ES2795291T3 (ru) |
| MX (1) | MX361099B (ru) |
| PL (1) | PL2956120T3 (ru) |
| RU (1) | RU2625550C2 (ru) |
| WO (1) | WO2014127118A1 (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2795291T3 (es) | 2013-02-13 | 2020-11-23 | Procter & Gamble | Medicamento con sabor a anís |
| CN105699555B (zh) * | 2016-03-24 | 2018-09-11 | 中国标准化研究院 | 一种丙烯基乙基愈创木酚的液相色谱制备方法 |
| US10086026B2 (en) * | 2016-06-27 | 2018-10-02 | Uwais M. Syed | Combined herbal and pharmaceutical composition and method |
| EP3506885A1 (en) * | 2016-09-01 | 2019-07-10 | The Procter and Gamble Company | Medication with improved taste and sensory experience |
| GR1009462B (el) * | 2017-10-05 | 2019-02-15 | Laboserve Φαρμακευτικη Βιομηχανια Α.Ε. | Ποσιμο φαρμακευτικο διαλυμα με συγκαλυμμενη γευση |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0714872B2 (ja) | 1990-02-06 | 1995-02-22 | 昭和薬品化工株式会社 | シロップ剤組成物 |
| WO1991012792A1 (en) | 1990-03-02 | 1991-09-05 | The Partnership Of Isaac G. Eliaz And Shmuel Gonen | Method and product for promoting hair growth and treating skin conditions |
| US5458879A (en) | 1994-03-03 | 1995-10-17 | The Procter & Gamble Company | Oral vehicle compositions |
| BE1011045A3 (fr) | 1997-03-14 | 1999-04-06 | Ucb Sa | Compositions pharmaceutiques pour la liberation controlee de substances actives. |
| US6599883B1 (en) | 1998-10-30 | 2003-07-29 | Nastech Pharmaceutical Company, Inc. | Nasal delivery of xylitol |
| CA2441352C (en) | 2001-02-15 | 2010-05-25 | Access Pharmaceuticals, Inc. | Liquid formulations for the prevention and treatment of mucosal diseases and disorders |
| US7544348B2 (en) | 2001-02-15 | 2009-06-09 | Access Pharmaceuticals, Inc. | Liquid formulations for the prevention and treatment of mucosal diseases and disorders |
| US20080300314A1 (en) | 2003-11-21 | 2008-12-04 | Givaudan Sa | Cooling Compounds |
| EP1685093B3 (en) | 2003-11-21 | 2012-04-11 | Givaudan SA | N-substituted p-menthane carboxamide and use of n-substituted p-menthane carboxamides |
| US20060188450A1 (en) | 2005-02-24 | 2006-08-24 | Tim Clarot | System and method for suppressing a cough |
| ES2488634T3 (es) | 2005-12-23 | 2014-08-28 | Intercontinental Great Brands Llc | Composición que proporciona una sensación refrescante significativamente similar a la que proporciona el mentol |
| US20080014267A1 (en) * | 2006-07-12 | 2008-01-17 | Everett Laboratories, Inc. | Compositions and methods for treatment of coughing, sneezing, rhinorrhea, and/or nasal obstruction |
| CA2636061C (en) | 2006-01-27 | 2015-06-02 | Cadbury Adams Usa Llc | Flavor-enhancing compositions, methods of manufacture, and methods of use |
| US10022339B2 (en) | 2006-04-21 | 2018-07-17 | The Procter & Gamble Company | Compositions and methods useful for treatment of respiratory illness |
| US20070249727A1 (en) | 2006-04-21 | 2007-10-25 | The Proctor & Gamble Company | Compositions and kits useful for treatment of respiratory illness |
| US9155769B2 (en) * | 2006-07-07 | 2015-10-13 | The Procter & Gamble Co | Flavor oils with reduced dimethyl sulfoxide content and use in oral compositions |
| US9005652B2 (en) | 2006-07-25 | 2015-04-14 | Wyeth | Chewable tablet containing phenylephrine |
| US9078824B2 (en) | 2007-09-24 | 2015-07-14 | The Procter & Gamble Company | Composition and method of stabilized sensitive ingredient |
| BRPI0819338A2 (pt) | 2007-11-21 | 2015-05-19 | Procter & Gamble | Preparações, métodos e kits úteis para o tratamento de tosse |
| PE20091084A1 (es) | 2007-12-07 | 2009-07-23 | Schering Plough Healthcare | Formulaciones farmaceuticas de fenilefrina y composiciones para absorcion transmucosal |
| JP5384641B2 (ja) | 2008-08-15 | 2014-01-08 | ザ プロクター アンド ギャンブル カンパニー | 消費者製品における感覚剤として有用なシクロヘキサン誘導体の合成 |
| ES2626230T3 (es) | 2008-11-20 | 2017-07-24 | The Procter & Gamble Company | Composiciones para la higiene personal que proporcionan una sensación refrescante mejorada |
| US8962057B2 (en) * | 2009-04-29 | 2015-02-24 | The Procter & Gamble Company | Methods for improving taste and oral care compositions with improved taste |
| US8664261B2 (en) | 2009-05-05 | 2014-03-04 | Givaudan S.A. | Organic compounds having cooling properties |
| US20110195042A1 (en) * | 2010-02-10 | 2011-08-11 | Thomas Edward Huetter | Compositions, Methods and Kits Useful for Treating a Respiratory Symptom |
| ES2795291T3 (es) | 2013-02-13 | 2020-11-23 | Procter & Gamble | Medicamento con sabor a anís |
| GB201314049D0 (en) | 2013-08-06 | 2013-09-18 | Rolls Royce Plc | Bearing cage deflector |
-
2014
- 2014-02-13 ES ES14707893T patent/ES2795291T3/es active Active
- 2014-02-13 MX MX2015010286A patent/MX361099B/es active IP Right Grant
- 2014-02-13 AU AU2014216275A patent/AU2014216275B2/en active Active
- 2014-02-13 EP EP14707893.5A patent/EP2956120B1/en active Active
- 2014-02-13 BR BR112015019347-1A patent/BR112015019347B1/pt active IP Right Grant
- 2014-02-13 CN CN201480005482.8A patent/CN104936578A/zh active Pending
- 2014-02-13 US US14/179,606 patent/US9457085B2/en active Active
- 2014-02-13 CA CA2899492A patent/CA2899492C/en active Active
- 2014-02-13 WO PCT/US2014/016238 patent/WO2014127118A1/en active Application Filing
- 2014-02-13 PL PL14707893T patent/PL2956120T3/pl unknown
- 2014-02-13 RU RU2015128789A patent/RU2625550C2/ru not_active IP Right Cessation
-
2016
- 2016-08-26 US US15/247,955 patent/US9839620B2/en active Active
-
2017
- 2017-11-09 US US15/807,668 patent/US10071067B2/en active Active
-
2018
- 2018-08-10 US US16/100,256 patent/US10588872B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10071067B2 (en) | 2018-09-11 |
| WO2014127118A1 (en) | 2014-08-21 |
| BR112015019347B1 (pt) | 2022-12-20 |
| ES2795291T3 (es) | 2020-11-23 |
| US20180344670A1 (en) | 2018-12-06 |
| US9839620B2 (en) | 2017-12-12 |
| RU2625550C2 (ru) | 2017-07-14 |
| US20140228391A1 (en) | 2014-08-14 |
| US9457085B2 (en) | 2016-10-04 |
| PL2956120T3 (pl) | 2020-08-10 |
| AU2014216275A1 (en) | 2015-08-06 |
| CA2899492C (en) | 2019-09-17 |
| CA2899492A1 (en) | 2014-08-21 |
| US20180064661A1 (en) | 2018-03-08 |
| EP2956120A1 (en) | 2015-12-23 |
| CN104936578A (zh) | 2015-09-23 |
| MX361099B (es) | 2018-11-27 |
| US20160361277A1 (en) | 2016-12-15 |
| BR112015019347A2 (pt) | 2017-07-18 |
| EP2956120B1 (en) | 2020-04-15 |
| US10588872B2 (en) | 2020-03-17 |
| AU2014216275B2 (en) | 2018-03-15 |
| MX2015010286A (es) | 2015-10-29 |
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