RU2015120467A - Контроль полового созревания у животных - Google Patents
Контроль полового созревания у животных Download PDFInfo
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- RU2015120467A RU2015120467A RU2015120467A RU2015120467A RU2015120467A RU 2015120467 A RU2015120467 A RU 2015120467A RU 2015120467 A RU2015120467 A RU 2015120467A RU 2015120467 A RU2015120467 A RU 2015120467A RU 2015120467 A RU2015120467 A RU 2015120467A
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Links
- 241001465754 Metazoa Species 0.000 title claims abstract 29
- 238000000034 method Methods 0.000 claims abstract 37
- 108090000623 proteins and genes Proteins 0.000 claims abstract 33
- 230000000955 neuroendocrine Effects 0.000 claims abstract 14
- 239000003795 chemical substances by application Substances 0.000 claims abstract 13
- 102000018120 Recombinases Human genes 0.000 claims abstract 12
- 108010091086 Recombinases Proteins 0.000 claims abstract 12
- 230000002779 inactivation Effects 0.000 claims abstract 10
- 210000004027 cell Anatomy 0.000 claims abstract 9
- 108020001507 fusion proteins Proteins 0.000 claims abstract 9
- 102000037865 fusion proteins Human genes 0.000 claims abstract 9
- 150000007523 nucleic acids Chemical group 0.000 claims abstract 9
- 101150075823 KISS1 gene Proteins 0.000 claims abstract 7
- 101150020170 KISS1R gene Proteins 0.000 claims abstract 7
- 238000010459 TALEN Methods 0.000 claims abstract 7
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 claims abstract 7
- 108091033409 CRISPR Proteins 0.000 claims abstract 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims abstract 6
- 210000001161 mammalian embryo Anatomy 0.000 claims abstract 5
- 210000000349 chromosome Anatomy 0.000 claims abstract 4
- 238000010354 CRISPR gene editing Methods 0.000 claims abstract 3
- 108700019146 Transgenes Proteins 0.000 claims abstract 3
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims abstract 3
- 210000004102 animal cell Anatomy 0.000 claims abstract 3
- 239000011159 matrix material Substances 0.000 claims abstract 3
- 108020004707 nucleic acids Proteins 0.000 claims abstract 3
- 102000039446 nucleic acids Human genes 0.000 claims abstract 3
- 230000009870 specific binding Effects 0.000 claims abstract 3
- 108020004414 DNA Proteins 0.000 claims abstract 2
- 230000002759 chromosomal effect Effects 0.000 claims abstract 2
- 108091023040 Transcription factor Proteins 0.000 claims 6
- 241000251468 Actinopterygii Species 0.000 claims 3
- 241000283690 Bos taurus Species 0.000 claims 3
- 241000283707 Capra Species 0.000 claims 3
- 241000287828 Gallus gallus Species 0.000 claims 3
- 241001494479 Pecora Species 0.000 claims 3
- 241000282898 Sus scrofa Species 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 108091062157 Cis-regulatory element Proteins 0.000 claims 2
- 102000006771 Gonadotropins Human genes 0.000 claims 2
- 108010086677 Gonadotropins Proteins 0.000 claims 2
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 2
- 210000002459 blastocyst Anatomy 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 210000004602 germ cell Anatomy 0.000 claims 2
- 239000002622 gonadotropin Substances 0.000 claims 2
- 238000003780 insertion Methods 0.000 claims 2
- 230000037431 insertion Effects 0.000 claims 2
- 230000002452 interceptive effect Effects 0.000 claims 2
- 230000005070 ripening Effects 0.000 claims 2
- 210000001082 somatic cell Anatomy 0.000 claims 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
- C12N15/877—Techniques for producing new mammalian cloned embryos
- C12N15/8778—Swine embryos
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/40—Fish
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Environmental Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Developmental Biology & Embryology (AREA)
- Veterinary Medicine (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261720187P | 2012-10-30 | 2012-10-30 | |
| US61/720,187 | 2012-10-30 | ||
| US201361870510P | 2013-08-27 | 2013-08-27 | |
| US61/870,510 | 2013-08-27 | ||
| PCT/US2013/067502 WO2014070887A1 (en) | 2012-10-30 | 2013-10-30 | Control of sexual maturation in animals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015120467A true RU2015120467A (ru) | 2016-12-20 |
Family
ID=50548813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015120467A RU2015120467A (ru) | 2012-10-30 | 2013-10-30 | Контроль полового созревания у животных |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20140123330A1 (enExample) |
| EP (1) | EP2914714A4 (enExample) |
| JP (2) | JP2015533284A (enExample) |
| KR (1) | KR20150100651A (enExample) |
| CN (1) | CN105073981A (enExample) |
| AP (1) | AP2015008495A0 (enExample) |
| AR (1) | AR093291A1 (enExample) |
| AU (1) | AU2013337951B2 (enExample) |
| BR (1) | BR112015009589A2 (enExample) |
| CA (1) | CA2889502A1 (enExample) |
| MX (1) | MX2015005255A (enExample) |
| NZ (1) | NZ629578A (enExample) |
| PH (1) | PH12015500957A1 (enExample) |
| RU (1) | RU2015120467A (enExample) |
| WO (1) | WO2014070887A1 (enExample) |
Families Citing this family (78)
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| US10920242B2 (en) | 2011-02-25 | 2021-02-16 | Recombinetics, Inc. | Non-meiotic allele introgression |
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| GB201122458D0 (en) | 2011-12-30 | 2012-02-08 | Univ Wageningen | Modified cascade ribonucleoproteins and uses thereof |
| ES2728782T3 (es) | 2012-05-25 | 2019-10-28 | Univ California | Métodos y composiciones para la modificación de ADN objetivo dirigida por ARN y para la modulación de la transcripción dirigida por ARN |
| DK3363902T3 (da) | 2012-12-06 | 2020-01-02 | Sigma Aldrich Co Llc | Crispr-baseret genommodifikation og -regulering |
| ES2749624T3 (es) | 2013-03-14 | 2020-03-23 | Caribou Biosciences Inc | Composiciones y métodos de ácidos nucleicos dirigidos a ácido nucleico |
| US20140359796A1 (en) * | 2013-05-31 | 2014-12-04 | Recombinetics, Inc. | Genetically sterile animals |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| ES2962492T3 (es) | 2013-10-25 | 2024-03-19 | Livestock Improvement Corporation Ltd | Marcadores genéticos y usos de los mismos |
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| US20150166984A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
| BR122023023211A2 (pt) | 2014-04-28 | 2024-01-23 | Recombinetics, Inc. | Método de fazer edições de genes multiplex em uma célula de vertebrado ou de embrião primário não-humano |
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| JP6837223B2 (ja) * | 2015-03-17 | 2021-03-03 | 国立研究開発法人水産研究・教育機構 | 生物個体群の縮小方法 |
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| CN109790551A (zh) * | 2016-06-16 | 2019-05-21 | 奥斯陆大学医院Hf | 改进的基因编辑 |
| WO2018027078A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
| AU2017308889B2 (en) | 2016-08-09 | 2023-11-09 | President And Fellows Of Harvard College | Programmable Cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
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| KR20240007715A (ko) | 2016-10-14 | 2024-01-16 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| GB201617559D0 (en) | 2016-10-17 | 2016-11-30 | University Court Of The University Of Edinburgh The | Swine comprising modified cd163 and associated methods |
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| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
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| CN107974466B (zh) * | 2017-12-07 | 2020-09-29 | 中国科学院水生生物研究所 | 一种鲟鱼CRISPR/Cas9基因编辑方法 |
| CN107760722B (zh) * | 2017-12-07 | 2020-11-06 | 中国科学院水生生物研究所 | 一种鲟鱼显微注射的方法及应用 |
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| MXPA05004380A (es) * | 2002-10-25 | 2005-11-23 | Paradigm Therapeutics Ltd | Mamiferos gpr54 knock out y metodos de investigacion que los utilizan. |
| KR20120097483A (ko) * | 2009-07-24 | 2012-09-04 | 시그마-알드리치 컴퍼니., 엘엘씨 | 게놈 편집을 위한 방법 |
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| PT2816112T (pt) * | 2009-12-10 | 2018-11-20 | Univ Iowa State Res Found Inc | Modificação do adn modificada pelo efector tal |
| MX363013B (es) * | 2011-02-25 | 2019-03-04 | Recombinetics Inc | Animales genéticamente modificados y métodos para su obtención. |
| WO2014052693A2 (en) * | 2012-09-29 | 2014-04-03 | The Trustees Of The University Of Pennsylvania | Veterinary composition and methods for non-surgical neutering and castration |
-
2013
- 2013-10-30 US US14/067,634 patent/US20140123330A1/en not_active Abandoned
- 2013-10-30 EP EP13851242.1A patent/EP2914714A4/en not_active Withdrawn
- 2013-10-30 MX MX2015005255A patent/MX2015005255A/es unknown
- 2013-10-30 CN CN201380067471.8A patent/CN105073981A/zh active Pending
- 2013-10-30 AR ARP130103958A patent/AR093291A1/es unknown
- 2013-10-30 NZ NZ629578A patent/NZ629578A/en not_active IP Right Cessation
- 2013-10-30 KR KR1020157014564A patent/KR20150100651A/ko not_active Ceased
- 2013-10-30 BR BR112015009589A patent/BR112015009589A2/pt not_active IP Right Cessation
- 2013-10-30 RU RU2015120467A patent/RU2015120467A/ru not_active Application Discontinuation
- 2013-10-30 WO PCT/US2013/067502 patent/WO2014070887A1/en not_active Ceased
- 2013-10-30 CA CA2889502A patent/CA2889502A1/en not_active Abandoned
- 2013-10-30 JP JP2015539942A patent/JP2015533284A/ja active Pending
- 2013-10-30 AP AP2015008495A patent/AP2015008495A0/xx unknown
- 2013-10-30 AU AU2013337951A patent/AU2013337951B2/en not_active Ceased
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2015
- 2015-04-29 PH PH12015500957A patent/PH12015500957A1/en unknown
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2018
- 2018-10-25 JP JP2018200938A patent/JP2019047794A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2889502A1 (en) | 2014-05-08 |
| AR093291A1 (es) | 2015-05-27 |
| AP2015008495A0 (en) | 2015-05-31 |
| EP2914714A4 (en) | 2016-09-21 |
| WO2014070887A1 (en) | 2014-05-08 |
| PH12015500957A1 (en) | 2015-08-10 |
| US20140123330A1 (en) | 2014-05-01 |
| CN105073981A (zh) | 2015-11-18 |
| JP2019047794A (ja) | 2019-03-28 |
| JP2015533284A (ja) | 2015-11-24 |
| AU2013337951A1 (en) | 2015-06-11 |
| MX2015005255A (es) | 2015-10-29 |
| KR20150100651A (ko) | 2015-09-02 |
| NZ629578A (en) | 2017-06-30 |
| BR112015009589A2 (pt) | 2017-11-14 |
| AU2013337951B2 (en) | 2019-10-03 |
| EP2914714A1 (en) | 2015-09-09 |
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