RU2014140358A - The method of obtaining nanocapsules of aspirin in sodium alginate - Google Patents

The method of obtaining nanocapsules of aspirin in sodium alginate Download PDF

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Publication number
RU2014140358A
RU2014140358A RU2014140358A RU2014140358A RU2014140358A RU 2014140358 A RU2014140358 A RU 2014140358A RU 2014140358 A RU2014140358 A RU 2014140358A RU 2014140358 A RU2014140358 A RU 2014140358A RU 2014140358 A RU2014140358 A RU 2014140358A
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RU
Russia
Prior art keywords
aspirin
sodium alginate
nanocapsules
obtaining nanocapsules
obtaining
Prior art date
Application number
RU2014140358A
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Russian (ru)
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RU2619329C2 (en
Inventor
Александр Александрович Кролевец
Илья Александрович Богачев
Original Assignee
Александр Александрович Кролевец
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Application filed by Александр Александрович Кролевец filed Critical Александр Александрович Кролевец
Priority to RU2014140358A priority Critical patent/RU2619329C2/en
Publication of RU2014140358A publication Critical patent/RU2014140358A/en
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Publication of RU2619329C2 publication Critical patent/RU2619329C2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B1/00—Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Способ получения нанокапсул аспирина в альгинате натрия, характеризующийся тем, что в качестве оболочки нанокапсул используется альгинат натрия, а в качестве ядра - аспирин при получении нанокапсул методом осаждения нерастворителем с применением бутилхлорида в качестве осадителя.A method of producing aspirin nanocapsules in sodium alginate, characterized in that sodium alginate is used as the shell of the nanocapsules, and aspirin is used as the core when nanocapsules are prepared by the non-solvent precipitation method using butyl chloride as a precipitant.

Claims (1)

Способ получения нанокапсул аспирина в альгинате натрия, характеризующийся тем, что в качестве оболочки нанокапсул используется альгинат натрия, а в качестве ядра - аспирин при получении нанокапсул методом осаждения нерастворителем с применением бутилхлорида в качестве осадителя. A method of producing aspirin nanocapsules in sodium alginate, characterized in that sodium alginate is used as the shell of the nanocapsules, and aspirin is used as the core when nanocapsules are prepared by the non-solvent precipitation method using butyl chloride as a precipitant.
RU2014140358A 2014-10-06 2014-10-06 Method of producing aspirin nanocapsules in sodium alginate RU2619329C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2014140358A RU2619329C2 (en) 2014-10-06 2014-10-06 Method of producing aspirin nanocapsules in sodium alginate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2014140358A RU2619329C2 (en) 2014-10-06 2014-10-06 Method of producing aspirin nanocapsules in sodium alginate

Publications (2)

Publication Number Publication Date
RU2014140358A true RU2014140358A (en) 2016-04-27
RU2619329C2 RU2619329C2 (en) 2017-05-15

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2014140358A RU2619329C2 (en) 2014-10-06 2014-10-06 Method of producing aspirin nanocapsules in sodium alginate

Country Status (1)

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RU (1) RU2619329C2 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1566297A (en) * 1975-10-30 1980-04-30 Stauffer Chemical Co Discrete polyurea microcapsules
SU676316A1 (en) * 1978-03-24 1979-07-30 Киевский Ордена Ленина Государственный Университет Им.Т.Г.Шевченко Method of making microcapsules
GB8522963D0 (en) * 1985-09-17 1985-10-23 Biocompatibles Ltd Microcapsules
JP2653255B2 (en) * 1990-02-13 1997-09-17 武田薬品工業株式会社 Long-term sustained release microcapsules
RU2134967C1 (en) * 1997-05-30 1999-08-27 Шестаков Константин Алексеевич Method of preparing microcapsulated preparations containing pyrethroid insecticides

Also Published As

Publication number Publication date
RU2619329C2 (en) 2017-05-15

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20171007