RU2014140357A - The method of obtaining nanocapsules of antibiotics in gellan gum - Google Patents

The method of obtaining nanocapsules of antibiotics in gellan gum Download PDF

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Publication number
RU2014140357A
RU2014140357A RU2014140357A RU2014140357A RU2014140357A RU 2014140357 A RU2014140357 A RU 2014140357A RU 2014140357 A RU2014140357 A RU 2014140357A RU 2014140357 A RU2014140357 A RU 2014140357A RU 2014140357 A RU2014140357 A RU 2014140357A
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RU
Russia
Prior art keywords
antibiotics
gellan gum
nanocapsules
obtaining nanocapsules
producing
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Application number
RU2014140357A
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Russian (ru)
Other versions
RU2619328C2 (en
Inventor
Александр Александрович Кролевец
Илья Александрович Богачев
Кирилл Сергеевич Никитин
Екатерина Евгеньевна Бойко
Яна Владимировна Медведева
Original Assignee
Александр Александрович Кролевец
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Priority to RU2014140357A priority Critical patent/RU2619328C2/en
Publication of RU2014140357A publication Critical patent/RU2014140357A/en
Application granted granted Critical
Publication of RU2619328C2 publication Critical patent/RU2619328C2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)

Abstract

Способ получения нанокапсул антибиотиков в геллановой камеди, характеризующийся тем, что в качестве оболочки нанокапсул используется геллановая камедь, а в качестве ядра - антибиотики при получении нанокапсул методом осаждения нерастворителем с применением бутилхлорида в качестве осадителя.A method for producing nanocapsules of antibiotics in gellan gum, characterized in that gellan gum is used as a shell of nanocapsules, and antibiotics are used as a core for producing nanocapsules by non-solvent precipitation using butyl chloride as a precipitant.

Claims (1)

Способ получения нанокапсул антибиотиков в геллановой камеди, характеризующийся тем, что в качестве оболочки нанокапсул используется геллановая камедь, а в качестве ядра - антибиотики при получении нанокапсул методом осаждения нерастворителем с применением бутилхлорида в качестве осадителя. A method for producing nanocapsules of antibiotics in gellan gum, characterized in that gellan gum is used as a shell of nanocapsules, and antibiotics are used as a core for producing nanocapsules by non-solvent precipitation using butyl chloride as a precipitant.
RU2014140357A 2014-10-06 2014-10-06 Method of producing antibiotic nanocapsules in gellan gum RU2619328C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2014140357A RU2619328C2 (en) 2014-10-06 2014-10-06 Method of producing antibiotic nanocapsules in gellan gum

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2014140357A RU2619328C2 (en) 2014-10-06 2014-10-06 Method of producing antibiotic nanocapsules in gellan gum

Publications (2)

Publication Number Publication Date
RU2014140357A true RU2014140357A (en) 2016-04-27
RU2619328C2 RU2619328C2 (en) 2017-05-15

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2014140357A RU2619328C2 (en) 2014-10-06 2014-10-06 Method of producing antibiotic nanocapsules in gellan gum

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Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2134967C1 (en) * 1997-05-30 1999-08-27 Шестаков Константин Алексеевич Method of preparing microcapsulated preparations containing pyrethroid insecticides
WO2010004594A1 (en) * 2008-07-08 2010-01-14 S.I.F.I. Societa' Industria Farmaceutica Italiana S.P.A. Ophthalmic compositions for treating pathologies of the posterior segment of the eye

Also Published As

Publication number Publication date
RU2619328C2 (en) 2017-05-15

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20171007