RU2014121335A - Иммуногенное лечение рака - Google Patents
Иммуногенное лечение рака Download PDFInfo
- Publication number
- RU2014121335A RU2014121335A RU2014121335A RU2014121335A RU2014121335A RU 2014121335 A RU2014121335 A RU 2014121335A RU 2014121335 A RU2014121335 A RU 2014121335A RU 2014121335 A RU2014121335 A RU 2014121335A RU 2014121335 A RU2014121335 A RU 2014121335A
- Authority
- RU
- Russia
- Prior art keywords
- immunomodulator
- cancer
- therapy
- paragraphs
- tumor
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title claims abstract 16
- 201000011510 cancer Diseases 0.000 title claims 3
- 230000002163 immunogen Effects 0.000 title claims 2
- 239000002955 immunomodulating agent Substances 0.000 claims abstract 41
- 230000002584 immunomodulator Effects 0.000 claims abstract 41
- 229940121354 immunomodulator Drugs 0.000 claims abstract 41
- 238000002560 therapeutic procedure Methods 0.000 claims abstract 19
- 241000186359 Mycobacterium Species 0.000 claims abstract 12
- 230000037449 immunogenic cell death Effects 0.000 claims abstract 12
- 230000001717 pathogenic effect Effects 0.000 claims abstract 8
- 230000010102 embolization Effects 0.000 claims abstract 6
- 238000002604 ultrasonography Methods 0.000 claims abstract 6
- 201000010099 disease Diseases 0.000 claims abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 5
- 238000010438 heat treatment Methods 0.000 claims abstract 4
- 238000002347 injection Methods 0.000 claims abstract 4
- 239000007924 injection Substances 0.000 claims abstract 4
- 230000001613 neoplastic effect Effects 0.000 claims abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract 3
- 206010020843 Hyperthermia Diseases 0.000 claims abstract 3
- 238000000315 cryotherapy Methods 0.000 claims abstract 3
- 230000006378 damage Effects 0.000 claims abstract 3
- 230000036031 hyperthermia Effects 0.000 claims abstract 3
- 238000002428 photodynamic therapy Methods 0.000 claims abstract 3
- 238000001959 radiotherapy Methods 0.000 claims abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 3
- 241000187473 Mycobacterium aurum Species 0.000 claims abstract 2
- 241000187918 Mycobacterium obuense Species 0.000 claims abstract 2
- 241001532512 Mycobacterium parafortuitum Species 0.000 claims abstract 2
- 241000187644 Mycobacterium vaccae Species 0.000 claims abstract 2
- 230000001394 metastastic effect Effects 0.000 claims abstract 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims abstract 2
- 230000002685 pulmonary effect Effects 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims 8
- 230000005865 ionizing radiation Effects 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 230000034994 death Effects 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 210000005229 liver cell Anatomy 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 230000006641 stabilisation Effects 0.000 claims 1
- 238000011105 stabilization Methods 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Radiology & Medical Imaging (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Radiation-Therapy Devices (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1120779.2 | 2011-12-02 | ||
| GBGB1120779.2A GB201120779D0 (en) | 2011-12-02 | 2011-12-02 | Cancer therapy |
| PCT/GB2012/052992 WO2013079980A1 (en) | 2011-12-02 | 2012-12-03 | Immunogenic treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014121335A true RU2014121335A (ru) | 2016-01-27 |
Family
ID=45509083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014121335A RU2014121335A (ru) | 2011-12-02 | 2012-12-03 | Иммуногенное лечение рака |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US20140356397A1 (enExample) |
| EP (1) | EP2785361B1 (enExample) |
| JP (1) | JP6085611B2 (enExample) |
| KR (1) | KR20140097419A (enExample) |
| CN (1) | CN104023733A (enExample) |
| AU (1) | AU2012343536B2 (enExample) |
| BR (1) | BR112014012880A2 (enExample) |
| CA (1) | CA2857429A1 (enExample) |
| GB (1) | GB201120779D0 (enExample) |
| IL (1) | IL232890A0 (enExample) |
| IN (1) | IN2014MN00955A (enExample) |
| MX (1) | MX2014006511A (enExample) |
| RU (1) | RU2014121335A (enExample) |
| SG (1) | SG11201402396XA (enExample) |
| WO (1) | WO2013079980A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2664597C1 (ru) * | 2017-12-12 | 2018-08-21 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) | Способ комбинированного лечения больных первично операбельным и местно-распространенным неоперабельным раком молочной железы |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11963716B2 (en) | 2010-07-19 | 2024-04-23 | Emblation Limited | Apparatus and method for the treatment of dermatological diseases or conditions |
| GB201120779D0 (en) * | 2011-12-02 | 2012-01-11 | Immodulon Therapeutics Ltd | Cancer therapy |
| GB201308325D0 (en) * | 2013-05-09 | 2013-06-19 | Immodulon Therapeutics Ltd | Cancer Therapy |
| MX390311B (es) | 2013-12-05 | 2025-03-20 | Rfemb Holdings Llc | Presentacion de antigeno de cancer mejorado a celulas que presentan por la descomposicion electrica de membrana por radiofrecuencia (rf-rmb) como un mecanismo adyuvante para la inmunoterapia. |
| GB201322725D0 (en) | 2013-12-20 | 2014-02-05 | Immodulon Therapeutics Ltd | Cancer therapy |
| CA2975123A1 (en) * | 2015-01-30 | 2016-08-04 | Rfemb Holdings, Llc | Radio frequency electrical membrane breakdown for the treatment of high risk and recurrent prostate cancer, unresectable pancreatic cancer, tumors of the breast, melanoma or other skin malignancies, sarcoma, soft tissue tumors, ductal carcinoma, neoplasia, and intra and extra luminal abnormal tissue |
| CA2990107A1 (en) * | 2015-06-24 | 2016-12-29 | Immodulon Therapeutics Limited | A checkpoint inhibitor and a whole cell mycobacterium for use in cancer therapy |
| RU2596505C1 (ru) * | 2015-07-02 | 2016-09-10 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский радиологический центр" Министерства здравоохранения Российской Федерации (ФГБУ "НМИРЦ" Минздрава России) | Способ лечения онкологических больных цитотоксическими лимфоцитами |
| US10478194B2 (en) | 2015-09-23 | 2019-11-19 | Covidien Lp | Occlusive devices |
| TW202428236A (zh) | 2016-01-15 | 2024-07-16 | 美商Ｒｆｅｍｂ控股有限公司 | 癌症之免疫治療 |
| EP3442653A4 (en) * | 2016-04-14 | 2020-02-26 | Feldreich Caro Ruiz AB | DEVICE FOR USE IN RADIATION THERAPY WITH AN IONIZING MODULE AND A UV LIGHT SOURCE |
| SG10202110763WA (en) | 2017-03-28 | 2021-11-29 | Emblation Ltd | Stenosis treatment |
| CN111479571A (zh) | 2017-07-21 | 2020-07-31 | 瓦里安医疗系统公司 | 超高剂量率辐射和治疗剂的使用方法 |
| BR112021010799A2 (pt) | 2018-12-03 | 2021-08-24 | Fusion Pharmaceuticals Inc. | Terapia combinada com radioimunoconjugados e inibidor do ponto de verificação |
| US20220098578A1 (en) * | 2019-01-31 | 2022-03-31 | Bar Ilan University | Neoantigens created by aberrant-induced splicing and uses thereof in enhancing immunotherapy |
| WO2021132636A1 (ja) * | 2019-12-27 | 2021-07-01 | 特定非営利活動法人Ｎｏｒｔｈ Ｅａｓｔ Ｊａｐａｎ Ｓｔｕｄｙ Ｇｒｏｕｐ | がん治療方法及び医薬 |
| WO2023007107A1 (en) * | 2021-07-27 | 2023-02-02 | Immodulon Therapeutics Limited | A mycobacterium for use in cancer therapy |
| CN114367060A (zh) * | 2022-01-13 | 2022-04-19 | 深圳大学 | 激光交变电场联合治疗仪 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5207223A (en) | 1990-10-19 | 1993-05-04 | Accuray, Inc. | Apparatus for and method of performing stereotaxic surgery |
| JPH06501479A (ja) * | 1990-11-08 | 1994-02-17 | スタンフオード・ルツク・リミテツド | 抗原担体 |
| US5458125A (en) | 1994-01-28 | 1995-10-17 | Board Of Directors Of The Leland Standford Jr. University | Treatment planning method and apparatus for radiosurgery and radiation therapy |
| CA2369542C (en) | 1999-04-23 | 2009-10-27 | Qlt Inc. | Immuno-adjuvant pdt treatment of metastatic tumors |
| US20020022032A1 (en) | 1999-04-23 | 2002-02-21 | Curry Patrick Mark | Immuno-adjuvant PDT treatment of metastatic tumors |
| AU2002353366A1 (en) * | 2001-12-10 | 2003-06-23 | Bakulesh Mafatlal Khamar | The process of manufacturing a pharmaceutical composition useful for management of cancer |
| AU2003281200A1 (en) | 2002-07-03 | 2004-01-23 | Tasuku Honjo | Immunopotentiating compositions |
| US20050175625A1 (en) | 2002-07-12 | 2005-08-11 | The Johns Hopkins University | Mesothelin vaccines and model systems |
| AU2006306521B2 (en) | 2005-10-21 | 2011-12-22 | Medical College Of Georgia Research Institute, Inc. | The induction of indoleamine 2,3-dioxygenase in dendritic cells by TLR ligands and uses thereof |
| US20080318252A1 (en) | 2007-04-23 | 2008-12-25 | Scott Kachlany | Rapid assay to test anti-cancer drugs under physiological conditions |
| GB0526033D0 (en) | 2005-12-21 | 2006-02-01 | Bioeos Ltd | Method |
| WO2007112316A2 (en) * | 2006-03-24 | 2007-10-04 | Morton Donald L | Mycobacterial immunotherapy for cancer treatment |
| WO2008110491A2 (en) | 2007-03-09 | 2008-09-18 | University Of Basel | Chemotherapy of neoplastic diseases using combinations of rapamycin and compounds modulating mtor pathway alone or in combination with heat |
| NZ600758A (en) | 2007-06-18 | 2013-09-27 | Merck Sharp & Dohme | Antibodies to human programmed death receptor pd-1 |
| DK2172211T3 (en) * | 2008-10-01 | 2015-02-16 | Immatics Biotechnologies Gmbh | Composition of tumor-associated peptides and related anti-cancer vaccine for the treatment of glioblastoma (GBM) and other cancers |
| US8367075B2 (en) | 2010-07-02 | 2013-02-05 | Indian Institute Of Science | Synergistic combination and method thereof |
| AU2012225298B2 (en) * | 2011-03-09 | 2017-05-11 | The Johns Hopkins University | Compounds and methods of use in ablative radiotherapy |
| EP2723381A4 (en) | 2011-06-21 | 2015-03-18 | Univ Johns Hopkins | FOCUSED RADIATION FOR THE REINFORCEMENT OF IMMUNE TREATMENTS AGAINST NEOPLASMS |
| GB201120779D0 (en) * | 2011-12-02 | 2012-01-11 | Immodulon Therapeutics Ltd | Cancer therapy |
| EP2620159A1 (en) | 2012-01-24 | 2013-07-31 | Institut Pasteur | Improved cancer treatment by immunotherapy with bcg or antigenically related non-pathogenic mycobacteria |
| KR20140126357A (ko) | 2012-02-01 | 2014-10-30 | 컴퓨젠 엘티디. | C1orf32 항체 및 이의 암 치료를 위한 용도 |
| US8617520B2 (en) | 2012-02-15 | 2013-12-31 | Immodulon Therapeutics Limited | Cancer therapy |
| GB201308325D0 (en) | 2013-05-09 | 2013-06-19 | Immodulon Therapeutics Ltd | Cancer Therapy |
| GB201322725D0 (en) | 2013-12-20 | 2014-02-05 | Immodulon Therapeutics Ltd | Cancer therapy |
| EP4070818A3 (en) | 2014-01-06 | 2023-01-11 | The Trustees of the University of Pennsylvania | Pd1 and pdl1 antibodies and vaccine combinations and use of same for immunotherapy |
| US10975112B2 (en) | 2015-06-16 | 2021-04-13 | Hangzhou Dac Biotech Co., Ltd. | Linkers for conjugation of cell-binding molecules |
| CA2990107A1 (en) | 2015-06-24 | 2016-12-29 | Immodulon Therapeutics Limited | A checkpoint inhibitor and a whole cell mycobacterium for use in cancer therapy |
| JP2021529741A (ja) | 2018-06-25 | 2021-11-04 | イモデュロン セラピューティクス リミテッド | がん治療 |
-
2011
- 2011-12-02 GB GBGB1120779.2A patent/GB201120779D0/en not_active Ceased
-
2012
- 2012-12-03 EP EP12799260.0A patent/EP2785361B1/en active Active
- 2012-12-03 US US14/361,992 patent/US20140356397A1/en not_active Abandoned
- 2012-12-03 JP JP2014543984A patent/JP6085611B2/ja active Active
- 2012-12-03 MX MX2014006511A patent/MX2014006511A/es unknown
- 2012-12-03 CN CN201280059421.0A patent/CN104023733A/zh active Pending
- 2012-12-03 BR BR112014012880A patent/BR112014012880A2/pt not_active IP Right Cessation
- 2012-12-03 WO PCT/GB2012/052992 patent/WO2013079980A1/en not_active Ceased
- 2012-12-03 KR KR1020147016935A patent/KR20140097419A/ko not_active Withdrawn
- 2012-12-03 CA CA2857429A patent/CA2857429A1/en not_active Abandoned
- 2012-12-03 SG SG11201402396XA patent/SG11201402396XA/en unknown
- 2012-12-03 RU RU2014121335A patent/RU2014121335A/ru unknown
- 2012-12-03 AU AU2012343536A patent/AU2012343536B2/en active Active
- 2012-12-03 IN IN955MUN2014 patent/IN2014MN00955A/en unknown
-
2014
- 2014-05-29 IL IL232890A patent/IL232890A0/en unknown
-
2018
- 2018-12-19 US US16/225,028 patent/US11318193B2/en active Active
-
2020
- 2020-06-30 US US16/916,194 patent/US11554166B2/en active Active
-
2023
- 2023-01-13 US US18/154,177 patent/US20230149525A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2664597C1 (ru) * | 2017-12-12 | 2018-08-21 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) | Способ комбинированного лечения больных первично операбельным и местно-распространенным неоперабельным раком молочной железы |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20140097419A (ko) | 2014-08-06 |
| EP2785361B1 (en) | 2018-11-28 |
| US20200338181A1 (en) | 2020-10-29 |
| AU2012343536A1 (en) | 2014-06-05 |
| SG11201402396XA (en) | 2014-10-30 |
| WO2013079980A1 (en) | 2013-06-06 |
| MX2014006511A (es) | 2014-12-05 |
| CA2857429A1 (en) | 2013-06-06 |
| AU2012343536B2 (en) | 2017-08-24 |
| US11318193B2 (en) | 2022-05-03 |
| IL232890A0 (en) | 2014-07-31 |
| BR112014012880A2 (pt) | 2017-06-13 |
| CN104023733A (zh) | 2014-09-03 |
| US11554166B2 (en) | 2023-01-17 |
| US20190224294A1 (en) | 2019-07-25 |
| JP6085611B2 (ja) | 2017-02-22 |
| GB201120779D0 (en) | 2012-01-11 |
| US20140356397A1 (en) | 2014-12-04 |
| IN2014MN00955A (enExample) | 2015-04-24 |
| EP2785361A1 (en) | 2014-10-08 |
| NZ624994A (en) | 2016-10-28 |
| US20230149525A1 (en) | 2023-05-18 |
| JP2014533743A (ja) | 2014-12-15 |
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