JP6085611B2 - 癌免疫療法 - Google Patents
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- JP6085611B2 JP6085611B2 JP2014543984A JP2014543984A JP6085611B2 JP 6085611 B2 JP6085611 B2 JP 6085611B2 JP 2014543984 A JP2014543984 A JP 2014543984A JP 2014543984 A JP2014543984 A JP 2014543984A JP 6085611 B2 JP6085611 B2 JP 6085611B2
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| RU2664597C1 (ru) * | 2017-12-12 | 2018-08-21 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) | Способ комбинированного лечения больных первично операбельным и местно-распространенным неоперабельным раком молочной железы |
| BR112021010799A2 (pt) | 2018-12-03 | 2021-08-24 | Fusion Pharmaceuticals Inc. | Terapia combinada com radioimunoconjugados e inibidor do ponto de verificação |
| US20220098578A1 (en) * | 2019-01-31 | 2022-03-31 | Bar Ilan University | Neoantigens created by aberrant-induced splicing and uses thereof in enhancing immunotherapy |
| WO2021132636A1 (ja) * | 2019-12-27 | 2021-07-01 | 特定非営利活動法人North East Japan Study Group | がん治療方法及び医薬 |
| WO2023007107A1 (en) * | 2021-07-27 | 2023-02-02 | Immodulon Therapeutics Limited | A mycobacterium for use in cancer therapy |
| CN114367060A (zh) * | 2022-01-13 | 2022-04-19 | 深圳大学 | 激光交变电场联合治疗仪 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5207223A (en) | 1990-10-19 | 1993-05-04 | Accuray, Inc. | Apparatus for and method of performing stereotaxic surgery |
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| CA2369542C (en) | 1999-04-23 | 2009-10-27 | Qlt Inc. | Immuno-adjuvant pdt treatment of metastatic tumors |
| US20020022032A1 (en) | 1999-04-23 | 2002-02-21 | Curry Patrick Mark | Immuno-adjuvant PDT treatment of metastatic tumors |
| AU2002353366A1 (en) * | 2001-12-10 | 2003-06-23 | Bakulesh Mafatlal Khamar | The process of manufacturing a pharmaceutical composition useful for management of cancer |
| AU2003281200A1 (en) | 2002-07-03 | 2004-01-23 | Tasuku Honjo | Immunopotentiating compositions |
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| AU2006306521B2 (en) | 2005-10-21 | 2011-12-22 | Medical College Of Georgia Research Institute, Inc. | The induction of indoleamine 2,3-dioxygenase in dendritic cells by TLR ligands and uses thereof |
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| GB0526033D0 (en) | 2005-12-21 | 2006-02-01 | Bioeos Ltd | Method |
| WO2007112316A2 (en) * | 2006-03-24 | 2007-10-04 | Morton Donald L | Mycobacterial immunotherapy for cancer treatment |
| WO2008110491A2 (en) | 2007-03-09 | 2008-09-18 | University Of Basel | Chemotherapy of neoplastic diseases using combinations of rapamycin and compounds modulating mtor pathway alone or in combination with heat |
| NZ600758A (en) | 2007-06-18 | 2013-09-27 | Merck Sharp & Dohme | Antibodies to human programmed death receptor pd-1 |
| DK2172211T3 (en) * | 2008-10-01 | 2015-02-16 | Immatics Biotechnologies Gmbh | Composition of tumor-associated peptides and related anti-cancer vaccine for the treatment of glioblastoma (GBM) and other cancers |
| US8367075B2 (en) | 2010-07-02 | 2013-02-05 | Indian Institute Of Science | Synergistic combination and method thereof |
| AU2012225298B2 (en) * | 2011-03-09 | 2017-05-11 | The Johns Hopkins University | Compounds and methods of use in ablative radiotherapy |
| EP2723381A4 (en) | 2011-06-21 | 2015-03-18 | Univ Johns Hopkins | FOCUSED RADIATION FOR THE REINFORCEMENT OF IMMUNE TREATMENTS AGAINST NEOPLASMS |
| GB201120779D0 (en) * | 2011-12-02 | 2012-01-11 | Immodulon Therapeutics Ltd | Cancer therapy |
| EP2620159A1 (en) | 2012-01-24 | 2013-07-31 | Institut Pasteur | Improved cancer treatment by immunotherapy with bcg or antigenically related non-pathogenic mycobacteria |
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| EP4070818A3 (en) | 2014-01-06 | 2023-01-11 | The Trustees of the University of Pennsylvania | Pd1 and pdl1 antibodies and vaccine combinations and use of same for immunotherapy |
| US10975112B2 (en) | 2015-06-16 | 2021-04-13 | Hangzhou Dac Biotech Co., Ltd. | Linkers for conjugation of cell-binding molecules |
| CA2990107A1 (en) | 2015-06-24 | 2016-12-29 | Immodulon Therapeutics Limited | A checkpoint inhibitor and a whole cell mycobacterium for use in cancer therapy |
| JP2021529741A (ja) | 2018-06-25 | 2021-11-04 | イモデュロン セラピューティクス リミテッド | がん治療 |
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| NZ624994A (en) | 2016-10-28 |
| US20230149525A1 (en) | 2023-05-18 |
| JP2014533743A (ja) | 2014-12-15 |
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