RU2014111818A - Композиции и способы для лечения или предупреждения легочной дисфункции, вызываемой лучевой терапией или химиотерапией - Google Patents
Композиции и способы для лечения или предупреждения легочной дисфункции, вызываемой лучевой терапией или химиотерапией Download PDFInfo
- Publication number
- RU2014111818A RU2014111818A RU2014111818/15A RU2014111818A RU2014111818A RU 2014111818 A RU2014111818 A RU 2014111818A RU 2014111818/15 A RU2014111818/15 A RU 2014111818/15A RU 2014111818 A RU2014111818 A RU 2014111818A RU 2014111818 A RU2014111818 A RU 2014111818A
- Authority
- RU
- Russia
- Prior art keywords
- composition
- csf
- pulmonary
- administered
- radiation
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 38
- 230000005980 lung dysfunction Effects 0.000 title claims abstract 15
- 238000001959 radiotherapy Methods 0.000 title claims abstract 8
- 238000000034 method Methods 0.000 title claims 3
- 238000002512 chemotherapy Methods 0.000 title claims 2
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims abstract 17
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims abstract 17
- 230000002685 pulmonary effect Effects 0.000 claims abstract 11
- 206010035664 Pneumonia Diseases 0.000 claims abstract 10
- 230000005855 radiation Effects 0.000 claims abstract 10
- 208000035143 Bacterial infection Diseases 0.000 claims abstract 9
- 206010017533 Fungal infection Diseases 0.000 claims abstract 9
- 208000031888 Mycoses Diseases 0.000 claims abstract 9
- 208000036142 Viral infection Diseases 0.000 claims abstract 9
- 230000001580 bacterial effect Effects 0.000 claims abstract 9
- 208000022362 bacterial infectious disease Diseases 0.000 claims abstract 9
- 230000002538 fungal effect Effects 0.000 claims abstract 9
- 230000009385 viral infection Effects 0.000 claims abstract 9
- 230000009545 invasion Effects 0.000 claims abstract 7
- 210000004072 lung Anatomy 0.000 claims abstract 7
- 208000015181 infectious disease Diseases 0.000 claims abstract 6
- 230000002265 prevention Effects 0.000 claims abstract 5
- 102000004127 Cytokines Human genes 0.000 claims abstract 2
- 108090000695 Cytokines Proteins 0.000 claims abstract 2
- 230000001154 acute effect Effects 0.000 claims abstract 2
- 230000000973 chemotherapeutic effect Effects 0.000 claims abstract 2
- 230000007123 defense Effects 0.000 claims abstract 2
- 230000001900 immune effect Effects 0.000 claims abstract 2
- 230000003313 weakening effect Effects 0.000 claims abstract 2
- 206010006448 Bronchiolitis Diseases 0.000 claims 3
- 206010061217 Infestation Diseases 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 208000001395 Acute radiation syndrome Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 206010067472 Organising pneumonia Diseases 0.000 claims 1
- 206010068142 Radiation sickness syndrome Diseases 0.000 claims 1
- 208000009470 Ventilator-Associated Pneumonia Diseases 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 201000009267 bronchiectasis Diseases 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- 238000013276 bronchoscopy Methods 0.000 claims 1
- 201000009805 cryptogenic organizing pneumonia Diseases 0.000 claims 1
- 206010062952 diffuse panbronchiolitis Diseases 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000008817 pulmonary damage Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 238000007910 systemic administration Methods 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 210000003437 trachea Anatomy 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- 230000003902 lesion Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Dispersion Chemistry (AREA)
- Otolaryngology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161528459P | 2011-08-29 | 2011-08-29 | |
| US61/528,459 | 2011-08-29 | ||
| PCT/DK2012/050320 WO2013029627A1 (en) | 2011-08-29 | 2012-08-29 | Compositions and methods for treating or preventing radiation- or chemotherapy-induced pulmonary dysfunction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014111818A true RU2014111818A (ru) | 2015-10-10 |
Family
ID=46888859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014111818/15A RU2014111818A (ru) | 2011-08-29 | 2012-08-29 | Композиции и способы для лечения или предупреждения легочной дисфункции, вызываемой лучевой терапией или химиотерапией |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US20140205658A1 (enExample) |
| EP (1) | EP2750696A1 (enExample) |
| JP (1) | JP2014529614A (enExample) |
| RU (1) | RU2014111818A (enExample) |
| WO (1) | WO2013029627A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2928759A1 (en) * | 2013-11-04 | 2015-05-07 | Board Of Regents, The University Of Texas System | Compositions and methods for administration of an enzyme to a subject's airway |
| WO2015110536A1 (en) * | 2014-01-22 | 2015-07-30 | Reponex Pharmaceuticals Aps | Granulocyte-macrophage colony-stimulating factor for the treatment and prevention of severe forms of bronchial asthma |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US5391485A (en) | 1985-08-06 | 1995-02-21 | Immunex Corporation | DNAs encoding analog GM-CSF molecules displaying resistance to proteases which cleave at adjacent dibasic residues |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| CA2668292C (en) * | 2006-11-03 | 2018-04-03 | Drugrecure Aps | Enhancing pulmonary host defense via administration of granulocyte-macrophage colony stimulating factor |
| US8530428B2 (en) * | 2007-03-07 | 2013-09-10 | Mayo Foundation For Medical Education And Research | Treating cancer with granulocyte-macrophage colony stimulating factor |
-
2012
- 2012-08-29 EP EP12762204.1A patent/EP2750696A1/en not_active Withdrawn
- 2012-08-29 RU RU2014111818/15A patent/RU2014111818A/ru not_active Application Discontinuation
- 2012-08-29 WO PCT/DK2012/050320 patent/WO2013029627A1/en not_active Ceased
- 2012-08-29 JP JP2014527498A patent/JP2014529614A/ja active Pending
- 2012-08-29 US US14/240,573 patent/US20140205658A1/en not_active Abandoned
-
2015
- 2015-11-06 US US14/934,713 patent/US20160256528A1/en not_active Abandoned
-
2016
- 2016-12-13 US US15/377,867 patent/US20170095534A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2750696A1 (en) | 2014-07-09 |
| US20140205658A1 (en) | 2014-07-24 |
| US20170095534A1 (en) | 2017-04-06 |
| WO2013029627A1 (en) | 2013-03-07 |
| JP2014529614A (ja) | 2014-11-13 |
| US20160256528A1 (en) | 2016-09-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20170808 |