RU2014070C1 - Contact medium for ultraphonophoresis - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: contact medium for ultraphonophoresis has the following components, wt.-%: water insoluble drug 2.5-5.0; dimexide 5-10; methylcellulose 75-80, and glycerol 10.0-12.5. Proposed composition of contact medium eliminates possibility of by-effect of drugs and their interaction with solvent and components of base. EFFECT: enhanced phonophoretic activity of ultrasonic by means of increased elimination rate of water insoluble compounds from the contact medium composition, being independent on the frequency. 3 tbl

Description

 The invention relates to medicine, namely to physiotherapy, and relates to a contact medium used in the phonophoresis of various diseases.

The aim of the invention is to increase the phonophoretic activity of ultrasound by increasing the rate of elimination of water-insoluble compounds from the composition of the contact medium, regardless of the frequency response, with the following components, wt.%: Water-insoluble drug substance 2.5-5, Dimethyl sulfoxide (dimexide) 5.0-10 0, methyl cellulose 80.0-75.0 glycerol 12.5-10.0
The composition is prepared as follows. The substance of the water-insoluble compound in the form of a powder (exact weight) is dissolved in dimethyl sulfoxide (100%) in an amount of 5.0-10.0 ml for complete dissolution of the drug substance. Dimexidum solution can be warmed to a temperature of 50-60 ^{° C} for 3-5 minutes to po- luchit complete dissolution of the drug substance. Methylcellulose powder is filled half of the required amount of water to obtain a 3% concentration was heated to 65-70 ^{° C,} left to stand for 30-40 minutes for swelling, and then stirred thoroughly (possible mechanical stirrer at a speed of 3000 rev / min), was added a solution of the drug in dimexide; glycerin is added during mixing to reduce dryness; a trituration ointment is formed.

 For phonophoresis, low-frequency ultrasound of 880 kHz is used in physiotherapy, but physiotherapeutic equipment for ultraphonophoresis at a frequency of 2640 kHz is currently produced and widely used. The use of dimexide as a solvent for water-insoluble compounds, due to its transporting properties, smoothes out the difference between low-frequency (880 kHz) and high-frequency (2640 kHz) ultrasounds in terms of the amount of drug transferred per unit time. The data are presented in table 1.

 The amount of drug administered during phonophoresis depends on the intensity of scoring. The use of demexide as a solvent of water-insoluble compounds with their content in a contact medium in the range of low and medium concentrations (0.5-5%), the formation of transport forms of dimexide with medicinal substances in a solution increases the amount of drug substance administered at these parameters. The results are presented in table.2.

 The use of methyl cellulose and dimethyl sulfoxide increases the phonophoretic activity of ultrasound due to an increase in the rate of elimination of water-insoluble drugs from the substrate, regardless of the frequency or depth of penetration of ultrasonic vibrations. The use of methyl cellulose, glycerol eliminates the interaction of water-insoluble compounds in dimexide with the components of the base, which increases the effectiveness of the therapeutic use of ultraphonophoresis.

 PRI me R 1. Patient A., born in 1954, a loader of the transport department, was in a neurological clinic for lumbar osteochondrosis with radicular syndrome on the left, severe pain. An anamnesis of the disease - sick for more than 10 years, associates annual exacerbations in spring or autumn with working conditions and physical activity. The last exacerbation was more than 3 months, at the place of residence he received medication, took hydrogen sulfide baths, heat therapy and novocaine electrophoresis - without result.

On admission: blood pressure 120/80 mm Hg, pulse 68 beats / min., Rhythmic, vesicular breathing, no wheezing. The abdomen is soft, painless, the liver is not enlarged, the projection point of the gallbladder is painless. Neurological status - on the part of the cranial nerves without pathological abnormalities. The motor sphere is a gentle gait, limited range of motion when leaning forward, to the right. The tension of the long muscles of the back, more on the left, pain on palpation along the left sciatic nerve. Positive symptom Lassega left (30 ° ^C), the left is positive symptom Neri and s.Hachaturova. Disorders of superficial sensitivity - hypesthesia on the outer surface of the left thigh and lower leg in the zone L ₃ -S ₁ . Tendon reflexes on the lower extremities D> S.

The patient received 12 procedures: 5% acetylsalicylic acid (ASA) - ultraphonophoresis according to the following method: apparatus UZT-1.01F. (frequency of ultrasonic vibrations of 880 (kHz) - on the lumbosacral region, a contact medium of the following composition was applied paravertebrally left and right, wt.% :, acetylsalicylic acid 5.0; dimethyl sulfoxide 10.0; methyl cellulose 75.0; glycerol 10.0 The exposure was carried out by ultrasound with an intensity of 0.2-0.4 W / cm ² - paravertebral and along the left sciatic nerve ("gluteal field", middle of the thigh, lower leg) with an intensity of 0.4-0.7 W / cm ² . - labile, method - contact, duration of the procedure 3 minutes per field.

 The patient tolerated the treatment well, a decrease in pain was noted after 6 procedures, after 11 procedures the pain went completely, was discharged with improvement.

 Objectively: the limitation of the range of motion in the lumbar spine disappeared, there was no pain during palpation along the left sciatic nerve. Symptoms of tension are negative. Violations of surface sensitivity were not detected.

 PRI me R 2. Patient D., 8 years old, was in the children's department for neurodermatitis with common skin process, severe course, stage of incomplete clinical remission. Anamnesis of the disease - sick from 1 year 6 months, there were abundant rashes on the hands, in the popliteal fossae. It was observed by a dermatologist. Used various ointments, hormonal drugs - without effect. The last exacerbation of the disease for more than 2 months, at the place of residence was treated in a hospital, took medication.

 Upon receipt - a satisfactory condition, proper physique, satisfactory nutrition. In the lungs, vesicular breathing, no wheezing. Pulse 66 beats / min. The abdomen is soft, painless, the liver is not enlarged. Rash on the skin of the face, dry skin on the elbows, back of the hands and popliteal fossae, peeling, traces of scratching, lichenization, crusts.

After a full clinical examination (analysis of blood, urine, analysis of duodenal contents, biochemical blood test, examination of an ENT doctor, dermatologist, examination of feces for worm eggs, cysts). Prescribed treatment: 2.5% Parmidin - ultraphonophoresis. Contact medium of the following composition% parmidin 2.5; dimexide 5.0; methyl cellulose 80.0; glycerol 12.5; It was applied to the skin and was subjected to ultrasound according to the following method. The device UZT-3.02D (frequency 2640 kHz), a vibrator with an area of 1.0 cm ² . The impact was carried out on segmental areas, taking into account the localization of the process and the foci of skin lesions, through the contact medium, which was prepared according to the method described above. Paravertebral (at a distance of 1.0-1.5 cm from the spinous processes at the level of C _IV -Th _IV on the left and right, the area of the fields 50-80 cm ² , the intensity of 0.05-0.2 W / cm ² on the lesions skin (ulnar folds, the back surface of the hands) 0.05-0.2 W / cm ² , the duration of scoring of one field 2-3 minutes In the next procedure, scoring was performed paravertebrally at the level of the lumbosacral to the left and right (L ₁ - S ₁ ), then locally - the region of the popliteal fossae, with an intensity of 0.5-0.1-0.2 W / cm ² .

 The patient tolerated the treatment well, itchy skin significantly decreased after the 8th procedure, there was no redness, the phenomena of lichenization of the skin decreased, dry skin became much less. Objectively - the patient was examined by a dermatologist after 12 procedures. Conclusion: skin infiltration and swelling decreased significantly, scratches disappeared, there were no crusts, new elements, dry skin became less. The result of treatment is improvement.

Table 3 summarizes the data on the amount of ASA released from the contact medium with varying its composition (ultrasound intensity) 1.0 W / m ² , exposure time 15 min).

 As follows from the above data (see Table 3), the proposed contact medium contains DMSO and 3% MC gel, which help to reduce the diffusion resistance of the skin and expand the therapeutic possibilities of ultraphonophoresis regardless of the frequency response, increasing the range of drugs used due to water-insoluble preparations from various pharmacological groups. The biopharmaceutical properties of the proposed contact section due to MC exclude the possibility of drug interactions with the components of the base and, in combination with DMSO, ultrasound increase the absolute bioavailability of the proposed drugs.

Claims (1)

CONTACT MEDIA FOR ULTRAPHONOPHORESIS, containing a water-insoluble drug, dimexide, hydrophilic ointment base, characterized in that, in order to increase the phonophoretic activity of ultrasound by increasing the elimination rate of the drug, regardless of the frequency response, it additionally contains methyl cellulose and glycerin in the ratio of components, wt. %:
Water-insoluble drug 2.5 - 5.0
Dimexide 5.0 - 10.0
Cellulose 75.0 - 80.0
Glycerin 10.0 - 12.5.

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