RU2013149168A - Аналоги эпоксиэйкозатриеновой кислоты и способы их получения и использования - Google Patents

Аналоги эпоксиэйкозатриеновой кислоты и способы их получения и использования Download PDF

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RU2013149168A
RU2013149168A RU2013149168/04A RU2013149168A RU2013149168A RU 2013149168 A RU2013149168 A RU 2013149168A RU 2013149168/04 A RU2013149168/04 A RU 2013149168/04A RU 2013149168 A RU2013149168 A RU 2013149168A RU 2013149168 A RU2013149168 A RU 2013149168A
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Джон Дэвид Имиг
Уилльям Б. Кэмпбелл
Джон Рассел Фок
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Дзе Медикал Колледж Оф Висконсин
Дзе Борд Оф Риджентс Оф Дзе Юниверсити Оф Техас Систем
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Abstract

1. Соединение, выбранное из группы, состоящей из2. Соединение по п. 1, где структура представляет собой3. Соединение по п. 1, где структура представляет собой4. Соединение, выбранное из группы, состоящей из5. Композиция, включающая соединение по п.1 или 4 и фармацевтически приемлемый носитель.5. Способ снижения гипертензии у субъекта, включающий введение субъекту терапевтически эффективного количества соединения по п.1 или 4, где гипертензия у указанного субъекта снижается.6. Применение соединения по п.1 или 4 для получения лекарственного средства для лечения гипертензии у субъекта.7. Соединение по п.1 или 4 для применения в лечении гипертензии у субъекта.8. Способ снижения нефротоксичности у субъекта, включающий введение субъекту терапевтически эффективного количества соединения по п.1 или 4, где нефротоксичность у указанного субъекта снижается.9. Способ по п. 8, где нефротоксичность является лекарственно-индуцированной.10. Способ по п. 9, где нефротоксичность является цисплатин-индуцированной.11. Применение соединения по п.1 или 4 для получения лекарственного средства для лечения лекарственно-индуцированной нефротоксичности у субъекта.12. Соединение по п.1 или 4 для применения в лечении лекарственно-индуцированной нефротоксичности у субъекта.13. Способ снижения цисплатин-индуцированной нефротоксичности у субъекта, включающий введение субъекту терапевтически эффективного количества соединения по п.1 или 4, где цисплатин-индуцированная нефротоксичность у указанного субъекта снижается.14. Применение соединения по п.1 или 4 для получения лекарственного препарата для лечения цисплатин-индуцированной нефротоксичности у субъе�

Claims (15)

1. Соединение, выбранное из группы, состоящей из
Figure 00000001
2. Соединение по п. 1, где структура представляет собой
Figure 00000002
3. Соединение по п. 1, где структура представляет собой
Figure 00000003
4. Соединение, выбранное из группы, состоящей из
Figure 00000004
5. Композиция, включающая соединение по п.1 или 4 и фармацевтически приемлемый носитель.
5. Способ снижения гипертензии у субъекта, включающий введение субъекту терапевтически эффективного количества соединения по п.1 или 4, где гипертензия у указанного субъекта снижается.
6. Применение соединения по п.1 или 4 для получения лекарственного средства для лечения гипертензии у субъекта.
7. Соединение по п.1 или 4 для применения в лечении гипертензии у субъекта.
8. Способ снижения нефротоксичности у субъекта, включающий введение субъекту терапевтически эффективного количества соединения по п.1 или 4, где нефротоксичность у указанного субъекта снижается.
9. Способ по п. 8, где нефротоксичность является лекарственно-индуцированной.
10. Способ по п. 9, где нефротоксичность является цисплатин-индуцированной.
11. Применение соединения по п.1 или 4 для получения лекарственного средства для лечения лекарственно-индуцированной нефротоксичности у субъекта.
12. Соединение по п.1 или 4 для применения в лечении лекарственно-индуцированной нефротоксичности у субъекта.
13. Способ снижения цисплатин-индуцированной нефротоксичности у субъекта, включающий введение субъекту терапевтически эффективного количества соединения по п.1 или 4, где цисплатин-индуцированная нефротоксичность у указанного субъекта снижается.
14. Применение соединения по п.1 или 4 для получения лекарственного препарата для лечения цисплатин-индуцированной нефротоксичности у субъекта.
15. Соединение по п.1 или 4 для применения в лечении цисплатин-индуцированной нефротоксичности у субъекта.
RU2013149168/04A 2011-04-06 2012-04-04 Аналоги эпоксиэйкозатриеновой кислоты и способы их получения и использования RU2013149168A (ru)

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BR112018070194A2 (pt) * 2016-04-01 2019-01-29 Max Delbrueck Centrum Fuer Molekulare Medizin composto e composição para uso
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EP3681887B1 (en) * 2017-09-15 2024-09-04 The Medical College of Wisconsin, Inc. Kidney-targeted epoxyeicosatrienoic acid (eet) analogs
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US9127027B2 (en) 2015-09-08
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ECSP13013012A (es) 2014-12-30
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CR20130569A (es) 2014-04-22
IL228708A (en) 2016-10-31
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NI201300102A (es) 2014-05-29
KR20140037075A (ko) 2014-03-26
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US20140113884A1 (en) 2014-04-24
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