RU2013145154A - Анализ экспрессии биомаркеров в клетках с помощью кластеров - Google Patents

Анализ экспрессии биомаркеров в клетках с помощью кластеров Download PDF

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Publication number
RU2013145154A
RU2013145154A RU2013145154/15A RU2013145154A RU2013145154A RU 2013145154 A RU2013145154 A RU 2013145154A RU 2013145154/15 A RU2013145154/15 A RU 2013145154/15A RU 2013145154 A RU2013145154 A RU 2013145154A RU 2013145154 A RU2013145154 A RU 2013145154A
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cell
cells
clusters
intensity
expression
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RU2013145154/15A
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English (en)
Russian (ru)
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Колин Крэйг МАККАЛЛОК
Фиона ДЖИНТИ
Кристофер Джеймс СЕВИНСКИ
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Дженерал Электрик Компани
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Publication of RU2013145154A publication Critical patent/RU2013145154A/ru

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    • G01N33/57555—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/21—Design or setup of recognition systems or techniques; Extraction of features in feature space; Blind source separation
    • G06F18/211—Selection of the most significant subset of features
    • G06F18/2115—Selection of the most significant subset of features by evaluating different subsets according to an optimisation criterion, e.g. class separability, forward selection or backward elimination
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/70—Arrangements for image or video recognition or understanding using pattern recognition or machine learning
    • G06V10/77—Processing image or video features in feature spaces; using data integration or data reduction, e.g. principal component analysis [PCA] or independent component analysis [ICA] or self-organising maps [SOM]; Blind source separation
    • G06V10/771—Feature selection, e.g. selecting representative features from a multi-dimensional feature space
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698—Matching; Classification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Artificial Intelligence (AREA)
  • Data Mining & Analysis (AREA)
  • Evolutionary Computation (AREA)
  • Multimedia (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Computing Systems (AREA)
  • Databases & Information Systems (AREA)
  • Software Systems (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Image Processing (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
RU2013145154/15A 2011-04-22 2012-04-23 Анализ экспрессии биомаркеров в клетках с помощью кластеров RU2013145154A (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161478224P 2011-04-22 2011-04-22
US61/478,224 2011-04-22
US13/252,080 US20120271553A1 (en) 2011-04-22 2011-10-03 Analyzing the expression of biomarkers in cells with clusters
US13/252,072 2011-10-03
US13/252,072 US20120269418A1 (en) 2011-04-22 2011-10-03 Analyzing the expression of biomarkers in cells with clusters
US13/252,080 2011-10-03
PCT/EP2012/057394 WO2012143561A2 (en) 2011-04-22 2012-04-23 Analyzing the expression of biomarkers in cells with clusters

Publications (1)

Publication Number Publication Date
RU2013145154A true RU2013145154A (ru) 2015-05-27

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Family Applications (3)

Application Number Title Priority Date Filing Date
RU2013145154/15A RU2013145154A (ru) 2011-04-22 2012-04-23 Анализ экспрессии биомаркеров в клетках с помощью кластеров
RU2013145151/15A RU2013145151A (ru) 2011-04-22 2012-04-23 Анализ экспрессии биомаркеров в клетках с помощью моментов распределения
RU2013145162/15A RU2013145162A (ru) 2011-04-22 2012-04-23 Анализ экспрессии биомаркеров в клетках с помощью кластеров

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RU2013145151/15A RU2013145151A (ru) 2011-04-22 2012-04-23 Анализ экспрессии биомаркеров в клетках с помощью моментов распределения
RU2013145162/15A RU2013145162A (ru) 2011-04-22 2012-04-23 Анализ экспрессии биомаркеров в клетках с помощью кластеров

Country Status (8)

Country Link
US (5) US20120271553A1 (enExample)
EP (4) EP2700036A2 (enExample)
JP (4) JP6143743B2 (enExample)
BR (4) BR112013027125A2 (enExample)
CA (4) CA2833295A1 (enExample)
RU (3) RU2013145154A (enExample)
SG (4) SG194588A1 (enExample)
WO (4) WO2012143561A2 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201111594D0 (en) * 2011-07-06 2011-08-24 Equateq Ltd New improved process
KR20150094618A (ko) 2012-12-06 2015-08-19 클래리언트 다이아그노스틱 서비시즈, 인크. 생물학적 시편의 분할 스크린 디스플레이와 그 레코드를 포착하기 위한 시스템 및 방법
US9488639B2 (en) * 2013-02-25 2016-11-08 Flagship Biosciences, Inc. Cell-based tissue analysis
US8995740B2 (en) 2013-04-17 2015-03-31 General Electric Company System and method for multiplexed biomarker quantitation using single cell segmentation on sequentially stained tissue
JP2016523550A (ja) * 2013-07-03 2016-08-12 コイン アイピー ホールディングス、 エルエルシー 化学的または生物学的物質に対する応答の予測方法
US9322051B2 (en) 2013-10-07 2016-04-26 General Electric Company Probing of biological samples
US9298968B1 (en) * 2014-09-12 2016-03-29 Flagship Biosciences, Inc. Digital image analysis of inflammatory cells and mediators of inflammation
AU2016209128B2 (en) 2015-01-22 2021-04-29 The Board Of Trustees Of The Leland Stanford Junior University Methods and systems for determining proportions of distinct cell subsets
US10672505B2 (en) 2015-06-03 2020-06-02 General Electric Company Biological data annotation and visualization
US9953133B2 (en) 2015-06-03 2018-04-24 General Electric Company Biological data annotation and visualization
JP6756339B2 (ja) * 2015-12-22 2020-09-16 株式会社ニコン 画像処理装置、及び画像処理方法
US20180032681A1 (en) * 2016-07-29 2018-02-01 General Electric Company Biological feature analysis technique
US11042551B2 (en) * 2016-12-02 2021-06-22 Fair Isaac Corporation Fast automatic explanation of scored observations
WO2018151223A1 (ja) * 2017-02-16 2018-08-23 国立大学法人京都大学 細胞評価方法、細胞評価装置、及び細胞評価プログラム
US10242473B2 (en) * 2017-03-22 2019-03-26 Sas Institute Inc. Computer system to generate scalable plots using clustering
CA3058195A1 (en) 2017-04-28 2018-11-01 4D Path Inc. Apparatus, systems, and methods for rapid cancer detection
KR101990430B1 (ko) * 2017-06-22 2019-06-18 한국과학기술원 암의 재발 예후 예측을 위한 바이오마커 발굴 시스템 및 방법
JP7545891B2 (ja) 2017-07-21 2024-09-05 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 混合細胞集団を分析するためのシステムおよび方法
US10706328B2 (en) * 2018-05-07 2020-07-07 Google Llc Focus-weighted, machine learning disease classifier error prediction for microscope slide images
WO2020056372A1 (en) * 2018-09-14 2020-03-19 Krishnan Ramanathan Multimodal learning framework for analysis of clinical trials
US11101043B2 (en) 2018-09-24 2021-08-24 Zasti Inc. Hybrid analysis framework for prediction of outcomes in clinical trials
US11128667B2 (en) * 2018-11-29 2021-09-21 Rapid7, Inc. Cluster detection and elimination in security environments
CA3120716A1 (en) * 2018-11-29 2020-06-04 Somalogic, Inc. Methods for determining disease risk combining downsampling of class-imbalanced sets with survival analysis
CN113158982A (zh) * 2021-05-17 2021-07-23 广东中卡云计算有限公司 一种半介入式的目标关键点标注方法
WO2023033056A1 (ja) * 2021-09-01 2023-03-09 イミュニティリサーチ株式会社 細胞集団同定システム、方法、およびプログラム
IT202200001817A1 (it) 2022-02-02 2023-08-02 Aizoon S R L Procedimento per la prognosi di una malattia in seguito ad un trattamento terapeutico, relativo sistema e prodotto informatico
IT202200005861A1 (it) 2022-03-24 2023-09-24 Aizoon S R L Procedimento per stimare una variabile di interesse associata ad una data malattia in funzione di una pluralità di diversi dati omici, relativo dispositivo e prodotto informatico
CA3207405A1 (en) 2022-07-25 2024-01-25 Aizoon S.r.l. Method for providing a clinical decision support, corresponding system for providing a clinical decision support, and computer program product

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6463438B1 (en) * 1994-06-03 2002-10-08 Urocor, Inc. Neural network for cell image analysis for identification of abnormal cells
US5740269A (en) * 1994-09-20 1998-04-14 Neopath, Inc. Method and apparatus for robust biological specimen classification
US6996549B2 (en) * 1998-05-01 2006-02-07 Health Discovery Corporation Computer-aided image analysis
US6282305B1 (en) * 1998-06-05 2001-08-28 Arch Development Corporation Method and system for the computerized assessment of breast cancer risk
US6337472B1 (en) * 1998-10-19 2002-01-08 The University Of Texas System Board Of Regents Light imaging microscope having spatially resolved images
AU2002245317A1 (en) * 2001-01-24 2002-08-06 Protein Design Labs Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer
US20060210129A1 (en) * 2002-07-30 2006-09-21 Deutsches Krebsforschungzentrum Method and apparatus for multiple labeling detection and evaluation of a plurality of particles
US20040121413A1 (en) * 2002-12-20 2004-06-24 Aebersold Rudolf H. Androgen-regulated genes and uses for diagnosis, prognosis and treatment of prostate neoplastic conditions
US20050265588A1 (en) * 2004-02-03 2005-12-01 Bioimagene, Inc. Method and system for digital image based flourescent in situ hybridization (FISH) analysis
US20060275844A1 (en) * 2005-04-19 2006-12-07 Linke Steven P Diagnostic markers of breast cancer treatment and progression and methods of use thereof
US8041090B2 (en) * 2005-09-10 2011-10-18 Ge Healthcare Uk Limited Method of, and apparatus and computer software for, performing image processing
US7933435B2 (en) * 2005-11-21 2011-04-26 Vala Sciences, Inc. System, method, and kit for processing a magnified image of biological material to identify components of a biological object
JP5406019B2 (ja) * 2006-05-17 2014-02-05 セルーメン、インコーポレイテッド 自動化組織分析のための方法
US7741045B2 (en) * 2006-11-16 2010-06-22 General Electric Company Sequential analysis of biological samples
US8019134B2 (en) * 2006-11-16 2011-09-13 Definiens Ag Automatic image analysis and quantification for fluorescence in situ hybridization
JP2010522554A (ja) * 2007-03-27 2010-07-08 ロゼッタ ゲノミックス エルティーディー． 癌の分類のための遺伝子発現サイン
JP2010527007A (ja) * 2007-05-07 2010-08-05 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション 細胞アッセイ及び組織の自動解析のためのシステム及び方法
WO2008143849A2 (en) * 2007-05-14 2008-11-27 Historx, Inc. Compartment segregation by pixel characterization using image data clustering
CN102395682B (zh) * 2007-09-06 2015-09-30 生物治疗诊断股份有限公司 肿瘤分级和癌症预后
CA3074969C (en) * 2008-07-25 2023-06-13 Fundacao D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud Systems and methods for treating, diagnosing and predicting the occurrence of a medical condition
US9779213B2 (en) * 2008-07-25 2017-10-03 Fundacao D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud System for evaluating a pathological stage of prostate cancer
US8320655B2 (en) * 2009-10-16 2012-11-27 General Electric Company Process and system for analyzing the expression of biomarkers in cells
US20110091081A1 (en) * 2009-10-16 2011-04-21 General Electric Company Method and system for analyzing the expression of biomarkers in cells in situ in their tissue of origin
WO2011087778A1 (en) * 2009-12-22 2011-07-21 The Children's Hospital Of Philadelphia Automated quantitative multidimensional volumetric analysis and visualization

Also Published As

Publication number Publication date
RU2013145151A (ru) 2015-05-27
US20120271553A1 (en) 2012-10-25
SG194594A1 (en) 2013-12-30
CA2833428A1 (en) 2012-10-26
JP2014517954A (ja) 2014-07-24
EP2700038B1 (en) 2021-04-21
EP2700042B1 (en) 2021-03-17
JP6163152B2 (ja) 2017-07-12
EP2700042A2 (en) 2014-02-26
WO2012143556A3 (en) 2013-05-30
CA2833804A1 (en) 2012-10-26
WO2012143558A3 (en) 2012-12-20
US20120269419A1 (en) 2012-10-25
WO2012143561A2 (en) 2012-10-26
JP2014521926A (ja) 2014-08-28
SG194592A1 (en) 2013-12-30
US20140185905A1 (en) 2014-07-03
BR112013027122A2 (pt) 2017-01-10
WO2012143562A2 (en) 2012-10-26
US20120270752A1 (en) 2012-10-25
WO2012143562A3 (en) 2013-02-28
US20120269418A1 (en) 2012-10-25
EP2700038A2 (en) 2014-02-26
BR112013027124A2 (pt) 2017-01-10
CA2833295A1 (en) 2012-10-26
SG194590A1 (en) 2013-12-30
EP2700037A2 (en) 2014-02-26
SG194588A1 (en) 2013-12-30
BR112013027125A2 (pt) 2017-01-10
JP6143743B2 (ja) 2017-06-07
EP2700036A2 (en) 2014-02-26
RU2013145162A (ru) 2015-05-27
JP6063446B2 (ja) 2017-01-18
BR112013027123A2 (pt) 2017-01-10
WO2012143561A3 (en) 2013-05-23
JP6063447B2 (ja) 2017-01-18
JP2014516413A (ja) 2014-07-10
CA2833497A1 (en) 2012-10-26
WO2012143558A2 (en) 2012-10-26
JP2014521925A (ja) 2014-08-28
WO2012143556A2 (en) 2012-10-26

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