RU2013145154A - Анализ экспрессии биомаркеров в клетках с помощью кластеров - Google Patents

Анализ экспрессии биомаркеров в клетках с помощью кластеров Download PDF

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RU2013145154A
RU2013145154A RU2013145154/15A RU2013145154A RU2013145154A RU 2013145154 A RU2013145154 A RU 2013145154A RU 2013145154/15 A RU2013145154/15 A RU 2013145154/15A RU 2013145154 A RU2013145154 A RU 2013145154A RU 2013145154 A RU2013145154 A RU 2013145154A
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cell
cells
clusters
intensity
expression
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RU2013145154/15A
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Russian (ru)
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Колин Крэйг МАККАЛЛОК
Фиона ДЖИНТИ
Кристофер Джеймс СЕВИНСКИ
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Дженерал Электрик Компани
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57555Immunoassay; Biospecific binding assay; Materials therefor for cancer of the prostate
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00Pattern recognition
    • G06F18/20Analysing
    • G06F18/21Design or setup of recognition systems or techniques; Extraction of features in feature space; Blind source separation
    • G06F18/211Selection of the most significant subset of features
    • G06F18/2115Selection of the most significant subset of features by evaluating different subsets according to an optimisation criterion, e.g. class separability, forward selection or backward elimination
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00Arrangements for image or video recognition or understanding
    • G06V10/70Arrangements for image or video recognition or understanding using pattern recognition or machine learning
    • G06V10/77Processing image or video features in feature spaces; using data integration or data reduction, e.g. principal component analysis [PCA] or independent component analysis [ICA] or self-organising maps [SOM]; Blind source separation
    • G06V10/771Feature selection, e.g. selecting representative features from a multi-dimensional feature space
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00Scenes; Scene-specific elements
    • G06V20/60Type of objects
    • G06V20/69Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698Matching; Classification
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/56Staging of a disease; Further complications associated with the disease
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/60Complex ways of combining multiple protein biomarkers for diagnosis

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Data Mining & Analysis (AREA)
  • Multimedia (AREA)
  • Evolutionary Computation (AREA)
  • Artificial Intelligence (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Software Systems (AREA)
  • Databases & Information Systems (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Computing Systems (AREA)
  • Evolutionary Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Image Processing (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
RU2013145154/15A 2011-04-22 2012-04-23 Анализ экспрессии биомаркеров в клетках с помощью кластеров RU2013145154A (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161478224P 2011-04-22 2011-04-22
US61/478,224 2011-04-22
US13/252,080 US20120271553A1 (en) 2011-04-22 2011-10-03 Analyzing the expression of biomarkers in cells with clusters
US13/252,072 2011-10-03
US13/252,080 2011-10-03
US13/252,072 US20120269418A1 (en) 2011-04-22 2011-10-03 Analyzing the expression of biomarkers in cells with clusters
PCT/EP2012/057394 WO2012143561A2 (en) 2011-04-22 2012-04-23 Analyzing the expression of biomarkers in cells with clusters

Publications (1)

Publication Number Publication Date
RU2013145154A true RU2013145154A (ru) 2015-05-27

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Application Number Title Priority Date Filing Date
RU2013145154/15A RU2013145154A (ru) 2011-04-22 2012-04-23 Анализ экспрессии биомаркеров в клетках с помощью кластеров
RU2013145151/15A RU2013145151A (ru) 2011-04-22 2012-04-23 Анализ экспрессии биомаркеров в клетках с помощью моментов распределения
RU2013145162/15A RU2013145162A (ru) 2011-04-22 2012-04-23 Анализ экспрессии биомаркеров в клетках с помощью кластеров

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RU2013145151/15A RU2013145151A (ru) 2011-04-22 2012-04-23 Анализ экспрессии биомаркеров в клетках с помощью моментов распределения
RU2013145162/15A RU2013145162A (ru) 2011-04-22 2012-04-23 Анализ экспрессии биомаркеров в клетках с помощью кластеров

Country Status (8)

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US (5) US20120269418A1 (enExample)
EP (4) EP2700042B1 (enExample)
JP (4) JP6063446B2 (enExample)
BR (4) BR112013027123A2 (enExample)
CA (4) CA2833804A1 (enExample)
RU (3) RU2013145154A (enExample)
SG (4) SG194592A1 (enExample)
WO (4) WO2012143556A2 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201111594D0 (en) * 2011-07-06 2011-08-24 Equateq Ltd New improved process
EP2929420B1 (en) * 2012-12-06 2022-03-02 Leica Microsystems CMS GmbH Systems and methods for split screen display of a biological specimen and for capturing records thereof
US9488639B2 (en) * 2013-02-25 2016-11-08 Flagship Biosciences, Inc. Cell-based tissue analysis
US8995740B2 (en) * 2013-04-17 2015-03-31 General Electric Company System and method for multiplexed biomarker quantitation using single cell segmentation on sequentially stained tissue
CA2916520A1 (en) * 2013-07-03 2015-01-08 Coyne Ip Holdings, Llc Methods for predicting responses to chemical or biologic substances
US9322051B2 (en) 2013-10-07 2016-04-26 General Electric Company Probing of biological samples
US9298968B1 (en) * 2014-09-12 2016-03-29 Flagship Biosciences, Inc. Digital image analysis of inflammatory cells and mediators of inflammation
CN107430588B (zh) 2015-01-22 2021-12-31 斯坦福大学托管董事会 用于确定不同细胞亚群的比例的方法和系统
US10672505B2 (en) 2015-06-03 2020-06-02 General Electric Company Biological data annotation and visualization
US9953133B2 (en) 2015-06-03 2018-04-24 General Electric Company Biological data annotation and visualization
US10796130B2 (en) * 2015-12-22 2020-10-06 Nikon Corporation Image processing apparatus
US20180032681A1 (en) * 2016-07-29 2018-02-01 General Electric Company Biological feature analysis technique
US11042551B2 (en) * 2016-12-02 2021-06-22 Fair Isaac Corporation Fast automatic explanation of scored observations
US11436719B2 (en) 2017-02-16 2022-09-06 Kyoto University Cell evaluation method, cell evaluation device, and recording medium storing cell evaluation program
US10127696B2 (en) * 2017-03-22 2018-11-13 Sas Institute Inc. Computer system to generate scalable plots using clustering
WO2018201072A2 (en) 2017-04-28 2018-11-01 4D Path Inc. Apparatus, systems, and methods for rapid cancer detection
KR101990430B1 (ko) * 2017-06-22 2019-06-18 한국과학기술원 암의 재발 예후 예측을 위한 바이오마커 발굴 시스템 및 방법
AU2018304381A1 (en) 2017-07-21 2020-02-06 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for analyzing mixed cell populations
US10706328B2 (en) 2018-05-07 2020-07-07 Google Llc Focus-weighted, machine learning disease classifier error prediction for microscope slide images
US10971255B2 (en) * 2018-09-14 2021-04-06 Zasti Inc. Multimodal learning framework for analysis of clinical trials
US11101043B2 (en) 2018-09-24 2021-08-24 Zasti Inc. Hybrid analysis framework for prediction of outcomes in clinical trials
US11128667B2 (en) * 2018-11-29 2021-09-21 Rapid7, Inc. Cluster detection and elimination in security environments
EP3886696A4 (en) * 2018-11-29 2022-08-24 SomaLogic Operating Co., Inc. PROCEDURE FOR DETERMINING DISEASE RISK USING A COMBINATION OF DOWNSAMPLING OF CLASS IMBALANCED DATASETS WITH SURVIVAL ANALYSIS
CN113158982A (zh) * 2021-05-17 2021-07-23 广东中卡云计算有限公司 一种半介入式的目标关键点标注方法
JP7368679B2 (ja) * 2021-09-01 2023-10-25 イミュニティリサーチ株式会社 細胞集団同定システム、方法、およびプログラム
IT202200001817A1 (it) 2022-02-02 2023-08-02 Aizoon S R L Procedimento per la prognosi di una malattia in seguito ad un trattamento terapeutico, relativo sistema e prodotto informatico
IT202200005861A1 (it) 2022-03-24 2023-09-24 Aizoon S R L Procedimento per stimare una variabile di interesse associata ad una data malattia in funzione di una pluralità di diversi dati omici, relativo dispositivo e prodotto informatico
AU2023208071A1 (en) 2022-07-25 2024-02-08 Aizoon S.r.l. Method for providing a clinical decision support, corresponding system for providing a clinical decision support, and computer program product

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6463438B1 (en) * 1994-06-03 2002-10-08 Urocor, Inc. Neural network for cell image analysis for identification of abnormal cells
US5740269A (en) * 1994-09-20 1998-04-14 Neopath, Inc. Method and apparatus for robust biological specimen classification
US6996549B2 (en) * 1998-05-01 2006-02-07 Health Discovery Corporation Computer-aided image analysis
US6282305B1 (en) * 1998-06-05 2001-08-28 Arch Development Corporation Method and system for the computerized assessment of breast cancer risk
US6337472B1 (en) * 1998-10-19 2002-01-08 The University Of Texas System Board Of Regents Light imaging microscope having spatially resolved images
CA2440703A1 (en) * 2001-01-24 2002-08-01 Protein Design Labs, Inc. Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer
WO2004013658A2 (en) * 2002-07-30 2004-02-12 Deutsches Krebsforschungszentrum Method and apparatus for multiple labeling detection and evaluation of a plurality of particles
US20040121413A1 (en) * 2002-12-20 2004-06-24 Aebersold Rudolf H. Androgen-regulated genes and uses for diagnosis, prognosis and treatment of prostate neoplastic conditions
US20050265588A1 (en) * 2004-02-03 2005-12-01 Bioimagene, Inc. Method and system for digital image based flourescent in situ hybridization (FISH) analysis
WO2006113747A2 (en) * 2005-04-19 2006-10-26 Prediction Sciences Llc Diagnostic markers of breast cancer treatment and progression and methods of use thereof
US8041090B2 (en) * 2005-09-10 2011-10-18 Ge Healthcare Uk Limited Method of, and apparatus and computer software for, performing image processing
US7933435B2 (en) * 2005-11-21 2011-04-26 Vala Sciences, Inc. System, method, and kit for processing a magnified image of biological material to identify components of a biological object
US8114615B2 (en) * 2006-05-17 2012-02-14 Cernostics, Inc. Method for automated tissue analysis
US8019134B2 (en) * 2006-11-16 2011-09-13 Definiens Ag Automatic image analysis and quantification for fluorescence in situ hybridization
US7741045B2 (en) * 2006-11-16 2010-06-22 General Electric Company Sequential analysis of biological samples
CA2678919A1 (en) * 2007-03-27 2008-10-02 Ranit Aharonov Gene expression signature for classification of cancers
EP2143043A4 (en) * 2007-05-07 2011-01-12 Ge Healthcare Bio Sciences SYSTEM AND METHOD FOR THE AUTOMATED ANALYSIS OF CELLULAR ASSAYS AND TISSUE
ES2374686T3 (es) * 2007-05-14 2012-02-21 Historx, Inc. Separación en compartimentos por caracterización de píxel usando agrupamiento de datos de imágenes.
WO2009108215A1 (en) * 2007-09-06 2009-09-03 Aviaradx, Inc. Tumor grading and cancer prognosis
CA3074969C (en) * 2008-07-25 2023-06-13 Fundacao D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud Systems and methods for treating, diagnosing and predicting the occurrence of a medical condition
US9779213B2 (en) * 2008-07-25 2017-10-03 Fundacao D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud System for evaluating a pathological stage of prostate cancer
US20110091081A1 (en) * 2009-10-16 2011-04-21 General Electric Company Method and system for analyzing the expression of biomarkers in cells in situ in their tissue of origin
US8320655B2 (en) * 2009-10-16 2012-11-27 General Electric Company Process and system for analyzing the expression of biomarkers in cells
WO2011087778A1 (en) * 2009-12-22 2011-07-21 The Children's Hospital Of Philadelphia Automated quantitative multidimensional volumetric analysis and visualization

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Publication number Publication date
SG194588A1 (en) 2013-12-30
JP2014517954A (ja) 2014-07-24
WO2012143556A3 (en) 2013-05-30
JP6163152B2 (ja) 2017-07-12
US20120271553A1 (en) 2012-10-25
JP6063446B2 (ja) 2017-01-18
US20120270752A1 (en) 2012-10-25
EP2700042B1 (en) 2021-03-17
BR112013027123A2 (pt) 2017-01-10
US20120269419A1 (en) 2012-10-25
SG194590A1 (en) 2013-12-30
SG194592A1 (en) 2013-12-30
RU2013145151A (ru) 2015-05-27
RU2013145162A (ru) 2015-05-27
CA2833497A1 (en) 2012-10-26
BR112013027122A2 (pt) 2017-01-10
JP2014521926A (ja) 2014-08-28
CA2833428A1 (en) 2012-10-26
SG194594A1 (en) 2013-12-30
BR112013027124A2 (pt) 2017-01-10
BR112013027125A2 (pt) 2017-01-10
CA2833804A1 (en) 2012-10-26
EP2700038B1 (en) 2021-04-21
JP6143743B2 (ja) 2017-06-07
WO2012143562A2 (en) 2012-10-26
WO2012143562A3 (en) 2013-02-28
JP6063447B2 (ja) 2017-01-18
JP2014521925A (ja) 2014-08-28
WO2012143558A2 (en) 2012-10-26
WO2012143561A2 (en) 2012-10-26
US20140185905A1 (en) 2014-07-03
EP2700038A2 (en) 2014-02-26
JP2014516413A (ja) 2014-07-10
EP2700037A2 (en) 2014-02-26
CA2833295A1 (en) 2012-10-26
US20120269418A1 (en) 2012-10-25
WO2012143561A3 (en) 2013-05-23
WO2012143558A3 (en) 2012-12-20
EP2700036A2 (en) 2014-02-26
WO2012143556A2 (en) 2012-10-26
EP2700042A2 (en) 2014-02-26

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