RU2013118325A - Лечение рака молочной железы - Google Patents
Лечение рака молочной железы Download PDFInfo
- Publication number
- RU2013118325A RU2013118325A RU2013118325/15A RU2013118325A RU2013118325A RU 2013118325 A RU2013118325 A RU 2013118325A RU 2013118325/15 A RU2013118325/15 A RU 2013118325/15A RU 2013118325 A RU2013118325 A RU 2013118325A RU 2013118325 A RU2013118325 A RU 2013118325A
- Authority
- RU
- Russia
- Prior art keywords
- cancer
- inhibitor
- cell
- rankl
- breast
- Prior art date
Links
- 206010006187 Breast cancer Diseases 0.000 title claims abstract 40
- 208000026310 Breast neoplasm Diseases 0.000 title claims abstract 24
- 238000011282 treatment Methods 0.000 title claims abstract 13
- 239000003112 inhibitor Substances 0.000 claims abstract 42
- 206010028980 Neoplasm Diseases 0.000 claims abstract 35
- 201000011510 cancer Diseases 0.000 claims abstract 35
- 102000014128 RANK Ligand Human genes 0.000 claims abstract 33
- 108010025832 RANK Ligand Proteins 0.000 claims abstract 33
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims abstract 9
- 230000002265 prevention Effects 0.000 claims abstract 8
- 239000003433 contraceptive agent Substances 0.000 claims abstract 5
- 238000002657 hormone replacement therapy Methods 0.000 claims abstract 5
- 239000003163 gonadal steroid hormone Substances 0.000 claims abstract 4
- 238000000034 method Methods 0.000 claims abstract 4
- 239000000186 progesterone Substances 0.000 claims abstract 3
- 229960003387 progesterone Drugs 0.000 claims abstract 3
- 239000000583 progesterone congener Substances 0.000 claims abstract 3
- 230000002250 progressing effect Effects 0.000 claims abstract 3
- 210000004027 cell Anatomy 0.000 claims 23
- 210000000270 basal cell Anatomy 0.000 claims 7
- 210000000481 breast Anatomy 0.000 claims 7
- 210000002919 epithelial cell Anatomy 0.000 claims 7
- 210000000130 stem cell Anatomy 0.000 claims 7
- 108020004459 Small interfering RNA Proteins 0.000 claims 5
- 229960001251 denosumab Drugs 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 3
- 230000000259 anti-tumor effect Effects 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 238000001794 hormone therapy Methods 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- 238000001959 radiotherapy Methods 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- -1 carrier Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003995 emulsifying agent Substances 0.000 claims 1
- 239000000262 estrogen Substances 0.000 claims 1
- 229940011871 estrogen Drugs 0.000 claims 1
- 210000004907 gland Anatomy 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10178346.2 | 2010-09-22 | ||
| EP10178346A EP2433644A1 (en) | 2010-09-22 | 2010-09-22 | Breast cancer therapeutics |
| PCT/EP2011/066511 WO2012038504A2 (en) | 2010-09-22 | 2011-09-22 | Breast cancer therapeutics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2013118325A true RU2013118325A (ru) | 2014-10-27 |
Family
ID=43498569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013118325/15A RU2013118325A (ru) | 2010-09-22 | 2011-09-22 | Лечение рака молочной железы |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10143747B2 (enExample) |
| EP (2) | EP2433644A1 (enExample) |
| JP (2) | JP6133778B2 (enExample) |
| KR (1) | KR20130118870A (enExample) |
| CN (1) | CN103384530A (enExample) |
| AU (1) | AU2011306917B2 (enExample) |
| BR (1) | BR112013006673A2 (enExample) |
| CA (1) | CA2811556A1 (enExample) |
| CL (1) | CL2013000801A1 (enExample) |
| IL (1) | IL225442A0 (enExample) |
| MX (1) | MX2013003076A (enExample) |
| NZ (1) | NZ608207A (enExample) |
| PH (1) | PH12013500543A1 (enExample) |
| RU (1) | RU2013118325A (enExample) |
| WO (1) | WO2012038504A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2433644A1 (en) | 2010-09-22 | 2012-03-28 | IMBA-Institut für Molekulare Biotechnologie GmbH | Breast cancer therapeutics |
| RS62297B1 (sr) | 2011-11-23 | 2021-09-30 | Therapeuticsmd Inc | Prirodne kombinovane hormonske supstitucione formulacije i terapije |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| JP2017516768A (ja) | 2014-05-22 | 2017-06-22 | セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． | 天然の併用ホルモン補充療法剤及び療法 |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| EP3458090A1 (en) * | 2016-05-19 | 2019-03-27 | Probiocon GmbH | Anti-cancer combination treatment |
| JOP20190255A1 (ar) | 2017-04-28 | 2019-10-27 | Amgen Inc | صيغ أجسام مضادة لـ rankl بشري، وطرق لاستخدامها |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2124967C (en) | 1991-12-17 | 2008-04-08 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| WO1998028424A2 (en) | 1996-12-23 | 1998-07-02 | Immunex Corporation | Receptor activator of nf-kappa b, receptor is member of tnf receptor superfamily |
| NZ332995A (en) | 1997-04-15 | 2000-07-28 | Snow Brand Milk Products Co Ltd | A protein which binds to osteoclastogenesis inhibitory factor (OCIF) |
| BR9808545A (pt) | 1997-04-16 | 2000-05-23 | Amgen Inc | ácido nucleico isolado, vetor de expressão, célula hospedeira, processos para produzir uma proteìna de ligação da osteoprotegerina, para detectar a presença de uma proteìna de ligação à osteoprotegerina em uma amostra biológica, para avaliar a capacidade de um composto candidato de ligar-se a uma proteìna de ligação da osteoprotegerina e de um composto de teste para aumentar ou reduzir a ligação da proteìna de ligação da osteoprotegerina a odar, para regular a expressão de uma proteìna de ligação da osteoprotegerina em um animal e para prevenir ou tratar de doença óssea em um mamìfero, polipeptìdeo, protéina de ligação da osteroprotegerina purificada e isolada, ou seu fragmento, análogo ou derivado, e, anticorpo ou seu fragmento |
| US5843678A (en) | 1997-04-16 | 1998-12-01 | Amgen Inc. | Osteoprotegerin binding proteins |
| CA2229449A1 (en) | 1997-04-25 | 1998-10-25 | Takeda Chemical Industries, Ltd. | Novel receptor protein and its use |
| AU7705098A (en) | 1997-05-29 | 1998-12-30 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like protein 8 |
| US6790823B1 (en) * | 1998-04-23 | 2004-09-14 | Amgen Inc. | Compositions and methods for the prevention and treatment of cardiovascular diseases |
| US6638727B1 (en) | 1999-01-26 | 2003-10-28 | Cytyc Health Corporation | Methods for identifying treating or monitoring asymptomatic patients for risk reduction or therapeutic treatment of breast cancer |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| DE10100586C1 (de) | 2001-01-09 | 2002-04-11 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Ziegens |
| DE10160151A1 (de) | 2001-01-09 | 2003-06-26 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens |
| AU2001245793A1 (en) | 2000-03-16 | 2001-09-24 | Cold Spring Harbor Laboratory | Methods and compositions for rna interference |
| US20020173478A1 (en) | 2000-11-14 | 2002-11-21 | The Trustees Of The University Of Pennsylvania | Post-transcriptional gene silencing by RNAi in mammalian cells |
| US20040167072A1 (en) | 2001-05-11 | 2004-08-26 | Aggarwal Bharat B. | Inhibitors of receptor activator of NF-kappaB and uses thereof |
| EP1432438A2 (en) | 2001-06-06 | 2004-06-30 | Immunex Corporation | Use of rank antagonists to treat cancer |
| AU2003207708A1 (en) | 2002-02-20 | 2003-09-09 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of map kinase genes |
| WO2005028633A2 (en) | 2003-09-17 | 2005-03-31 | Isis Pharmaceuticals, Inc. | Modulation of rankl expression |
| WO2005060627A2 (en) | 2003-12-10 | 2005-07-07 | Auxeris Therapeutics, Inc. | Methods of assessing the risk of non-traumatic bone fracture |
| US20080107597A1 (en) | 2006-01-12 | 2008-05-08 | Anaptys Biosciences, Inc. | Isolation of antibodies that cross-react and neutralize rankl originating from multiple species |
| EP1854458A1 (en) | 2006-05-08 | 2007-11-14 | IMBA-Institut für Molekulare Biotechnologie GmbH | Use of a compound with RANKL activity |
| TW201019959A (en) | 2008-08-19 | 2010-06-01 | Regeneron Pharma | Human antibodies to human RANKL |
| EP2433644A1 (en) | 2010-09-22 | 2012-03-28 | IMBA-Institut für Molekulare Biotechnologie GmbH | Breast cancer therapeutics |
-
2010
- 2010-09-22 EP EP10178346A patent/EP2433644A1/en not_active Withdrawn
-
2011
- 2011-09-22 PH PH1/2013/500543A patent/PH12013500543A1/en unknown
- 2011-09-22 NZ NZ608207A patent/NZ608207A/en not_active IP Right Cessation
- 2011-09-22 WO PCT/EP2011/066511 patent/WO2012038504A2/en not_active Ceased
- 2011-09-22 CA CA2811556A patent/CA2811556A1/en not_active Abandoned
- 2011-09-22 RU RU2013118325/15A patent/RU2013118325A/ru not_active Application Discontinuation
- 2011-09-22 JP JP2013529652A patent/JP6133778B2/ja not_active Expired - Fee Related
- 2011-09-22 US US13/825,655 patent/US10143747B2/en not_active Expired - Fee Related
- 2011-09-22 CN CN2011800544541A patent/CN103384530A/zh active Pending
- 2011-09-22 AU AU2011306917A patent/AU2011306917B2/en not_active Ceased
- 2011-09-22 EP EP11758242.9A patent/EP2618833B1/en not_active Revoked
- 2011-09-22 MX MX2013003076A patent/MX2013003076A/es unknown
- 2011-09-22 KR KR1020137009817A patent/KR20130118870A/ko not_active Ceased
- 2011-09-22 BR BR112013006673A patent/BR112013006673A2/pt not_active IP Right Cessation
-
2013
- 2013-03-21 IL IL225442A patent/IL225442A0/en unknown
- 2013-03-22 CL CL2013000801A patent/CL2013000801A1/es unknown
-
2016
- 2016-10-28 JP JP2016212111A patent/JP2017039771A/ja active Pending
-
2018
- 2018-10-12 US US16/158,504 patent/US20190030161A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2618833B1 (en) | 2018-05-02 |
| CA2811556A1 (en) | 2012-03-29 |
| US20190030161A1 (en) | 2019-01-31 |
| US20130216550A1 (en) | 2013-08-22 |
| KR20130118870A (ko) | 2013-10-30 |
| AU2011306917B2 (en) | 2015-01-29 |
| JP6133778B2 (ja) | 2017-05-24 |
| WO2012038504A3 (en) | 2012-06-21 |
| EP2618833A2 (en) | 2013-07-31 |
| NZ608207A (en) | 2014-08-29 |
| IL225442A0 (en) | 2013-06-27 |
| PH12013500543A1 (en) | 2021-08-09 |
| US10143747B2 (en) | 2018-12-04 |
| CN103384530A (zh) | 2013-11-06 |
| EP2433644A1 (en) | 2012-03-28 |
| JP2013542190A (ja) | 2013-11-21 |
| JP2017039771A (ja) | 2017-02-23 |
| WO2012038504A2 (en) | 2012-03-29 |
| MX2013003076A (es) | 2013-07-29 |
| AU2011306917A1 (en) | 2013-04-04 |
| BR112013006673A2 (pt) | 2016-06-07 |
| CL2013000801A1 (es) | 2013-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA94 | Acknowledgement of application withdrawn (non-payment of fees) |
Effective date: 20180410 |