RU2013094C1 - Herb mixture for treating a patient suffered from chronic bronchitis - Google Patents

Abstract

FIELD: bronchology. SUBSTANCE: herb mixture consisting of common licorice roots, wild rosemary grass, common origanum grass, and coltsfoot grass (in dry mixture ratio of 2: 2: 1: 1, parts by weight, respectively) is administered to a patient suffered from obstructive bronchitis. For treatment of a patient with non- obstructive bronchitis there is used herb mixture consisting of pine buds, licorice roots, common dooryard plantain leaves, garden sage leaves and European elder flowers ( in dry mixture ratio of 2: 1: 1: 1: 1, parts by weight, respectively). Such herb mixtures are used both for oral administration as their decoctions in a dosage of 50-70 ml thrice a day prior to eating for 14-21 days, and as inhalations clinically during 10-day treatment period with subsequent ambulant therapy of a patient by administration of their decoctions per os in the same dosage for 2.5-3 months. EFFECT: increased effectiveness of treatment. 1 tbl

Description

 The invention relates to medicine, namely to medicines for treating patients with various forms of chronic bronchitis.

 Antibiotics, sulfonamides, non-steroidal anti-inflammatory drugs, glucocorticoids are known. As a result of the use of these funds, side effects and allergic complications often occur.

 A known mixture of medicinal herbs (eucalyptus, thyme, chamomile), which, together with the protein of a raw egg and rosehip syrup and after passing through oxygen, is prescribed before meals for 12-20 days. A mixture of medicinal herbs is used together with oxygen, therefore, in patients with chronic bronchitis with respiratory failure, the clinical effect may be associated with oxygen therapy, which gives a short-term clinical effect.

 The purpose of the invention is to increase the rehabilitation effect in patients with chronic obstructive and non-obstructive bronchitis.

 This goal is achieved by the fact that for the treatment of patients with various forms of chronic bronchitis, a collection of medicinal herbs is proposed, combined on the basis of a similar mechanism of action of each of the ingredients of the mixture. Herbal preparations are used simultaneously inside for inhalation.

 Suggested 2 collection of medicinal herbs. The first collection of medicinal herbs, including oregano and mother and stepmothers, additionally contains licorice root, ledum grass (with the following ratio of components 1: 1: 2: 2), has a predominantly bronchodilating effect and is therefore prescribed for patients with obstructive chronic bronchitis. The 2nd collection of medicinal herbs, including pine buds, plantain leaves, additionally contains licorice root, sage leaves and black elderberry flowers in the following ratio of components 2: 1: 1: 1: 1, the dominant effect of which is bactericidal; collection is used in patients with chronic non-obstructive bronchitis. After discharge of patients from the hospital, they were prescribed the same fees for medicinal herbs that they received in the clinic for 2.5-3 months.

 All herbs that are part of the mixtures are approved by the pharmacological committee for clinical use. The mixtures were prepared centrally in the pharmacy of the regional clinical hospital in the form of decoctions (20.0 g of each mixture in 400 ml of water) and were used 50-70 ml 3 times a day before meals for 14-21 days.

 At the same time, in a hospital, patients with obstructive chronic bronchitis were given inhalations of the first collection, and for patients with an obstructive, the second collection of decoctions of medicinal herbs. The course of treatment consisted of 10 inhalations carried out daily 1 time per day on an inhaler company "Spira" (Finland).

 Thus, the first collection of medicinal herbs was applied (by mouth and inhalation) in 20 patients with chronic obstructive bronchitis in the acute phase, the second collection (by mouth and inhalation) in 22 patients with exacerbation of chronic non-obstructive bronchitis.

 To objectify the results of treatment, a control group of patients with chronic bronchitis was taken (21 patients, 10 of them with obstructive and 11 with non-obstructive bronchitis), standardized to the clinical experience of the disease, gender, age. Patients in the control group received traditional treatment for chronic bronchitis, but without the use of medicinal herbs. Comparative data on the experimental and control groups are given in table. 3.

 The bed-day rate in the experimental group with obstructive bronchitis was 5.4 days, and for non-obstructive - 4.5 days less than in the corresponding control groups. The difference is statistically significant, which indicates a reduction in treatment time for both variants of the disease.

 When evaluating the effectiveness of treatment, patients with chronic bronchitis were divided into 4 groups depending on the end result of treatment: good effectiveness, moderate, no effect, worsening. It turned out that during treatment according to the claimed method, good efficacy was higher (in case I - 80% of patients, in case of II - 81.8%) than in the prototype method (73% of patients). The treatment efficiency in our method was also higher than in the control group of patients (table).

 When applying a complex phytotherapeutic treatment, the well-being of patients and adverse effects were not noted. In only one case of chronic obstructive bronchitis, the initial increase in the amount of sputum was incorrectly regarded by patients as deterioration, which, however, subsequently allowed to complete the course of treatment with effect.

 Thus, they noted the good tolerability of mixtures of medicinal herbs inside and in inhalations, including in 12 patients with obstructive and 13 with obstructive bronchitis (60% of patients of the experimental group) with concomitant pathology of the cardiovascular system (IHD, hypertension, chronic decompensated pulmonary a heart).

 The definition of the rehabilitation effect is carried out as follows. In what percentage of cases the patients were discharged from the hospital in a state of clinical remission. For this, subjective (cough, amount and nature of sputum, degree of dyspnea, sweating), objective (change in the nature of breathing, wheezing) and laboratory blood and sputum parameters were determined during discharge. It turned out that in the experimental group, residual signs of exacerbation (table) are found in 25% and 18.2% of patients (obstructive and non-obstructive forms of bronchitis), while in the control group of patients complete remission was not achieved, respectively, in 40% and 36.4 % of patients.

 Thus, the rehabilitation effect of the use of phytotherapeutic mixtures affects the achievement in a greater number of experienced patients with chronic bronchitis of complete remission in a hospital. In addition, a remote study was conducted for 42 patients of the experimental group who were questioned 4-5 months after discharge from the hospital. Questionnaires were received back from 31 patients. It turned out that out of 18 patients with obstructive bronchitis who received the 1st collection, 9 patients (50%), and of 13 patients with obstructive bronchitis - 9 patients (70%) who were treated in the hospital with the 2nd collection, noted an improvement in health compared to previous exacerbation. Deterioration of health was noted only in 2 cases of obstructive bronchitis, these were patients who, after discharge from the hospital, stopped taking the recommended I collection of medicinal herbs.

PRI me R 1. Patient G., medical history N 4481, 48 years old. Diagnosis: chronic simple non-obstructive bronchitis in the acute phase. Focal pneumosclerosis. Respiratory failure, Art. Satellite diagnosis: ischemic heart disease, angina pectoris, II functional class. Hypertension II Art. Suffers from chronic bronchitis for about 10 years, first treatment in 1989. Upon admission to the hospital complaints of increased cough, an increase in the amount of viscous light yellow sputum up to 50-70 g / day, for the first time for 3-4 days there was a slight hemoptysis, shortness of breath with physical activity. Smokes for 25 years. About 10 years suffering from hypertension, the last 5 years was diagnosed with coronary heart disease. Objective upon admission: hard vesicular breathing in the lungs, dry rales on both sides in the lower sections. Heart sounds are muffled, the rhythm is correct, the heart rate is 96 beats / min, blood pressure is 170/100 mm RT. Art. General sputum analysis: white blood cells - 3-5 in the field of view, squamous epithelium 3-6 in the field of view, a little Gr ⁺ cocci. Complete blood count: erythrocytes -4.7 ˙10 ¹² / l, HB-145 g / l, white blood cells - 4.8˙10 ⁹ / l, eosinophils - 3, stab-nuclei - 1, segmented neutrophils - 68, lymphocytes - 22, monocytes - 6, ESR - 13 mm / h.

 ECG: sinus rhythm, horizontal position of the electrical axis of the heart, signs of left ventricular hypertrophy. X-ray of the lungs: on the right in the lower lobe, the amplification and deformation of the pulmonary pattern is determined. The roots are structureless. Bronchoscopy: the mucous membrane of the bronchi of both lungs is hyperemic with a mild longitudinal folding. The lumens of all bronchi within the examined are free. Detachable mucopurulent, viscous in moderation in the bronchi of both lungs.

 After the initiation of therapy in the hospital (mucaltin, aminophylline, furasemide, clonidine, chimes, ultraviolet irradiation on the chest), the patient's well-being did not significantly improve, and therefore, on the tenth day of treatment, a daily oral dose of 50-70 g / 3 times was prescribed per day before meals and inhalation 1 time per day (10 min) application of II collection of medicinal herbs.

 As a result of the therapy, the patient’s well-being improved significantly: cough, sputum and shortness of breath significantly decreased. In the lungs, vesicular breathing, dry rales stopped listening. Blood pressure - 140/90 mm RT. Art. The improvement in the patient's condition is confirmed by the data of a functional study of the lungs, see table. 1.

 On the 13th day of the start of herbal treatment (inhalation course was 10 procedures), the patient was discharged in satisfactory condition. According to the results of the survey within 4 months after the hospital exacerbation of notes.

 PRI me R 2. Patient M., a medical history N 4914, 35 years. Diagnosis: chronic obstructive bronchitis in the acute phase. Focal pneumosclerosis. Respiratory failure, Art. Concomitant diagnosis: hypertension II Art. with predominant damage to the vessels of the brain.

 The duration of the disease is about 10 years, annual exacerbations 1-2 times a year, the last year began to notice the appearance of significant shortness of breath, difficulty exhaling. The duration of this exacerbation at the time of hospitalization is 1.5 months; treatment with aminophylline, theofedrine, metacyclin without a significant effect. Suffers from hypertension II tbsp. for 7-8 years.

 Upon admission, she complained of severe cough with scanty, viscous, difficult to separate sputum, shortness of breath and difficulty breathing at rest. Objectively: a patient with increased nutrition (obesity of the 1st century), in the lungs with auscultation - an extended expiration, a mass of dry wheezing and buzzing wheezing on inspiration and expiration. Heart sounds are clear, the rhythm is correct, the heart rate is 78 beats / min, blood pressure is 160/110 mm RT. Art.

Complete blood count: red blood cells - 4.5ты10 ¹² / l, white blood cells - 6.6 --10 ⁹ / l, white blood cell count unchanged, ESR - 9 mm / h. ECG: sinus rhythm, horizontal position of the electrical axis of the heart. An X-ray examination of light shadows of an infiltrative nature was not found.

 On the 3rd day of admission to the hospital, given the obstructive nature of chronic bronchitis, the patient was prescribed treatment with decoctions of herbs (I collection) inside 50-70 ml 3 times a day before meals and in inhalations daily. As a result of treatment, the patient's well-being improved (cough and shortness of breath decreased, the number of dry rales in the lungs decreased significantly); objective indicators of functional examination of the lungs also improved, see table. 2.

 In satisfactory condition, after 15 days the patient was discharged from the hospital. Within 4 months after discharge against the background of the ongoing intake of the first collection of medicinal herbs, the condition is satisfactory, occasionally notes a slight periodic shortness of breath.

 Thus, the collection of medicinal herbs for the treatment of chronic obstructive and non-obstructive bronchitis are effective methods of treating this pathology, reduce the time of inpatient treatment, increase the number of patients discharged from the hospital in a state of clinical remission, reduce the recurrence rate of the disease, have good tolerance, including in patients with concomitant cardiovascular pathology; the advantages of the claimed method should also include the economic profitability of treatment with medicinal herbs, the possibility of use in wide clinical practice, as well as the high "subjective readiness" of patients for this type of treatment.

Claims (2)

 1. COLLECTION OF MEDICINAL HERBS FOR TREATMENT OF CHRONIC BRONCHITIS, including oregano and coltsfoot, characterized in that, in order to increase the rehabilitation effect in patients with obstructive disease, the collection additionally contains licorice root, rosemary grass at a ratio of 1: 1 : 2: 2.  2. The collection of herbs for the treatment of chronic bronchitis, including pine buds and plantain leaves, characterized in that, in order to increase the rehabilitation effect in patients with an obstructive form of the disease, the collection additionally contains licorice root, sage leaves and black elderberry flowers with a ratio of 2 : 1: 1: 1: 1.

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