RU2012126441A - METHOD FOR PRODUCING 1-HYDROXYADAMANTAN-4-OH (CEMANTANE) - Google Patents

METHOD FOR PRODUCING 1-HYDROXYADAMANTAN-4-OH (CEMANTANE) Download PDF

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RU2012126441A
RU2012126441A RU2012126441/04A RU2012126441A RU2012126441A RU 2012126441 A RU2012126441 A RU 2012126441A RU 2012126441/04 A RU2012126441/04 A RU 2012126441/04A RU 2012126441 A RU2012126441 A RU 2012126441A RU 2012126441 A RU2012126441 A RU 2012126441A
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hydroxyadamantan
producing
cbrcl
adamantanone
cemantane
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RU2012126441/04A
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Russian (ru)
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RU2507191C1 (en
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Усеин Меметович Джемилев
Равил Исмагилович Хуснутдинов
Альфия Руслановна Байгузина
Зиля Рашитовна Сагитова
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Федеральное государственное бюджетное учреждение науки Институт нефтехимии и катализа Российской академии наук
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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Pyridine Compounds (AREA)

Abstract

Способ получения 1-гидроксиадамантан-4-она формулы (1)из адамантанона-2, отличающийся тем, что адамантанон-2 бромируют с помощью CBrClпод действием катализатора Мо(CO), активированного пиридином при мольном соотношении [Mo]:[Py]:[AdO]:[CBrCl]:=1-10:200-1000:1000:1000-2500, при температуре 175°C, в течение 6-20 ч, с последующим гидролизом образующегося 1-бромадамантан-4-она.A method for producing 1-hydroxyadamantan-4-one of formula (1) from adamantanone-2, characterized in that adamantanone-2 is brominated with CBrCl under the action of a Mo (CO) catalyst activated with pyridine in a molar ratio of [Mo]: [Py]: [ AdO]: [CBrCl]: = 1-10: 200-1000: 1000: 1000-2500, at a temperature of 175 ° C, for 6-20 hours, followed by hydrolysis of the resulting 1-bromadamantan-4-one.

Claims (1)

Способ получения 1-гидроксиадамантан-4-она формулы (1)The method of obtaining 1-hydroxyadamantan-4-one of the formula (1)
Figure 00000001
Figure 00000001
 из адамантанона-2, отличающийся тем, что адамантанон-2 бромируют с помощью CBrCl3 под действием катализатора Мо(CO)6, активированного пиридином при мольном соотношении [Mo]:[Py]:[AdO]:[CBrCl3]:=1-10:200-1000:1000:1000-2500, при температуре 175°C, в течение 6-20 ч, с последующим гидролизом образующегося 1-бромадамантан-4-она. from adamantanone-2, characterized in that adamantanone-2 is brominated with CBrCl 3 under the action of a Mo (CO) 6 catalyst activated with pyridine in a molar ratio of [Mo]: [Py]: [AdO]: [CBrCl 3 ]: = 1 -10: 200-1000: 1000: 1000-2500, at a temperature of 175 ° C, for 6-20 hours, followed by hydrolysis of the resulting 1-bromadamantan-4-one.
RU2012126441/04A 2012-06-25 2012-06-25 Method of obtaining 1-hydroxyadamantan-4-one (kemantane) RU2507191C1 (en)

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Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2104994C1 (en) * 1994-06-23 1998-02-20 Научно-исследовательский институт фармакологии РАМН Method of synthesis of 1-hydroxyadamantane-4-one (medicinal agent "kemantan")
JP2000219650A (en) * 1999-01-29 2000-08-08 Daicel Chem Ind Ltd Production of hydroxyadamantanone derivative
RU2197468C2 (en) * 2000-11-09 2003-01-27 Институт нефтехимии и катализа АН РБ и УНЦ РАН Method of preparing 1-chloroadamantan-4-on
JP4314814B2 (en) * 2002-11-22 2009-08-19 三菱瓦斯化学株式会社 Method for producing hydroxyadamantanone derivative
RU2342358C2 (en) * 2007-02-05 2008-12-27 Институт нефтехимии и катализа РАН Method of obtaining 1-hydroxyadamanthan-4-on

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