RU2012120691A - Новый режим дозирования и способ лечения - Google Patents

Новый режим дозирования и способ лечения Download PDF

Info

Publication number
RU2012120691A
RU2012120691A RU2012120691/15A RU2012120691A RU2012120691A RU 2012120691 A RU2012120691 A RU 2012120691A RU 2012120691/15 A RU2012120691/15 A RU 2012120691/15A RU 2012120691 A RU2012120691 A RU 2012120691A RU 2012120691 A RU2012120691 A RU 2012120691A
Authority
RU
Russia
Prior art keywords
day
weeks
dosage regimen
administered
cancer
Prior art date
Application number
RU2012120691/15A
Other languages
English (en)
Russian (ru)
Inventor
Джон ЛАМБЕРТ
Джеймс Дж. О'ЛИРИ
Джоанн Элизабет Сара ШИНДЛЕР
Стивен УИТМАН
Альберт КИН
Original Assignee
Иммьюноджен, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Иммьюноджен, Инк. filed Critical Иммьюноджен, Инк.
Publication of RU2012120691A publication Critical patent/RU2012120691A/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2012120691/15A 2009-10-21 2010-10-21 Новый режим дозирования и способ лечения RU2012120691A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25380409P 2009-10-21 2009-10-21
US61/253,804 2009-10-21
PCT/US2010/053579 WO2011050180A1 (en) 2009-10-21 2010-10-21 Novel dosing regimen and method of treatment

Publications (1)

Publication Number Publication Date
RU2012120691A true RU2012120691A (ru) 2013-11-27

Family

ID=43898626

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2012120691/15A RU2012120691A (ru) 2009-10-21 2010-10-21 Новый режим дозирования и способ лечения

Country Status (13)

Country Link
US (1) US20110097345A1 (OSRAM)
EP (1) EP2490715A4 (OSRAM)
JP (1) JP2013508400A (OSRAM)
KR (1) KR20120094472A (OSRAM)
CN (1) CN102630165A (OSRAM)
AU (1) AU2010310577A1 (OSRAM)
BR (1) BR112012009250A2 (OSRAM)
CA (1) CA2775806A1 (OSRAM)
IL (1) IL219279A0 (OSRAM)
IN (1) IN2012DN02826A (OSRAM)
MX (1) MX2012004406A (OSRAM)
RU (1) RU2012120691A (OSRAM)
WO (1) WO2011050180A1 (OSRAM)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
AU2011207362B2 (en) * 2010-01-21 2013-10-17 Immunogen, Inc. Compositions and methods for treatment of ovarian cancer
EP2524929A1 (en) * 2011-05-17 2012-11-21 Sanofi Use of anti-CD19 maytansinoid immunoconjugate antibody for the treatment of CD19+ B-cell malignancies syptoms
WO2014018563A2 (en) * 2012-07-23 2014-01-30 The Board Of Trustees Of The Leland Stanford Junior University Methods for the treatment of cancer
WO2014052876A1 (en) * 2012-09-28 2014-04-03 Immunogen Inc. Methods for increasing efficacy of cd56- based therapy
WO2014089177A2 (en) 2012-12-04 2014-06-12 Massachusetts Institute Of Technology Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
SG11201509043RA (en) * 2013-05-14 2015-12-30 Immunogen Inc Anti-folr1 immunoconjugate dosing regimens
LT3055332T (lt) * 2013-10-08 2020-04-10 Immunogen, Inc. Anti-folr1 imunokonjugato dozavimo režimai
CN106456748A (zh) 2014-01-08 2017-02-22 小利兰·斯坦福大学托管委员会 小细胞肺癌的靶向疗法
AU2015282627B2 (en) 2014-06-30 2020-04-02 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
JP6998938B2 (ja) * 2016-08-10 2022-02-04 セルジーン クオンティセル リサーチ,インク. 再発性および/または難治性の固形腫瘍および非ホジキンリンパ腫の処置
KR102487144B1 (ko) 2016-11-21 2023-01-12 에이리온 테라퓨틱스, 인코포레이티드 큰 물질의 경피 전달
WO2018209239A1 (en) 2017-05-11 2018-11-15 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
AU2019294510A1 (en) * 2018-06-26 2021-01-21 Immunogen, Inc. Immunoconjugates targeting ADAM9 and methods of use thereof
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
US20230322933A1 (en) * 2020-06-04 2023-10-12 Bioinvent International Ab Model for prediction of tolerability issues in connection with intravenous administration of therapeutic antibodies
US12030888B2 (en) 2021-02-24 2024-07-09 Massachusetts Institute Of Technology Himastatin derivatives, and processes of preparation thereof, and uses thereof
WO2024230793A1 (en) * 2023-05-10 2024-11-14 Nanjing Legend Biotech Co., Ltd. Chimeric antigen receptors and methods of use thereof
CN120053673A (zh) * 2025-02-11 2025-05-30 暨南大学 纳米前药及其制备方法和用途
CN120173115A (zh) * 2025-05-20 2025-06-20 苏州欣协生物科技有限公司 一种抗人cd56蛋白工程抗体及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208020A (en) * 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US5639641A (en) * 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
US7303749B1 (en) * 1999-10-01 2007-12-04 Immunogen Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
EP2266607A3 (en) * 1999-10-01 2011-04-20 Immunogen, Inc. Immunoconjugates for treating cancer
MXPA03012022A (es) * 2001-09-20 2005-07-01 Cornell Res Foundation Inc Metodos y composiciones para tratar o prevenir padecimientos de la piel, utilizando agentes de enlace especificos para el antigeno de membrana especifico de prostata.
US20040126379A1 (en) * 2002-08-21 2004-07-01 Boehringer Ingelheim International Gmbh Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and chemotherapeutic agents
CN1816356A (zh) * 2003-05-14 2006-08-09 免疫原公司 药物缀合物组合物
WO2005000230A2 (en) * 2003-06-05 2005-01-06 Charles Achkar Methods of treating hyperproliferative cell disorders
US8101720B2 (en) * 2004-10-21 2012-01-24 Xencor, Inc. Immunoglobulin insertions, deletions and substitutions
ZA200708694B (en) * 2005-04-15 2009-01-28 Immunogen Inc Elimination of heterogeneous or mixed cell population in tumors
NZ576122A (en) * 2006-09-26 2012-09-28 Genmab As Anti-cd38 plus corticosteroids plus a non-corticosteroid chemotherapeutic for treating tumors
AU2009271401A1 (en) * 2008-06-16 2010-01-21 Immunogen Inc. Novel synergistic effects
AU2011207362B2 (en) * 2010-01-21 2013-10-17 Immunogen, Inc. Compositions and methods for treatment of ovarian cancer
WO2012138537A1 (en) * 2011-04-01 2012-10-11 Immunogen, Inc. Compositions and methods for treatment of ovarian, peritoneal, and fallopian tube cancer

Also Published As

Publication number Publication date
US20110097345A1 (en) 2011-04-28
IN2012DN02826A (OSRAM) 2015-07-24
KR20120094472A (ko) 2012-08-24
MX2012004406A (es) 2012-05-08
AU2010310577A1 (en) 2012-04-19
CN102630165A (zh) 2012-08-08
EP2490715A4 (en) 2013-06-26
CA2775806A1 (en) 2011-04-28
IL219279A0 (en) 2012-06-28
BR112012009250A2 (pt) 2017-06-20
WO2011050180A1 (en) 2011-04-28
EP2490715A1 (en) 2012-08-29
JP2013508400A (ja) 2013-03-07

Similar Documents

Publication Publication Date Title
RU2012120691A (ru) Новый режим дозирования и способ лечения
Cho et al. Cancer stem cells as a potential target to overcome multidrug resistance
JP2013508400A5 (OSRAM)
Sumanasuriya et al. Treatment of advanced prostate cancer—A review of current therapies and future promise
US20220323475A1 (en) Combination therapy for cancer
Li et al. Ergosterol peroxide activates Foxo3-mediated cell death signaling by inhibiting AKT and c-Myc in human hepatocellular carcinoma cells
US20230149436A1 (en) Combination therapy
AU2015418015B2 (en) Combination therapy
JP2018065859A (ja) 癌を治療するための方法及び組成物
CN106470672A (zh) 包括吉西他滨前药的制剂
AU2015278899A1 (en) Gemcitabine prodrugs
IL272095B (en) Cortexolone 17alpha-valerate for use in the treatment of epithelial tumor diseases
Misir et al. circRNAs in drug resistance of breast cancer
JP2017516802A5 (OSRAM)
Gordon et al. Success using tacrolimus in patients with proliferative and membranous lupus nephritis and refractory proteinuria
CN116490165A (zh) 阿比特龙前药
Schwarzlmueller et al. Steroid hormones as modulators of anti-tumoural immunity
CN107773556A (zh) 一种具有抗肿瘤药物功效的联合用药物
Liang et al. Role of the AKT signaling pathway in regulating tumor-associated macrophage polarization and in the tumor microenvironment: A review
US20200197430A1 (en) Combination Therapy
CN119136813A (zh) 阿比特龙前药
McAuley et al. Chromosome 1 Alterations in Multiple Myeloma: Considerations for Precision Therapy
JP2020172471A (ja) ヒト化抗ヒトcd26抗体を含有する医薬組成物
KR20240134470A (ko) 글루코코르티코이드계 화합물을 포함하는 암의 예방 또는 치료용 약학적 조성물
Schmidt Novel therapeutic approaches to overcome acquired resistance to enzalutamide in patients with advanced prostate cancer