RU2012114146A - Нерадиоактивные фосфолипидные соединения, композиции и способы их применения - Google Patents

Нерадиоактивные фосфолипидные соединения, композиции и способы их применения Download PDF

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Publication number
RU2012114146A
RU2012114146A RU2012114146/15A RU2012114146A RU2012114146A RU 2012114146 A RU2012114146 A RU 2012114146A RU 2012114146/15 A RU2012114146/15 A RU 2012114146/15A RU 2012114146 A RU2012114146 A RU 2012114146A RU 2012114146 A RU2012114146 A RU 2012114146A
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RU
Russia
Prior art keywords
radioactive
group
iodine
cancer
compound
Prior art date
Application number
RU2012114146/15A
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English (en)
Russian (ru)
Inventor
Анатолий ПИНЧУК
Марк ЛОНДЖИНО
Джейми П. УЭЙЧЕРТ
Уилльям Р. КЛАРК
Абрам М. ВАККАРО
Иравати КАНДЕЛА
Original Assignee
Селлектар, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Селлектар, Инк. filed Critical Селлектар, Инк.
Publication of RU2012114146A publication Critical patent/RU2012114146A/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0408—Phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/688—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols both hydroxy compounds having nitrogen atoms, e.g. sphingomyelins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2012114146/15A 2009-09-11 2010-09-10 Нерадиоактивные фосфолипидные соединения, композиции и способы их применения RU2012114146A (ru)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US24175909P 2009-09-11 2009-09-11
US24176209P 2009-09-11 2009-09-11
US61/241,762 2009-09-11
US61/241,759 2009-09-11
US30918710P 2010-03-01 2010-03-01
US30921310P 2010-03-01 2010-03-01
US61/309,213 2010-03-01
US61/309,187 2010-03-01
PCT/US2010/048351 WO2011031919A2 (en) 2009-09-11 2010-09-10 Non-radioactive phospholipid compounds, compositions, and methods of use

Publications (1)

Publication Number Publication Date
RU2012114146A true RU2012114146A (ru) 2013-10-20

Family

ID=43730778

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2012114146/15A RU2012114146A (ru) 2009-09-11 2010-09-10 Нерадиоактивные фосфолипидные соединения, композиции и способы их применения

Country Status (5)

Country Link
US (2) US20110064661A1 (enExample)
EP (1) EP2475400A2 (enExample)
JP (1) JP2013504590A (enExample)
RU (1) RU2012114146A (enExample)
WO (1) WO2011031919A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
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EP2044960B1 (en) 2004-03-02 2013-11-20 Cellectar, Inc. Phospholipid analogue for the in vivo diagnosis of cancers
US8540968B2 (en) 2004-03-02 2013-09-24 Cellectar, Inc. Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof
DK3708192T3 (da) * 2009-06-12 2023-11-06 Cellectar Inc Etherphospholipidforbindelser til behandling af cancer og billeddannelse og detektering af cancerstamceller
US20110064661A1 (en) * 2009-09-11 2011-03-17 Pinchuk Anatoly Non-radioactive phospholipid compounds, compositions, and methods of use
EP3750545B1 (en) * 2014-11-17 2024-03-27 Cellectar Biosciences, Inc. Phospholipid ether analogs as cancer-targeting drug vehicles
CN112272556B (zh) 2018-04-10 2023-12-19 塞勒科塔生物科学公司 磷脂-flavagline缀合物及将其用于靶向癌症治疗的方法
US20230066517A1 (en) * 2019-09-12 2023-03-02 Cellectar Biosciences, Inc. Phospholipid Ether Conjugates as Cancer-Targeting Drug Vehicles
JP7631329B2 (ja) 2019-10-10 2025-02-18 セレクター・バイオサイエンシズ・インコーポレイテッド リン脂質－フラバグリン抱合体及び標的化されたがん治療のためのリン脂質－フラバグリン抱合体の使用方法

Family Cites Families (24)

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US4925649A (en) * 1987-06-12 1990-05-15 The University Of Michigan Radioiodinated diacylglycerol analogues and methods of use
US4965391A (en) * 1987-10-23 1990-10-23 The University Of Michigan Radioiodinated phospholipid ether analogues
US5087721A (en) * 1987-10-23 1992-02-11 The University Of Michigan Radioiodinated phosphate esters
US5347030A (en) * 1987-10-23 1994-09-13 The Board Of Regents Of The University Of Michigan Radioiodinated phospholipid ether analogues and methods of using same
US5369097A (en) * 1991-04-25 1994-11-29 The University Of British Columbia Phosphonates as anti-cancer agents
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5626654A (en) * 1995-12-05 1997-05-06 Xerox Corporation Ink compositions containing liposomes
WO1998024480A1 (en) * 1996-12-04 1998-06-11 The Regents Of The University Of Michigan Radioiodinated phospholipid ether analogs and methods of using the same
US6255519B1 (en) * 1996-12-04 2001-07-03 Regents Of The University Of Michigan Radioiodinated phospholipid ether analogs and methods of using the same
US6503478B2 (en) * 1999-01-13 2003-01-07 Lightouch Medical, Inc. Chemically specific imaging of tissue
US7220539B1 (en) * 2002-06-12 2007-05-22 The Salk Institute For Biological Studies Protein kinase B/Akt modulators and methods for the use thereof
US8540968B2 (en) * 2004-03-02 2013-09-24 Cellectar, Inc. Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof
EP2044960B1 (en) * 2004-03-02 2013-11-20 Cellectar, Inc. Phospholipid analogue for the in vivo diagnosis of cancers
US7632644B2 (en) * 2004-03-02 2009-12-15 Cellectar, Inc. Imaging and selective retention of phospholipid ether analogs
US7803764B2 (en) * 2004-03-29 2010-09-28 The Arizona Board Of Regents On Behalf Of The University Of Arizona Amphipathic glycopeptides
EP1773408A2 (en) * 2004-07-08 2007-04-18 Cellectar, Llc Virtual colonoscopy with radiolabeled phospholipid ether analogs
US20060115426A1 (en) * 2004-08-11 2006-06-01 Weichert Jamey P Methods of detecting breast cancer, brain cancer, and pancreatic cancer
US7041859B1 (en) * 2004-09-09 2006-05-09 University Of Tennessee Research Foundation Method for halogenating or radiohalogenating a chemical compound
MX2007007497A (es) * 2004-12-20 2008-01-11 Cellectar Llc Analogos de fosfolipido eter para la deteccion y tratamiento del cancer.
CA2660778A1 (en) * 2006-08-15 2009-01-08 Cellectar, Inc. Near infrared-fluorescence using phospholipid ether analog dyes in endoscopic applications
US7893286B2 (en) * 2007-06-01 2011-02-22 Cellectar, Inc. Method for the synthesis of phospholipid ethers
DK3708192T3 (da) * 2009-06-12 2023-11-06 Cellectar Inc Etherphospholipidforbindelser til behandling af cancer og billeddannelse og detektering af cancerstamceller
WO2011031911A1 (en) * 2009-09-11 2011-03-17 Cellectar, Inc. Deuterated alkyl phospholipid compounds, compositions, and methods of use
US20110064661A1 (en) * 2009-09-11 2011-03-17 Pinchuk Anatoly Non-radioactive phospholipid compounds, compositions, and methods of use

Also Published As

Publication number Publication date
WO2011031919A3 (en) 2014-03-27
EP2475400A2 (en) 2012-07-18
WO2011031919A2 (en) 2011-03-17
US20110064661A1 (en) 2011-03-17
JP2013504590A (ja) 2013-02-07
US20120156133A1 (en) 2012-06-21

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