MX2022003044A - Conjugados de éter de fosfolípido como vehículos de fármacos que focalizan el cáncer. - Google Patents
Conjugados de éter de fosfolípido como vehículos de fármacos que focalizan el cáncer.Info
- Publication number
- MX2022003044A MX2022003044A MX2022003044A MX2022003044A MX2022003044A MX 2022003044 A MX2022003044 A MX 2022003044A MX 2022003044 A MX2022003044 A MX 2022003044A MX 2022003044 A MX2022003044 A MX 2022003044A MX 2022003044 A MX2022003044 A MX 2022003044A
- Authority
- MX
- Mexico
- Prior art keywords
- cancer
- targeting drug
- phospholipid ether
- drug vehicles
- therapeutic compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/688—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols both hydroxy compounds having nitrogen atoms, e.g. sphingomyelins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/60—Quinoline or hydrogenated quinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
Abstract
Se describen en la presente compuestos terapéuticos capaces de focalizar una amplia gama de células tumorales; la presente descripción está dirigida además a composiciones que comprenden los compuestos terapéuticos, métodos de fabricación de los compuestos terapéuticos, y métodos para tratar el cáncer, que comprenden administrar los compuestos terapéuticos.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962899618P | 2019-09-12 | 2019-09-12 | |
US201962899611P | 2019-09-12 | 2019-09-12 | |
US201962899615P | 2019-09-12 | 2019-09-12 | |
US201962946870P | 2019-12-11 | 2019-12-11 | |
US202062956907P | 2020-01-03 | 2020-01-03 | |
US202062956844P | 2020-01-03 | 2020-01-03 | |
PCT/US2020/050459 WO2021050917A1 (en) | 2019-09-12 | 2020-09-11 | Phospholipid ether conjugates as cancer-targeting drug vehicles |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022003044A true MX2022003044A (es) | 2022-06-02 |
Family
ID=74866023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022003044A MX2022003044A (es) | 2019-09-12 | 2020-09-11 | Conjugados de éter de fosfolípido como vehículos de fármacos que focalizan el cáncer. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20230066517A1 (es) |
EP (1) | EP4028018A4 (es) |
JP (1) | JP2022547331A (es) |
KR (1) | KR20220062363A (es) |
CN (1) | CN114599371A (es) |
AU (1) | AU2020346898A1 (es) |
BR (1) | BR112022004482A2 (es) |
CA (1) | CA3150991A1 (es) |
IL (1) | IL291197A (es) |
MX (1) | MX2022003044A (es) |
WO (1) | WO2021050917A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113816990B (zh) * | 2021-03-22 | 2023-08-22 | 联宁(苏州)生物制药有限公司 | 修饰的氨基酸及其在adc中的应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8540968B2 (en) * | 2004-03-02 | 2013-09-24 | Cellectar, Inc. | Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof |
EP2475400A2 (en) * | 2009-09-11 | 2012-07-18 | Cellectar, Inc. | Non-radioactive phospholipid compounds, compositions, and methods of use |
SI3229810T1 (sl) * | 2014-11-17 | 2021-01-29 | Cellestar Biosciences, Inc. | Analogi fosfolipidnega etra kot vehikli zdravil, usmerjenih proti raku |
SI3469367T1 (sl) * | 2016-06-14 | 2023-10-30 | Cellectar Biosciences, Inc. | Analogi fosfolipidnega etra za identifikacijo in izolacijo tumorskih celic v obtoku |
CA3095515A1 (en) * | 2018-04-10 | 2019-10-17 | Cellectar Biosciences, Inc. | Phospholipid-flavagline conjugates and methods of using the same for targeted cancer therapy |
-
2020
- 2020-09-11 KR KR1020227011911A patent/KR20220062363A/ko active Search and Examination
- 2020-09-11 AU AU2020346898A patent/AU2020346898A1/en active Pending
- 2020-09-11 CA CA3150991A patent/CA3150991A1/en active Pending
- 2020-09-11 US US17/642,561 patent/US20230066517A1/en active Pending
- 2020-09-11 JP JP2022516159A patent/JP2022547331A/ja active Pending
- 2020-09-11 BR BR112022004482A patent/BR112022004482A2/pt unknown
- 2020-09-11 CN CN202080074564.3A patent/CN114599371A/zh active Pending
- 2020-09-11 EP EP20862948.5A patent/EP4028018A4/en active Pending
- 2020-09-11 MX MX2022003044A patent/MX2022003044A/es unknown
- 2020-09-11 WO PCT/US2020/050459 patent/WO2021050917A1/en unknown
-
2022
- 2022-03-08 IL IL291197A patent/IL291197A/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2021050917A1 (en) | 2021-03-18 |
EP4028018A4 (en) | 2023-10-11 |
EP4028018A1 (en) | 2022-07-20 |
US20230066517A1 (en) | 2023-03-02 |
BR112022004482A2 (pt) | 2022-05-31 |
CA3150991A1 (en) | 2021-03-18 |
IL291197A (en) | 2022-05-01 |
CN114599371A (zh) | 2022-06-07 |
AU2020346898A1 (en) | 2022-04-07 |
JP2022547331A (ja) | 2022-11-11 |
KR20220062363A (ko) | 2022-05-16 |
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