RU2008122708A - Органические соединения - Google Patents
Органические соединения Download PDFInfo
- Publication number
- RU2008122708A RU2008122708A RU2008122708/04A RU2008122708A RU2008122708A RU 2008122708 A RU2008122708 A RU 2008122708A RU 2008122708/04 A RU2008122708/04 A RU 2008122708/04A RU 2008122708 A RU2008122708 A RU 2008122708A RU 2008122708 A RU2008122708 A RU 2008122708A
- Authority
- RU
- Russia
- Prior art keywords
- alkyl
- alkoxy
- formula
- salt
- halogen
- Prior art date
Links
- 150000002894 organic compounds Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims abstract 73
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 40
- 238000000034 method Methods 0.000 claims abstract 35
- 150000001875 compounds Chemical class 0.000 claims abstract 34
- 229910052736 halogen Inorganic materials 0.000 claims abstract 31
- 150000002367 halogens Chemical group 0.000 claims abstract 31
- 150000003839 salts Chemical class 0.000 claims abstract 30
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 22
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims abstract 20
- 125000003282 alkyl amino group Chemical group 0.000 claims abstract 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 15
- 150000002431 hydrogen Chemical group 0.000 claims abstract 13
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 13
- 239000001257 hydrogen Substances 0.000 claims abstract 13
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims abstract 11
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract 9
- -1 C1-7alkoxy Chemical group 0.000 claims abstract 4
- 238000007142 ring opening reaction Methods 0.000 claims abstract 3
- 238000005984 hydrogenation reaction Methods 0.000 claims abstract 2
- 125000003342 alkenyl group Chemical group 0.000 claims 7
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- ZPSJGADGUYYRKE-UHFFFAOYSA-N 2H-pyran-2-one Chemical compound O=C1C=CC=CO1 ZPSJGADGUYYRKE-UHFFFAOYSA-N 0.000 claims 2
- UXOWGYHJODZGMF-QORCZRPOSA-N Aliskiren Chemical compound COCCCOC1=CC(C[C@@H](C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C)=CC=C1OC UXOWGYHJODZGMF-QORCZRPOSA-N 0.000 claims 2
- OKJIRPAQVSHGFK-UHFFFAOYSA-N N-acetylglycine Chemical compound CC(=O)NCC(O)=O OKJIRPAQVSHGFK-UHFFFAOYSA-N 0.000 claims 2
- QIAFMBKCNZACKA-UHFFFAOYSA-N N-benzoylglycine Chemical compound OC(=O)CNC(=O)C1=CC=CC=C1 QIAFMBKCNZACKA-UHFFFAOYSA-N 0.000 claims 2
- 102100028255 Renin Human genes 0.000 claims 2
- 108090000783 Renin Proteins 0.000 claims 2
- 229960004601 aliskiren Drugs 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- RGUOJYYIMVSCNC-UHFFFAOYSA-N n,n-dimethylformamide;2-methylpropanoic acid Chemical compound CN(C)C=O.CC(C)C(O)=O RGUOJYYIMVSCNC-UHFFFAOYSA-N 0.000 claims 2
- NCIMAYPZWJQYGN-UHFFFAOYSA-N 1-methoxy-n,n,n',n'-tetramethylmethanediamine Chemical compound COC(N(C)C)N(C)C NCIMAYPZWJQYGN-UHFFFAOYSA-N 0.000 claims 1
- 150000008065 acid anhydrides Chemical class 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- MUMVIYLVHVCYGI-UHFFFAOYSA-N n,n,n',n',n",n"-hexamethylmethanetriamine Chemical compound CN(C)C(N(C)C)N(C)C MUMVIYLVHVCYGI-UHFFFAOYSA-N 0.000 claims 1
- HXRAMSFGUAOAJR-UHFFFAOYSA-N n,n,n',n'-tetramethyl-1-[(2-methylpropan-2-yl)oxy]methanediamine Chemical compound CN(C)C(N(C)C)OC(C)(C)C HXRAMSFGUAOAJR-UHFFFAOYSA-N 0.000 claims 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0522789.7 | 2005-11-08 | ||
| GBGB0522789.7A GB0522789D0 (en) | 2005-11-08 | 2005-11-08 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2008122708A true RU2008122708A (ru) | 2009-12-20 |
Family
ID=35516565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008122708/04A RU2008122708A (ru) | 2005-11-08 | 2006-11-06 | Органические соединения |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20090318714A1 (https=) |
| EP (1) | EP1948592A1 (https=) |
| JP (1) | JP2009514914A (https=) |
| KR (1) | KR20080065287A (https=) |
| CN (1) | CN101304966A (https=) |
| AU (1) | AU2006312663B2 (https=) |
| BR (1) | BRPI0618641A2 (https=) |
| CA (1) | CA2626705A1 (https=) |
| GB (1) | GB0522789D0 (https=) |
| RU (1) | RU2008122708A (https=) |
| WO (1) | WO2007054254A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8203005B2 (en) | 2009-10-29 | 2012-06-19 | Carbo Design Llc | Manufacturing process for enantiomerically pure 8-aryloctanoic acids as Aliskiren |
| WO2012078147A1 (en) * | 2010-12-08 | 2012-06-14 | Watson Laboratories, Inc. | A process for the preparation of intermediates useful in the production of aliskiren |
| US8703976B2 (en) | 2011-10-02 | 2014-04-22 | Milan Soukup | Manufacturing process for 8-aryloctanoic acids such as Aliskiren |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4178449A (en) | 1978-04-17 | 1979-12-11 | American Cyanamid Company | Pyrazolo[1,5-a]pyrimidines and imidazo-[1,5-a]pyrimidines |
| JPH03148264A (ja) * | 1989-11-01 | 1991-06-25 | Sumitomo Chem Co Ltd | ５―アルキル―２，４―ジフェニルピリミジン誘導体、その製造法およびそれを有効成分とする除草剤 |
| US5795905A (en) * | 1995-06-06 | 1998-08-18 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
| ES2274847T3 (es) | 2000-12-14 | 2007-06-01 | Speedel Pharma Ag | Proceso para preparar ariloctanoil-amidas. |
| GB0419361D0 (en) | 2004-08-31 | 2004-10-06 | Novartis Ag | Organic compounds |
-
2005
- 2005-11-08 GB GBGB0522789.7A patent/GB0522789D0/en not_active Ceased
-
2006
- 2006-11-06 CA CA002626705A patent/CA2626705A1/en not_active Abandoned
- 2006-11-06 AU AU2006312663A patent/AU2006312663B2/en not_active Ceased
- 2006-11-06 JP JP2008539317A patent/JP2009514914A/ja active Pending
- 2006-11-06 WO PCT/EP2006/010612 patent/WO2007054254A1/en not_active Ceased
- 2006-11-06 KR KR1020087010960A patent/KR20080065287A/ko not_active Ceased
- 2006-11-06 US US12/091,574 patent/US20090318714A1/en not_active Abandoned
- 2006-11-06 RU RU2008122708/04A patent/RU2008122708A/ru not_active Application Discontinuation
- 2006-11-06 CN CNA2006800417846A patent/CN101304966A/zh active Pending
- 2006-11-06 EP EP06818380A patent/EP1948592A1/en not_active Withdrawn
- 2006-11-06 BR BRPI0618641-6A patent/BRPI0618641A2/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US20090318714A1 (en) | 2009-12-24 |
| AU2006312663A1 (en) | 2007-05-18 |
| KR20080065287A (ko) | 2008-07-11 |
| JP2009514914A (ja) | 2009-04-09 |
| BRPI0618641A2 (pt) | 2011-09-06 |
| AU2006312663B2 (en) | 2010-06-17 |
| GB0522789D0 (en) | 2005-12-14 |
| EP1948592A1 (en) | 2008-07-30 |
| CA2626705A1 (en) | 2007-05-18 |
| WO2007054254A1 (en) | 2007-05-18 |
| CN101304966A (zh) | 2008-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA94 | Acknowledgement of application withdrawn (non-payment of fees) |
Effective date: 20121217 |