RU2007149399A - METHOD FOR TREATING PATIENTS WITH COLORECTAL CANCER WITH LIVER METASTASES - Google Patents
METHOD FOR TREATING PATIENTS WITH COLORECTAL CANCER WITH LIVER METASTASES Download PDFInfo
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- RU2007149399A RU2007149399A RU2007149399/14A RU2007149399A RU2007149399A RU 2007149399 A RU2007149399 A RU 2007149399A RU 2007149399/14 A RU2007149399/14 A RU 2007149399/14A RU 2007149399 A RU2007149399 A RU 2007149399A RU 2007149399 A RU2007149399 A RU 2007149399A
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Abstract
Способ лечения больных колоректальным раком с множественными метастазами в печень путем химиотерапии, заключающейся во внутриартериальном, регионарном введении оксалиплатина в дозе 150 мг/м2 в виде 12-часовой непрерывной инфузии в общую печеночную артерию, отличающийся тем, что лечение осуществляют поэтапно: первый этап, заключающийся в неадьювантной внутриартериальной химиотерапии и биотерапии, включает дополнительное введение Томудекс в дозе 3 мг/м2 в виде 24-часовой непрерывной инфузии, после окончания химиотерапии вводят Авастин внутриартериально 10 мг/кг веса больного в течение 2-х ч; второй этап, заключающийся в оперативном лечении, осуществляют через 4 недели после химиотерапии, и третий этап, заключающийся в проведении адьювантной внутриартериальной химиотерапии и биотерапии как в первом этапе; продолжительность лечения состоит из 4-6 курсов внутриартериальной регионарной инфузии.A method of treating patients with colorectal cancer with multiple liver metastases by chemotherapy, which consists in the intra-arterial, regional administration of oxaliplatin at a dose of 150 mg / m2 in the form of a 12-hour continuous infusion into the common hepatic artery, characterized in that the treatment is carried out in stages: the first stage, which consists in non-adjuvant intraarterial chemotherapy and biotherapy, includes an additional administration of Tomudex at a dose of 3 mg / m2 as a 24-hour continuous infusion, after the end of chemotherapy Avastin is administered int rearterially 10 mg / kg of patient weight for 2 hours; the second stage, consisting in surgical treatment, is carried out 4 weeks after chemotherapy, and the third stage, which consists in conducting adjuvant intra-arterial chemotherapy and biotherapy as in the first stage; the duration of treatment consists of 4-6 courses of intra-arterial regional infusion.
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RU2007149399/14A RU2372089C2 (en) | 2007-12-26 | 2007-12-26 | Method of treating patients suffering from colorectal cancer with liver metastases |
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RU2007149399/14A RU2372089C2 (en) | 2007-12-26 | 2007-12-26 | Method of treating patients suffering from colorectal cancer with liver metastases |
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RU2007149399A true RU2007149399A (en) | 2009-07-10 |
RU2372089C2 RU2372089C2 (en) | 2009-11-10 |
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RU2007149399/14A RU2372089C2 (en) | 2007-12-26 | 2007-12-26 | Method of treating patients suffering from colorectal cancer with liver metastases |
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Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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RU2489150C1 (en) * | 2012-05-21 | 2013-08-10 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Method of adjuvant therapy of colorectal cancer |
RU2764955C1 (en) * | 2021-01-11 | 2022-01-24 | Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр" Российской академии наук ("Томский НИМЦ") | Method for combined treatment of metastatic colorectal cancer in patients with resectable hepatic metastases and in the absence of mutations in the kras and braf genes |
RU2760174C1 (en) * | 2021-01-11 | 2021-11-22 | Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр" Российской академии наук ("Томский НИМЦ") | Method for combined treatment of metastatic colorectal cancer in patients with resectable hepatic metastases and in presence of mutations in kras and braf genes |
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Effective date: 20091227 |