RU2007143558A - MEDICINAL PRODUCT OF TRIMETAZIDINE IN THE FORM OF THE MATRIX TABLET WITH PROLONGED ACTION (OPTIONS) AND METHOD FOR PRODUCING IT - Google Patents
MEDICINAL PRODUCT OF TRIMETAZIDINE IN THE FORM OF THE MATRIX TABLET WITH PROLONGED ACTION (OPTIONS) AND METHOD FOR PRODUCING IT Download PDFInfo
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- RU2007143558A RU2007143558A RU2007143558/15A RU2007143558A RU2007143558A RU 2007143558 A RU2007143558 A RU 2007143558A RU 2007143558/15 A RU2007143558/15 A RU 2007143558/15A RU 2007143558 A RU2007143558 A RU 2007143558A RU 2007143558 A RU2007143558 A RU 2007143558A
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- trimetazidine
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- drug
- polymer
- methacrylic acid
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1. Лекарственное средство триметазидина в форме матриксной таблетки с пролонгированным действием, которое включает действующее вещество, воск монтановый гликолевый, полимер метакриловой кислоты, вспомогательные вещества, отличающееся тем, что для обеспечения пористой структуры матриксной таблетки оно дополнительно содержит микрокристаллическую целлюлозу и маннитол при следующем соотношении компонентов, мас.%: ! триметазидин17,5-25воск монтановый гликолевый20-31полимер метакриловой кислоты15-27микрокристаллическая целлюлоза12-14маннитол2,5-10вспомогательные веществадо 100 ! 2. Лекарственное средство по п.1, отличающееся тем, что в качестве полимера метакриловой кислоты используют ойдрагит RS РО. ! 3. Лекарственное средство по п.1, отличающееся тем, что в качестве вспомогательных веществ в его состав входят скользящие вещества. ! 4. Лекарственное средство по п.3, отличающееся тем, что как скользящие вещества используют магния стеарат или кальция стеарат. ! 5. Лекарственное средство по п.3, отличающееся тем, что количество скользящих веществ составляет 0,8-1% от общей массы таблетки-ядра. ! 6. Лекарственное средство триметазидина в форме матриксной таблетки с пролонгированным действием, которое включает действующее вещество, воск монтановый гликолевый, полимер, вспомогательные вещества, отличающееся тем, что для обеспечения пористой структуры матриксной таблетки оно дополнительно содержит микрокристаллическую целлюлозу, маннитол, гидрофильный полимер при следующем соотношении компонентов, мас.%: ! триметазидин17,5-25воск монтановый гликолевый20-31полимер метакриловой кислоты15-27полимер гидрофильный3-10микрокристаллическая ц�1. The drug trimetazidine in the form of a matrix tablet with a prolonged action, which includes the active substance, montan glycol wax, a polymer of methacrylic acid, excipients, characterized in that to ensure the porous structure of the matrix tablet, it additionally contains microcrystalline cellulose and mannitol in the following ratio of components , wt.%:! trimetazidine 17.5-25wax montan glycol wax 20-31 methacrylic acid polymer 15-27 microcrystalline cellulose 12-14 mannitol 2.5-10 excipients up to 100! 2. The drug according to claim 1, characterized in that oudragit RS PO is used as the methacrylic acid polymer. ! 3. The drug according to claim 1, characterized in that, as auxiliary substances, it includes moving substances. ! 4. The drug according to claim 3, characterized in that as a moving substance use magnesium stearate or calcium stearate. ! 5. The drug according to claim 3, characterized in that the amount of glidants is 0.8-1% of the total weight of the tablet core. ! 6. The drug trimetazidine in the form of a matrix tablet with a prolonged action, which includes the active substance, montan glycol wax, polymer, excipients, characterized in that, to ensure the porous structure of the matrix tablet, it additionally contains microcrystalline cellulose, mannitol, a hydrophilic polymer in the following ratio components, wt.%:! trimetazidine 17.5-25 wax montan glycol 20-31 methacrylic acid polymer 15-27 hydrophilic polymer 3-10 microcrystalline
Claims (18)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2007143558/15A RU2377989C2 (en) | 2007-11-27 | 2007-11-27 | Trimetazidine preparation as matrix tablet of prolonged action and method for making thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2007143558/15A RU2377989C2 (en) | 2007-11-27 | 2007-11-27 | Trimetazidine preparation as matrix tablet of prolonged action and method for making thereof |
Publications (2)
Publication Number | Publication Date |
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RU2007143558A true RU2007143558A (en) | 2009-06-10 |
RU2377989C2 RU2377989C2 (en) | 2010-01-10 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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RU2007143558/15A RU2377989C2 (en) | 2007-11-27 | 2007-11-27 | Trimetazidine preparation as matrix tablet of prolonged action and method for making thereof |
Country Status (1)
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RU (1) | RU2377989C2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA021368B1 (en) * | 2011-06-21 | 2015-06-30 | Общество С Ограниченной Ответственностью "Консорциум-Пик" | Preparation of cardioprotective action |
US20210401834A1 (en) * | 2020-06-30 | 2021-12-30 | Imbria Pharmaceuticals, Inc. | Modified release formulations of modified forms of trimetazidine |
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2007
- 2007-11-27 RU RU2007143558/15A patent/RU2377989C2/en not_active IP Right Cessation
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Publication number | Publication date |
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RU2377989C2 (en) | 2010-01-10 |
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Date | Code | Title | Description |
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MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20131128 |