RU2007137690A - Water-dispersible organic drug substance in the form of micronized powder of N-carbamoyl-methyl-4-phenyl-2-pyrrolidone and the method of micronization - Google Patents

Water-dispersible organic drug substance in the form of micronized powder of N-carbamoyl-methyl-4-phenyl-2-pyrrolidone and the method of micronization Download PDF

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Publication number
RU2007137690A
RU2007137690A RU2007137690/15A RU2007137690A RU2007137690A RU 2007137690 A RU2007137690 A RU 2007137690A RU 2007137690/15 A RU2007137690/15 A RU 2007137690/15A RU 2007137690 A RU2007137690 A RU 2007137690A RU 2007137690 A RU2007137690 A RU 2007137690A
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RU
Russia
Prior art keywords
carbamoyl
phenyl
methyl
pyrrolidone
micronization
Prior art date
Application number
RU2007137690/15A
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Russian (ru)
Other versions
RU2423969C2 (en
Inventor
Валерий Сергеевич Комаров (RU)
Валерий Сергеевич Комаров
Original Assignee
ОТКРЫТОЕ АКЦИОНЕРНОЕ ОБЩЕСТВО "Валента Фармацевтика" (RU)
Открытое Акционерное Общество "Валента Фармацевтика"
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Application filed by ОТКРЫТОЕ АКЦИОНЕРНОЕ ОБЩЕСТВО "Валента Фармацевтика" (RU), Открытое Акционерное Общество "Валента Фармацевтика" filed Critical ОТКРЫТОЕ АКЦИОНЕРНОЕ ОБЩЕСТВО "Валента Фармацевтика" (RU)
Priority to RU2007137690/15A priority Critical patent/RU2423969C2/en
Priority to PCT/RU2008/000321 priority patent/WO2009048352A1/en
Publication of RU2007137690A publication Critical patent/RU2007137690A/en
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Publication of RU2423969C2 publication Critical patent/RU2423969C2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

1. Вододиспергируемая органическая лекарственная субстанция в виде микронизированного порошка N-карбамоил-метил-4-фенил-2-пирролидона, отличающаяся тем, что размер частиц, образующих порошок последнего, не превышают 3,5 мкм. ! 2. Способ микронизации N-карбамоил-метил-4-фенил-2-пирролидона путем его испарения в нейтральной разряженной газовой среде и последующего осаждение паров последнего на поверхность со стабильной температурой, отличающийся тем, что испарение N-карбамоил-метил-4-фенил-2-пирролидона осуществляют в нейтральной газовой среде с разряжением 950-10 Па, а осаждение его паров производят со скоростью 1015-1017 молек./с·см2 на поверхность осаждения, имеющую температуру - 120-30°С, при этом поверхность осаждения наклонена под углом 15-80° относительно направления вектора скорости осаждения. ! 3. Способ микронизации по п.1,отличающийся тем, что скорость испарения N-карбамоил-метил-4-фенил-2-пирролидона превышает скорость их осаждения в 1,2-2,5 раза.1. A water-dispersible organic drug substance in the form of a micronized powder of N-carbamoyl-methyl-4-phenyl-2-pyrrolidone, characterized in that the size of the particles forming the powder of the latter does not exceed 3.5 microns. ! 2. The method of micronization of N-carbamoyl-methyl-4-phenyl-2-pyrrolidone by evaporation in a neutral rarefied gas medium and subsequent vapor deposition of the latter on a surface with a stable temperature, characterized in that the evaporation of N-carbamoyl-methyl-4-phenyl -2-pyrrolidone is carried out in a neutral gas medium with a discharge of 950-10 Pa, and its vapor is deposited at a rate of 1015-1017 molecules / s · cm2 on the deposition surface having a temperature of 120-30 ° C, while the deposition surface is inclined at an angle of 15-80 ° relative to the direction of torus deposition rate. ! 3. The micronization method according to claim 1, characterized in that the evaporation rate of N-carbamoyl-methyl-4-phenyl-2-pyrrolidone exceeds their deposition rate by 1.2-2.5 times.

Claims (3)

1. Вододиспергируемая органическая лекарственная субстанция в виде микронизированного порошка N-карбамоил-метил-4-фенил-2-пирролидона, отличающаяся тем, что размер частиц, образующих порошок последнего, не превышают 3,5 мкм.1. A water-dispersible organic drug substance in the form of a micronized powder of N-carbamoyl-methyl-4-phenyl-2-pyrrolidone, characterized in that the size of the particles forming the powder of the latter does not exceed 3.5 microns. 2. Способ микронизации N-карбамоил-метил-4-фенил-2-пирролидона путем его испарения в нейтральной разряженной газовой среде и последующего осаждение паров последнего на поверхность со стабильной температурой, отличающийся тем, что испарение N-карбамоил-метил-4-фенил-2-пирролидона осуществляют в нейтральной газовой среде с разряжением 950-10 Па, а осаждение его паров производят со скоростью 1015-1017 молек./с·см2 на поверхность осаждения, имеющую температуру - 120-30°С, при этом поверхность осаждения наклонена под углом 15-80° относительно направления вектора скорости осаждения.2. The method of micronization of N-carbamoyl-methyl-4-phenyl-2-pyrrolidone by evaporation in a neutral gas atmosphere and the subsequent deposition of vapor of the latter on a surface with a stable temperature, characterized in that the evaporation of N-carbamoyl-methyl-4-phenyl -2-pyrrolidone is carried out in a neutral gas medium with a discharge of 950-10 Pa, and its vapor is deposited at a rate of 10 15 -10 17 molecules / s · cm 2 on the deposition surface having a temperature of 120-30 ° C, while the deposition surface is inclined at an angle of 15-80 ° relative to the direction projector of deposition rate. 3. Способ микронизации по п.1,отличающийся тем, что скорость испарения N-карбамоил-метил-4-фенил-2-пирролидона превышает скорость их осаждения в 1,2-2,5 раза.3. The micronization method according to claim 1, characterized in that the evaporation rate of N-carbamoyl-methyl-4-phenyl-2-pyrrolidone exceeds their deposition rate by 1.2-2.5 times.
RU2007137690/15A 2007-10-12 2007-10-12 Method of micronisation of n-carbamoyl-methyl-4-phenyl-2-pyrrolidone and medication, containing water-dispersed organic medicinal substance in form of micronised powder of n-carbamoyl-methyl-4-phenyl-2-pyrrolodone RU2423969C2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
RU2007137690/15A RU2423969C2 (en) 2007-10-12 2007-10-12 Method of micronisation of n-carbamoyl-methyl-4-phenyl-2-pyrrolidone and medication, containing water-dispersed organic medicinal substance in form of micronised powder of n-carbamoyl-methyl-4-phenyl-2-pyrrolodone
PCT/RU2008/000321 WO2009048352A1 (en) 2007-10-12 2008-05-22 Water-dispersible organic medicinal substance in the form of a micronised powder of n-carbamoil-methyl-4-phenyl-2-pyrrolidone and a method for micronising it

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2007137690/15A RU2423969C2 (en) 2007-10-12 2007-10-12 Method of micronisation of n-carbamoyl-methyl-4-phenyl-2-pyrrolidone and medication, containing water-dispersed organic medicinal substance in form of micronised powder of n-carbamoyl-methyl-4-phenyl-2-pyrrolodone

Publications (2)

Publication Number Publication Date
RU2007137690A true RU2007137690A (en) 2009-04-20
RU2423969C2 RU2423969C2 (en) 2011-07-20

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RU2007137690/15A RU2423969C2 (en) 2007-10-12 2007-10-12 Method of micronisation of n-carbamoyl-methyl-4-phenyl-2-pyrrolidone and medication, containing water-dispersed organic medicinal substance in form of micronised powder of n-carbamoyl-methyl-4-phenyl-2-pyrrolodone

Country Status (2)

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RU (1) RU2423969C2 (en)
WO (1) WO2009048352A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2480214C1 (en) 2011-09-22 2013-04-27 Валентина Ивановна Ахапкина Formulation possessing modulatory activity with adequate effect, pharmaceutical substance (versions), use of pharmaceutical substance, pharmaceutical and parapharmaceutical composition (versions), method for preparing pharmaceutical formulations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2050851C1 (en) * 1990-08-28 1995-12-27 Институт медико-биологических проблем Substance exhibiting nootropic activity
RU2301058C1 (en) * 2006-07-19 2007-06-20 Валерий Сергеевич Комаров Method for micronization of organic medicinal substance

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WO2009048352A1 (en) 2009-04-16
RU2423969C2 (en) 2011-07-20

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