RU2007101309A - Боросодержащее соединение и способы применения - Google Patents
Боросодержащее соединение и способы применения Download PDFInfo
- Publication number
- RU2007101309A RU2007101309A RU2007101309/04A RU2007101309A RU2007101309A RU 2007101309 A RU2007101309 A RU 2007101309A RU 2007101309/04 A RU2007101309/04 A RU 2007101309/04A RU 2007101309 A RU2007101309 A RU 2007101309A RU 2007101309 A RU2007101309 A RU 2007101309A
- Authority
- RU
- Russia
- Prior art keywords
- alkyl
- optionally substituted
- aryl
- group
- amino
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 9
- 239000002023 wood Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims abstract 45
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 10
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract 8
- 125000003118 aryl group Chemical group 0.000 claims abstract 8
- 229910052736 halogen Inorganic materials 0.000 claims abstract 8
- 150000002367 halogens Chemical class 0.000 claims abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 8
- 239000001257 hydrogen Substances 0.000 claims abstract 8
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 7
- 150000002431 hydrogen Chemical class 0.000 claims abstract 7
- 125000003107 substituted aryl group Chemical group 0.000 claims abstract 7
- -1 2- (morpholino) ethoxy Chemical group 0.000 claims abstract 6
- 241001465754 Metazoa Species 0.000 claims abstract 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 6
- 125000004104 aryloxy group Chemical group 0.000 claims abstract 4
- 125000004475 heteroaralkyl group Chemical group 0.000 claims abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 4
- 239000012453 solvate Substances 0.000 claims abstract 3
- 150000004677 hydrates Chemical class 0.000 claims abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 2
- 125000004076 pyridyl group Chemical group 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- ZTLSOLUCMQEGEA-UHFFFAOYSA-N bis(3-chloro-4-methylphenyl)boranyl 3-hydroxypyridine-2-carboxylate Chemical compound C1=C(Cl)C(C)=CC=C1B(C=1C=C(Cl)C(C)=CC=1)OC(=O)C1=NC=CC=C1O ZTLSOLUCMQEGEA-UHFFFAOYSA-N 0.000 claims 3
- 125000004288 oxazolidin-2-yl group Chemical group [H]N1C([H])([H])C([H])([H])OC1([H])* 0.000 claims 3
- 208000002874 Acne Vulgaris Diseases 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 241001303601 Rosacea Species 0.000 claims 2
- 206010000496 acne Diseases 0.000 claims 2
- 201000008937 atopic dermatitis Diseases 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 230000000770 proinflammatory effect Effects 0.000 claims 2
- 201000004700 rosacea Diseases 0.000 claims 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 208000028169 periodontal disease Diseases 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57942104P | 2004-06-14 | 2004-06-14 | |
| US60/579,421 | 2004-06-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2007101309A true RU2007101309A (ru) | 2008-07-20 |
Family
ID=35276660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007101309/04A RU2007101309A (ru) | 2004-06-14 | 2005-06-14 | Боросодержащее соединение и способы применения |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7652000B2 (enExample) |
| EP (1) | EP1765358B1 (enExample) |
| JP (1) | JP2008502696A (enExample) |
| KR (1) | KR20070043776A (enExample) |
| CN (1) | CN1972695A (enExample) |
| AR (1) | AR049915A1 (enExample) |
| AT (1) | ATE499105T1 (enExample) |
| AU (1) | AU2005254095B2 (enExample) |
| BR (1) | BRPI0512054A (enExample) |
| CA (1) | CA2570477A1 (enExample) |
| DE (1) | DE602005026524D1 (enExample) |
| IL (1) | IL179616A0 (enExample) |
| MX (1) | MXPA06014416A (enExample) |
| NZ (1) | NZ551726A (enExample) |
| RU (1) | RU2007101309A (enExample) |
| TW (1) | TW200612966A (enExample) |
| WO (1) | WO2005123094A2 (enExample) |
| ZA (1) | ZA200610353B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7767657B2 (en) | 2005-02-16 | 2010-08-03 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| ES2872962T3 (es) | 2005-02-16 | 2021-11-03 | Anacor Pharmaceuticals Inc | Boronoftalidas para uso terapéutico |
| MX2007011486A (es) * | 2005-03-24 | 2007-11-20 | Anacor Pharmaceuticals Inc | Formulaciones topicas de antibioticos de acido borinico y sus metodos de uso. |
| EP1965647A2 (en) * | 2005-12-28 | 2008-09-10 | Anacor Pharmaceuticals, Inc. | Process for manufacturing picolinate borinic esters |
| RU2642628C2 (ru) | 2006-02-16 | 2018-01-25 | Анакор Фармасьютикалз, Инк. | Бор-содержащие малые молекулы в качестве противовоспалительных средств |
| BRPI0713010A2 (pt) * | 2006-06-12 | 2012-10-09 | Anacor Pharmaceuticals Inc | compostos para o tratamento de doença periodontal |
| EP3246034A1 (en) | 2008-03-06 | 2017-11-22 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-inflammatory agents |
| WO2010018836A2 (ja) * | 2008-08-11 | 2010-02-18 | 独立行政法人科学技術振興機構 | ポリグルタミン凝集阻害剤 |
| WO2010027975A1 (en) | 2008-09-04 | 2010-03-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| US8461336B2 (en) | 2008-09-04 | 2013-06-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| US9493489B2 (en) * | 2008-10-15 | 2016-11-15 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-protozoal agents |
| TW201110996A (en) | 2009-06-03 | 2011-04-01 | Colgate Palmolive Co | Borinic compositions |
| AP4039A (en) * | 2009-08-14 | 2017-02-28 | Daitao Chen | Boron-containing small molecules as antiprotozoal agents |
| WO2011049971A1 (en) | 2009-10-20 | 2011-04-28 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antiprotozoal agents |
| US8461134B2 (en) | 2009-11-11 | 2013-06-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| US8716478B2 (en) | 2010-01-27 | 2014-05-06 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| WO2011116348A1 (en) | 2010-03-19 | 2011-09-22 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-protozoal agent |
| DK2613788T3 (en) | 2010-09-07 | 2017-08-07 | Anacor Pharmaceuticals Inc | BENZOXABOROLD DERIVATIVES FOR TREATMENT OF BACTERIA INFECTIONS |
| US9585396B2 (en) | 2013-01-30 | 2017-03-07 | Agrofresh Inc. | Volatile applications against pathogens |
| US10070649B2 (en) | 2013-01-30 | 2018-09-11 | Agrofresh Inc. | Volatile applications against pathogens |
| US8669207B1 (en) | 2013-01-30 | 2014-03-11 | Dow Agrosciences, Llc. | Compounds and compositions |
| AR094666A1 (es) | 2013-01-30 | 2015-08-19 | Dow Agrosciences Llc | Uso de benzoxaborolas como agentes antimicrobianos volátiles en carnes, plantas o partes de plantas |
| US11039617B2 (en) | 2013-01-30 | 2021-06-22 | Agrofresh Inc. | Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness |
| KR101756785B1 (ko) * | 2015-03-10 | 2017-07-12 | 한국화학연구원 | 4배위 유기 붕소 화합물의 제조방법 |
| IES86830B2 (en) * | 2015-06-24 | 2017-10-04 | Oriel Seasalt Company Ltd | A super-concentrated seawater mineral extract and uses thereof |
| WO2017155879A1 (en) | 2016-03-07 | 2017-09-14 | Agrofresh Inc. | Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops |
| US10961261B2 (en) | 2017-03-01 | 2021-03-30 | Anacor Pharmaceuticals, Inc. | Oxaborole analogs and uses thereof |
| WO2022043936A1 (en) | 2020-08-31 | 2022-03-03 | Pfizer Inc. | Methods of protecting rna |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE790627A (fr) * | 1971-10-27 | 1973-04-27 | Lilly Co Eli | L'antibiotique a477 et son procede de preparation |
| US5348947A (en) * | 1993-05-07 | 1994-09-20 | American Cyanamid Company | Diarylboron ester and thioester fungicidal agents |
| US6123925A (en) * | 1998-07-27 | 2000-09-26 | Healthshield Technologies L.L.C. | Antibiotic toothpaste |
| US6350786B1 (en) * | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
| EP1233772A4 (en) | 1999-11-19 | 2004-06-16 | Topgene Inc | Boron compounds and complexes as anti-inflammatories |
| MXPA05006685A (es) * | 2002-12-18 | 2005-12-14 | Anacor Pharmaceuticals Inc | Antibioticos que contienen complejos de acido borinico y metodos de uso. |
-
2005
- 2005-06-13 AR ARP050102416A patent/AR049915A1/es unknown
- 2005-06-14 CA CA002570477A patent/CA2570477A1/en not_active Abandoned
- 2005-06-14 CN CNA2005800196020A patent/CN1972695A/zh active Pending
- 2005-06-14 ZA ZA200610353A patent/ZA200610353B/xx unknown
- 2005-06-14 NZ NZ551726A patent/NZ551726A/en unknown
- 2005-06-14 RU RU2007101309/04A patent/RU2007101309A/ru not_active Application Discontinuation
- 2005-06-14 MX MXPA06014416A patent/MXPA06014416A/es active IP Right Grant
- 2005-06-14 KR KR1020077000568A patent/KR20070043776A/ko not_active Ceased
- 2005-06-14 DE DE602005026524T patent/DE602005026524D1/de not_active Expired - Lifetime
- 2005-06-14 BR BRPI0512054-3A patent/BRPI0512054A/pt not_active IP Right Cessation
- 2005-06-14 EP EP05786265A patent/EP1765358B1/en not_active Expired - Lifetime
- 2005-06-14 WO PCT/US2005/021165 patent/WO2005123094A2/en not_active Ceased
- 2005-06-14 AU AU2005254095A patent/AU2005254095B2/en not_active Ceased
- 2005-06-14 JP JP2007516688A patent/JP2008502696A/ja not_active Withdrawn
- 2005-06-14 US US11/153,765 patent/US7652000B2/en not_active Expired - Fee Related
- 2005-06-14 AT AT05786265T patent/ATE499105T1/de not_active IP Right Cessation
- 2005-06-14 TW TW094119690A patent/TW200612966A/zh unknown
-
2006
- 2006-11-27 IL IL179616A patent/IL179616A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008502696A (ja) | 2008-01-31 |
| EP1765358A2 (en) | 2007-03-28 |
| BRPI0512054A (pt) | 2008-02-06 |
| EP1765358B1 (en) | 2011-02-23 |
| NZ551726A (en) | 2010-09-30 |
| IL179616A0 (en) | 2007-05-15 |
| AR049915A1 (es) | 2006-09-13 |
| US20060009422A1 (en) | 2006-01-12 |
| AU2005254095B2 (en) | 2010-06-03 |
| TW200612966A (en) | 2006-05-01 |
| DE602005026524D1 (de) | 2011-04-07 |
| MXPA06014416A (es) | 2007-03-08 |
| WO2005123094A3 (en) | 2006-02-23 |
| CA2570477A1 (en) | 2005-12-29 |
| US7652000B2 (en) | 2010-01-26 |
| ATE499105T1 (de) | 2011-03-15 |
| WO2005123094A2 (en) | 2005-12-29 |
| ZA200610353B (en) | 2010-07-28 |
| AU2005254095A1 (en) | 2005-12-29 |
| KR20070043776A (ko) | 2007-04-25 |
| CN1972695A (zh) | 2007-05-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20110316 |