RU2005131004A - Способ оределения молекулярной массы соединения, содержащего моноэфир фосфорной кислоты, и добавка для масс-спектрометрии - Google Patents
Способ оределения молекулярной массы соединения, содержащего моноэфир фосфорной кислоты, и добавка для масс-спектрометрии Download PDFInfo
- Publication number
- RU2005131004A RU2005131004A RU2005131004/28A RU2005131004A RU2005131004A RU 2005131004 A RU2005131004 A RU 2005131004A RU 2005131004/28 A RU2005131004/28 A RU 2005131004/28A RU 2005131004 A RU2005131004 A RU 2005131004A RU 2005131004 A RU2005131004 A RU 2005131004A
- Authority
- RU
- Russia
- Prior art keywords
- compound
- additive
- mass spectrometry
- phosphoric acid
- acid monoester
- Prior art date
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6818—Sequencing of polypeptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/16—Phosphorus containing
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Claims (8)
1. Способ определения молекулярной массы соединения, содержащего моноэфир фосфорной кислоты, содержит этапы
(1) смешение комплексного соединения, включающего в себя соединение (I), имеющее один вид изотопов цинка, и образца в растворителе для получения раствора и затем регистрация масс-спектра раствора
где R от R1 до R4 представляет собой атомы водорода или заместители,
(2) смешение комплексного соединения, включающего в себя соединение (I), имеющего другой вид изотопов цинка, и образца в растворителе для получения раствора и затем регистрация масс-спектра раствора и
(3) определение молекулярной массы соединения, содержащего моноэфир фосфорной кислоты, сравнением масс-спектров.
2. Способ по п.1, в котором все R от R1 до R4 в комплексном соединении, используемом в способе, представляют собой атомы водорода.
3. Добавка для масс-спектрометрии, используемая для определения молекулярной массы соединения, содержащего моноэфир фосфорной кислоты, содержит реагент, имеющий комплексное соединение, включающее в себя соединение (I), имеющее один вид изотопов цинка, и реагент, имеющий комплексное соединение, включающее в себя соединение (I), имеющее другой вид изотопов цинка;
где R от R1 до R4 представляет собой атомы водорода или заместители.
4. Добавка для масс-спектрометрии по п.3, причем все R от R1 до R4 комплексного соединения в реагенте представляют собой атомы водорода.
5. Добавка для масс-спектрометрии по п.3 или 4, причем комплексное соединение дополнительно образует комплекс соединения (I) и ацетатного иона.
6. Добавка для масс-спектрометрии по п.4, причем комплексное соединение дополнительно образует комплекс соединения (I) и ацетатного иона.
7. Добавка для масс-спектрометрии по п.3, причем реагент находится в виде соли.
8. Добавка для масс-спектрометрии по п.3, причем реагент находится в виде раствора.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003-61939 | 2003-03-07 | ||
| JP2003061939 | 2003-03-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005131004A true RU2005131004A (ru) | 2006-03-20 |
| RU2326377C2 RU2326377C2 (ru) | 2008-06-10 |
Family
ID=32958986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005131004/28A RU2326377C2 (ru) | 2003-03-07 | 2003-12-24 | Способ определения молекулярной массы соединения, содержащего моноэфир фосфорной кислоты, и добавка для масс-спектрометрии |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7476738B2 (ru) |
| EP (1) | EP1602923B1 (ru) |
| CN (1) | CN100422732C (ru) |
| AU (1) | AU2003296059B2 (ru) |
| CA (1) | CA2518495C (ru) |
| DE (1) | DE60333040D1 (ru) |
| RU (1) | RU2326377C2 (ru) |
| TW (1) | TW200508606A (ru) |
| WO (1) | WO2004079358A1 (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050269267A1 (en) * | 2004-03-19 | 2005-12-08 | Perkinelmer Las, Inc. | Separations platform based upon electroosmosis-driven planar chromatography |
| US20080064608A1 (en) * | 2004-07-13 | 2008-03-13 | Toyo Boseki Kabushiki Kaisha | Method Of Detecting Phosphorylation By Spr Using Zinc Chelating Reagent |
| WO2007067731A2 (en) * | 2005-12-08 | 2007-06-14 | Perkinelmer Las, Inc. | Micelle- and microemulsion-assisted planar separations platform for proteomics |
| WO2007087339A2 (en) * | 2006-01-24 | 2007-08-02 | Perkinelmer Las, Inc. | Multiplexed analyte quantitation by two-dimensional planar electrochromatography |
| WO2007127988A2 (en) | 2006-04-28 | 2007-11-08 | Perkinelmer Las, Inc. | Detecting phospho-transfer activity |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2172145C (en) * | 1994-07-25 | 2010-09-21 | Hans-Peter Josel | Metal complexes with a charged linker |
| WO2000011208A1 (en) * | 1998-08-25 | 2000-03-02 | University Of Washington | Rapid quantitative analysis of proteins or protein function in complex mixtures |
| DE10297577B4 (de) * | 2001-12-21 | 2007-11-22 | Tohru Koike | Zinkkomplexe, die fähig sind, Substanzen, die anionische Substituenten haben, abzufangen |
| US7202093B2 (en) * | 2003-03-03 | 2007-04-10 | Kabushiki Kaisha Nard Kenkyusho | Method for labeling phosphorylated peptides, method for selectively adsorbing phosphorylated peptides, complex compounds used in the methods, process for producing the complex compounds, and raw material compounds for the complex compounds |
| WO2004078342A1 (ja) | 2003-03-04 | 2004-09-16 | Manac Inc. | アニオン性置換基を有する物質の捕捉剤 |
-
2003
- 2003-12-23 TW TW092136511A patent/TW200508606A/zh not_active IP Right Cessation
- 2003-12-24 WO PCT/JP2003/016512 patent/WO2004079358A1/ja active Application Filing
- 2003-12-24 AU AU2003296059A patent/AU2003296059B2/en not_active Ceased
- 2003-12-24 DE DE60333040T patent/DE60333040D1/de not_active Expired - Lifetime
- 2003-12-24 CA CA2518495A patent/CA2518495C/en not_active Expired - Fee Related
- 2003-12-24 CN CNB200380110118XA patent/CN100422732C/zh not_active Expired - Fee Related
- 2003-12-24 EP EP03786241A patent/EP1602923B1/en not_active Expired - Lifetime
- 2003-12-24 RU RU2005131004/28A patent/RU2326377C2/ru not_active IP Right Cessation
- 2003-12-24 US US10/547,972 patent/US7476738B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| TWI301889B (ru) | 2008-10-11 |
| TW200508606A (en) | 2005-03-01 |
| CA2518495C (en) | 2011-08-02 |
| RU2326377C2 (ru) | 2008-06-10 |
| CN1756954A (zh) | 2006-04-05 |
| EP1602923B1 (en) | 2010-06-16 |
| CN100422732C (zh) | 2008-10-01 |
| AU2003296059A1 (en) | 2004-09-28 |
| DE60333040D1 (de) | 2010-07-29 |
| AU2003296059B2 (en) | 2009-02-19 |
| CA2518495A1 (en) | 2004-09-16 |
| US7476738B2 (en) | 2009-01-13 |
| EP1602923A1 (en) | 2005-12-07 |
| WO2004079358A1 (ja) | 2004-09-16 |
| US20060183237A1 (en) | 2006-08-17 |
| EP1602923A4 (en) | 2007-07-25 |
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| Date | Code | Title | Description |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20141225 |