RU2004138524A - METHOD FOR PREPARING ERYTHROCITAR DIAGNOSTICUM FOR DETERMINING ANTIBODIES TO LIVER TISSUE - Google Patents

METHOD FOR PREPARING ERYTHROCITAR DIAGNOSTICUM FOR DETERMINING ANTIBODIES TO LIVER TISSUE Download PDF

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Publication number
RU2004138524A
RU2004138524A RU2004138524/15A RU2004138524A RU2004138524A RU 2004138524 A RU2004138524 A RU 2004138524A RU 2004138524/15 A RU2004138524/15 A RU 2004138524/15A RU 2004138524 A RU2004138524 A RU 2004138524A RU 2004138524 A RU2004138524 A RU 2004138524A
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RU
Russia
Prior art keywords
liver tissue
sodium chloride
chloride solution
preparing
isotonic sodium
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RU2004138524/15A
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Russian (ru)
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RU2280867C1 (en
Inventor
Иван Алексеевич Никулин (RU)
Иван Алексеевич Никулин
Юрий Александрович Шумилин (RU)
Юрий Александрович Шумилин
Original Assignee
Федеральное государственное образовательное учреждение высшего профессионального образовани "Воронежский государственный аграрный университет им. Г.Д. Глинки" (ФГОУ ВПО ВГАУ им. К.Д. Глинки) (RU)
Федеральное государственное образовательное учреждение высшего профессионального образования "Воронежский государственный аграрный университет им. Г.Д. Глинки" (ФГОУ ВПО ВГАУ им. К.Д. Глинки)
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Application filed by Федеральное государственное образовательное учреждение высшего профессионального образовани "Воронежский государственный аграрный университет им. Г.Д. Глинки" (ФГОУ ВПО ВГАУ им. К.Д. Глинки) (RU), Федеральное государственное образовательное учреждение высшего профессионального образования "Воронежский государственный аграрный университет им. Г.Д. Глинки" (ФГОУ ВПО ВГАУ им. К.Д. Глинки) filed Critical Федеральное государственное образовательное учреждение высшего профессионального образовани "Воронежский государственный аграрный университет им. Г.Д. Глинки" (ФГОУ ВПО ВГАУ им. К.Д. Глинки) (RU)
Priority to RU2004138524/15A priority Critical patent/RU2280867C1/en
Publication of RU2004138524A publication Critical patent/RU2004138524A/en
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Publication of RU2280867C1 publication Critical patent/RU2280867C1/en

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Claims (2)

1. Способ приготовления эритроцитарного диагностикума для определения антител к тканям печени, включающий получение антигена из ткани печени крупного рогатого скота экстракцией в изотоническом растворе натрия хлорида, подготовку эритроцитов с проведением процессов отмывания в изотоническом растворе натрия хлорида, суспензирования и выдержки в растворе фиксатора, танизации и их сенсибилизацию путем смешивания с последующим отмыванием в изотоническом растворе натрия хлорида и ресуспензированием в консерванте до концентрации готового препарата, отличающийся тем, что экстракцию печени осуществляют при соотношении объемов ткани печени и изотонического раствора натрия хлорида 1:4 соответственно в течение 18-20 ч при 4°С, а в качестве фиксатора в процессе подготовки эритроцитов используют 0,3% раствор формальдегида, при этом выдержку осуществляют при температуре 37°С в течение 4 ч, а изотонический раствор натрия хлорида для отмывания эритроцитов смешивают с фосфатным буфером в соотношении 9:1 соответственно.1. A method of preparing an erythrocyte diagnosticum for determining antibodies to liver tissue, including obtaining antigen from liver tissue of cattle by extraction in an isotonic sodium chloride solution, preparing red blood cells with washing processes in an isotonic sodium chloride solution, suspension and soaking in a fixative solution, tanization and their sensitization by mixing, followed by washing in isotonic sodium chloride solution and resuspension in a preservative to a concentration is ready o preparation, characterized in that the extraction of the liver is carried out at a ratio of the volume of liver tissue and isotonic sodium chloride solution 1: 4, respectively, for 18-20 hours at 4 ° C, and 0.3% formaldehyde solution is used as a fixative during the preparation of red blood cells while the exposure is carried out at a temperature of 37 ° C for 4 hours, and the isotonic sodium chloride solution for washing red blood cells is mixed with phosphate buffer in a ratio of 9: 1, respectively. 2. Способ по п.1, отличающийся тем, что эритроциты ресуспензируют до 3% концентрации.2. The method according to claim 1, characterized in that the red blood cells resuspend to 3% concentration.
RU2004138524/15A 2004-12-28 2004-12-28 Method for preparing erythrocytic diagnostic kit for detecting antibodies to hepatic tissues RU2280867C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2004138524/15A RU2280867C1 (en) 2004-12-28 2004-12-28 Method for preparing erythrocytic diagnostic kit for detecting antibodies to hepatic tissues

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Application Number Priority Date Filing Date Title
RU2004138524/15A RU2280867C1 (en) 2004-12-28 2004-12-28 Method for preparing erythrocytic diagnostic kit for detecting antibodies to hepatic tissues

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RU2004138524A true RU2004138524A (en) 2006-06-10
RU2280867C1 RU2280867C1 (en) 2006-07-27

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RU2004138524/15A RU2280867C1 (en) 2004-12-28 2004-12-28 Method for preparing erythrocytic diagnostic kit for detecting antibodies to hepatic tissues

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101476999B (en) * 2009-01-23 2011-03-16 赵宝忠 Method for fixing organization blocks by methanal stationary liquid

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101476999B (en) * 2009-01-23 2011-03-16 赵宝忠 Method for fixing organization blocks by methanal stationary liquid

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Publication number Publication date
RU2280867C1 (en) 2006-07-27

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Effective date: 20061229