RU2004129739A - Рекомбинантные споры - Google Patents
Рекомбинантные споры Download PDFInfo
- Publication number
- RU2004129739A RU2004129739A RU2004129739/13A RU2004129739A RU2004129739A RU 2004129739 A RU2004129739 A RU 2004129739A RU 2004129739/13 A RU2004129739/13 A RU 2004129739/13A RU 2004129739 A RU2004129739 A RU 2004129739A RU 2004129739 A RU2004129739 A RU 2004129739A
- Authority
- RU
- Russia
- Prior art keywords
- dispute
- protein
- spore
- therapeutically active
- active compound
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 claims 17
- 102000004169 proteins and genes Human genes 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 8
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 230000001575 pathological effect Effects 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 239000002243 precursor Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 206010061218 Inflammation Diseases 0.000 claims 3
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 230000003054 hormonal effect Effects 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 230000000968 intestinal effect Effects 0.000 claims 3
- 230000036407 pain Effects 0.000 claims 3
- 230000028327 secretion Effects 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 230000001086 cytosolic effect Effects 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
- 230000002068 genetic effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 230000001131 transforming effect Effects 0.000 claims 2
- XFTWUNOVBCHBJR-UHFFFAOYSA-N Aspergillomarasmine A Chemical group OC(=O)C(N)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O XFTWUNOVBCHBJR-UHFFFAOYSA-N 0.000 claims 1
- 241000193830 Bacillus <bacterium> Species 0.000 claims 1
- 102000009025 Endorphins Human genes 0.000 claims 1
- 108010049140 Endorphins Proteins 0.000 claims 1
- 108700028146 Genetic Enhancer Elements Proteins 0.000 claims 1
- 108010055044 Tetanus Toxin Proteins 0.000 claims 1
- 101710182223 Toxin B Proteins 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 230000000202 analgesic effect Effects 0.000 claims 1
- 229940035676 analgesics Drugs 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 210000001198 duodenum Anatomy 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000012239 gene modification Methods 0.000 claims 1
- 230000005017 genetic modification Effects 0.000 claims 1
- 235000013617 genetically modified food Nutrition 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 210000001630 jejunum Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001323 posttranslational effect Effects 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 230000004763 spore germination Effects 0.000 claims 1
- 239000003270 steroid hormone Substances 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 229940118376 tetanus toxin Drugs 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N3/00—Spore forming or isolating processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0205376.7A GB0205376D0 (en) | 2002-03-07 | 2002-03-07 | Spore germination |
| GB0205376.7 | 2002-03-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2004129739A true RU2004129739A (ru) | 2005-09-20 |
Family
ID=9932499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004129739/13A RU2004129739A (ru) | 2002-03-07 | 2003-03-07 | Рекомбинантные споры |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20050287168A1 (https=) |
| EP (1) | EP1495110A1 (https=) |
| JP (1) | JP2005519123A (https=) |
| KR (1) | KR20040099293A (https=) |
| CN (1) | CN1639322A (https=) |
| AU (1) | AU2003214391A1 (https=) |
| GB (1) | GB0205376D0 (https=) |
| RU (1) | RU2004129739A (https=) |
| WO (1) | WO2003074681A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0503509D0 (en) * | 2005-02-19 | 2005-03-30 | New Royal Holloway & Bedford | An improved delivery agent |
| JP2008231063A (ja) * | 2007-03-22 | 2008-10-02 | Takano Foods Kk | 納豆菌ワクチン |
| US9610333B2 (en) * | 2008-07-11 | 2017-04-04 | Tufts University | Methods, compositions and kits for vegetative cell-based vaccines and spore-based vaccines |
| WO2010006326A2 (en) * | 2008-07-11 | 2010-01-14 | Tufts University | Methods and compositions for spore-based vaccines |
| WO2011111783A1 (ja) * | 2010-03-12 | 2011-09-15 | カルピス株式会社 | 大腸におけるビフィズス菌の増加及び減少抑制剤 |
| EP4077359B1 (en) | 2019-12-18 | 2026-03-18 | LivingMed Biotech S.R.L. | Genetically modified clostridium strains and uses thereof |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5668255A (en) * | 1984-06-07 | 1997-09-16 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| DE69002817T2 (de) * | 1989-11-28 | 1993-12-09 | Wellcome Found | Vakzine. |
| US6280721B1 (en) * | 1989-12-18 | 2001-08-28 | Valent Biosciences, Inc. | Production of Bacillus thuringiensis integrants |
| JP3415145B2 (ja) * | 1991-03-05 | 2003-06-09 | ザ ウエルカム ファウンデーション リミテッド | 弱毒化細菌における組換えタンパク質の発現 |
| US5340577A (en) * | 1992-07-29 | 1994-08-23 | The United States Of America, As Represented By The Secretary Of Agriculture | Probiotic for control of salmonella |
| GB9401787D0 (en) * | 1994-01-31 | 1994-03-23 | Medeva Holdings Bv | Vaccine compositions |
| GB9400650D0 (en) * | 1994-01-14 | 1994-03-09 | Smithkline Beecham Biolog | Expression of surface lazer proteins |
| US5533973A (en) * | 1995-01-13 | 1996-07-09 | Abbott Laboratories | Alteration of nutritional product during enteral tube feeding |
| US5531681A (en) * | 1995-01-13 | 1996-07-02 | Abbott Laboratories | Apparatus for altering composition of nutritional product during enteral tube feeding |
| US5531734A (en) * | 1995-01-13 | 1996-07-02 | Abbott Laboratories | Method of altering composition of nutritional product during enteral tube feeding |
| US5800821A (en) * | 1995-03-10 | 1998-09-01 | New England Medical Center Hospitals, Inc. | Bacterial spores as a heat stable vaccine delivery system |
| US5707353A (en) * | 1995-12-21 | 1998-01-13 | Abbott Laboratories | Oral administration of beneficial agents |
| WO1997035612A1 (fr) * | 1996-03-23 | 1997-10-02 | The Research Foundation For Microbial Diseases Of Osaka University | Antigene a fragment fonctionnel de la toxine du tetanos, et vaccin contre le tetanos |
| US5707127A (en) * | 1996-06-26 | 1998-01-13 | Kain; Meira | Three-dimensional image viewing apparatus |
| DK0862863T4 (da) * | 1997-01-09 | 2008-12-01 | Nestle Sa | Kornprodukt indeholdende probiotika |
| US7923216B2 (en) * | 1997-08-14 | 2011-04-12 | Institut Pasteur | In vivo modulation of neuronal transport |
| US7923015B2 (en) * | 1997-08-14 | 2011-04-12 | Institut Pasteur | Methods for direct visualization of active synapses |
| US6730499B1 (en) * | 1998-07-03 | 2004-05-04 | Research Corporation Technologies, Inc. | Promoter for the Pichia pastoris formaldehyde dehydrogenase gene FLD1 |
| US6080401A (en) * | 1998-11-19 | 2000-06-27 | Reddy; Malireddy S. | Herbal and pharmaceutical drugs enhanced with probiotics |
| US6090417A (en) * | 1999-03-24 | 2000-07-18 | Kraft Foods, Inc. | Nutritional fortification of natural cheese and method of making |
| US7186560B2 (en) * | 1999-09-21 | 2007-03-06 | Rutgers, The State University Of New Jersey | High level expression of immunogenic proteins in the plastids of higher plants |
| GB0009470D0 (en) * | 2000-04-17 | 2000-06-07 | Univ Southampton | Materials and methods relating to immune responses to fusion proteins |
| EP1292686A1 (en) * | 2000-06-07 | 2003-03-19 | Smittskyddsinstitutet | Gene expression cassette and its use |
| US6881558B1 (en) * | 2000-06-26 | 2005-04-19 | The Trustees Of The University Of Pennsylvania | Expression system for cloning toxic genes |
| US20030165538A1 (en) * | 2000-06-26 | 2003-09-04 | Maxygen Incorporated | Methods and compositions for developing spore display systems for medicinal and industrial applications |
| US20020150594A1 (en) * | 2000-06-26 | 2002-10-17 | Maxygen, Inc. | Methods and compositions for developing spore display systems for medicinal and industrial applications |
| KR20020045400A (ko) * | 2000-12-08 | 2002-06-19 | 반재구 | 포자 표면발현 방법 |
| GB0130789D0 (en) * | 2001-12-21 | 2002-02-06 | King S College London | Application of spores |
-
2002
- 2002-03-07 GB GBGB0205376.7A patent/GB0205376D0/en not_active Ceased
-
2003
- 2003-03-07 AU AU2003214391A patent/AU2003214391A1/en not_active Abandoned
- 2003-03-07 WO PCT/GB2003/000966 patent/WO2003074681A1/en not_active Ceased
- 2003-03-07 EP EP03709962A patent/EP1495110A1/en not_active Withdrawn
- 2003-03-07 RU RU2004129739/13A patent/RU2004129739A/ru not_active Application Discontinuation
- 2003-03-07 JP JP2003573134A patent/JP2005519123A/ja not_active Withdrawn
- 2003-03-07 CN CNA038054248A patent/CN1639322A/zh active Pending
- 2003-03-07 US US10/506,749 patent/US20050287168A1/en not_active Abandoned
- 2003-03-07 KR KR10-2004-7013611A patent/KR20040099293A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN1639322A (zh) | 2005-07-13 |
| AU2003214391A1 (en) | 2003-09-16 |
| KR20040099293A (ko) | 2004-11-26 |
| WO2003074681A1 (en) | 2003-09-12 |
| JP2005519123A (ja) | 2005-06-30 |
| EP1495110A1 (en) | 2005-01-12 |
| GB0205376D0 (en) | 2002-04-24 |
| US20050287168A1 (en) | 2005-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20070711 |