RU2004111994A - Синергическая композиция для ингибирования вич - Google Patents
Синергическая композиция для ингибирования вич Download PDFInfo
- Publication number
- RU2004111994A RU2004111994A RU2004111994/15A RU2004111994A RU2004111994A RU 2004111994 A RU2004111994 A RU 2004111994A RU 2004111994/15 A RU2004111994/15 A RU 2004111994/15A RU 2004111994 A RU2004111994 A RU 2004111994A RU 2004111994 A RU2004111994 A RU 2004111994A
- Authority
- RU
- Russia
- Prior art keywords
- hiv inhibition
- synergic composition
- glycyrrhizic acid
- synergistic composition
- synergic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (3)
1. Синергическая композиция для ингибирования ВИЧ, содержащая азидотимидин и препарат производного глицирризиновой кислоты в концентрациях, физиологически достижимых в крови.
2. Синергическая композиция по п.1, отличающаяся тем, что в качестве препарата производного глицирризиновой кислоты используют пента-О-никотинат глицирризиновой кислоты (ниглизин).
3. Синергическая композиция по п.1 и 2, отличающаяся тем, что физиологически достижимые концентрации для азидотимидина составляют от 0,0037 до 0,0254 мкМ, а для ниглизина - от 0,052 до 9,64 мкМ.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2004111994/15A RU2272631C2 (ru) | 2004-04-20 | 2004-04-20 | Синергическая композиция для ингибирования вич |
| PCT/RU2004/000469 WO2005102360A1 (fr) | 2004-04-20 | 2004-11-29 | Composition synergique pour inhiber le virus de l'immunodeficience humaine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2004111994/15A RU2272631C2 (ru) | 2004-04-20 | 2004-04-20 | Синергическая композиция для ингибирования вич |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2004111994A true RU2004111994A (ru) | 2005-10-10 |
| RU2272631C2 RU2272631C2 (ru) | 2006-03-27 |
Family
ID=35196734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004111994/15A RU2272631C2 (ru) | 2004-04-20 | 2004-04-20 | Синергическая композиция для ингибирования вич |
Country Status (2)
| Country | Link |
|---|---|
| RU (1) | RU2272631C2 (ru) |
| WO (1) | WO2005102360A1 (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008035998A1 (fr) * | 2006-09-18 | 2008-03-27 | Obschestvo S Ogranichennoy Otvetstvennostyu 'sibfarmakon' | Formulation médicinale destinée à inhiber la propagation du virus de l'immunodéficience humaine |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4950652A (en) * | 1987-03-23 | 1990-08-21 | Hem Research, Inc. | dsRNAs for combination therapy in the treatment of viral diseases |
| RU2024547C1 (ru) * | 1991-03-04 | 1994-12-15 | Институт органической химии УНЦ РАН | АМИД β-ГЛИЦИРРИЗИНОВОЙ КИСЛОТЫ С 6-АМИНО-2-ТИО-УРАЦИЛОМ, ПРОЯВЛЯЮЩИЙ АНТИ-СПИД-АКТИВНОСТЬ |
-
2004
- 2004-04-20 RU RU2004111994/15A patent/RU2272631C2/ru not_active IP Right Cessation
- 2004-11-29 WO PCT/RU2004/000469 patent/WO2005102360A1/ru active Application Filing
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008035998A1 (fr) * | 2006-09-18 | 2008-03-27 | Obschestvo S Ogranichennoy Otvetstvennostyu 'sibfarmakon' | Formulation médicinale destinée à inhiber la propagation du virus de l'immunodéficience humaine |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2272631C2 (ru) | 2006-03-27 |
| WO2005102360A1 (fr) | 2005-11-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TK4A | Correction to the publication in the bulletin (patent) |
Free format text: AMENDMENT TO CHAPTER -FG4A- IN JOURNAL: 9-2006 FOR TAG: (73) |
|
| PD4A | Correction of name of patent owner | ||
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20150421 |