RU2002124522A - 2-OXO-1-pyrrolidine derivatives, method for their preparation and use - Google Patents
2-OXO-1-pyrrolidine derivatives, method for their preparation and useInfo
- Publication number
- RU2002124522A RU2002124522A RU2002124522/04A RU2002124522A RU2002124522A RU 2002124522 A RU2002124522 A RU 2002124522A RU 2002124522/04 A RU2002124522/04 A RU 2002124522/04A RU 2002124522 A RU2002124522 A RU 2002124522A RU 2002124522 A RU2002124522 A RU 2002124522A
- Authority
- RU
- Russia
- Prior art keywords
- hydrogen
- alkyl
- halogen
- phenyl
- compound according
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 63
- 239000001257 hydrogen Substances 0.000 claims 63
- 125000000217 alkyl group Chemical group 0.000 claims 44
- 150000001875 compounds Chemical class 0.000 claims 41
- -1 hydroxy, amino Chemical group 0.000 claims 38
- 150000002431 hydrogen Chemical class 0.000 claims 37
- 229910052736 halogen Inorganic materials 0.000 claims 31
- 150000002367 halogens Chemical class 0.000 claims 31
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 24
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 22
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 21
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 21
- 125000001424 substituent group Chemical group 0.000 claims 20
- 208000006673 Asthma Diseases 0.000 claims 16
- 125000003118 aryl group Chemical group 0.000 claims 14
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 14
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 12
- 125000005843 halogen group Chemical group 0.000 claims 11
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 10
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 10
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 10
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 10
- 125000000623 heterocyclic group Chemical group 0.000 claims 9
- 208000004296 Neuralgia Diseases 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 8
- 239000001301 oxygen Substances 0.000 claims 8
- 125000003342 alkenyl group Chemical group 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 7
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 7
- 125000000304 alkynyl group Chemical group 0.000 claims 6
- 125000003368 amide group Chemical group 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 239000011780 sodium chloride Substances 0.000 claims 6
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 6
- 206010004938 Bipolar disease Diseases 0.000 claims 5
- 206010015037 Epilepsy Diseases 0.000 claims 5
- 206010027599 Migraine Diseases 0.000 claims 5
- 208000008085 Migraine Disorders Diseases 0.000 claims 5
- 208000002193 Pain Diseases 0.000 claims 5
- 208000006011 Stroke Diseases 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 238000006467 substitution reaction Methods 0.000 claims 5
- 125000001544 thienyl group Chemical group 0.000 claims 5
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 4
- 206010052613 Allergic bronchitis Diseases 0.000 claims 4
- 206010002855 Anxiety Diseases 0.000 claims 4
- 206010057666 Anxiety disease Diseases 0.000 claims 4
- 206010003119 Arrhythmia Diseases 0.000 claims 4
- 206010066091 Bronchial hyperreactivity Diseases 0.000 claims 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
- 206010007521 Cardiac arrhythmias Diseases 0.000 claims 4
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 4
- 206010008129 Cerebral palsy Diseases 0.000 claims 4
- 208000000094 Chronic Pain Diseases 0.000 claims 4
- 206010010254 Concussion Diseases 0.000 claims 4
- 206010010904 Convulsion Diseases 0.000 claims 4
- 206010026749 Mania Diseases 0.000 claims 4
- 208000008238 Muscle Spasticity Diseases 0.000 claims 4
- 206010061533 Myotonia Diseases 0.000 claims 4
- 206010053643 Neurodegenerative disease Diseases 0.000 claims 4
- 206010033799 Paralysis Diseases 0.000 claims 4
- 206010061536 Parkinson's disease Diseases 0.000 claims 4
- 206010039085 Rhinitis allergic Diseases 0.000 claims 4
- 208000001319 Vasomotor Rhinitis Diseases 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 4
- 125000004414 alkyl thio group Chemical group 0.000 claims 4
- 201000010105 allergic rhinitis Diseases 0.000 claims 4
- 230000036506 anxiety Effects 0.000 claims 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 201000006474 brain ischemia Diseases 0.000 claims 4
- 230000036427 bronchial hyperreactivity Effects 0.000 claims 4
- 239000004044 bronchoconstricting agent Substances 0.000 claims 4
- 230000002741 bronchospastic Effects 0.000 claims 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 4
- 230000036461 convulsion Effects 0.000 claims 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 4
- 125000002541 furyl group Chemical group 0.000 claims 4
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 4
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 201000009457 movement disease Diseases 0.000 claims 4
- 230000000926 neurological Effects 0.000 claims 4
- 125000004076 pyridyl group Chemical group 0.000 claims 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 4
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 4
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 4
- 201000010874 syndrome Diseases 0.000 claims 4
- 206010002026 Amyotrophic lateral sclerosis Diseases 0.000 claims 3
- 206010010741 Conjunctivitis Diseases 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 125000003884 phenylalkyl group Chemical group 0.000 claims 3
- 125000000168 pyrrolyl group Chemical group 0.000 claims 3
- 125000003831 tetrazolyl group Chemical group 0.000 claims 3
- 125000000335 thiazolyl group Chemical group 0.000 claims 3
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 3
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 2
- 206010013663 Drug dependence Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- FDDDEECHVMSUSB-UHFFFAOYSA-N Sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 claims 2
- JSPLKZUTYZBBKA-UHFFFAOYSA-N Trioxidane Chemical compound OOO JSPLKZUTYZBBKA-UHFFFAOYSA-N 0.000 claims 2
- 125000005037 alkyl phenyl group Chemical group 0.000 claims 2
- 125000005466 alkylenyl group Chemical group 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000002047 benzodioxolyl group Chemical group O1OC(C2=C1C=CC=C2)* 0.000 claims 2
- 125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 2
- 125000005708 carbonyloxy group Chemical group [*:2]OC([*:1])=O 0.000 claims 2
- 201000006145 cocaine dependence Diseases 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000001893 nitrooxy group Chemical group [O-][N+](=O)O* 0.000 claims 2
- 125000002971 oxazolyl group Chemical group 0.000 claims 2
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 229960001663 sulfanilamide Drugs 0.000 claims 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-N sulfonic acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 claims 2
- 230000001225 therapeutic Effects 0.000 claims 2
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 2
- 125000000858 thiocyanato group Chemical group *SC#N 0.000 claims 2
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims 2
- 125000001425 triazolyl group Chemical group 0.000 claims 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 2
- 125000006730 (C2-C5) alkynyl group Chemical group 0.000 claims 1
- DNSISZSEWVHGLH-UHFFFAOYSA-N Butyramide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 claims 1
- JSLASWSJHUAUMT-UHFFFAOYSA-N C=1C=CC=CC=1S(=O)(=O)OC1=NN=NN1 Chemical compound C=1C=CC=CC=1S(=O)(=O)OC1=NN=NN1 JSLASWSJHUAUMT-UHFFFAOYSA-N 0.000 claims 1
- 206010008190 Cerebrovascular accident Diseases 0.000 claims 1
- 206010029331 Neuropathy peripheral Diseases 0.000 claims 1
- ZBYZQILPNKOESD-UHFFFAOYSA-N S=C=NOC#N Chemical compound S=C=NOC#N ZBYZQILPNKOESD-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004848 alkoxyethyl group Chemical group 0.000 claims 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 125000005110 aryl thio group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atoms Chemical group C* 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 125000005677 ethinylene group Chemical group [*:2]C#C[*:1] 0.000 claims 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims 1
- 125000000262 haloalkenyl group Chemical group 0.000 claims 1
- KPJPHPFMCOKUMW-UHFFFAOYSA-N iodomethane Chemical group I[CH2] KPJPHPFMCOKUMW-UHFFFAOYSA-N 0.000 claims 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- KAESVJOAVNADME-UHFFFAOYSA-N pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 125000005031 thiocyano group Chemical group S(C#N)* 0.000 claims 1
- 125000004205 trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims 1
Claims (39)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0004297.8 | 2000-02-23 | ||
GBGB0004297.8A GB0004297D0 (en) | 2000-02-23 | 2000-02-23 | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2005125645/04A Division RU2005125645A (en) | 2000-02-23 | 2005-08-12 | 2-OXO-1-pyrrolidine derivative and its use |
Publications (3)
Publication Number | Publication Date |
---|---|
RU2002124522A true RU2002124522A (en) | 2004-04-20 |
RU2291860C2 RU2291860C2 (en) | 2007-01-20 |
RU2291860C3 RU2291860C3 (en) | 2017-11-16 |
Family
ID=9886259
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2002124865/04A RU2292336C2 (en) | 2000-02-23 | 2001-02-21 | Derivatives of 2-oxo-1-pyrrolidine, methods for their preparing and using |
RU2002124522A RU2291860C3 (en) | 2000-02-23 | 2001-02-21 | DERIVATIVES 2-OXO-1-PYRROLIDINE, METHOD FOR THEIR PRODUCTION AND APPLICATION |
RU2006125756/04A RU2355680C2 (en) | 2000-02-23 | 2001-02-21 | 2-oxo-1-pyrrolidine derivatives, method of obtainment |
RU2005125569/04A RU2005125569A (en) | 2000-02-23 | 2005-08-11 | 2-OXO-1-pyrrolidine derivative and its use |
RU2005125645/04A RU2005125645A (en) | 2000-02-23 | 2005-08-12 | 2-OXO-1-pyrrolidine derivative and its use |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2002124865/04A RU2292336C2 (en) | 2000-02-23 | 2001-02-21 | Derivatives of 2-oxo-1-pyrrolidine, methods for their preparing and using |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2006125756/04A RU2355680C2 (en) | 2000-02-23 | 2001-02-21 | 2-oxo-1-pyrrolidine derivatives, method of obtainment |
RU2005125569/04A RU2005125569A (en) | 2000-02-23 | 2005-08-11 | 2-OXO-1-pyrrolidine derivative and its use |
RU2005125645/04A RU2005125645A (en) | 2000-02-23 | 2005-08-12 | 2-OXO-1-pyrrolidine derivative and its use |
Country Status (43)
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FR2961098A1 (en) | 2010-06-09 | 2011-12-16 | Oreal | COMPOSITION COMPRISING AT LEAST ONE 2-PYRROLIDONE FUNCTIONALIZED IN POSITION 4 BY A CARBOXYLIC OR AMIDE ACID, AND AT LEAST ONE DIRECT COLOR OR PIGMENT FOR DYING KERATIN FIBERS |
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2002
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2011
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2016
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