LV15614A - 2-(2-oxo-3-pyrolin-1-yl)acetamides as anticonvulsants - Google Patents

2-(2-oxo-3-pyrolin-1-yl)acetamides as anticonvulsants

Info

Publication number
LV15614A
LV15614A LVP-20-49A LVP2020000049A LV15614A LV 15614 A LV15614 A LV 15614A LV P2020000049 A LVP2020000049 A LV P2020000049A LV 15614 A LV15614 A LV 15614A
Authority
LV
Latvia
Prior art keywords
anticonvulsants
pyrolin
acetamides
oxo
eto
Prior art date
Application number
LVP-20-49A
Other languages
Latvian (lv)
Inventor
Līga ZVEJNIECE
Maija Dambrova
Baiba ŠVALBE
Edijs VĀVERS
Grigorijs Veinbergs
Maksims Vorona
Jevgēņijs KUZŅECOVS
Natalja ORLOVA
Ivars KALVIŅŠ
Original Assignee
Latvijas Organiskās Sintēzes Institūts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Latvijas Organiskās Sintēzes Institūts filed Critical Latvijas Organiskās Sintēzes Institūts
Priority to LVP-20-49A priority Critical patent/LV15614A/en
Priority to PCT/IB2021/055990 priority patent/WO2022023839A1/en
Priority to CA3183942A priority patent/CA3183942A1/en
Publication of LV15614A publication Critical patent/LV15614A/en
Priority to DKPA202270605A priority patent/DK202270605A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention refers to the acquisition of new acetamide with a formula (1a-c) and their use as anticonvulsants, where:a) R=Ph, R1=Me; b) R=Ph, R1=i-Pr; c) R=EtO, R1=Et.
LVP-20-49A 2020-07-30 2020-07-30 2-(2-oxo-3-pyrolin-1-yl)acetamides as anticonvulsants LV15614A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
LVP-20-49A LV15614A (en) 2020-07-30 2020-07-30 2-(2-oxo-3-pyrolin-1-yl)acetamides as anticonvulsants
PCT/IB2021/055990 WO2022023839A1 (en) 2020-07-30 2021-07-05 2-(2-oxo-3-pyrolin-1-yl)acetamides as anticonvulsants
CA3183942A CA3183942A1 (en) 2020-07-30 2021-07-05 2-(2-oxo-3-pyrolin-1-yl)acetamides as anticonvulsants
DKPA202270605A DK202270605A1 (en) 2020-07-30 2022-12-13 2-(2-oxo-3-pyrolin-1-yl)acetamides as anticonvulsants

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LVP-20-49A LV15614A (en) 2020-07-30 2020-07-30 2-(2-oxo-3-pyrolin-1-yl)acetamides as anticonvulsants

Publications (1)

Publication Number Publication Date
LV15614A true LV15614A (en) 2022-02-20

Family

ID=77021675

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-20-49A LV15614A (en) 2020-07-30 2020-07-30 2-(2-oxo-3-pyrolin-1-yl)acetamides as anticonvulsants

Country Status (4)

Country Link
CA (1) CA3183942A1 (en)
DK (1) DK202270605A1 (en)
LV (1) LV15614A (en)
WO (1) WO2022023839A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008132142A2 (en) * 2007-04-27 2008-11-06 Ucb Pharma S.A. New heterocyclic derivatives useful for the treatment of cns disorders

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0004297D0 (en) 2000-02-23 2000-04-12 Ucb Sa 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses
EP2147911A1 (en) 2008-07-24 2010-01-27 ZaCh System S.p.A. Process for the preparation of levetiracetam
CN102924357A (en) * 2011-08-09 2013-02-13 重庆圣华曦药业股份有限公司 Preparation method for oxiracetam intermediate
RU2480214C1 (en) * 2011-09-22 2013-04-27 Валентина Ивановна Ахапкина Formulation possessing modulatory activity with adequate effect, pharmaceutical substance (versions), use of pharmaceutical substance, pharmaceutical and parapharmaceutical composition (versions), method for preparing pharmaceutical formulations
PL3371150T3 (en) 2015-11-03 2022-01-17 UCB Biopharma SRL Process for preparing brivaracetam
US10556863B1 (en) * 2016-10-24 2020-02-11 Chongqing Ruzer Pharmaceutical Company Limited Crystalline form of (R)-4-hydroxy-2-oxo-1-pyrrolidineacetamide, preparation method therefor and use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008132142A2 (en) * 2007-04-27 2008-11-06 Ucb Pharma S.A. New heterocyclic derivatives useful for the treatment of cns disorders

Also Published As

Publication number Publication date
CA3183942A1 (en) 2022-02-03
DK202270605A1 (en) 2022-12-22
WO2022023839A1 (en) 2022-02-03

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