RU2001118542A - The method of obtaining substances using microorganisms - Google Patents

The method of obtaining substances using microorganisms

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Publication number
RU2001118542A
RU2001118542A RU2001118542/13A RU2001118542A RU2001118542A RU 2001118542 A RU2001118542 A RU 2001118542A RU 2001118542/13 A RU2001118542/13 A RU 2001118542/13A RU 2001118542 A RU2001118542 A RU 2001118542A RU 2001118542 A RU2001118542 A RU 2001118542A
Authority
RU
Russia
Prior art keywords
target substance
respiratory chain
obtaining
microorganism
substance according
Prior art date
Application number
RU2001118542/13A
Other languages
Russian (ru)
Other versions
RU2238325C2 (en
Inventor
Юта НАКАИ
Казуо НАКАНИСИ
Йосио КАВАХАРА
Хисао ИТО
Осаму КУРАХАСИ
Original Assignee
Адзиномото Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2000204252A external-priority patent/JP4380029B2/en
Application filed by Адзиномото Ко., Инк. filed Critical Адзиномото Ко., Инк.
Publication of RU2001118542A publication Critical patent/RU2001118542A/en
Application granted granted Critical
Publication of RU2238325C2 publication Critical patent/RU2238325C2/en

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Claims (9)

1. Способ получения целевого вещества с использованием микроорганизма, включающий стадии выращивания микроорганизма в среде для продуцирования и накопления целевого вещества в среде и сбора целевого вещества, где микроорганизм создан из родительского штамма микроорганизма, имеющего путь дыхательной цепи с высоким энергетическим выходом и путь дыхательной цепи с низким энергетическим выходом в качестве путей дыхательной цепи, и этот микроорганизм представляет собой мутантный штамм или штамм генетического рекомбинанта, имеющего одну или обе из следующих характеристик: (A) путь дыхательной цепи с высоким энергетическим выходом усилен, (B) путь дыхательной цепи с низким энергетическим выходом является дефицитным.1. The method of obtaining the target substance using a microorganism, comprising the steps of growing the microorganism in a medium for producing and accumulating the target substance in the medium and collecting the target substance, where the microorganism is created from a parent strain of the microorganism having a high energy output respiratory chain path and a respiratory chain path with low energy output as pathways of the respiratory chain, and this microorganism is a mutant strain or a strain of a genetic recombinant having one or both of the following characteristics: (A) the path of the respiratory chain with a high energy output is enhanced, (B) the path of the respiratory chain with a high energy output is scarce. 2. Способ получения целевого вещества по п. 1, где путь дыхательной цепи с высоким энергетическим выходом усилен путем увеличения копийности гена, кодирующего фермент, вовлеченный в дыхательную цепь, или модификации регулирующей экспрессию последовательности гена.2. The method of obtaining the target substance according to claim 1, where the pathway of the respiratory chain with a high energy yield is enhanced by increasing the copy number of the gene encoding the enzyme involved in the respiratory chain, or by modifying the expression of the gene sequence. 3. Способ получения целевого вещества по п. 1 или 2, где путь дыхательной цепи с низким энергетическим выходом сделан дефицитным путем разрушения гена, кодирующего фермент, вовлеченный в дыхательную цепь.3. The method of obtaining the target substance according to claim 1 or 2, where the path of the respiratory chain with a low energy output is made deficient by destroying the gene encoding the enzyme involved in the respiratory chain. 4. Способ получения целевого вещества по любому из пп. 1-3, где ферменты пути дыхательной цепи с высоким энергетическим выходом представляют собой SoxM-оксидазу, bcl-комплекс, NDH-1 или два или три вида из них.4. The method of obtaining the target substance according to any one of paragraphs. 1-3, where the enzymes of the pathway of the respiratory chain with a high energy yield are SoxM oxidase, bcl complex, NDH-1, or two or three of them. 5. Способ получения целевого вещества по любому из пп. 1-4, где ферменты пути дыхательной цепи с низким энергетическим выходом представляют собой цитохромоксидазу bd, NDH-II или обе из них.5. The method of obtaining the target substance according to any one of paragraphs. 1-4, where the enzymes of the respiratory chain path with a low energy output are cytochrome oxidase bd, NDH-II, or both of them. 6. Способ получения целевого вещества по любому из пп. 1-5, где в микроорганизме активность SoxM-оксидазы усилена, а NDH-II сделана дефицитной.6. The method of obtaining the target substance according to any one of paragraphs. 1-5, where in the microorganism the activity of SoxM oxidase is enhanced, and NDH-II is made deficient. 7. Способ получения целевого вещества по любому из пп. 1-6, где SoxM-оксидаза представляет собой цитохромоксидазу bo.7. The method of obtaining the target substance according to any one of paragraphs. 1-6, where SoxM oxidase is a cytochrome oxidase bo. 8. Способ получения целевого вещества по любому из пп. 1-7, где микроорганизм выбирают из группы, включающей бактерии, принадлежащие к роду Escherichia, и коринеформных бактерий.8. The method of obtaining the target substance according to any one of paragraphs. 1-7, where the microorganism is selected from the group comprising bacteria belonging to the genus Escherichia, and coryneform bacteria. 9. Способ получения целевого вещества по любому из пп. 1-8, где целевое вещество выбирают из группы, включающей L-аминокислоты и нуклеиновые кислоты.9. The method of obtaining the target substance according to any one of paragraphs. 1-8, where the target substance is selected from the group comprising L-amino acids and nucleic acids.
RU2001118542A 2000-07-05 2001-07-04 Method for preparing l-amino acid using microorganism RU2238325C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000204252A JP4380029B2 (en) 2000-07-05 2000-07-05 Manufacturing method of substances using microorganisms
JP2000-204252 2000-07-05

Publications (2)

Publication Number Publication Date
RU2001118542A true RU2001118542A (en) 2003-06-20
RU2238325C2 RU2238325C2 (en) 2004-10-20

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Country Status (16)

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US (2) US8586334B2 (en)
EP (2) EP1170376B1 (en)
JP (1) JP4380029B2 (en)
KR (1) KR100805644B1 (en)
CN (1) CN1280419C (en)
AT (2) ATE442453T1 (en)
AU (1) AU782560B2 (en)
BR (1) BRPI0102666B1 (en)
DE (2) DE60144205D1 (en)
DK (2) DK2067864T3 (en)
ES (2) ES2331601T3 (en)
MY (1) MY127434A (en)
PE (1) PE20020172A1 (en)
PL (1) PL206590B1 (en)
RU (1) RU2238325C2 (en)
TW (1) TWI238192B (en)

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