RU2001105186A - DIAGNOSTIC TESTS BASED ON TETRAZOLIA COMPOUNDS - Google Patents

DIAGNOSTIC TESTS BASED ON TETRAZOLIA COMPOUNDS

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Publication number
RU2001105186A
RU2001105186A RU2001105186/14A RU2001105186A RU2001105186A RU 2001105186 A RU2001105186 A RU 2001105186A RU 2001105186/14 A RU2001105186/14 A RU 2001105186/14A RU 2001105186 A RU2001105186 A RU 2001105186A RU 2001105186 A RU2001105186 A RU 2001105186A
Authority
RU
Russia
Prior art keywords
reagent
strip
analyte
flavin
test
Prior art date
Application number
RU2001105186/14A
Other languages
Russian (ru)
Other versions
RU2269784C2 (en
Inventor
Тианмей ОУЯНГ
Йеунг Сиу Ю
Original Assignee
Лайфскен, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/513,071 external-priority patent/US6656697B1/en
Application filed by Лайфскен, Инк. filed Critical Лайфскен, Инк.
Publication of RU2001105186A publication Critical patent/RU2001105186A/en
Application granted granted Critical
Publication of RU2269784C2 publication Critical patent/RU2269784C2/en

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Claims (22)

1. Реагент для измерения концентрации анализируемого вещества в биологической жидкости, содержащей гемоглобин, включающий в себя
a) флавин-зависимый фермент, который содержит связанный с ним флавин и обладает специфичностью в отношении анализируемого вещества,
b) предшественник тетразольного красителя,
c) агент, осуществляющий перенос электронов,
d) нитритную соль.1. The reagent for measuring the concentration of the analyte in the biological fluid containing hemoglobin, including
a) a flavin-dependent enzyme that contains a flavin associated with it and has specificity for the analyte,
b) a tetrazole dye precursor,
c) an electron transfer agent,
d) nitrite salt. 2. Реагент по п. 1, отличающийся тем, что анализируемое вещество является глюкозой, а фермент является глюкозооксидазой. 2. The reagent according to claim 1, characterized in that the analyte is glucose, and the enzyme is glucose oxidase. 3. Реагент по п. 1, отличающийся тем, что предшественник красителя растворим в воде. 3. The reagent according to claim 1, characterized in that the dye precursor is soluble in water. 4. Реагент по п. 1, отличающийся тем, что агент, осуществляющий перенос электронов, содержит метосульфат феназина (PMS) или его аналог. 4. The reagent according to claim 1, characterized in that the electron transfer agent contains phenazine methosulfate (PMS) or its analogue. 5. Реагент по п. 1, отличающийся тем, что кроме того содержит стабилизатор - двухвалентный металл. 5. The reagent according to claim 1, characterized in that in addition it contains a stabilizer - a divalent metal. 6. Реагент для измерения концентрации анализируемого вещества в биологической жидкости, содержащей гемоглобин, включающий в себя
а) флавин-зависимый фермент, который обладает специфичностью в отношении анализируемого вещества и не содержит связанный с ним флавин,
b) флавинмононуклеотид (FMN) или флавинадениндинуклеотид (FAD),
c) предшественник тетразольного красителя,
d) агент, осуществляющий перенос электронов, и
e) нитритную соль.6. A reagent for measuring the concentration of an analyte in a biological fluid containing hemoglobin, including
a) a flavin-dependent enzyme that has specificity for the analyte and does not contain flavin associated with it,
b) flavin mononucleotide (FMN) or flavin adenine dinucleotide (FAD),
c) tetrazole dye precursor,
d) an electron transfer agent, and
e) nitrite salt. 7. Реагент по п. 6, отличающийся тем, что предшественник красителя растворим в воде. 7. The reagent according to claim 6, characterized in that the dye precursor is soluble in water. 8. Реагент по п. 6, отличающийся тем, что агент, осуществляющий перенос электронов, включает в себя PMS или его аналог. 8. The reagent according to claim 6, characterized in that the electron transfer agent includes PMS or an analog thereof. 9. Реагент по п. 6, отличающийся тем, что кроме того содержит стабилизатор - двухвалентный металл. 9. The reagent according to claim 6, characterized in that in addition it contains a stabilizer - a divalent metal. 10. Сухая реагентная полоска для измерения концентрации анализируемого вещества в биологической жидкости, содержащей гемоглобин, заключающая в себе слой подложки, на котором находится тест-прокладка, имеющая покрытие из реагента по п. 1. 10. A dry reagent strip for measuring the concentration of an analyte in a biological fluid containing hemoglobin, which contains a layer of a substrate on which there is a test strip having a reagent coating according to claim 1. 11. Сухая реагентная полоска для измерения концентрации анализируемого вещества в биологической жидкости, содержащей гемоглобин, заключающая в себе слой подложки, на котором находится тест-прокладка, имеющая покрытие из реагента по п. 6. 11. A dry reagent strip for measuring the concentration of an analyte in a biological fluid containing hemoglobin, containing a layer of a substrate on which there is a test strip having a reagent coating according to claim 6. 12. Полоска по п. 10, отличающаяся тем, что тест-прокладка имеет положительно заряженную поверхность. 12. The strip according to claim 10, characterized in that the test strip has a positively charged surface. 13. Полоска по п. 10, отличающаяся тем, что тест-прокладка содержит полиамид. 13. The strip according to claim 10, characterized in that the test strip contains polyamide. 14. Полоска по п. 10, отличающаяся тем, что кроме того содержит впитывающий влагу верхний слой, покрывающий тест-прокладку. 14. The strip according to claim 10, characterized in that it also contains a moisture-absorbing top layer covering the test strip. 15. Сухая реагентная полоска для измерения концентрации анализируемого вещества в биологической жидкости, содержащей гемоглобин, заключающая в себе слой подложки, на котором находится тест-прокладка, и верхний слой, покрывающий тест-прокладку, в которой первая часть реагента по п. 1 находится на тест-прокладке, а вторая часть реагента находится на подложке и/или верхнем слое. 15. A dry reagent strip for measuring the concentration of an analyte in a biological fluid containing hemoglobin, comprising a substrate layer on which the test pad is located, and an upper layer covering the test pad, in which the first part of the reagent according to claim 1 is on test pad, and the second part of the reagent is on the substrate and / or the upper layer. 16. Сухая реагентная полоска для измерения концентрации анализируемого вещества в биологической жидкости, содержащей гемоглобин, заключающая в себе слой подложки, на котором находится тест-прокладка, и верхний слой, покрывающий тест-прокладку, в которой первая часть реагента по п. 6 находится на тест-прокладке, а вторая часть реагента находится на подложке и/или верхнем слое. 16. A dry reagent strip for measuring the concentration of the analyte in a biological fluid containing hemoglobin, comprising a substrate layer on which the test pad is located, and an upper layer covering the test pad, in which the first part of the reagent according to claim 6 is on test pad, and the second part of the reagent is on the substrate and / or the upper layer. 17. Полоска по п. 15, отличающаяся тем, что верхний слой является впитывающим влагу. 17. The strip according to claim 15, characterized in that the top layer is absorbent. 18. Полоска по п. 15, отличающаяся тем, что кроме того содержит промежуточную пластинку и канал между верхним слоем и тест-прокладкой, чтобы обеспечить капиллярный путь между верхним слоем и прокладкой. 18. The strip according to p. 15, characterized in that it further comprises an intermediate plate and a channel between the upper layer and the test gasket to provide a capillary path between the upper layer and the gasket. 19. Полоска по п. 15, отличающаяся тем, что анализируемое вещество является глюкозой, а фермент является глюкозооксидазой. 19. The strip of claim 15, wherein the analyte is glucose and the enzyme is glucose oxidase. 20. Полоска по п. 15, отличающаяся тем, что предшественник тетразольного красителя представляет собой динатриевую соль 2,2'-дибензотиазолил-5,5'-бис[4-ди(2-сульфоэтил)-карбамоилфенил] -3,3'-(3,3'-диметокси-4,4'-бифенилен)дитетразолия (WST-5). 20. The strip of claim 15, wherein the tetrazole dye precursor is the disodium salt of 2,2'-dibenzothiazolyl-5,5'-bis [4-di (2-sulfoethyl) -carbamoylphenyl] -3,3'- (3,3'-dimethoxy-4,4'-biphenylene) ditetrazolium (WST-5). 21. Сухая реагентная тест-полоска для измерения концентрации глюкозы в биологической жидкости, содержащей гемоглобин, содержащая
a) слой подложки,
b) на слое подложки тест-прокладку, имеющую покрытие, которое включает в себя
i) глюкозооксидазу, которая содержит связанный с ней флавин,
ii) предшественник тетразольного красителя, и
iii) PMS или его аналог, и
c) на тест-прокладке впитывающий влагу верхний слой, который покрыт нитритной солью.21. Dry reagent test strip for measuring the concentration of glucose in a biological fluid containing hemoglobin containing
a) a substrate layer,
b) on a substrate layer, a test pad having a coating that includes
i) glucose oxidase, which contains the associated flavin,
ii) a tetrazole dye precursor, and
iii) PMS or its equivalent, and
c) on the test pad, a moisture-absorbing top layer that is coated with nitrite salt. 22. Сухая реагентная тест-полоска для измерения концентрации глюкозы в биологической жидкости, содержащей гемоглобин, содержащая
a) слой подложки,
b) на слое подложки тест-прокладку, имеющую покрытие, которое включает в себя
i) флавинзависимый фермент, который не содержит связанный с ним флавин,
ii) FMN или FAD,
iii) предшественник тетраэольного красителя, и
iv) PMS или его аналог, и
c) на тест-прокладке впитывающий влагу верхний слой, который покрыт нитритной солью.22. Dry reagent test strip for measuring the concentration of glucose in a biological fluid containing hemoglobin containing
a) a substrate layer,
b) on a substrate layer, a test pad having a coating that includes
i) a flavin-dependent enzyme that does not contain an associated flavin,
ii) FMN or FAD,
iii) a tetraeol dye precursor, and
iv) PMS or its equivalent, and
c) on the test pad, a moisture-absorbing top layer that is coated with nitrite salt.
RU2001105186/15A 2000-02-25 2001-02-23 Diagnostic tests based on tetrazolium compounds RU2269784C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/513,071 2000-02-25
US09/513,071 US6656697B1 (en) 1998-09-28 2000-02-25 Diagnostics based on tetrazolium compounds

Publications (2)

Publication Number Publication Date
RU2001105186A true RU2001105186A (en) 2002-12-20
RU2269784C2 RU2269784C2 (en) 2006-02-10

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US (3) US6656697B1 (en)
EP (1) EP1130111B1 (en)
JP (1) JP2001292795A (en)
KR (1) KR20010085564A (en)
CN (1) CN1214117C (en)
AR (1) AR027544A1 (en)
AT (1) ATE278804T1 (en)
AU (1) AU782774B2 (en)
BR (1) BR0102467A (en)
CA (1) CA2337562A1 (en)
DE (1) DE60106110T2 (en)
DK (1) DK1130111T3 (en)
ES (1) ES2230240T3 (en)
HK (1) HK1038772A1 (en)
IL (1) IL141580A0 (en)
MX (1) MXPA01002062A (en)
MY (1) MY134005A (en)
NO (1) NO20010939L (en)
PT (1) PT1130111E (en)
RU (1) RU2269784C2 (en)
SG (1) SG100621A1 (en)
ZA (1) ZA200101543B (en)

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