RU2001105086A - Новые пептиды для применения в иммунотерапии аутоиммунных заболеваний - Google Patents
Новые пептиды для применения в иммунотерапии аутоиммунных заболеванийInfo
- Publication number
- RU2001105086A RU2001105086A RU2001105086/04A RU2001105086A RU2001105086A RU 2001105086 A RU2001105086 A RU 2001105086A RU 2001105086/04 A RU2001105086/04 A RU 2001105086/04A RU 2001105086 A RU2001105086 A RU 2001105086A RU 2001105086 A RU2001105086 A RU 2001105086A
- Authority
- RU
- Russia
- Prior art keywords
- amino acid
- acid sequence
- seq
- autoimmune diseases
- immunotherapy
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 4
- 208000023275 Autoimmune disease Diseases 0.000 title claims 3
- 238000009169 immunotherapy Methods 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Rehabilitation Therapy (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Claims (7)
1. Пептид, обладающий аминокислотной последовательностью из 9-55 аминокислотных остатков, включающий в себя аминокислотную последовательность FTLASAETT (SEQ ID NO:1).
2. Пептид по п.1, включающий в себя аминокислотную последовательность HSFTLASAETTVG (SEQ ID NO:2).
3. Пептид по п.1 или 2, имеющий аминокислотную последовательность до 25 аминокислотных остатков.
4. Пептид по п.1 или 2, имеющий аминокислотную последовательность FTLASAETT (SEQ ID NO:1) или HSFTLASAETTVG (SEQ ID NO:2).
5. Пептиды по любому из пп.1-4 для применения в качестве терапевтического вещества.
6. Фармацевтическая композиция для лечения аутоиммунных заболеваний, содержащая один или более пептидов по пп.1-4 и фармацевтически приемлемый носитель.
7. Пептиды по пп.1-4 для получения фармацевтического препарата для индукции специфической толерантности Т-клеток к аутоантигену у больных, страдающих от аутоиммунных нарушений, более конкретно, артрита.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98202470.5 | 1998-07-23 | ||
| EP98202470 | 1998-07-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2001105086A true RU2001105086A (ru) | 2004-01-20 |
| RU2233290C2 RU2233290C2 (ru) | 2004-07-27 |
Family
ID=8233961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2001105086/04A RU2233290C2 (ru) | 1998-07-23 | 1999-07-16 | Новые пептиды для применения в иммунотерапии аутоиммунных заболеваний |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6964766B1 (ru) |
| EP (1) | EP1100823A2 (ru) |
| JP (1) | JP2002521388A (ru) |
| KR (1) | KR20010071020A (ru) |
| CN (1) | CN1310724A (ru) |
| AU (1) | AU758310B2 (ru) |
| BR (1) | BR9912378A (ru) |
| CA (1) | CA2334947A1 (ru) |
| CO (1) | CO5090903A1 (ru) |
| CZ (1) | CZ2001286A3 (ru) |
| HU (1) | HUP0103384A3 (ru) |
| ID (1) | ID27998A (ru) |
| IL (1) | IL140825A0 (ru) |
| NO (1) | NO20010355L (ru) |
| NZ (1) | NZ509417A (ru) |
| PE (1) | PE20000931A1 (ru) |
| PL (1) | PL345958A1 (ru) |
| RU (1) | RU2233290C2 (ru) |
| SK (1) | SK1042001A3 (ru) |
| TR (1) | TR200100175T2 (ru) |
| WO (1) | WO2000005254A2 (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7265208B2 (en) | 2001-05-01 | 2007-09-04 | The Regents Of The University Of California | Fusion molecules and treatment of IgE-mediated allergic diseases |
| BR0211468A (pt) | 2001-07-24 | 2004-11-23 | Univ Yale | Métodos de tratar e de prevenir uma doença inflamátoria em um mamìfero e de identificar um composto útil para tratar uma doença inflamatória em um mamìfero, composto, e kits para tratar e para prevenir uma doença inflamatória em um mamìfero |
| CN1169829C (zh) | 2002-06-27 | 2004-10-06 | 北京大学人民医院 | 非t细胞结合肽及其用途 |
| RU2667423C1 (ru) * | 2017-06-28 | 2018-09-19 | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "ПраймБиоМед" | Мышиная гибридома ykl-39, клон 1b2 g4 - продуцент моноклонального антитела, обладающего специфичностью к цитоплазматическому антигену ykl-39 человека |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL115744A (en) * | 1994-10-27 | 2000-07-16 | Akzo Nobel Nv | Peptides comprising a subsequence of human cartilage glycoprotein - 39 |
| TW575583B (en) * | 1996-04-24 | 2004-02-11 | Akzo Nobel Nv | Novel peptides suitable for use in antigen specific immunosuppressive therapy |
| EP0805206A3 (en) * | 1996-05-03 | 1999-09-15 | Smithkline Beecham Corporation | Human cartilage glycoprotein |
| AU6693996A (en) * | 1996-08-09 | 1998-03-06 | Human Genome Sciences, Inc. | Human chitinase alpha and chitinase alpha-2 |
-
1999
- 1999-07-16 JP JP2000561210A patent/JP2002521388A/ja not_active Withdrawn
- 1999-07-16 PL PL99345958A patent/PL345958A1/xx not_active Application Discontinuation
- 1999-07-16 US US09/744,170 patent/US6964766B1/en not_active Expired - Fee Related
- 1999-07-16 EP EP99940012A patent/EP1100823A2/en not_active Withdrawn
- 1999-07-16 HU HU0103384A patent/HUP0103384A3/hu unknown
- 1999-07-16 NZ NZ509417A patent/NZ509417A/xx unknown
- 1999-07-16 WO PCT/EP1999/005050 patent/WO2000005254A2/en not_active Application Discontinuation
- 1999-07-16 IL IL14082599A patent/IL140825A0/xx unknown
- 1999-07-16 CN CN99808862A patent/CN1310724A/zh active Pending
- 1999-07-16 AU AU54112/99A patent/AU758310B2/en not_active Ceased
- 1999-07-16 SK SK104-2001A patent/SK1042001A3/sk unknown
- 1999-07-16 RU RU2001105086/04A patent/RU2233290C2/ru not_active IP Right Cessation
- 1999-07-16 BR BR9912378-9A patent/BR9912378A/pt not_active IP Right Cessation
- 1999-07-16 CZ CZ2001286A patent/CZ2001286A3/cs unknown
- 1999-07-16 ID IDW20010192A patent/ID27998A/id unknown
- 1999-07-16 KR KR1020017000992A patent/KR20010071020A/ko not_active Application Discontinuation
- 1999-07-16 TR TR2001/00175T patent/TR200100175T2/xx unknown
- 1999-07-16 CA CA002334947A patent/CA2334947A1/en not_active Abandoned
- 1999-07-21 PE PE1999000730A patent/PE20000931A1/es not_active Application Discontinuation
- 1999-07-22 CO CO99046229A patent/CO5090903A1/es unknown
-
2001
- 2001-01-22 NO NO20010355A patent/NO20010355L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TR200100175T2 (tr) | 2001-09-21 |
| AU5411299A (en) | 2000-02-14 |
| NO20010355L (no) | 2001-03-20 |
| JP2002521388A (ja) | 2002-07-16 |
| BR9912378A (pt) | 2001-04-17 |
| CN1310724A (zh) | 2001-08-29 |
| CA2334947A1 (en) | 2000-02-03 |
| KR20010071020A (ko) | 2001-07-28 |
| EP1100823A2 (en) | 2001-05-23 |
| CZ2001286A3 (en) | 2001-08-15 |
| SK1042001A3 (en) | 2001-09-11 |
| AU758310B2 (en) | 2003-03-20 |
| US6964766B1 (en) | 2005-11-15 |
| RU2233290C2 (ru) | 2004-07-27 |
| PL345958A1 (en) | 2002-01-14 |
| ID27998A (id) | 2001-05-03 |
| CO5090903A1 (es) | 2001-10-30 |
| IL140825A0 (en) | 2002-02-10 |
| WO2000005254A2 (en) | 2000-02-03 |
| NZ509417A (en) | 2003-03-28 |
| WO2000005254A3 (en) | 2000-06-15 |
| HUP0103384A3 (en) | 2004-06-28 |
| NO20010355D0 (no) | 2001-01-22 |
| PE20000931A1 (es) | 2000-09-16 |
| HUP0103384A2 (hu) | 2001-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20050717 |