RS56757B1 - Postupci davanja i procene lekova za uklanjanje azota za lečenje hepatične encefalopatije - Google Patents
Postupci davanja i procene lekova za uklanjanje azota za lečenje hepatične encefalopatijeInfo
- Publication number
- RS56757B1 RS56757B1 RS20180035A RSP20180035A RS56757B1 RS 56757 B1 RS56757 B1 RS 56757B1 RS 20180035 A RS20180035 A RS 20180035A RS P20180035 A RSP20180035 A RS P20180035A RS 56757 B1 RS56757 B1 RS 56757B1
- Authority
- RS
- Serbia
- Prior art keywords
- administering
- treatment
- methods
- hepatic encephalopathy
- nitrogen scavenging
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4925—Blood measuring blood gas content, e.g. O2, CO2, HCO3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Ecology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261728967P | 2012-11-21 | 2012-11-21 | |
US201361759292P | 2013-01-31 | 2013-01-31 | |
EP13857455.3A EP2922576B1 (en) | 2012-11-21 | 2013-11-21 | Methods of administering and evaluating nitrogen scavenging drugs for the treatment of hepatic encephalopathy |
PCT/US2013/071333 WO2014081977A1 (en) | 2012-11-21 | 2013-11-21 | Methods of administering and evaluating nitrogen scavenging drugs for the treatment of hepatic encephalopathy |
Publications (1)
Publication Number | Publication Date |
---|---|
RS56757B1 true RS56757B1 (sr) | 2018-04-30 |
Family
ID=50728524
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RS20180035A RS56757B1 (sr) | 2012-11-21 | 2013-11-21 | Postupci davanja i procene lekova za uklanjanje azota za lečenje hepatične encefalopatije |
Country Status (20)
Country | Link |
---|---|
US (3) | US9289406B2 (sr) |
EP (2) | EP3335735A1 (sr) |
JP (1) | JP2016506378A (sr) |
KR (1) | KR20150086510A (sr) |
CN (1) | CN104797272A (sr) |
AU (1) | AU2013347905B2 (sr) |
BR (1) | BR112015011778A2 (sr) |
CA (1) | CA2891657A1 (sr) |
CY (1) | CY1120163T1 (sr) |
DK (1) | DK2922576T3 (sr) |
ES (1) | ES2654774T3 (sr) |
HK (2) | HK1210699A1 (sr) |
HR (1) | HRP20180041T1 (sr) |
HU (1) | HUE036133T2 (sr) |
LT (1) | LT2922576T (sr) |
PL (1) | PL2922576T3 (sr) |
PT (1) | PT2922576T (sr) |
RS (1) | RS56757B1 (sr) |
SI (1) | SI2922576T1 (sr) |
WO (1) | WO2014081977A1 (sr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG174982A1 (en) | 2009-04-03 | 2011-11-28 | Ocera Therapeutics Inc | L-ornithine phenyl acetate and methods of making thereof |
ES2517340T3 (es) | 2009-06-08 | 2014-11-03 | Ucl Business Plc | Tratamiento de la hipertensión portal usando L-ornitina y fenilacetato |
ES2629859T3 (es) | 2011-09-30 | 2017-08-16 | Horizon Therapeutics, Llc | Fármacos para eliminar nitrógeno para su uso en un procedimiento para tratar un trastorno de retención de nitrógeno |
CN104540507A (zh) | 2012-04-20 | 2015-04-22 | 海波龙治疗公司 | 苯乙酸前药的治疗性监测方法 |
LT2922576T (lt) * | 2012-11-21 | 2018-02-12 | Horizon Therapeutics, Llc | Azotą surišančių vaistų, skirtų kepenų encefalopatijos gydymui, skyrimo ir įvertinimo būdai |
KR20230018526A (ko) | 2014-11-24 | 2023-02-07 | 유씨엘 비즈니스 리미티드 | 암모니아-저감 치료를 이용한 간성상세포 활성화와 연관된 질병의 치료 |
CA2995823A1 (en) | 2015-08-18 | 2017-02-23 | Ocera Therapeutics, Inc. | Treatment and prevention of muscle loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
US9914692B2 (en) | 2016-05-25 | 2018-03-13 | Horizon Therapeutics, Llc | Procedure for the preparation of 4-phenyl butyrate and uses thereof |
KR20200024145A (ko) | 2017-05-11 | 2020-03-06 | 오세라 테라퓨틱스, 아이엔씨. | L-오르니틴 페닐아세테이트의 제조방법 |
US10668040B2 (en) | 2017-09-11 | 2020-06-02 | Horizon Therapeutics, Llc | Treatment of urea cycle disorders in neonates and infants |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4284647A (en) | 1980-03-31 | 1981-08-18 | The Johns Hopkins University | Process for waste nitrogen removal |
US4457942A (en) | 1982-08-20 | 1984-07-03 | Brusilow Saul W | Process for waste nitrogen removal |
US5635532A (en) | 1991-10-21 | 1997-06-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Compositions and methods for therapy and prevention of pathologies including cancer, AIDS and anemia |
US5879657A (en) | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
DE69612755T2 (de) | 1995-02-07 | 2001-08-23 | Brusilow Entpr Llc | Triglyceride und ethylester von phenylalkansäuren und phenylalkensäuren zur behandlung verschiedener erkrankungen |
US6219567B1 (en) | 1999-06-21 | 2001-04-17 | Cardiox Corporation | Monitoring of total ammoniacal concentration in blood |
US20030195255A1 (en) | 2002-04-12 | 2003-10-16 | Summar Marshall L. | Method for treating hepatic encephalopathies |
US20040229948A1 (en) * | 2002-04-12 | 2004-11-18 | Summar Marshall L. | Method for preventing hepatic encephalopathic episodes |
US20050273359A1 (en) | 2004-06-03 | 2005-12-08 | Young David E | System and method of evaluating preoperative medical care and determining recommended tests based on patient health history and medical condition and nature of surgical procedure |
CN1778963A (zh) * | 2004-11-23 | 2006-05-31 | 苏州艾杰生物科技有限公司 | 血氨含量测定方法及血氨诊断试剂盒 |
ES2537974T3 (es) | 2004-11-26 | 2015-06-16 | Ucl Business Plc | Composiciones que comprenden ornitina y fenilacetato o fenilbutirato para el tratamiento de la encefalopatía hepática |
US20060135612A1 (en) | 2004-12-17 | 2006-06-22 | U.S. Department Of Veterans Affairs | Method of ameliorating or abrogating the effects of a neurodegenerative disorder, such as amyotrophic lateral sclerosis (ALS), by using a HDAC inhibiting agent |
US20070004805A1 (en) | 2005-07-01 | 2007-01-04 | Navinta Llc | Process for preparation of liquid dosage form containing sodium 4-phenylbutyrate |
WO2007059031A2 (en) | 2005-11-10 | 2007-05-24 | Massachusetts Institute Of Technology | Methods and compositions for raising levels and release of gamma aminobutyric acid |
US8094521B2 (en) | 2007-02-28 | 2012-01-10 | Nightingale Products LLC | Caregiver personal alert device |
CA2711807A1 (en) | 2008-01-08 | 2009-07-16 | Akthelia Pharmaceuticals | Agonists for antimicrobial peptide systems |
PL3133396T3 (pl) | 2008-04-29 | 2019-03-29 | Horizon Therapeutics, Llc | Sposób leczenia z zastosowaniem leków wychwytujących amoniak |
WO2010025303A1 (en) | 2008-08-29 | 2010-03-04 | Hyperion Therapeutics | Dosing and monitoring patients on nitrogen-scavenging drugs |
ES2695534T3 (es) * | 2008-08-29 | 2019-01-08 | Horizon Therapeutics Llc | Métodos de tratamiento usando fármacos de captación de amoniaco |
WO2011011781A1 (en) | 2009-07-24 | 2011-01-27 | Baylor College Of Medicine | Methods of modulation of branched chain acids and uses thereof |
JP6049619B2 (ja) | 2010-08-31 | 2016-12-21 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | ナノヒドロキシアパタイトを含む多孔質多糖足場、及び骨形成のための使用 |
ES2629859T3 (es) * | 2011-09-30 | 2017-08-16 | Horizon Therapeutics, Llc | Fármacos para eliminar nitrógeno para su uso en un procedimiento para tratar un trastorno de retención de nitrógeno |
CN104540507A (zh) * | 2012-04-20 | 2015-04-22 | 海波龙治疗公司 | 苯乙酸前药的治疗性监测方法 |
LT2922576T (lt) * | 2012-11-21 | 2018-02-12 | Horizon Therapeutics, Llc | Azotą surišančių vaistų, skirtų kepenų encefalopatijos gydymui, skyrimo ir įvertinimo būdai |
WO2015048818A1 (en) | 2013-09-30 | 2015-04-02 | Hyperion Therapeutics, Inc. | Diagnosing, grading, monitoring, and treating hepatic encephalopathy |
RS59429B1 (sr) | 2013-10-14 | 2019-11-29 | Immedica Pharma Ab | Postupci tretmana poremećaja ciklusa uree |
-
2013
- 2013-11-21 LT LTEP13857455.3T patent/LT2922576T/lt unknown
- 2013-11-21 PL PL13857455T patent/PL2922576T3/pl unknown
- 2013-11-21 AU AU2013347905A patent/AU2013347905B2/en not_active Ceased
- 2013-11-21 HU HUE13857455A patent/HUE036133T2/hu unknown
- 2013-11-21 EP EP17200153.9A patent/EP3335735A1/en not_active Withdrawn
- 2013-11-21 KR KR1020157016078A patent/KR20150086510A/ko not_active Application Discontinuation
- 2013-11-21 CN CN201380061003.XA patent/CN104797272A/zh active Pending
- 2013-11-21 JP JP2015544137A patent/JP2016506378A/ja active Pending
- 2013-11-21 BR BR112015011778A patent/BR112015011778A2/pt not_active IP Right Cessation
- 2013-11-21 ES ES13857455.3T patent/ES2654774T3/es active Active
- 2013-11-21 EP EP13857455.3A patent/EP2922576B1/en active Active
- 2013-11-21 PT PT138574553T patent/PT2922576T/pt unknown
- 2013-11-21 WO PCT/US2013/071333 patent/WO2014081977A1/en active Application Filing
- 2013-11-21 SI SI201330898T patent/SI2922576T1/en unknown
- 2013-11-21 RS RS20180035A patent/RS56757B1/sr unknown
- 2013-11-21 DK DK13857455.3T patent/DK2922576T3/en active
- 2013-11-21 CA CA2891657A patent/CA2891657A1/en not_active Withdrawn
- 2013-11-21 US US14/086,870 patent/US9289406B2/en active Active
-
2015
- 2015-11-19 HK HK15111438.0A patent/HK1210699A1/xx unknown
-
2016
- 2016-02-15 US US15/043,859 patent/US20160223520A1/en not_active Abandoned
- 2016-02-18 HK HK16101726.1A patent/HK1213778A1/zh not_active IP Right Cessation
-
2017
- 2017-08-08 US US15/672,196 patent/US20180017546A1/en not_active Abandoned
-
2018
- 2018-01-09 HR HRP20180041TT patent/HRP20180041T1/hr unknown
- 2018-01-25 CY CY20181100103T patent/CY1120163T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US20160223520A1 (en) | 2016-08-04 |
BR112015011778A2 (pt) | 2017-07-11 |
PT2922576T (pt) | 2018-01-24 |
AU2013347905A1 (en) | 2015-04-30 |
SI2922576T1 (en) | 2018-04-30 |
KR20150086510A (ko) | 2015-07-28 |
HUE036133T2 (hu) | 2018-06-28 |
PL2922576T3 (pl) | 2018-08-31 |
CA2891657A1 (en) | 2014-05-30 |
US9289406B2 (en) | 2016-03-22 |
JP2016506378A (ja) | 2016-03-03 |
CN104797272A (zh) | 2015-07-22 |
US20180017546A1 (en) | 2018-01-18 |
EP2922576A4 (en) | 2016-05-04 |
AU2013347905B2 (en) | 2018-10-04 |
HK1213778A1 (zh) | 2016-07-15 |
HK1210699A1 (en) | 2016-05-06 |
EP2922576A1 (en) | 2015-09-30 |
CY1120163T1 (el) | 2018-12-12 |
LT2922576T (lt) | 2018-02-12 |
HRP20180041T1 (hr) | 2018-06-01 |
US20140142186A1 (en) | 2014-05-22 |
EP3335735A1 (en) | 2018-06-20 |
WO2014081977A1 (en) | 2014-05-30 |
ES2654774T3 (es) | 2018-02-15 |
DK2922576T3 (en) | 2018-01-15 |
EP2922576B1 (en) | 2017-11-08 |
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