RS50580B - Novi inhibitori enzima zavisnih od folne kiseline - Google Patents
Novi inhibitori enzima zavisnih od folne kiselineInfo
- Publication number
- RS50580B RS50580B RSP-2008/0231A RSP20080231A RS50580B RS 50580 B RS50580 B RS 50580B RS P20080231 A RSP20080231 A RS P20080231A RS 50580 B RS50580 B RS 50580B
- Authority
- RS
- Serbia
- Prior art keywords
- folic acid
- dependent enzymes
- novel inhibitors
- alkyl
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Jedinjenje formule I, ili njena farmaceutski prihvatljiva so: u kojoj je: Z = O ili S; n= 1-3;R3= -CO2R8, -C(O)SR8, -C(O)NHR8, -C(S)OR8, -C(S)SR8, -C(S)NHR8, -C(NH)SR8 ili -C(NH)NHR8,gde je R8 -H ili alkil;R4 = -H, -CH2R5 ili -CH2CH2R5,gde R5 svaki za sebe ima jedno od značenja za R3;B = -NR2-, -CH2NR2-, -CH2CH2NR2-, -CH2CHR7- ili -CH2O-,gde je R2 H ili C1-3 alkil, alkenil ili alkinil grupa, iR7 je H ili C1-3 alkil ili alkoksi grupa;A= u kojoj je R1 = -NH2 ili -OH,C i D su svaki za sebe nezavisno, 5- ili 6-očlani, supstituisani ili nesupstituisani, aromatični ili nearomatični prsten koji može takodje da sadrži jedan ili više heteroatoma, i gde je C povezan za grupu B u bilo kojem od raspoloživih položaja. Prijava sadrži još 28 zavisnih patentnih zahteva.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05107582A EP1754484A1 (en) | 2005-08-17 | 2005-08-17 | Condensed pyrimidine derivatives as inhibitors of foic acid-dependent enzymes |
| PCT/EP2006/065380 WO2007020277A2 (en) | 2005-08-17 | 2006-08-16 | Condensed pyrimidine derivatives as inhibitors of foic acid-dependent enzymes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS50580B true RS50580B (sr) | 2010-05-07 |
Family
ID=35501134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RSP-2008/0231A RS50580B (sr) | 2005-08-17 | 2006-08-16 | Novi inhibitori enzima zavisnih od folne kiseline |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US7718660B2 (sr) |
| EP (2) | EP1754484A1 (sr) |
| JP (2) | JP4637911B2 (sr) |
| AT (1) | ATE395918T1 (sr) |
| AU (1) | AU2006281359B2 (sr) |
| CA (1) | CA2583437C (sr) |
| CY (1) | CY1108237T1 (sr) |
| DE (1) | DE602006001291D1 (sr) |
| DK (1) | DK1809292T3 (sr) |
| ES (1) | ES2308749T3 (sr) |
| HR (1) | HRP20080194T3 (sr) |
| NZ (1) | NZ553911A (sr) |
| PL (1) | PL1809292T3 (sr) |
| PT (1) | PT1809292E (sr) |
| RS (1) | RS50580B (sr) |
| SI (1) | SI1809292T1 (sr) |
| WO (1) | WO2007020277A2 (sr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1754484A1 (en) * | 2005-08-17 | 2007-02-21 | Dan Stoicescu | Condensed pyrimidine derivatives as inhibitors of foic acid-dependent enzymes |
| EP1958632A1 (en) | 2007-02-14 | 2008-08-20 | Dan Stoicescu | Use of condensed pyrimidine derivatives for the treatment of autoimmune and inflammatory diseases |
| JP2013510163A (ja) | 2009-11-06 | 2013-03-21 | チェルシー・セラピューティクス，インコーポレイテッド | 酵素阻害化合物 |
| CN103755706B (zh) * | 2014-02-11 | 2015-08-12 | 新发药业有限公司 | 一种合成叶酸的环保制备方法 |
| CN103896945B (zh) * | 2014-03-11 | 2015-07-01 | 新发药业有限公司 | 一种简便的叶酸环保生产方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2512572A (en) * | 1950-06-20 | Substituted pteridines and method | ||
| US2522572A (en) | 1947-01-30 | 1950-09-19 | Machlett Lab Inc | Cable terminal |
| US4079056A (en) | 1975-03-31 | 1978-03-14 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Method of making pteridine compounds |
| CH630380A5 (de) | 1977-08-12 | 1982-06-15 | Lonza Ag | Verfahren zur herstellung von l-methotrexat. |
| GB2070607A (en) * | 1980-03-04 | 1981-09-09 | Sandoz Ltd | 1-(3,5- Ditrifluoromethylphenyl)-5- phenyl-1,2,3-triazole derivatives useful as plant growth regulating agents |
| US4684653A (en) | 1985-03-08 | 1987-08-04 | The Trustees Of Princeton University | Pyrido(2,3-d)pyrimidine derivatives |
| JPS63218666A (ja) * | 1987-03-09 | 1988-09-12 | Mitsubishi Kasei Corp | ピリダジノン誘導体またはその塩類 |
| KR0162654B1 (ko) | 1989-12-11 | 1998-11-16 | 알렌 제이. 시니스갤리 | N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체 |
| GB9013615D0 (en) * | 1990-06-19 | 1990-08-08 | Wellcome Found | Pharmaceutical compounds |
| US5698556A (en) * | 1995-06-07 | 1997-12-16 | Chan; Carcy L. | Methotrexate analogs and methods of using same |
| US20060083681A1 (en) * | 2004-10-18 | 2006-04-20 | Ajay Purohit | Compounds for myocardial perfusion imaging |
| DE102004057594A1 (de) * | 2004-11-29 | 2006-06-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substitueirte Pteridine zur Behandlung von entzündlichen Erkrankungen |
| EP1754484A1 (en) | 2005-08-17 | 2007-02-21 | Dan Stoicescu | Condensed pyrimidine derivatives as inhibitors of foic acid-dependent enzymes |
| CA2652840C (en) * | 2006-05-24 | 2014-09-09 | Boehringer Ingelheim International Gmbh | 2-piperazino-6-chloro-pteridines as pde4-inhibitors for the treatment of inflammatory diseases |
| EP1958632A1 (en) * | 2007-02-14 | 2008-08-20 | Dan Stoicescu | Use of condensed pyrimidine derivatives for the treatment of autoimmune and inflammatory diseases |
-
2005
- 2005-08-17 EP EP05107582A patent/EP1754484A1/en not_active Withdrawn
-
2006
- 2006-08-16 PL PL06792859T patent/PL1809292T3/pl unknown
- 2006-08-16 DE DE602006001291T patent/DE602006001291D1/de active Active
- 2006-08-16 AU AU2006281359A patent/AU2006281359B2/en not_active Ceased
- 2006-08-16 RS RSP-2008/0231A patent/RS50580B/sr unknown
- 2006-08-16 WO PCT/EP2006/065380 patent/WO2007020277A2/en active Application Filing
- 2006-08-16 PT PT06792859T patent/PT1809292E/pt unknown
- 2006-08-16 EP EP06792859A patent/EP1809292B1/en active Active
- 2006-08-16 ES ES06792859T patent/ES2308749T3/es active Active
- 2006-08-16 JP JP2007531773A patent/JP4637911B2/ja not_active Expired - Fee Related
- 2006-08-16 AT AT06792859T patent/ATE395918T1/de active
- 2006-08-16 DK DK06792859T patent/DK1809292T3/da active
- 2006-08-16 SI SI200630033T patent/SI1809292T1/sl unknown
- 2006-08-16 US US11/663,567 patent/US7718660B2/en not_active Expired - Fee Related
- 2006-08-16 NZ NZ553911A patent/NZ553911A/en not_active IP Right Cessation
- 2006-08-16 CA CA2583437A patent/CA2583437C/en not_active Expired - Fee Related
-
2008
- 2008-04-07 US US12/080,842 patent/US20080207652A1/en not_active Abandoned
- 2008-04-07 US US12/080,844 patent/US7875716B2/en not_active Expired - Fee Related
- 2008-04-29 HR HR20080194T patent/HRP20080194T3/xx unknown
- 2008-08-04 CY CY20081100816T patent/CY1108237T1/el unknown
- 2008-11-17 JP JP2008293362A patent/JP2009114192A/ja active Pending
-
2010
- 2010-06-08 US US12/796,481 patent/US8518954B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE395918T1 (de) | 2008-06-15 |
| DE602006001291D1 (de) | 2008-07-03 |
| PL1809292T3 (pl) | 2008-11-28 |
| US20080207652A1 (en) | 2008-08-28 |
| JP4637911B2 (ja) | 2011-02-23 |
| AU2006281359A1 (en) | 2007-02-22 |
| NZ553911A (en) | 2010-06-25 |
| HRP20080194T3 (en) | 2008-06-30 |
| SI1809292T1 (sl) | 2008-08-31 |
| US20070265444A1 (en) | 2007-11-15 |
| EP1809292A2 (en) | 2007-07-25 |
| US7718660B2 (en) | 2010-05-18 |
| WO2007020277A2 (en) | 2007-02-22 |
| PT1809292E (pt) | 2008-06-16 |
| US8518954B2 (en) | 2013-08-27 |
| AU2006281359B2 (en) | 2009-03-12 |
| ES2308749T3 (es) | 2008-12-01 |
| DK1809292T3 (da) | 2008-09-01 |
| CY1108237T1 (el) | 2014-02-12 |
| US7875716B2 (en) | 2011-01-25 |
| JP2008513418A (ja) | 2008-05-01 |
| EP1809292B1 (en) | 2008-05-21 |
| CA2583437C (en) | 2010-03-30 |
| US20100249141A1 (en) | 2010-09-30 |
| US20080214550A1 (en) | 2008-09-04 |
| EP1754484A1 (en) | 2007-02-21 |
| JP2009114192A (ja) | 2009-05-28 |
| CA2583437A1 (en) | 2007-02-22 |
| WO2007020277A3 (en) | 2007-04-26 |
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