RS20050734A - Oral formulations of cladribine - Google Patents

Oral formulations of cladribine

Info

Publication number
RS20050734A
RS20050734A YUP-2005/0734A YUP20050734A RS20050734A RS 20050734 A RS20050734 A RS 20050734A YU P20050734 A YUP20050734 A YU P20050734A RS 20050734 A RS20050734 A RS 20050734A
Authority
RS
Serbia
Prior art keywords
cladribine
oral formulations
cyclodextrin
compositions
oral administration
Prior art date
Application number
YUP-2005/0734A
Other languages
English (en)
Inventor
Nicholas Bodor
Yogesh Dandiker
Original Assignee
Ares Trading S.A.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading S.A., filed Critical Ares Trading S.A.,
Publication of RS20050734A publication Critical patent/RS20050734A/sr
Publication of RS51115B publication Critical patent/RS51115B/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Obezbeđene su kompozicije kladribina i ciklodesktrina koje su naročito pogodne za oralno davanje kladribina.
YUP-2005/0734A 2003-03-28 2004-03-26 Oralne formulacije kladribina RS51115B (sr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US45892203P 2003-03-28 2003-03-28
US48475603P 2003-07-02 2003-07-02
US54124704P 2004-02-04 2004-02-04
PCT/US2004/009387 WO2004087101A2 (en) 2003-03-28 2004-03-26 Oral formulations of cladribine

Publications (2)

Publication Number Publication Date
RS20050734A true RS20050734A (en) 2008-06-05
RS51115B RS51115B (sr) 2010-10-31

Family

ID=33135982

Family Applications (2)

Application Number Title Priority Date Filing Date
YUP-2005/0734A RS51115B (sr) 2003-03-28 2004-03-26 Oralne formulacije kladribina
YUP-2005/0735A RS20050735A (en) 2003-03-28 2004-03-26 Cladribine formulations for improved oral and transmucosal delivery

Family Applications After (1)

Application Number Title Priority Date Filing Date
YUP-2005/0735A RS20050735A (en) 2003-03-28 2004-03-26 Cladribine formulations for improved oral and transmucosal delivery

Country Status (28)

Country Link
US (2) US7888328B2 (sr)
EP (1) EP1608344B1 (sr)
JP (1) JP5256611B2 (sr)
KR (1) KR101129816B1 (sr)
AT (1) ATE476177T1 (sr)
AU (2) AU2004226437B2 (sr)
BR (2) BRPI0408848B8 (sr)
CA (1) CA2520523C (sr)
CY (2) CY1112591T1 (sr)
DE (1) DE602004028448D1 (sr)
DK (2) DK2272503T3 (sr)
EA (1) EA009944B1 (sr)
ES (1) ES2409884T3 (sr)
HK (2) HK1089654A1 (sr)
HR (1) HRP20050925A2 (sr)
HU (1) HUS1800013I1 (sr)
IL (1) IL213853A0 (sr)
IS (1) IS2799B (sr)
LT (1) LTC1608344I2 (sr)
LU (1) LUC00065I2 (sr)
ME (1) ME00249B (sr)
MX (1) MXPA05010329A (sr)
NO (1) NO20054945L (sr)
PL (1) PL1608344T3 (sr)
PT (1) PT1608344E (sr)
RS (2) RS51115B (sr)
SG (1) SG175450A1 (sr)
WO (1) WO2004087101A2 (sr)

Families Citing this family (14)

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ES2584183T3 (es) * 2003-03-28 2016-09-26 Ares Trading S.A. Formulaciones de cladribina para suministro mejorado oral y transmucosa
CA3087419C (en) 2004-12-22 2023-03-07 Merck Serono S.A. Cladribine regimen for treating multiple sclerosis
WO2007135172A2 (en) * 2006-05-24 2007-11-29 Laboratoires Serono S.A. Cladribine regimen for treating multiple sclerosis
EP2343074A1 (en) 2009-12-23 2011-07-13 Merck Serono S.A. Use of purine analogues for treating airway diseases
EP2428201A1 (en) 2010-09-08 2012-03-14 Merck Serono S.A. Oral administration of nucleoside monophosphates
WO2012097867A1 (en) 2011-01-18 2012-07-26 Synthon Bv Cladribine particles and pharmaceutical compositions comprising them
JP2021504363A (ja) 2017-11-24 2021-02-15 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 進行型多発性硬化症の処置における使用のためのクラドリビン処方計画
EP3628310A1 (en) 2018-09-25 2020-04-01 Synbias Pharma AG Pharmaceutical composition comprising solid dispersions of amorphous cladribine and pharmaceutically acceptable water soluble carrier
RU2748311C1 (ru) * 2020-01-29 2021-05-21 Общество с ограниченной ответственностью "ФармЭко" Фармацевтическая композиция, содержащая твердые дисперсии аморфного кладрибина и фармацевтически приемлемый водорастворимый носитель
BR112023003432A2 (pt) 2020-09-10 2023-03-21 Merck Patent Gmbh Regime de tratamento para o tratamento de doenças autoimunes
WO2022184867A1 (en) 2021-03-03 2022-09-09 Merck Patent Gmbh Improved treatment methods using dmds for the treatment of autoimmune diseases, and biomarker for predicting and/or optimising said treatment methods
RU2758436C1 (ru) * 2021-04-05 2021-10-28 Общество с ограниченной ответственностью «ФармЭко» Способ получения аморфных ко-эвапоратов кладрибина с циклодекстринами
WO2022229761A1 (en) * 2021-04-28 2022-11-03 Biophore India Pharmaceuticals Pvt Ltd SOLID FORM OF 2-CHLORO-2'-DEOXY-ADENOSINE COMPLEX WITH HPβCD
WO2023242285A1 (en) 2022-06-15 2023-12-21 Vektor Pharma Tf Gmbh Sublingual formulation of anticancer compound for use in the treatment of autoimmune neurodegenerative diseases

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Also Published As

Publication number Publication date
BRPI0408848B1 (pt) 2018-11-27
AU2010214777A1 (en) 2010-09-23
EP1608344B1 (en) 2010-08-04
BRPI0408848A8 (pt) 2017-12-26
US8785415B2 (en) 2014-07-22
LTC1608344I2 (lt) 2019-03-12
HK1150266A1 (en) 2011-11-18
AU2004226437A1 (en) 2004-10-14
WO2004087101A3 (en) 2005-02-03
KR101129816B1 (ko) 2012-03-26
CY2018005I1 (el) 2018-06-27
DK2272503T3 (da) 2013-05-21
DK1608344T3 (da) 2010-09-06
KR20060015487A (ko) 2006-02-17
PL1608344T3 (pl) 2011-01-31
US20070197468A1 (en) 2007-08-23
NO20054945D0 (no) 2005-10-25
ES2409884T3 (es) 2013-06-28
AU2010214777B2 (en) 2013-01-31
JP2006521403A (ja) 2006-09-21
HK1089654A1 (en) 2006-12-08
RS51115B (sr) 2010-10-31
BRPI0408848B8 (pt) 2021-07-27
LUC00065I1 (sr) 2018-02-14
LTPA2018502I1 (lt) 2018-03-12
EP1608344A2 (en) 2005-12-28
RS20050735A (en) 2008-06-05
DE602004028448D1 (de) 2010-09-16
BR122018068797B1 (pt) 2021-04-27
US20110097306A1 (en) 2011-04-28
IS2799B (is) 2012-09-15
ME00249B (me) 2011-05-10
MXPA05010329A (es) 2006-05-31
ATE476177T1 (de) 2010-08-15
MEP34308A (en) 2011-02-10
CA2520523C (en) 2011-10-11
EA200600404A1 (ru) 2006-08-25
US7888328B2 (en) 2011-02-15
HRP20050925A2 (en) 2006-08-31
HUS1800013I1 (hu) 2018-03-28
SG175450A1 (en) 2011-11-28
CA2520523A1 (en) 2004-10-14
IS8051A (is) 2005-09-28
BRPI0408848A (pt) 2006-04-04
AU2004226437B2 (en) 2010-06-03
IL213853A0 (en) 2011-07-31
NO20054945L (no) 2005-11-24
EA009944B1 (ru) 2008-04-28
CY2018005I2 (el) 2018-06-27
PT1608344E (pt) 2010-09-02
JP5256611B2 (ja) 2013-08-07
CY1112591T1 (el) 2016-02-10
WO2004087101A2 (en) 2004-10-14
LUC00065I2 (sr) 2018-03-28

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