RO92344B - Procedeu pentru prepararea unor derivati de cefalosporina - Google Patents
Procedeu pentru prepararea unor derivati de cefalosporinaInfo
- Publication number
- RO92344B RO92344B RO120580A RO12058084A RO92344B RO 92344 B RO92344 B RO 92344B RO 120580 A RO120580 A RO 120580A RO 12058084 A RO12058084 A RO 12058084A RO 92344 B RO92344 B RO 92344B
- Authority
- RO
- Romania
- Prior art keywords
- phenyl
- chloride
- preparing
- methylisoxazol
- general formula
- Prior art date
Links
- HOKIDJSKDBPKTQ-UHFFFAOYSA-N 3-(acetyloxymethyl)-7-[(5-amino-5-carboxypentanoyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical class S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)C(NC(=O)CCCC(N)C(O)=O)C12 HOKIDJSKDBPKTQ-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- AJYXPNIENRLELY-UHFFFAOYSA-N 2-thiophen-2-ylacetyl chloride Chemical compound ClC(=O)CC1=CC=CS1 AJYXPNIENRLELY-UHFFFAOYSA-N 0.000 abstract 1
- -1 3-phenyl-5-methylisoxazol-4-yl Chemical group 0.000 abstract 1
- SXNYZGXPHZNWCR-UHFFFAOYSA-N 4-chloro-5-methyl-3-phenyl-1,2-oxazole Chemical compound ClC1=C(C)ON=C1C1=CC=CC=C1 SXNYZGXPHZNWCR-UHFFFAOYSA-N 0.000 abstract 1
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Cephalosporin Compounds (AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea unor derivati de cefalosporina cu formula generala I : în care R1 reprezinta alchil cu 1..4 atomi de carbon, alchenil cu 2,,4 atomi de carbon, fenil sau benzil, ultimii fiind eventual substituiti cu unul sau 2 atomi de halogen, R2 reprezinta 3-fenil-5-metilizoxazol-4-il, daca b este 0,2-tienil daca b este 1, constînd din aceea ca un derivat de acid 7-aminocetalosporanic cu formula generala II : în care R1 are semnificatiile de mai sus se trateaza cu o clorura acida, aleasa dintre clorura de 3 fenil-5-metilizoxazol-4-il si clorura de 2 tienilacetil, în prezenta unui amestec de apa si acetona ca solvent, la o temperatura cuprinsa între 0 si 25 degree C si la un pH de 7..8, dupa care daca se doreste, compusul cu formula I obtinut se transforma într-o sare acceptabila farmaceutic prin metode în sine cunoscute.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU800883 | 1983-04-19 | ||
| PCT/HU1984/000026 WO1984004096A1 (en) | 1983-04-19 | 1984-04-19 | Novel cephalosporin derivatives, pharmaceutical compositions containing the same, their use in therapy as antibiotics and a process for the preparation of the novel compounds |
| HU409684 | 1984-10-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO92344B true RO92344B (ro) | 1987-09-02 |
| RO92344A RO92344A (ro) | 1988-06-30 |
Family
ID=27270034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO84120580A RO92344A (ro) | 1983-04-19 | 1984-12-17 | Procedeu pentru prepararea unor derivati de cefalosporina |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO92344A (ro) |
-
1984
- 1984-12-17 RO RO84120580A patent/RO92344A/ro unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RO92344A (ro) | 1988-06-30 |
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